Ahmad Fazilat

• Doctor of Philosophy
• Researcher at Motamed Cancer Institute Breast Cancer Research Centre

The tumor microenvironment (TME) contains tumor cells, surrounding cells, and secreted factors. It provides a favorable environment for the maintenance of cancer stem cells (CSCs), the spread of cancer cells to metastatic sites, angiogenesis, and apoptosis, as well as the growth, proliferation, invasion, and drug resistance of cancer cells. Cancer...

Ferroptosis is a type of cell death that multiple mechanisms and pathways contribute to the positive and negative regulation of it. For example, increased levels of reactive oxygen species (ROS) induce ferroptosis. ferroptosis unlike apoptosis, it is not dependent on caspases, but is dependent on iron. Exosomes are membrane‐bound vesicles with a si...

Autism spectrum disorder (ASD) is a pervasive neurobehavioral condition characterized by disruption of behavioral and emotional patterns in individuals with this condition. Given that various environmental and genetic factors play a fundamental role in the pathophysiology of ASD, it can be said that ASD is a multifaceted disease. This study used sc...

One of the biggest challenges of today's society is cancer, which imposes a significant financial, emotional and spiritual burden on human life. Breast cancer (BC) is one of the most common cancers that affects people in society, especially women, and due to advanced treatment strategies and primary prevention, it is still the second cause of cance...

Objectives Breast cancer (BC) stands as the second-leading cause of female-specific cancer-related fatalities globally, necessitating comprehensive research to address its critical aspects. This study aimed to explore the time intervals between surgery and disease recurrence in BC patients and their survival utilizing various parametric and semi-pa...

Breast cancer (BC) is one of the most common cancers among women and can be fatal if not diagnosed and treated on time. Various genetic and environmental factors play a significant role in the development and progression of BC. Within the body, different signaling pathways have been identified that contribute to cancer progression, or conversely, c...

Cell culture-based technologies are widely utilized in various domains such as drug evaluation, toxicity assessment, vaccine and biopharmaceutical development, reproductive technology, and regenerative medicine. It has been demonstrated that pre-adsorption of extracellular matrix (ECM) proteins including collagen, laminin and fibronectin provide mo...

Background Ovulatory PCOS (OPCOS) is the mildest form of polycystic ovarian syndrome among all four determined phenotypes. Though the females with OPCOS are ovulating, but hyperandrogenism and polycystic ovarian morphology increase the susceptibility of cardiovascular diseases, insulin resistance, hyperlipidemia and metabolic syndrome in these fema...

Objective: Many studies have showed that foot ulcer is the most frequent occurrence among diabetic patients in the south Indian origin. This study aimed to investigate on the hypothesis that in patients with diabetic foot ulcer in south Indian subjects there is a substitution within nucleotide sequence of coding region related to insulin gene and t...

Background/Objectives: To understand the genotoxicity and cytotoxicity potentials in tobacco-chewing habitues from coastal Andhra Population. Place and Duration of Study: Translational Research Institute of Molecular Sciences, between October 2013 to October 2014. Methods/Statistical Analysis: Present study was carried out using 35 individuals (28...