Agnieszka Kamińska

Agnieszka Kamińska
Polish Academy of Sciences | PAN · Institute of Physical Chemistry

Associate Professor

About

89
Publications
15,621
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2,028
Citations

Publications

Publications (89)
Article
Full-text available
We present here that the surface-enhanced Raman spectroscopy (SERS) technique in conjunction with the partial least squares analysis is as a potential tool for the differentiation of pleural effusion in the course of the cancerous disease and a tool for faster diagnosis of lung cancer. Pleural effusion occurs mainly in cancer patients due to the sp...
Data
Table S1: Sample classification based onto histopathological and immunohistochemical staining; Table S2: The RMSE and R2 along with number of important PCs or Fs and their corresponding percentage values data obtained from PCR and PLS multivariate analysis; Table S3: The first three or five components/factors with their calculated weight (absolute...
Article
We present herein a label‐free method based on surface‐enhanced Raman spectroscopy (SERS) that was performed using a silicon‐based SERS platform. The differentiation between primary and secondary brain tumors SERS data was completed partial least squares (PLS) method with a very high 85% of accuracy (in only first and second factors), whereas calcu...
Data
Fig. 1S. Representative Raman mean spectra from RI of neoplastic and healthy salivary glands tissues (A) presented together with the tissues images and components analysis based on the gathered data (B). Presented Raman spectra averages, for both healthy and tumour tissues, are based onto 40 spectra (within total 1600 spectra for each region). The...
Article
In this study, two approaches to salivary glands studies are presented: Raman imaging (RI) of tissue cross-section and surface-enhanced Raman spectroscopy (SERS) of tissue homogenates prepared according to elaborated protocol. Collected and analyzed data demonstrate the significant potential of SERS combined with multivariate analysis for distingui...
Article
The surface-enhanced Raman scattering (SERS) has been widely tested for its usefulness in microbiological studies, providing many information-rich spectra which are a kind of ‘whole-organism fingerprint’ and enabling identification of bacterial species. Here we show, previously not considered, the comprehensive SERS-chemometric analysis of five bac...
Article
Full-text available
Recently, Porphyromonas gingivalis, the keystone pathogen implicated in the development of gum disease (periodontitis), was detected in the brains of Alzheimer’s disease patients, opening up a fascinating possibility that it is also involved in the pathobiology of this neurodegenerative illness. To verify this hypothesis, an unbiased, specific, and...
Article
Full-text available
Surface-enhanced Raman spectroscopy (SERS) is a research method in which a lack of cost-effective, versatile platforms with high enhancement factor (EF) is still a major obstacle to its widespread use. The platforms should be also easy to manufacture, stable in time (for weeks or even for months) and manufactured with a highly reproducible method....
Article
Full-text available
Surface-enhanced Raman spectroscopy (SERS) is a vibrational method successfully applied in analytical chemistry, molecular biology and medical diagnostics. In this article, we demonstrate the combination of the negative dielectrophoretic (nDEP) phenomenon and a flexible surface-enhanced Raman platform for quick isolation (3 min), concentration and...
Article
Full-text available
The circulating tumor cells (CTCs) isolation and characterization has a great potential for non-invasive biopsy. In the present research, the surface–enhanced Raman spectroscopy (SERS)-based assay utilizing magnetic nanoparticles and solid SERS-active support integrated in the external field assisted microfluidic device was designed for efficient i...
Data
Figure S1. Scheme of the magnetically controlled SERS-based microfluidic setup. Figure S2. The morphology of SERS-active substrates (Ag/FLS) were visualized by the scanning electron microscopy (SEM). (A) surface of the silicon after laser ablation, (B) after laser ablation and sputtering with 100 nm of silver via PVD process.
Data
Fig. 1S. SERS spectra of p-MBA absorbed onto the SERS substrates from 10-6 M solution with 10, 40, 70 and 100 nm of the sputtered Ag/Au thicknesses and the Raman spectrum recorded for the p-MBA crystals. Either SERS and Raman spectra were recorded using a 785 nm laser excitation (the laser power was below 5 mW) with one accumulations for one second...
Article
Selectin ligands are present on the surface of tumor cells, for this reason lowering the L‐selectin level in the blood and lymph can indicate presence of the tumor. Therefore the selectin level in the plasma are potential targets for anticancer therapy. We demonstrate the surface enhanced Raman spectroscopy (SERS)‐based sensor for the determination...
Article
According to EU summary report on zoonoses, zoonotic agents and food‐borne outbreaks in 2017, Campylobacter was the most commonly reported gastrointestinal bacterial pathogen in humans in the EU. Unfortunately, the standard methods for detection of thermotolerant Campylobacter spp. in foods are time‐consuming. Additionally, the qualified staff is o...
Article
One of the biggest challenge for modern medicine is to make a discrimination among healthy and cancerous tissues. Therefore, nowadays big effort of scientist are devoted to find a new way for as fast as possible diagnosis with as much as possible accuracy in distinguishing healthy from cancerous tissues. That issues are probably the most important...
Data
Page Figure S1 Chemical structure of the pesticides used in the experiments: Thiram (a) and Carbaryl (b) 2 Figure S2 Picture of the experimental setup (a) and dielectric barrier discharge between the High Voltage electrode and PET/ITO substrate (b). 3 Figure S3 AFM of the pure PET/ITO foil (a) 2D view and (b) 3D view, roughness of the surface (c)....
Article
Full-text available
Isolation and detection of circulating tumor cells (CTCs) from human blood plays an important role in non- invasive screening of cancer evolution and in predictive therapeutic treatment. Here, we present the novel tool utilizing: (i) the microfluidic device with (ii) incorporated photovoltaic (PV) based SERS-active platform, and (iii) shell-isolate...
Article
The authors would like to call the reader’s attention to the fact that unfortunately following information was missing in the original article: “Evelin Witkowska is supported by the Foundation of Polish Science (FNP).”
Article
Full-text available
The detection and monitoring of circulating tumor cells (CTCs) in blood is an important strategy for early cancer evidence, analysis, monitoring of therapeutic response, and optimization of cancer therapy treatments. In this work, tailor-made membranes (MBSP) for surface-enhanced Raman spectroscopy (SERS)-based analysis, which permitted the separat...
Article
Full-text available
The surface-enhanced Raman spectroscopy (SERS)-based analysis of bacteria suffers from the lack of a standard SERS detection protocol (type of substrates, excitation frequencies, and sampling methodologies) that could be employed throughout laboratories to produce repeatable and valuable spectral information. In this work, we have examined several...
Article
Full-text available
Surface-enhanced Raman scattering (SERS) has been intensively used recently as a highly sensitive, non-destructive, chemical specific, and label-free technique for a variety of studies. Here, we present a novel SERS substrate for: (i) the standard ultra-trace analysis, (ii) detection of whole microorganisms, and (iii) spectroelectrochemical measure...
Article
Full-text available
In this paper, we present novel type of Surface-enhanced Raman spectroscopy (SERS) platform, based on stainless steel wire mesh (SSWM) covered with thin silver layer. The stainless steel wire mesh, typically used in chemical engineering industry, is a cheap and versatile substrate for SERS platforms. SSWM consists of multiple steel wires with diame...
Article
Full-text available
One of the potential applications of surface-enhanced Raman spectroscopy (SERS) is the detection of biological compounds and microorganisms. Here we demonstrate that SERS coupled with principal component analysis (PCA) serves as a perfect method for determining the taxonomic affiliation of bacteria at the strain level. We demonstrate for the first...
Article
Surface-enhanced Raman spectroscopy (SERS) has been widely used in a variety of biomedical, analytical, forensic and environmental investigations due to its chemical specificity, label-free nature combined with high sensitivity. Here, we report a simple method for the fabrication of reproducible and reliable, well-defined, stable SERS substrates wi...
Article
Full-text available
SERS-active nanostructures incorporated into a microfluidic device have been developed for rapid and multiplex monitoring of selected Type 1 cytokine (interleukins: IL-6, IL-8, IL-18) levels in blood plasma. Multiple analyses have been performed by using nanoparticles, each coated with different Raman reporter molecules: 5,5′-dithio-bis(2-nitro-ben...
Article
Full-text available
An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed. The SERS sensing originates from unique features of the diatom frustules, which are capable of enhancing the localized surface-plasm...
Article
This paper demonstrates that surface-enhanced Raman spectroscopy (SERS) coupled with principal component analysis (PCA) can serve as a fast and reliable technique for the detection and identification of human fungal pathogens, such as Trichophyton rubrum, Candida krusei, Scopulariopsis brumptii, and Aspergillus flavus. Fungal infections have become...
Article
Full-text available
We show that surface-enhanced Raman spectroscopy (SERS) coupled with principal component analysis (PCA) can serve as a fast, reliable, and easy method for detection and identification of food-borne bacteria, namely Salmonella spp., Listeria monocytogenes, and Cronobacter spp., in different types of food matrices (salmon, eggs, powdered infant formu...
Article
Full-text available
Abstract The three of the most common meningitis pathogens, Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae have been successfully detected and identified in clinical cerebrospinal fluid (CSF) samples using a new class of a surface-enhanced Raman scattering (SERS) assay. Bacterial meningitis is a disease of a nervous sy...
Article
Full-text available
A highly efficient recognition unit based on surface-enhanced Raman spectroscopy (SERS) was developed as a promising, fast, and sensitive tool for detection of meningococcal meningitis, which is an extremely serious and often fatal disease of the nervous system (an inflammation of the lining around the brain and spinal cord). The results of this st...
Article
Full-text available
The article presents surface enhanced Raman scattering (SERS) technique associated with the principal component analysis (PCA) as a fast and reliable method for the study of interactions between the A, B, AB and O (abr. ABO) blood groups antigen and complementary monoclonal A and B antibodies. The possibility of simultaneous detection and different...
Article
Full-text available
An efficient and low-cost surface-enhanced Raman scattering (SERS) substrates based on Au coated zinc oxide layers for the detection of neopterin were prepared. These substrates presented high sensitivity to p-mercaptobenzoic acid (p-MBA) at a low concentration of 10-9 M and the enhancement factor of over 107 was achieved. The uniform density of SE...
Article
Full-text available
Novel surface enhanced Raman spectroscopy (SERS) platforms have been prepared and used for the bacteria detection. Unlike typical, expensive SERS platforms prepared from gold or silver, the presented platforms are prepared using copper. A new, simple, cost-efficient and fast high pressure method is used for platform fabrication, through the decompo...
Chapter
Full-text available
Raman spectra are presented for twenty proteinogenic amino acids, recorded for solid samples using four different laser wavelengths: 325, 514.5, 632.8, and 785 nm. In general, the intensity patterns are very similar for all excitation wavelengths. The spectra are analysed in terms of similarity. Possibilities of determination of amino acids in mult...
Article
Full-text available
A highly sensitive immunoassay utilizing surface-enhanced Raman scattering (SERS) has been developed with a new Raman reporter and a unique SERS-active substrate incorporated into a microfluidic device. An appropriately designed Raman reporter, basic fuchsin (FC), gives strong SERS enhancement and has the ability to bind both the antibody and gold...
Article
Full-text available
This paper demonstrates a renewed procedure for the quantification of surface-enhanced Raman scattering (SERS) enhancement factors with improved precision. The principle of this method relies on deducting the resonance Raman scattering (RRS) contribution from surface-enhanced resonance Raman scattering (SERRS) to end up with the surface enhancement...
Article
This communication presents a new pathway for the more precise quantification of surface-enhanced Raman scattering (SERS) enhancement factor via deducing resonance Raman scattering (RRS) effect from surface-enhanced resonance Raman scattering (SERRS). To achieve this, a self-assembled monolayer of 1,8,15,22-tetraaminophthalocyanatocobalt(II) (4α-Co...
Article
Full-text available
The procedure of identifying components in a mixture was developed and tested on Raman spectra of mixtures of solid amino acids, using the spectra of single amino acids as templates. The method is based on finding the optimum scaling coefficients of the linear combination of template spectra that minimize the Canberra distance between measured and...
Article
Full-text available
This work demonstrates the development of a new class of SERS substrates that allows for the simultaneous: (i) filtration of bacteria from any solution (blood, urine, water, or milk), (ii) immobilization of bacteria on the SERS platform, and (iii) enhancing the Raman signal of bacteria. The proposed platform is based on an electrospun polymer mat c...
Article
Structural and magnetic properties of (In,Ga)As-(Ga,Mn)As core-shell nanowires grown by molecular beam epitaxy on GaAs(111)B substrate with gold catalyst have been investigated. (In,Ga)As core nanowires were grown at high temperature (500 °C) whereas (Ga,Mn)As shells were deposited on the {110} side facets of the cores at much lower temperature (22...
Article
Full-text available
Surface-enhanced Raman spectroscopy (SERS) is a potentially important tool in the rapid and accurate detection of pathogenic bacteria in biological fluids. However, for diagnostic application of this technique, it is necessary to develop a highly sensitive, stable, biocompatible and reproducible SERS-active substrate. In this work, we have develope...
Article
Full-text available
This article describes the detection of DNA mutations using novel Au-Ag coated GaN substrate as SERS (surface-enhanced Raman spectroscopy) diagnostic platform. Oligonucleotide sequences corresponding to the BCR-ABL (breakpoint cluster region-Abelson) gene responsible for development of chronic myelogenous leukemia were used as a model system to dem...
Patent
Full-text available
The invention relates to a substrate for surface enhanced Raman scattering studies comprising a semiconductor surface with whiskers, coated with metal selected from the group consisting of silver, gold, platinum, copper and/or alloys thereof, where the semiconductor mentioned is a gallium-containing nitride and essentially each whisker contains a l...
Article
Full-text available
Shell isolated silver nanoparticles with an ultrathin silica layer (Ag@SiO2NPs) are used as a surface-enhanced resonance Raman scattering (SERRS) substrate for probing metmyoglobin (metMb) in aqueous solution. The ultrathin silica layer protects metMb from reaching the bare silver surface and conserves the heme pocket during SERRS analysis with a R...
Article
The fabrication procedure of efficient surface enhanced Raman scattering (SERS) platforms is demonstrated based on reproducibly photo-etched GaN epitaxial layers covered by a thin Au-Ag layer and subjected to partial de-alloying. Using a gold-rich Au57Ag43 alloy (70/30 wt. %), it is possible to preserve about 19 at. % of silver in the layer, even a...
Article
In order to obtain uniform and reproducible surface enhanced Raman spectroscopy (SERS) platforms, a novel method for deposition of well adhered multifarious gold particles on a tin doped indium oxide electrode through electrogeneration at an electrode gold compound, in toluenelaqueous-electrolyte three-phase junction was developed. The electrodepos...
Article
Optically tuned silver nanoparticles (AgNP's) functionalized with ω-mercaptoalkanoic acids are synthesized and used as a signal amplifier for the surface-enhanced resonance Raman scattering (SERRS) study of heme cofactor in methemoglobin (metHb). Even though both mercaptopropionic acid (MPA)- and mercaptononanoic acid (MNA)-functionalized AgNP's ex...
Conference Paper
Full-text available
Micro-Raman measurements were performed to study the vibrational properties of molecular beam epitaxy grown ZnTe nanowires (NWs) with atomic layer deposited (Zn,Co) oxides shell. A significant decrease of relative intensity of structures related to the ZnTe (NWs core) and Te (precipitates) phonons, resulting from the overgrowth of the NWs by the ox...
Article
We report an innovative application of a true “bottom-up” approach for preparation of functional material. Three consecutive self-assembly steps were utilized for formation of a complex surface enhanced Raman spectroscopy (SERS) platform. First the Langmuir–Blodgett technique was used to deposit gold nanoparticles on a solid substrate. Thus prepare...
Article
Galactose oxidase (GalOD) was immobilized on self-assembled monolayers of thiols on silver and gold surfaces using trans-stilbene (4,4′-diisothiocyanate)-2,2′disulphonic acid (DIDS) as the bridging compound. DIDS is the symmetrical bifunctional reagent that reacted with the amine moiety of the thiol and with primary amino groups of enzyme. The Rama...
Article
Galactose oxidase (GalOD) was immobilized on self‐assembled monolayers of thiols on silver and gold surfaces using trans‐stilbene (4,4′‐diisothiocyanate)‐2,2′disulphonic acid (DIDS) as the bridging compound. DIDS is the symmetrical bifunctional reagent that reacted with the amine moiety of the thiol and with primary amino groups of enzyme. The Rama...