Ahmed Ibrahim Abd Elneam

• professor ( Assistant) of human molecular genetics
• Assistant professor of human molecular genetics at Human genetic institute . National Research Center Egypt

Background: Diabetic retinopathy is one of the leading causes of blindness globally, among individuals with diabetes mellitus. Early detection through screening can help in preventing disease progression. In recent advancements artificial Intelligence assisted screening has emerged as an alternative to traditional manual screening methods. This dia...

Vitiligo is a chronic skin disorder characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The molecular mechanisms underlying vitiligo remain incompletely understood, with recent studies highlighting the role of non-coding RNAs in disease pathogenesis. To identify and analyze the roles of miRNAs, (circular RNAs) ci...

Aim This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in the epidermis, by examining their structural, functional, and regulatory roles in skin biology. The study explores the intricate processes of keratinocyte differentiation, proliferation, and immune interactions, emphasizing their essential contrib...

Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss. Despite the growing understanding of its immune-related pathogenesis, biomarkers for early diagnosis and disease severity assessment remain limited. Recent studies have suggested that microRNAs (miRNAs) play a crucial role in regulating immune responses and infl...

Introduction Alopecia areata (AA), is a common autoimmune nonscarring alopecia. Vitamin D is involved in various biological processes such as immune regulation, cellular growth, and specialization, as well as the maintenance of the hair cycle. We aimed to explore the impact of different Tru9I variant genotypes on serum vitamin D levels and vitamin...

Introduction Female genital self-image (FGSI) refers to one’s perception of the external and internal appearance of female genitalia. FGSI is a multidisciplinary research area influenced by psychological, sociocultural, and clinical factors, influencing sexual satisfaction, desire, self-perception, and partner perception. Objectives The review aim...

Introduction Hair removal is a fundamental aspect of daily life, with various hair removal methods evolving throughout hair removal history to meet cultural, aesthetic, and spiritual needs. Traditional hair removal practices have long sought effective hair removal products that not only remove hair but also promote skin health. Cyperus rotundus L....

Background Mucocutaneous leishmaniasis (MCL) is a severe form of leishmaniasis causing chronic and destructive lesions. Accurate diagnosis is crucial for effective treatment. Traditional methods, such as the Montenegro skin test is delayed hypersensitivity test. Polymerase chain reaction (PCR) has emerged as a superior diagnostic tool for detecting...

Background Depigmentation of specific areas of the skin is a persistent and long-lasting dermatologic disorder known as vitiligo, stemming from the impairment and disruption of melanocytes both structurally and functionally, leading to the loss of pigmentation in those regions. Aim Our objective was to identify the pivotal genes and upstream regul...

The Background: The etiology of numerous medical conditions, such as metabolic irregularities, is interconnected with the insufficiency of vitamin D. Furthermore, a theoretical association between the resistance to insulin and the insufficiency of vitamin D has been postulated. This concept is substantiated by empirical evidence obtained through va...

The Background: The etiology of numerous medical conditions, such as metabolic irregularities, is interconnected with the insufficiency of vitamin D. Furthermore, a theoretical association between the resistance to insulin and the insufficiency of vitamin D has been postulated. This concept is substantiated by empirical evidence obtained through va...

Background Acne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on the face, upper limbs, torso, and back, with comedones formation being the primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, and psychological i...

Background MicroRNAs (miRNAs) are small RNA molecules that play a regulatory role in various biological processes by acting as intracellular mediators. They hold great potential as therapeutic agents for targeting human disease pathways; however, there is still much to be uncovered about their mechanism of gene regulation. Alopecia areata (AA) is a...

Background Alopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, and alopecia universalis. It can affect a person's psychological health and overall quality of life. Elevated C‐reactive protein...

Background MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression in diverse biological processes. They hold promise as therapeutic candidates for targeting human disease pathways, although our understanding of their gene regulatory mechanism remains incomplete. Alopecia areata (AA) is a prevalent inflammatory ailment distinguishe...

Background and aims Psoriasis is a chronic, non‐contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, and erythrodermic psoriasis are the five primary kinds. About 90% of cases are of plaque ps...

Background Insulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood glucose levels. Interleukin‐12 (IL‐12), a cytokine, regulates the immune system. High levels of IL‐12 can lead to chronic inflammation, exacerbate resistance to insulin, and contribute to type 2 diabetes. Al...

Background: Acne vulgaris (AV) is a chronic, multifactorial inflammatory disease of the pilosebaceous unit brought on by hormonal imbalance, excessive sebum production, follicular hyperkeratinization, inflammation and Cutibacterium acne. Acne patients are characterized by alteration of the lipid profile. Apolipoprotein B gene (ApoB) plays an essen...

Background: The contribution of insulin to acne is that it stimulates the synthesis of androgenic hormones, which are important in the development of excess sebum, hyperkeratinization, and sebaceous gland cell growth. Objective: To ascertain whether the lipid profile abnomalies seen in acne vulgaris are genetically induced, we also seek to estab...

Background Macrophage scavenger receptor 1 gene (MSR1), is responsible for producing macrophage scavenger receptors. MSR1 is primarily located on the surfaces of various macrophage types and is known to exert a range of effects on the human body. These effects include influencing innate and adaptive immunological reactions, as well as contributing...

A series of chalcones were synthesized and characterized by different spectroscopic techniques. The antioxidant properties of the compounds were evaluated through different free radical-scavenging assays. It was observed that some compounds exhibited strong scavenging activity against nitric oxide, DPPH, and hydroxyl radicals. The synthesized compo...

Key Clinical Message Teledermatology is a branch of dermatology that transmits medical data over several miles using telecommunications technologies. It involves the diagnosis of skin lesions using digital photographs and related patient data, and it can be especially helpful for patients in remote areas who might not have convenient access to derm...

Background and Aims Acne is a frequently diagnosed skin condition that causes pilosebaceous apparatus clogs and/or inflammatory responses in the majority of teenagers. It is a multifactorial disease that can develop due to various factors. We aimed to evaluate lipid profiles and hormonal levels in patients with acne and correlate them to acne sever...

Background The incidence of alopecia areata (AA) has increased over the last few decades. Trichoscopy is a noninvasive procedure performed in dermatology clinics and is a helpful tool in determining the correct diagnosis of hair loss presentations. Objective Through mapping the researches that have been done to represent the spectrum of trichoscop...

ABSTRACT Background : Vitamin D (VD) insufficiency has been linked to a number of autoimmune illnesses including, alopecia areata (AA). To distinguish between clinically common hair problems, trichoscopy is a beneficial non-invasive, rapid, and affordable procedure that is yet neglected. Objective : to evaluate trichoscopic patterns and severit...

Background: Many clinical features of psoriasis include a rash with itchy, scaly patches, most frequently on the knees, elbows, trunk, and scalp. By studying genes involved with psoriasis receptivity, the pathologic pathways of psoriasis become clearer and more understood. Aim: To predict the participation of rs1544410 in serum vitamin D levels (SD...

Immunotherapy has emerged as a critical therapeutic tool for the treatment of warts. Immunotherapy for warts is currently restricted to recalcitrant lesions.Conventional therapy is not working despite the fact that there are numerous immunotherapeutic agents available. A small number of regimens appear to be extremely effective. Furthermore, there...

Impetigo is a prevalent bacterial skin infection of the youngsters. Ozenoxacin is a new quinolone topical antibacterial agent that was developed as a 1% cream for the treatment of impetigo. The purpose of this study, which included a systematic review and meta-analysis, was to map the research and present the effectiveness of ozenoxacin 1% topic...

Background and aim: Psoriasis is a chronic, relapsing and inflammatory multisystemic disease with both genetic predisposition and autoimmune pathogenic traits. Several types of vitamin D receptor (VDR) polymorphisms have been investigated as a predisposing factor for psoriasis susceptibility with controversial results. However, the exact pathophys...

Background During and after the coronavirus disease 2019 (COVID-19) pandemic, there was a significant increase in the demand for aesthetic procedures nationwide. We believe that one of the factors contributing to this increase was the use of video conferencing apps. Therefore, the purpose of this study was to analyze the aesthetic concerns that wer...

Background: Several types of polymorphisms in vitamin D receptor (VDR) have been found in psoriasis. Aim: this study looked at the role of the TaqI polymorphism in the VDR gene as a factor in changing plasma 25-hydroxyvitamin D (25(OH)D) levels in psoriasis patients and to see if it had any relationship with disease severity. Subjects and Method...

Background: Immunotherapy has emerged as a critical therapeutic tool for the treatment of warts. Immunotherapy for warts is currently restricted to recalcitrant lesions. A small number of regimens appear to be extremely effective. Furthermore, there is a scarcity of evidence-based research. Objective: Furthermore, in the majority of cases, their...

.ABSTRACT: Background. Psoriasis vulgaris is a chronic, relapsing, inflammatory disorder marked by an intensified immune response. The role of immunogenetics in psoriasis is still poorly understood; however, experts agree that its expression depends on proinflammatory cytokines. Forkhead box class O3A (FOXO3a), a transcription factor, plays a cruci...

Background: Several types of polymorphisms in vitamin D receptor (VDR) have been found in psoriasis. Aim: this study looked at the role of the TaqI polymorphism in the VDR gene as a factor in changing plasma 25-hydroxyvitamin D (25(OH)D) levels in psoriasis patients and to see if it had any relationship with disease severity. Subjects and Methods:...

The study of the toxicological effect of nicotine is very important to understand the mechanism of tobacco-induced human diseases and to evaluate the potential risk factors associated with the therapeutic use of nicotine as an aid in quitting smoking. There are 15 male albino rats divided into two groups; group I; the control group administered nor...

Background Acne vulgaris is a common chronic inflammatory skin disorder of pilosebaceous units. Isotretinoin (13-cis retinoic acid) is the most effective multifunctional treatment for moderate-to-severe and nodulocystic acne. Vitamin D plays a role in the immune system, and its deficiency might contribute to the pathogenesis of acne. Objective To...

[This corrects the article DOI: 10.2147/CCID.S271500.].

Background Vitamin D plays a significant role in the function of the immune system and it influences many dermatological diseases such as psoriasis and atopic dermatitis. The prevalence of vitamin D deficiency is growing globally, with around 30–50% of people are known to have low levels of vitamin D. Acne vulgaris is a common inflammatory disorder...

Phototherapy: broadband UVB (BUVB), narrowband UVB (NB-UVB) and heliotherapy) is commonly used treatment modalities for widespread psoriasis. Vitamin D3, cholecalciferol, is produced in the epidermis by ultraviolet radiation (290-315 nm) of 7-dehydrocholesterol. 25-hydroxyvitamin D [25(OH) D], and 1, 25-dihydroxyvitamin D [1, 25(OH) 2D] are the maj...

BACKGROUND: Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder. AIM: To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis....

BACKGROUND: Diabetic nephropathy (DN) is known as an acute microvascular complexity as a subsequence progression in diabetes mellitus type 1 and 2. Many evidence pointed that the proinflammatory cytokine Interleukin (IL)-18 might be involved in the pathogenesis of DN. AIM: The current study aimed to evaluate the association of serum IL-18 and its...

Apo lipoprotein E (Apo E) plays a role in some diseases related to lipid metabolism. 122 obese adult females (BMI ≥30 Kg/m2): 56 of them with visceral obesity (≥7cm by abdominal ultrasound) and 66 without visceral obesity and 36 age matched non-obese (BMI ≤25 kg/m2) without visceral obesity were studied. Anthropometric assessment, visceral obesity...

Background: Regional distribution of adipose tissue is more important than total amount of body fat in predicting complications associated with obesity. Apolipoprotein B (Apo B) plays a central role in lipid metabolism. Aim: To investigate the importance of the XbaI polymorphism of Apo B gene (C7673T) as risk factor for visceral obesity and its inf...

OBJECTIVE: To determine the human brucellosis incidence rate and trends and its pre-disposing patients' characteristics (age, gender) over a period of five years (2010-2014) in Central Saudi Arabia (DawadmiGovernate) METHODS: This is a retrospective study involved the review of 2600 medical records of suspected human brucellosis patients in a Dawad...

Aim: Mitochondrial DNA (mtDNA) content is essential for maintaining normal mitochondrial function, and the mitochondrial function is critical for the production and the release of insulin in type 2 diabetes mellitus. We investigated whether peripheral blood mtDNA content was reduced in type 2 diabetes. Methods: Fifteen Egyptian Type 2 diabetes (T2D...