Ah-Lai Law

Ah-Lai Law
King's College London | KCL · Randall Division of Cell and Molecular Biophysics

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10
Publications
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297
Citations

Publications

Publications (10)
Article
Full-text available
Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. Here we identify Nance-Horan Syndr...
Preprint
Full-text available
Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. We have identified Nance-Horan Syn...
Data
Video S1: Intravital imaging of ZsGreen-Ctrl-shRNA tumor.? Representative 30 minute time lapse movie from multiphoton imaging of a ZsGreen-Ctrl-shRNA tumor. Cyan= Zsgreen-positive cells, red= collagen fibers. Images were taken every 2 min for 30 min. Video is played at 5 frames per second. Video S2: Intravital imaging of ZsGreen-Lpd-shRNA2 tumor.?...
Article
Full-text available
Phagocytosis of apoptotic cells by macrophages and spent photoreceptor outer segments (POS) by retinal pigment epithelial (RPE) cells requires several proteins including MerTK receptors and associated Gas6 and Protein S ligands. In the retina, POS phagocytosis is rhythmic and MerTK is activated promptly after light onset via the alphavbeta5 integri...
Article
Full-text available
Cell migration is essential for development, but its deregulation causes metastasis. The Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, but its regulation in vivo is enigmatic. Lamellipodin (Lpd) controls lamellipodium formation through an unknown mechanism. Here, we report that Lpd directly binds...
Article
Full-text available
The epidermal growth factor receptor (EGFR) plays an essential role during development and diseases including cancer. Lamellipodin (Lpd) is known to control lamellipodia protrusion by regulating actin filament elongation via Ena/VASP proteins. However, it is unknown whether this mechanism supports endocytosis of the EGFR. Here, we have identified a...
Article
Full-text available
Mitochondrial homeostasis is critical in meeting cellular energy demands, shaping calcium signals and determining susceptibility to apoptosis. Here we report a role for anxA6 in the regulation of mitochondrial morphogenesis, and show that in cells lacking anxA6 mitochondria are fragmented, respiration is impaired and mitochondrial membrane potentia...
Article
Full-text available
Photoreceptor shedding and its phagocytosis by the retinal pigment epithelium is a crucial process in the renewal of the light-sensitive photoreceptor outer segments (POS). This internalization process shares many components used by macrophages in apoptotic cell clearance, but is unique in that this process is rhythmic. This chapter discusses the m...
Article
Full-text available
The daily phagocytosis of shed photoreceptor outer segments by pigment epithelial cells is critical for the maintenance of the retina. In a subtractive polymerase chain reaction analysis, we found that functional differentiation of human ARPE19 retinal pigment epithelial (RPE) cells is accompanied by up-regulation of annexin (anx) A2, a major Src s...

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