Agustin Ibanez

Agustin Ibanez
Universidad Adolfo Ibáñez · Latin American Brain Health Institute (BrainLat)

PhD
Researcher

About

519
Publications
164,747
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
10,882
Citations
Introduction
Agustin Ibanez is an Argentinean neuroscientist interested in global approaches to dementia and social, cognitive, and affective neuroscience. He is a full professor and Director of the Latin American Brain Health Institute (BrainLat) at Universidad Adolfo Ibáñez (UAI, Chile), an Associate Research Professor at GBHI-Trinity College Dublin, and Team Leader of Predictive Brain Health Modelling Group, Trinity College Dublin. Also, he is a Senior Atlantic Fellow at GBHI-UCSF.
Additional affiliations
April 2016 - present
Universidad Adolfo Ibáñez
Position
  • Senior Researcher
March 2016 - present
National Scientific and Technical Research Council
Position
  • Institute of Cognitive and Translational Neuroscience (INCYT)
March 2014 - present
Favaloro University
Position
  • Reseacher

Publications

Publications (519)
Book
Full-text available
From the robust to the nonreplicable, from the trivial to the groundbreaking, virtually all findings in cognitive neuroscience stem from the same approach: divide and conquer. Indeed, the field’s ethos has long been to decompose mental phenomena into a series of separate mechanisms which can be individually operationalized. Imagine we want to explo...
Article
Full-text available
The study of moral emotions (i.e., Schadenfreude and envy) is critical to understand the ecological complexity of everyday interactions between cognitive, affective, and social cognition processes. Most previous studies in this area have used correlational imaging techniques and framed Schadenfreude and envy as unified and monolithic emotional doma...
Article
As shown by the Office of the United Nations High Commissioner for Human Rights, terrorism is one of the most pernicious threats to contemporary societies. In addition to obliterating the freedom and physical integrity of victims, terrorist practices can destabilize governments, undermine civil harmony and threaten economic development1. This is tr...
Article
View largeDownload slide Social bargaining requires the ability to integrate one’s own preferences with inferences about another’s choices. Melloni et al . investigate the structural correlates, ongoing brain dynamics, and fMRI networks of social negotiation in individuals with neurodegeneration or stroke. A successful self-other integration strat...
Article
Full-text available
View largeDownload slide Central to moral cognition is the detection of intentional harm. Using direct electrophysiological recordings in human subjects, Hesse et al. show that scenes of intentional harm induce early activation of the amygdala. This activation predicts intention attribution and engages a frontotemporal network, supporting the ‘man...
Book
This handbook introduces neurosemiotics, a pluralistic framework to reconsider semiosis as an emergent phenomenon at the interface of biology and culture. Across individual and interpersonal settings, meaning is influenced by external and internal processes bridging phenomenological and biological dimensions. Yet, each of these dyads has been segr...
Article
Objective: The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study of dementia highlight the critical role of biomarkers. Thus, novel c...
Article
With the exponential growth in investment attention to brain health—solutions spanning brain wellness to mental health to neurological disorders—tech giants, payers, and biotechnology companies have been making forays into this field to identify technology solutions and pharmaceutical amplifiers. So far, their investments have had mixed results. Th...
Article
Full-text available
Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up, and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global ch...
Article
Full-text available
The prevalence of dementia, including Alzheimer's disease (AD), is on the rise globally with screening and intervention of particular importance and benefit to those with limited access to healthcare. Electroencephalogram (EEG) is an inexpensive, scalable, and portable brain imaging technology that could deliver AD screening to those without local...
Article
Full-text available
At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied ma...
Article
Full-text available
Alzheimer's Disease (AD) shows both complex alterations of functional dependencies between brain regions and a decreased ability to perform Visual Short-Term Memory Binding (VSTMB) tasks. Recent advances in network neuroscience toward understanding the complexity of hierarchical brain function here enables us to establish a link between these two p...
Article
Full-text available
Latin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs.
Article
Full-text available
Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global cha...
Article
Full-text available
Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eye...
Poster
Full-text available
Hypnotic suggestions can produce a broad range of perceptual experiences, including hallucinations. Visual hypnotic hallucinations differ in many ways from regular mental images. For example, they are usually experienced as automatic, vivid, and real images, typically compromising the sense of reality. While both hypnotic hallucination and mental i...
Article
Full-text available
Within many societies and cultures around the world, older adults are too often undervalued and underappreciated. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of tremendous value at both an individual and societal level. We propose a new approach to elevate healt...
Article
Alzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta and tauopathy proteins in the brain. Very recently, the first disease-modifying drug has been licensed with reserve (i.e., Ad...
Article
Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we...
Article
Full-text available
Socioeconomic status (SES) negatively impacts cognitive and executive functioning in older adults, yet its effects on socioemotional abilities have not been studied in this population. Also, evidence on neurocognitive processes associated with ageing primarily comes from Western, educated, industrialized, rich, and democratic (WEIRD) populations, h...
Article
Background: Processing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers. Methods: Here we examined oscillatory, neuroanatomical...
Article
Full-text available
Can motor expertise be robustly predicted by the organization of frequency-specific oscillatory brain networks? To answer this question, we recorded high-density electroencephalography (EEG) in expert Tango dancers and naïves while viewing and judging the correctness of Tango-specific movements and during resting. We calculated task-related and res...
Article
To solve existential brain challenges spanning neurology, mental health, education, workforce development, and neuroscience—we need a fresh approach to technologies and investing. We need a new investment opportunity: Brain Capital. https://www.psychiatrictimes.com/view/brain-capital-an-emerging-investment-opportunity
Article
Full-text available
Discussions on linguistic deficits in neurodegenerative diseases are often circumscribed to primary progressive aphasia. Yet, verbal dysfunctions are also pervasive across neurodegenerative diseases typified by mnesic, socio-cognitive, or motoric alterations (García et al., 2022). This has been shown, for instance, in Alzheimer's disease (AD) (Tale...
Article
Patients with atrophy in motor brain regions exhibit selective deficits in processing action-related meanings, suggesting a link between movement conceptualization and the amount of regional tissue. Here we examine such a relation in a unique opposite model: a rare patient with a double cortex (due to subcortical band heterotopia) in primary/supple...
Article
Full-text available
As research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's Association International Conference Satellite Symposium in Athens, Greece in 2021. Due to the COVID‐19 pandemic, the meeting was...
Article
Background The predictive coding theory of allostatic interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs and environmental demands. These functions seems to be distinctly compromised in behavioral variant frontotemporal dementia...
Article
Full-text available
Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and str...
Article
Full-text available
Introduction: Automated speech analysis has emerged as a scalable, cost-effective tool to identify persons with Alzheimer's disease dementia (ADD). Yet, most research is undermined by low interpretability and specificity. Methods: Combining statistical and machine learning analyses of natural speech data, we aimed to discriminate ADD patients fr...
Article
Full-text available
Background: The cognitive and neuropsychiatric deficits present in patients with behavioral variant frontotemporal dementia (bvFTD) are associated with loss of functionality in the activities of daily living (ADLs). The main purpose of this study was to examine and explore the association between the cognitive and neuropsychiatric features that mig...
Article
Full-text available
The SARS-CoV-2 pandemic has imposed widespread negative impacts (economically, psychologically, neurologically, and societally), and has changed daily behaviors on a global scale. Such impacts are more significant and pervasive in countries with higher levels of inequality and reduced Government capacity and responsiveness, such as those in the Glo...
Article
Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial...
Article
Mainstream theories of first- and second-language (L1, L2) processing in bilinguals are crucially informed by word translation research. A core finding is the translation asymmetry effect, typified by slower performance during forward translation (FT, from L1 into L2) than backward translation (BT, from L2 into L1). Yet, few studies have explored i...
Article
Full-text available
Dementia prevention interventions that address modifiable risk factors for dementia require extensive lifestyle and behavior changes. Strategies are needed to enhance engagement and personalization of the experience at a population level. Precision Population Brain Health aims to improve brain health across the lifespan at a population level. Psych...
Article
The proposal to use brain connectivity as a biomarker for dementia phenotyping can be potentiated by conducting large-scale multicentric studies using high-density electroencephalography (hd- EEG). Nevertheless, several barriers preclude the development of a systematic “ConnEEGtome” in dementia research. Here we review critical sources of variabili...
Article
Background: LAC-CD has recently reported that challenges faced by LAC countries are very similar to those experienced by HIC, and that regional networks will be needed to bridge gaps. ReDLat is a US-LAC multi-partner consortium aimed at expanding dementia research in LAC. The UK-Latin America Brain Connectivity Research Network (UL-BCRN) focuses o...
Article
Full-text available
Objective: To describe the demographic characteristics, initial psychiatric diagnoses, and the time to reach a diagnosis of probable behavioral variant frontotemporal dementia (bvFTD) in a public psychiatric hospital in Cali, Colombia. Methods: We retrospectively reviewed the medical records of 28 patients who were diagnosed with probable bvFTD ba...
Article
Full-text available
The Action-sentence Compatibility Effect (ACE) is a well-known demonstration of the role of motor activity in the comprehension of language. Participants are asked to make sensibility judgments on sentences by producing movements toward the body or away from the body. The ACE is the finding that movements are faster when the direction of the moveme...
Article
Full-text available
The latent structure of executive functions (EFs) remains controversial. Confirmatory factorial analysis (CFA) has provided support for both multidimensional (assumes EFs to be functionally separable but related components) and bifactor (proposes all components are nested within a common factor) models. However, these CFA models have never been com...
Preprint
Full-text available
The Trail Making Test (TMT) is one of the most popular neuropsychological tests in the clinical assessment of executive functions (EF) and research in a wide range of clinical conditions. In addition to its sensitivity to executive dysfunction, the TMT presents several strengths: it is simple and intuitive, it is easy to understand for patients, an...
Article
Full-text available
Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the pheno...
Article
Full-text available
Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the develo...
Article
Full-text available
Simposio Humberto Maturana 1928-2021. La sección Simposio de autor de la revista Estudios Públicos es un espacio para elanálisis de las ideas y obra de un pensador clásico o contemporáneo desde distintas perspectivas disciplinares.
Article
Built on neurodegenerative lesions models, the disrupted motor grounding hypothesis (DMGH) posits that motor-system alterations selectively impair action comprehension. However, major doubts remain concerning the dissociability, neural signatures, and etiological generalizability of such deficits. Few studies have compared action-concept outcomes b...
Article
Full-text available
Objectives We developed (a) a survey to investigate the knowledge of childhood health experts on public policies and behavioural insights (BI), as well as its use in Latin American and the Caribbean countries (LACs), and (b) an intervention (randomised controlled trial) to test the influence of nudges on the effect of a simulated public health prog...
Article
Full-text available
The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about...
Article
Full-text available
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since su...
Article
Full-text available
Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD). However, no previous study has used social cognition and other cognitive tasks to predict diagnoses of these conditions, let alone report...
Article
Tearful crying is a ubiquitous and likely uniquely human phenomenon. Scholars have argued that emotional tears serve an attachment function: Tears are thought to act as a social glue by evoking social support intentions. Initial experimental studies supported this proposition across several methodologies, but these were conducted almost exclusively...
Article
Full-text available
Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day ra...
Article
Full-text available
Hypnotic suggestions can produce a broad range of perceptual experiences, including hallucinations. Visual hypnotic hallucinations differ in many ways from regular mental images. For example, they are usually experienced as automatic, vivid, and real images, typically compromising the sense of reality. While both hypnotic hallucination and mental i...
Article
Full-text available
Frontotemporal dementia (FTD) includes a group of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders, affecting the fronto-insular-temporal regions of the brain. Clinically, FTD is characterized by progressive deficits in behavior, executive function, and language and its diagnosis relies mainly on the clinical ex...
Article
The brain mechanisms by which we transition from sleep to a conscious state remain largely unknown in humans, partly because of methodological challenges. Here we study a pre-existing dataset of waking up participants originally designed for a study of dreaming (Horikawa, Tamaki, Miyawaki, & Kamitani, 2013) and suggest that suddenly awakening from...
Article
Full-text available
Behavioral embodied research shows that words evoking limb-specific meanings can affect responses performed with the corresponding body part. However, no study has explored this phenomenon's neural dynamics under implicit processing conditions, let alone by disentangling its conceptual and motoric stages. Here, we examined whether the blending of h...
Article
Brains are indispensable drivers of human progress. Why not invest more heavily in them? We seek to place Brain Capital at the center of a new narrative to fuel economic and societal recovery and resilience.
Article
Social emotions require the correct integration of emotional, cognitive, and social processes and are critical for complex social interactions. Adolescent criminal offenders (AOs) show abnormalities in the experience of basic emotions. However, most research has focused solely on basic emotions, neglecting complex social emotions that could be crit...