Agustina Endharti

• University of Brawijaya

Context: Breast cancer is characterized by the abnormal growth of cells in the ducts and lobules of the breast. Numerous therapeutic targets for breast cancer are currently under investigation, one of which is matrix metalloproteinase-2 (MMP-2), a heterodimeric protein highly expressed in circulating tumor cells from patients with pancreatic carcin...

While the beneficial effects of colchicine on inflammation and infarcted myocardium have been documented, its impact on cardiac fibroblast activation in the context of myocardial infarction (MI) remains unknown. This study aimed to investigate the effect of colchicine on the regulation of NOD-like receptor family, pyrin domain containing 3 (NLRP3)...

Context: The dysregulation of the phosphoinositide 3-kinase protein kinase B (PI3K/AKT) signaling pathway has been associated with diabetes and its complications. Cinnamaldehyde (CA) can potentially inhibit diabetes complications through its pleiotropic effects, including anti-inflammatory, anti-oxidative, and anti-apoptosis. However, whether these...

Context: Cancer is one of the causes of death throughout the world. There are around 9.6 million deaths from cancer every year throughout the world, with 70% of cancer deaths occurring in developing countries in the world. Natural species like Anredera cordifolia is the old-world diamond flower. It is historically important in traditional Chinese m...

Context: Endometriosis is a condition marked by the presence of endometrial epithelium and stromal cells outside the uterus. Previous studies have shown that prostaglandin E2 has a role in the development of endometriosis via the action of local estrogen and estrogen receptors. Aims: To analyze the molecular docking between Phaleria macrocarpa flav...

Background: Caspase-1 (reflects NOD-like receptor protein 3 inflammasome activity), transforming growth factor-β (TGF-β), and Galectin-3 play significant roles in post-AMI fibrosis and inflammation. Recently, colchicine was shown to dampen inflammation after AMI; however, its direct benefit remains controversial. Objectives: This study aimed to ana...

While the beneficial effects of colchicine on inflammation and infarcted myocardium have been documented, its impact on cardiac fibroblast activation in the context of MI remains unknown. This study aimed to investigate the effect of colchicine on the regulation of NLRP3 inflammasome activation and IL-1β expression in fibroblasts. The 3T3 fibroblas...

Background: Caspase-1 (reflects NOD-like receptor protein 3 inflammasomes activity), transforming growth factor-β (TGF-β), and Galectin-3 play significant role in post-AMI fibrosis and inflammation. Recently, colchicine was shown to dampen inflammation after AMI, however, its direct benefit remains controversial. Objectives. This study aimed to ana...

Context: Cancer represents a significant global health challenge, marked by elevated morbidity and mortality rates. Evodia suaveolens is a native medicinal plant from Papua, Indonesia. Earlier studies hinted at the possibility that E. suaveolens may have anticancer properties, likely due to its high levels of antioxidants. Aims: To evaluate antican...

Hepatocellular carcinoma (HCC) with high epidemiological report data. Pathogenesis in HCC also involves several signaling pathways. This study aims to evaluate the in vitro activity of Moringa seed NanoChitosan against Hep G2 liver cancer cells and Co-Treatment with Doxorubicin. Initially, nanoparticles were prepared by extracting Moringa seeds, fo...

Inflammation is an important process that fights infections and allows the repair of tissues; however, chronic inflammation is implicated in many diseases, including autoimmune diseases and tumorigenesis. Central to this process are the Interleukin-1 receptor and Tumor Necrosis Factor receptor that mediate the action of the pro-inflammatory cytokin...

Context: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the therapeutic potential of the ethanol extract derived from Volvariella volvacea in combination with cetuximab for CRC. Aims: To evaluate the inhibition of topoisomerase II alpha (TOP2A) and...

Basis research was done for long-term exploration of herbal medicines or therapeutical combination ingredients in the standard drug model doxorubicin to minimize long-term side effects on patients, especially in breast cancer cases. This study focuses on exploring the effect of Moringa seeds encapsulated with nanoparticle-based chitosan or their in...

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by uncontrolled proliferation of myeloid progenitor cells in the bone marrow. The standard chemotherapy in treating AML cases is anthracycline, including doxorubicin; however, it could cause severe side effects if administered continuously at high doses, making it less tolerab...

Since the majority of the current therapies lack effectiveness and efficiency in treating Multiple Sclerosis, in addition to their high cost, monitoring during usage, and the serious side effects associated with using this therapy, which in some cases may be fatal, for these reasons, there is a necessary need for effective therapy in the clinical s...

Background Lymphomas are malignant lymphocyte neoplasms that globally account for 10% of cancers in individuals aged <20 years. Malignant lymphomas are divided into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Despite the availability of many therapeutic modalities for lymphoma, such as Brentuximab vedotin, Nivolumab, and Pembrolizumab...

Context: On a cellular level, osteoporosis is a metabolic bone disease caused by osteoclastic bone resorption that is not offset by osteoblastic bone synthesis. This increases the risk of fractures by making bones weak and brittle. The selective inactivation of the epidermal growth factor receptor (EGFR) in osteoblast lineage cells demonstrated tha...

Context: Breast cancer expresses high levels of the estrogen receptor alpha (ER-α). Aims: To investigate the potential anticancer activity of nanoliposome Hedyotis corymbosa in breast cancer cells by specifically targeting the ER-α through a combination of in silico and in vitro studies. Methods: This study used molecular docking to analyze the int...

Introduction: Osteosarcoma is the most common primary non-hematopoietic malignant bone tumor, which reportedly has a high incidence in several regions of the world including South-east Asia. However in Indonesia, the data regarding osteosarcoma trends and clinicopathological features are still lacking. Therefore, this paper aims to describe the cli...

Introduction Immunotherapy has been widely used in the treatment of various malignancies with satisfactory results. One of the agents for immunotherapy is an inhibitor of programmed cell death-1 and its ligands (PD-1 and PD-L1). However, attempts at utilizing PD-1/PD-L1 immunotherapy in osteosarcoma have not yielded favorable results. This may be d...

Invasive non-typhoidal Salmonella is an important pathogen that causes life-threatening bloodstream infections. Antibiotic resistance in non-typhoidal Salmonella has emerged as a result of the increasing use of antibiotics; therefore, an alternative source of therapeutic agents is required. This study aimed to investigate the active compound and an...

Lymphomas are a lymphocyte-driven malignancy that comprise up to 10% of cancers diagnosed in individuals < 20 years of age globally. Malignant lymphomas are divided into Hodgkin Lymphoma (HL) and Non Hodgkin Lymphoma (NHL). In 2019 at United States, more than 82.000 new patients diagnosed with lymphoma. Since the epidemiology of Lymphoma is differe...

Interleukin 6 (IL-6) has been identified as a predictor of severity and mortality in COVID-19. Although morbidity and mortality generally increase with age, it remains uncertain whether there is a correlation between age and IL-6 levels, thereby exacerbating the severity of COVID-19 in patients. The objective of this study was to examine the correl...

A common neurodegenerative condition that still presents clinical challenges is Multiple Sclerosis (MS). Effective multiple sclerosis treatments are sorely needed in clinical settings. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model of multiple sclerosis, a T-cell-mediated disease. Active T-cells differentiate into the Th9 and Th...

Malaria is a disease caused by Plasmodium infection. Of the 5 species that infect humans, Plasmodium vivax and Plasmodium falciparum are the two most common species found in Indonesia. Early and accurate diagnosis is crucial for effective treatment and disease management. Conventional diagnostic methods, microscopy, and rapid diagnostic tests (RDTs...

Sepsis merupakan disfungsi organ yang mengancam nyawa yang terjadi akibat respons host yang buruk terhadap adanya infeksi. Sepsis menyebabkan morbiditas dan mortalitas yang tinggi khususnya pada kondisi sepsis berat atau syok sepsis. Salah satu pendekatan yang dapat dilakukan untuk mengatasi hal tersebut adalah dengan diagnosis dan tata laksana din...

Introduction Keloids are excessive fibroproliferative diseases that are caused by abnormal wound healing. The anti-proliferative activity of Physalis angulata compounds has potential as a keloid therapeutic agent. This study aimed to observe the effects of P. angulata on fibroblast viability and collagen type I, tissue inhibitor of metalloproteinas...

Background: The most common type of lips and oral cavity cancer is oral squamous cell carcinoma (OSCC). Doxorubicin (DX) is commonly used as a chemotherapy drug, but its use is limited due to risk factors and drug resistance. Chrysanthemum cinerariifolium (Trev.) (CC) has potential as an anticancer agent. Combining the plant extract and chemotherap...

Malaria remains to be a national and global challenge and priority, as stated in the strategic plan of the Indonesian Ministry of Health and Sustainable Development Goals. In Indonesia, it is targeted that malaria elimination can be achieved by 2030. Unfortunately, the development and spread of antimalarial resistance inflicts a significant risk to...

Background COVID-19 is caused by SARS-CoV-2 and has a wide range of symptoms. While Diabetes Mellitus (DM) is a common comorbidity in COVID-19 patients, it is the main comorbidity in non-surviving COVID-19 patients. Interleukin-8 (IL-8) is a cytokine that has been correlated with severity and mortality in COVID-19 patients, but its role in COVID-19...

Purpose Candida albicans (C. albicans) is a fungus that causes superficial and invasive candidiasis in its host. Caspofungin, has been widely used as a synthetic antifungal, whereas holothurin has been shown to have potential as a natural antifungal. The purpose of this study was to see how holothurin and caspofungin affected the number of C. albic...

Colorectal cancer is a malignant neoplasm disease and is defined as a malignancy that occurs in the large intestine. In the world colon cancer ranks fourth meanwhile in Indonesia, colon cancer placed in the third rank after another cancer. The aim of this study is to find alternative way to help chemotherapy agent that already exist which is 5-FU f...

Purpose During Plasmodium berghei (P. berghei) infection, infected erythrocytes are sequestered in gut tissues through microvascular circulation, leading to dysbiosis. This study aimed to investigate the effect of Lactobacillus casei (L. casei) and Bifidobacterium longum (B. longum) administration on the parasitemia level, gut microbiota compositio...

Until now, the modality of choice for patients with acute myeloid leukemia (AML) is chemotherapy. However, chemotherapy has resulted in severe side effects, especially for AML patients aged over 60 years. In addition, cases of multidrug resistance (MDR) have been reported. Pleurotus ostreatus or oyster mushroom has been widely known to possess anti...

Immunosenescence triggers increased morbidity in geriatrics; therefore, therapeutic intervention is required. This study aims to find out the effect of mango mistletoes/Dendrophthoe pentandra (MM/Dp) towards CD4/CD8 ratio, CD4⁺CD28⁻ percentage, CD8⁺CD28⁻ percentage, and IL-2 level on old female mice. The mango mistletoes leaves were extracted using...

Leukemia ranked 11th in the incidence rate of all cancers worldwide, and acute myeloid leukemia (AML) has the highest leukemia mortality rate at 62%. Protein inhibition in the autophagy mechanism combined with cytarabine as the main chemotherapy treatment for AML can improve the effectiveness of drugs that have already developed resistance. Protein...

Targeted therapy treatment in Colorectal Cancer (CRC) works specifically on a protein or target cell in cancer. It plays a role in the survival of cancer cells. Targeted therapy involves several monoclonal antibodies, one of which is cetuximab which targets the Epidermal Growth Factor Receptor (EGFR). However, there are cases of cetuximab resistanc...

BACKGROUND: The previous studies have identified chemical compounds in sea cucumbers that have antifungal properties. However, further information on the underlying antifungal needed to be updated. AIM: This study aimed to discover efficient antifungal treatments against candidiasis disease. MATERIALS AND METHODS: This study analyzed the antifungal...

Background Update diagnostic methods play essential roles in dealing with the current global malaria situation and decreasing malaria incidence. Aim Global malaria control programs require the availability of adequate laboratory tests in the quick and convenient field. Results There are several methods to find out the existence of parasites withi...

Background and aim: The morbidity and mortality of Shigella infections remain a global challenge. Epitope-based vaccine development is an emerging strategy to prevent bacterial invasion. This study aimed to identify the ability of the 49.8 kDa pili subunit adhesin protein epitope of Shigella flexneri to induce an intestinal immune response in mice...

BACKGROUND: Fertility is affected by both the reproductive organs and external factors (genetics, hormones, radiation exposure, use of insecticides, and nutrition). The histological structure of the ovaries is an indicator of reproductive function. Insect repellent use with pyrethroid active ingredients and its impact on health has become a discuss...

Objectives: This study investigates the amino acid sequence and identifies antigenic epitopes of 49.8 kilodalton (kDa) pili protein Shigella flexneri, which will be used as candidates for the shigellosis vaccine. Materials and methods: Our study is a prospectively descriptive laboratory. We used bacterial isolate of S. flexneri pili isolation wa...

MicroRNAs (miRNAs) have ability to down-regulate gene expressions. hsa-miR-17-5p, has been confirmed as an oncogene or tumor suppressor. However, the existence on human adipose-derived stem cells (ADSCs) or adipocytes, is still unclear. Many researchers emphasizing the role of hsa-miR-17-5p on cellular senescence, aging and cancer, but not specific...

Thymoquinone is an active compound in Nigella sativa which has potential immunomodulatory effect. Mycobacterium tuberculosis could alter the Th1 and Th2 balance by stimulating phagocyte IL-1β production, and subsequent Th2 differentiation. We aim to evaluate the effect of thymoquinone (TQ) in restore the Th1 and Th2 balance in Mycobacterium tubercu...

Background: Based on thermal temperatures around the breast, thermography is considered a promising approache providing information about the condition of the breast without any side effects. Objective: Using thermography, breast screening is highly dependent on the process of heat recognition. The angular effects in the process of thermal patte...

The aim of this study is to investigate the combination treatments of paclitaxel and chitosan-Dendrophthoe pentandra leaves extract nanoparticles (NPDP) on MCF-7 breast cancer cells. Chitosan-NPDP nanoparticles were characterized by Fourier-transform infrared (FTIR), scanning electron microscopy (SEM), and assessed by using immunofluorescence micro...

Background: The senescence process in human dermal fibroblasts (HDFs) is caused by cell cycle withdrawal processes, one of which is the result of the retinoblastoma (Rb) protein being in a hypo-phosphorylated state. Since adipose-derived stem cells (ADSCs) have a paracrine effect, ADSCs were utilized to improve the senescence process of HDFs. The u...

About 70-75% of reproductive women have experienced vulvovaginal candidiasis at least once and 40-45% will have recurrences. Candida albicans is the most etiology of vulvovaginal candidiasis and is able to form biofilm that can lead to antifungal resistances and recurrences. One of the natural products that have an antibiofilm effect is propolis. T...

Vulvovaginal candidiasis occurs in 70 - 75% of women. About 40 - 45% of them experience vulvovaginal candidiasis for the second time. Approximately 70 - 89% of these infections are caused by Candida albicans. Candida albicans forming biofilm are reported to have a higher resistance to most anti-fungal drugs, including fluconazole. Objective: To det...

BACKGROUND: In the senescence process, the retinoblastoma (Rb) protein binds to E2F in hypophosphorylated conditions, preventing the cell to enter the S-phase in the cell cycle. Human Forkhead Box M1 (FOXM1) protein, key regulator G1/S and G2/M phases, decreases in the senescence process. Many studies have been carried out to reverse this system, o...

BACKGROUND: Population aging is considered to be a global phenomenon today. Age-associated immune system dysfunction or “immunosenescence” is indicated by increased susceptibility to infections and chronic diseases, such as hypertension, diabetes mellitus, autoimmune diseases, heart disease, and atherosclerosis. One of the immunosenescence markers...

Kurangnya pengetahuan masyarakat tentang COVID-19, lupus, reumatik, dan alergi mempengaruhi keberhasilan terapi, penurunan angka kejadian, dan pencegahan kekambuhan. Tujuan pengabdian masyarakat adalah membangun desa-desa binaan tanggap COVID-19, lupus, reumatik, dan alergi di Malang oleh Tim Kelompok Kajian Lupus, Autoimun, Reumatik, dan Alergi (L...

About 70-75% of reproductive women have experienced vulvovaginal candidiasis at least once and 40-45% will have recurrences. Candida albicans is the most etiology of vulvovaginal candidiasis and is able to form biofilm that can lead to antifungal resistances and recurrences. One of the natural products that have an antibiofilm effect is propolis. T...

Background: Triple-negative breast cancer (TNBC) tends to be aggressive and metastatic, characteristics attributable to its cellular migration capabilities. Afzelin is a chemical compound with anti-metastatic potentials. This study aimed to predict proteins involved in TNBC cell migration which could be inhibited by afzelin. Methods: The protein...

Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic eff...

Different doses of allergen lead to different T lymphocyte responses which partly explain the phenomenon of low or high dose tolerance. Dendritic cells (DC) are responsible for driving the T lymphocyte responses to a variety of exogenous stimuli, but the mechanisms are not completely understood. Elucidate the mechanisms of how DCs drive the differe...

Ulcerative colitis is a major risk factor that increases the occurrence of colorectal cancer. In colorectal cancer due to colitis, intestinal inflammation plays an important role which causes DNA damage. The aim of this study is to investigate the anticancer effect of coelomic fluid of Eisenia fetida (CFEF) and cetuximab combinations. Colitis assoc...

Background: Although there have been many studies investigating the effects of electromagnetic fields on humans cells and tissues, the effects of radiofrequency electromagnetic fields exposure on the cells of the immune system are still controversial. Objective: To investigate the effects of 1800 MHz RF-EMF exposure on peripheral blood mononucle...

Background: Breast cancer screening techniques have been developing rapidly in the field of imaging systems. One of these techniques is thermography, which is an alternative modality for mammography to detect breast lesions. Thermography utilization has been progressively developing as various models and methods of object processing improvement. C...

BACKGROUND: The development of an oral typhoid fever vaccine need more effective and having high-efficacy in preventing typhoid fever. The use of liposomes as a vaccine vehicle can be formulated to target a specific location or trigger the release of antigens on its target. β-Glucan derived from Candida albicans cell wall as immunoadjuvant can stre...

Triple-negative breast cancer (TNBC) has the worst prognosis and the highest rate of metastasis among other types of breast cancer. These characteristics are supported by the dysregulation of focal adhesion kinase (FAK) and Rac1 which are the key players of mesenchymal cell migration on TNBC. Afzelin is a secondary metabolite that is contained in a...

Background: Typhoid fever caused by Salmonella Typhi remains as an infectious disease that still becomes a health problem, especially in developing countries due to its fairly high morbidity. Vaccine development efforts, particularly about proteins that play a role in enhancing immunity, are adhesin protein (Protein AdhO36) and the addition of immu...

The use of insect repellent is a disease preventive effort due to mosquito vectors as well as sources of pollutants that disrupt human health, especially reproductive health. This study aimed to determine the effect of γ-Oryzanol on the expression of Foxo3a, TNF-α, GDF-9 in the folliculogenesis of mice (Rattus Novergicus) exposed to pyrethroid aero...

Background: Malaria eradication has been complicated by the repeated emergence of antimalarial drug resistances. We aimed to determine whether a metabolite extract of Streptomyces hygrocopicus subsp. hygroscopicus could decrease the viability of Plasmodium falciparum 3D7 in vitro. Methods: S. hygroscopicus subsp. hygroscopicus isolates were inocul...

The different malignancy advancing systems related with focal adhesion kinase (FAK) can be attentive in the progression of colorectal cancer. By inhibiting the growth mechanism of mixture of 5-Fluorouracil (5-FU) and earthworm therapy could enhance the affectability of malignant growth cells. The objective of this research was to explore the antipr...

Coelomic fluid of Lumbricus rubellus (CFL) has attracted interest due to its pharmacological properties, including antitumor effect. Furthermore, it is necessary to evaluate the response to treatment with new cancer therapeutic agents. This study aims to investigate whether the combination of CFL and 5-fluorouracil could reduce FAK protein level an...

This study has investigated the effect of chemotherapy drugs combined Coelomic Fluid (CF) derived from Lumbricus rubellus in HT-29 cells. HT-29 cells were treated with a combination of 5-fluorouracil (5-FU) (5 μg/ml) and Coelomic Fluid Lumbricus (CFL) (5 μg/ml, 10 μg/ml, or 20 μg/ml), respectively. The cells were incubated for 24 hours and then ana...

Purpose: To evaluate the anti-cancer activity of Indonesian Pasuruan propolis extract (PPE) against HT-29 human colon carcinoma cell line. Methods: HT-29 cells were cultured and treated in different concentrations of PPE (50, 100, 200, 400 μg/mL) for 24 h. The cells were evaluated by several indicators such as cell proliferation and apoptosis as we...

This study examined the effects of endurance exercise training on muscle Insulin Growth Factor-1 (mIGF-1) and PAX7 transcription factor of satellite cell activation in a tibialis anterior muscle of rat. Rat were subjected to treadmill, divided into three groups, each containing 6 rats. Groups of high, moderate and low doses of exercise received 28,...

Dendrophthoe pentandra is a parasitic plant that has anticancer activity. The leaf of Dendrophthoe pentandra traditionally has been used for anticancer agents. The aim of this study was to investigate whether the combination of Dendrophthoe pentandra leaves extract (DPE) and doxorubicin reduces intracellular calcium concentration [iCa²⁺] and surviv...

Mango mistletoe (Dendrophthoe pentandra L. Miq) (MMDP) leaf extract which contained quercetin inhibits cancer cells. MMDP increasing effectively of 5-Fluorouracil (5-FU) as a chemotherapy agent. This study aimed to investigate the synergistic effects of MMDP combined with 5-FU to determine the percentage of apoptosis, p21, and survivin in HeLa cell...

Helminths may alter the immunoinflammatory reactions of colitis. Proteins derived from H. polygyrus have prospective therapy for colitis. The goal of this study was to interpret the protective mechanisms of L4 somatic antigen (LSA) from Heligmosomoides polygyrus against an inflammatory response to the pathogenesis of DNBS-induced colitis. Colitis w...

Indonesia is still included in high endemic area of malaria infection. Early detection as well as appropriate and quick treatment is needed to be able to prevent and treat malaria in Indonesia. Laboratory examination using a microscopic method is still used as the gold standard to diagnose malaria cases. However, the morphology similarity of some P...

Nigella sativa extract (NSE) is known to be an effective antibacterial and immuno-modulating agent. This study aimed to demonstrate that treatment of Salmonella eterica subsp. eterica serovars typhimurium-infected mice with NSE would cause an increase in T-regulatory (T-reg) and Th2 cells and a decrease in the number of spleen bacterial colonies. M...

Kerusakan jaringan hospes yang terinfeksi malaria dapat disebabkan oleh radikal bebas yang dihasilkan akibat respons imun yang berlebihan dan mekanisme kerja artemisin. Kandungan beta-karoten dan tokoferol yang tinggi dalam minyak buah merah berfungsi sebagai antioksidan dan imunostimulator. Penelitian ini bertujuan mengetahui pengaruh terapi komb...

Background: Bacterial vaginosis is commonly experienced by women of reproductive age. The Nugent score is the gold standard for diagnosing bacterial vaginosis. Prebiotic lucomannan hydrolysates (GMH) as a therapy in the treatment of bacterial vaginosis and has an immunomodulatory effect on the immune system and provides cellular immunity. The purpo...

Background Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extract could increase Foxp3 regulatory T cells and inhibits development of Th17 cells. Methods Colitis was induced in Balb/c mice...

Introduction: Systemic Lupus Erythematosus (SLE) is a very complicated autoimmune disease which is characterized by the presence of abnormal neutrophils known as Low Density Granulocytes (LDGs). These LDGs have increased capacity to produce Neutrophil Extracellular Traps (NETs). Vitamin D levels in SLE patients were significantly lower than that of...

Objective: To investigate the anti-inflammatory effect of the protein derived from the soluble factor of Heligmosomoides polygyrus (H. polygyrus) excretory-secretory in a colitis model. Methods: Colitis was induced by providing drinking water containing 3% dextran sodium sulfate (DSS) for a week. DSS was administrated in a cycle protocol, each cycl...

Objective: To investigate clinically severe malaria patients with Plasmodium falciparum (P. falciparum), Plasmodium vivax (P. vivax) and mixed species infections. Methods: This study was conducted at Dr. Saiful Anwar General Hospital, Malang, Indonesia, from December 2011 to May 2013. Twenty nine patients (mean age of 41 years, 22% female), who suf...

Background Indonesian mistletoe grows on various trees. Mango Mistletoes (Dendrophthoe pentandra) is one type of mistletoe that grown on mango tree (.benalu mangga in bahasa Indonesia). Our study used mistletoe as a parasitic plant that has been used for traditional medicine. It has been known that Dendrophtoe pentandra extract (DPE) anti-inflammat...

Renin distal enhancer plays a crucial role in regulating renin gene (REN) expression. REN C-5312T enhancer polymorphism increased enhancer activity. REN C-5434T was also identified which supposed to part of enhancer region. Therefore, this study aimed to investigate contribution of both C-5312T and C-5434T to serum angiotensin I in response to angi...

The aim of this study was to determine the role of vitamin A in modulating T helper 17 (Th17) and regulatory T cell (Treg) balance in systemic lupus erythematosus (SLE) patients. Sixty-two female SLE patients and sixty-two female controls were measured for vitamin A levels from serum by enzyme-linked immunosorbent assay (ELISA) and percentages of T...

Imunoterapi alergen-spesifik dan reduksi alergen merupakan intervensi pada penyakit alergi yang berpotensi untuk mengurangi gejala alergi jangka panjang. Penurunan sel T CD4+ dan CD8+ type 2 berkorelasi erat dengan mekanisme regulasi dari imunoterapi. Sejauh ini belum ada penelitian yang mengkaji pemberian jangka panjang imunoterapi, probiotik dan...

The human REN has been widely known involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to REN transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few reports exist that discussed serum renin levels on C-543...

The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few reports exist that discussed serum r...

Introduction The balance between T helper 17 (Th17) and regulatory T cells (Treg) is a new paradigm in the pathogenesis of systemic lupus erythematosus (SLE). Currently, there are no drugs that able to modulate Th17/Treg balance specifically in SLE. Curcumin is a bioactive agent that has a specific action against hyperproliferative cells. However,...

Objectives: This study aims to investigate the relationship between the molecular heterogeneity of prolactin (PRL) and anti-doublestranded deoxyribonucleic acid (anti-dsDNA), anti-C1q, and complement 3 (C3) levels in patients with systemic lupus erythematosus (SLE). Patients and methods: This study included 30 premenopausal females with SLE from th...

Aim: to investigate the effects of Vitamin D calcitriol/1,25(OH)2D3 on NETosis in systemic lupus erythematosus (SLE) patients with hypovitamin D. Methods: neutrophlis of five SLE patients with hypovitamin D were divided into 4 groups, P0 (0 nM/control), P1 (1 nM), P2 (10 nM), and P3 (100 nM) as cultured samples. Phorbol Myristate Acetate (PMA) w...