Agung eru Wibowo

• Researcher at Badan Riset dan Inovasi Nasional

Objective The objective of this study was to investigate the effectiveness and safety of seahorse (Hippocampus comes L.) extract on hematological profile and body weight on rats induced by depo medroxyprogesterone acetate (DMPA). Materials and Methods Thirty adult male Sprague-Dawley rats with 200–250 gm and 8 weeks old. All rats were intramuscula...

This study aimed to evaluate the anti-inflammatory activity of the combination of Ardisia humilis Vahl. and Curcuma xanthorrhiza Roxb. (AC) extract in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rat model. AC was administered orally to OA rats (240, 480, and 960 mg/kg bw) for three weeks. The control and model groups comprised OA rats...

Andaliman (Zanthoxylum acanthopodium D.C) is a plant widely used by the Batak people in North Sumatera. Several studies demonstrated that Andaliman fruit exhibits antioxidant activities and cytotoxic effects on cancer cells. Quality of Andaliman fruit could affected by post-harvest process including storage time. This research aims to analyze the c...

Hyperglycaemia is one condition related to inflammation leading to insulin signalling impairment. This study was conducted to investigate the insulin sensitivity improvement of Sambiloto (Andrographis paniculata (Burm. f.)) Nees extract in insulin resistance-induced HepG2 (IR-HepG2) cells by stimulating insulin sensitivities and inhibiting inflamma...

How to cite: Mundijo R, Suyatna FD, Wibowo AE, Lestari SW, Yusra Y, Midoen YH. The seahorse (Hippocampus comes L.) extract ameliorates sperm qualities, testosterone level, and serum biochemistry in rats induced by depo medroxyprogesterone acetate. J Adv Vet Anim Res 2023; 10(1):126-131. ABSTRACT Objective: The percentage of infertility cases...

Beluntas leaf (Pluchea indica L. Less) and red ginger rhizome (Zingiber officinale Roscoe) is a plan have activity as antibacterial causes acne. Beluntas leaf contain antibacterial compounds from alkaloid, flavonoid free type flavonol, steroid and tannin. Red ginger rhizome extract compounds flavonoid, essential oil, polifenol, and saponin. This st...

Objective: Indonesia is an archipelagic country with a mega biodiversity, among others, in the marine area. Seahorses (Hippocampus spp.) are a marine fish known to have biocompounds used in traditional medicine "Jamu," such as Hippocampus comes L. (HCL). The present study aims to analyze and compare the chemical contents of cultured seahorse (CS)...

Seahorse (Hippocampus spp) is marine fish and have pharmacological activity, such as an antiinflammatory, antioxidative, antifatigue and improve the fertility. Depot medroxyprogesterone acetate (DMPA) is a contraception drug for male and affect the endocrine system by inhibiting pituitary gonadotropin with reduce testosterone levels in 12 weeks. Th...

Tetrahidrokurkumin (THC) adalah salah satu senyawa polifenol yang memiliki khasiat sebagai pencerah kulit. THC merupakan turunan kurkumin dimana THC memiliki warna serbuk kuning muda hingga putih. Penelitian ini bertujuan untuk mengetahui potensi aktivitas penghambatan enzim tirosinase terbaik dari senyawa tetrahidrokurkumin yang diformulasi dalam...

Ketombe adalah suatu kelainan yang ditandai dengan skuamasi yang berlebihan , rasa gatal pada kulit kepala. Salah satu penyebab masalah ketombe adalah berkembangnya jamur dikulit kepala yaitu jamur Pitysporum Ovale (P. Ovale). Selain rasa gatal ketombe bisa menyebabkan kerontokan rambut meskipun tidak menyebabkan kebotakan permanen. Salah satu fakt...

Abstrak Kemiri dan Bawang Putih adalah tanaman yang memiliki efek pada pertumbuhan rambut. Bahan kimia yang terkandung dalam tanaman kaya akan nutrisi yang dibutuhkan untuk pertumbuhan rambut atau alis seperti alkaloid, saponin, sterol / terpenoid. Khasiat minyak kemiri dan minyak bawang putih dengan tiga konsentrasi 1000 ppm, 500 ppm dan 100 ppm d...

Microorganisms in nature are highly diverse biological resources, which can be explored for drug discovery. Some countries including Brazil, Columbia, Indonesia, China, and Mexico, which are blessed with geographical uniqueness with diverse climates display remarkable megabiodiversity, potentially provide microorganismal resources for such exploita...

Efficacy of candlenut oil and garlic oil with three concentrations of 1000 ppm, 500 ppm and 100 ppm tested its activity as a fertilizer of rabbit fur by applying hazelnut oil and garlic oil each of approximately 1 ml at spot prepared twice daily for 28 days. The result of the third activity test of this concentration tested the data with statistics...

Kosmetik digunakan untuk berbagai tujuan misalnya untuk membuat penampilan menarik. Dari sekian banyak jenis kosmetik yang digunakan, krim pencerah kulit banyak diminati terutama oleh para wanita di Asia, termasuk Indonesia, agar diperoleh tampilan kulit wajah yang putih dan bersih. Tujuan dari penelitian ini adalah untuk mengembangkan formulasi se...

Penggunaan sabun dan air sebagai pencuci badan pada waktu mandi relatif kurang efektif untuk mencegah bau badan. Sehingga dapat dilakukan beberapa alternatif tindakan lain, seperti menggunakan sediaan kosmetik anti bau badan (deodorant). Berdasarkan hasil penelitian dari 90% populasi di dunia ini telah menggunakan deodorant untuk mengontrol keringa...

[This corrects the article DOI: 10.1371/journal.pone.0240020.].

Daun beluntas (Pluchea indica L. Less) dan rimpang jahe merah (Zinngiber officinalle Roscoe) merupakan tanaman yang mempunyai aktivitas sebagai antibakteri penyebab jerawat. Daun beluntas mengandung senyawa anti bakteri yang berasal dari alkaloid, flavonoid bebas jenis flavonol, steroid dan tanin. Ekstrak rimpang jahe merah mengandung flavonoid, mi...

Breast cancer stem cells (BCSCs) express high levels of the anti-apoptotic protein, survivin. This study aimed to discover a natural active compound with anti-cancer properties that targeted survivin in human breast cancer stem cells. From the seven examined compounds, andrographolide was selected as a lead compound through in silico molecular dock...

Present investigation shows that the extract of C. aeruginosa attenuates DMBA-induced spleen carcinogenesis in Wistar rats. Three-week female Wistar rats were treated with three different C. aeruginosa extract doses (CA1: 40 mg/200 g body weight, BW; CA2: 80 mg/200 g BW; CA3: 160 mg/200 g BW) and were induced with DMBA after one-week administration...

The quality of a medicinal plant is influenced by agronomic conditions and harvesting time. Objective: This study aimed to evaluate the effect of planting method (openair (OA) and shedding house (SH)) and harvesting time (2, 4, 6 months) of Lampeni (Ardisia humilis Vahl.) toward the inhibitory activity of alpha-glucosidase. Methods: The Lampeni see...

Background: Acne is a skin problem that is common in everyday life. Expressions of acne can cause psychological problems because of appearance. Moringa leaf extract and herbs contain alkaloid compounds, flavonoids, saponins, tannins and phenolics that can be used as antibacterial, reduce inflammation, reduce sebum glands and moisturize the skin. Th...

Allicin and ajoene are active compounds in garlic which have proven to be of benefit as antifungal. Meanwhile, the content of oleic acid and triglycerides from the custard apple seeds extract showed anti-fungal activity in vitro. This study aimed to obtain a preparation of creambath combination of garlic extract and custard apple seeds extract whic...

Aglaia elliptica Blume belongs to Meliaceae family which contain an active compound of rocaglamid as anticancer. The research was conducted to evaluate the biological activities of ethyl acetate fraction of Aglaia elliptica Blume leaves. The dry powder of Aglaia elliptica Blume leaves was extracted with methanol using maceration method, then was fr...

Indonesian medicinal herbs have so many biological activity, including anticancer activity. This assay aims to evaluate three Indonesian medicinal plants (Trigonella foenum-graecum L. (TFG), Aglaia elliptica Blume. (AE) and Foeniculum vulgare Mill. (FV)) which have potency in anticancer activity. The experiment was done by MTT assay to observe the...

Kedokteran regenerative dengan memanfaatkan potensi sel punca membutuhkan sumber sel yang banyak seperti fibrobast asal preputium hasil khitan. Subpopulasi sel punca mesenkin dapat di isolasi dari kultur fibroblas menggunakan penanda CD105. Penggunaan system isolasi berbasis magnet yaitu MACS memungkinkan isolasi subpopulasi sel yang mengekpresikan...

Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against var...

There are many methods for development of mammae cancer animal model, one of which is chemical induction using carcinogenic agent, DMBA. This research aimed to explore the influence of dose and time regimens of DMBA on development of mammae carcinogenesis on Sprague dawley female rats. The first study was 50 rats treated with 20 mg/kg bw of DMBA or...