Agneta MARIA Pusztai

• Medical Doctor at Victor Babeș University of Medicine and Pharmacy Timișoara

Background and Aims Glomerular injury and proximal tubule (PT) dysfunction have intricate mechanisms in diabetic kidney disease (DKD). Pro-inflammatory cytokines are involved in the initiation and progression of DKD through mediating the inflammatory response, both at glomerular and proximal tubular level. miRNAs are able to modulate cellular and b...

Background: Genetic information is used very frequently in human identification in civil or judicial cases. Establishing the kinship relationship between a child and his biological father involves many ethical facts. We describe a DNA paternity case with two alleged fathers and an inconsistency between alleged father-2 and the child at D3S1358 locu...

Human helminth zoonosis is one of the most encountered helminthiases worldwide. Representative diseases include Toxocara canis and Toxocara cati, which are common nematodes prevalent in dogs and cats. The infiltration of these roundworms in the human body through contaminated food or nematode eggs could lead to central nervous system injury as the...

The authors report a case of a 74-year-old woman found to have an extremely rare case highlighted by multidetector computed tomography (MDCT) angiography, with the presence of a replaced right hepatic artery (RRHA) arising from the splenic artery (SA). In this case, the SA arose from a gastrosplenic trunk (GST). The GST had an endoluminal diameter...

Neck and back pain may be noted like a first symptom in rare diseases: spinal cord ischemia and spinal dural arteriovenous fistula (SDAVF). Spinal cord ischemia is a rarer pathology, compared with cerebral ischemia, yet the morbidity and mortality are comparable in both cases; furthermore, classifying the acute loss of function in the spine, encoun...

Background and Aims Interactions among multiple molecules and signalling pathways contribute to the pathogenesis and progression of diabetic kidney disease (DKD). Long noncoding RNAs (lncRNAs) play key roles in the pathophysiology of DKD involving actions of microRNAs (miRNAs). The aim of the study was to establish the involvement of selected lncRN...

Background: The association of vascular remodeling in the kidney and the brain with a particular microRNAs (miRNA) profile is not well studied. Methods: Seventy-six patients with Type 2 diabetes and 11 healthy subjects were assessed concerning urine albumin: creatinine ratio (UACR), biomarkers of podocyte injury and of proximal tubule (PT) dysfunct...

Aim: The involvement of proinflammatory interleukins (ILs) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. Materials & methods: A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed. Resul...

Background Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process. The aim of our study was to show the relationship between the levels of s-Klotho and tubular injury in patient...

The authors illustrate a case of a 61-year-old male who presented an extremely rare association of anatomical variations highlighted by multi-detector computed tomography (MDCT) angiography, with a replaced right hepatic artery (RRHA) arising from inferior pancreaticoduodenal artery (IPDA), in association with left multiple renal arteries (RAs). Th...

We report a very rare case of a 57-year-old male who presented four left renal arteries (RAs) [one main RA and three additional renal arteries (AdRAs)] highlighted incidentally on multidetector computed tomography (MDCT) angiography, which was used to investigate the vascular system of the lower limbs. The distance between the extreme points of RAs...

The authors report the case of a 53-year-old male found to have an extremely rare case of a triple anatomical variation highlighted by multidetector computed tomography (MDCT) angiography, with the presence of a hepato-spleno-mesenteric trunk (HSMT) in association with an accessory left hepatic artery (ALHA) and a common trunk origin of right (RIPA...

We report a very rare case of a 67-year-old male with the presence of a common hepatic artery (CHA) arising from the left gastric artery (LGA) in association with a presence of a gastro-splenic trunk (GST), found incidentally on multidetector computed tomography (MDCT) angiography, used to investigate peripheral vascular disease. The GST arises fro...

Background Previous genome-wide association studies (GWAS) identified IGF1 , IRS1 , GCKR , PPARG , GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). We investigated the associations of these previously reported common variants in these genes with insulin resistance in overweight children from Romania and Moldova....

Background: Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process. The aim of our study was to show the relationship between the levels of s-Klotho and tubular injury in patie...

Over time, anatomists have been concerned with the preservation of anatomical parts for a long time. Thus, in the modern era, both colouring and fixing substances, as well as plastic and corrosive materials have been used in the manufacture of corrosion and plastinated specimens. The ultimate aim was to make the dissected anatomical specimens as la...

Background: Genetic information is used very frequently in human identification in civil or judicial cases. Establishing the kinship relationship between a child and his biological father involves many ethical facts. We describe a DNA paternity case with two alleged fathers and an inconsistency between alleged father-2 and the child at D3S1358 loc...

6-ethyl chenodeoxycholic acid (6ECDA) and deoxycholic acid (DCA) are two similar-structured cholanoic acids, the first being used in the treatment of primary biliary cholangitis, while the second is one of the natural secondary bile acids, currently being tested as a treatment component in the destruction of gallstones. This study was realised as n...

Prochlorperazine (PCP) and promethazine (PMT) are dopamine (D2) receptor antagonists with a phenothiazinic structure that used nowadays mainly for their antiemetic properties, including for the pre- and postoperative setting. In this paper, the thermal behavior of PCP and PMT was studied, including a complete kinetic analysis for the evaluation of...

In this paper, we present the spectroscopic description (by the means of UATR-FTIR spectroscopy) for four naturally occurring bile acids, namely lithocholic acid (LC), taurocholic acid sodium salt hydrate (TC), taurodeoxycholic acid sodium salt hydrate (TDC) and chenodeoxycholic acid (CDC), as well as their thermal behaviour in dynamic oxidative at...

The authors describe a case of a 61-year-old female patient, which presented on multidetector computed tomographic (MDCT) angiography a gastrosplenic trunk (GST) and common hepatic artery (CHA) arose independently from abdominal aorta (AA). The GST arose from the anterior wall of the AA, at the level of upper edge of the L1 vertebral body. The left...

MicroRNAs (miRNAs) are short non-coding RNA species that are important post-transcriptional regulators of gene expression. The aim of the study was to establish a potential explanation of podocyte damage and proximal tubule (PT) dysfunction induced by deregulated miRNAs expression in the course of type 2 diabetes mellitus (DM). A total of 68 patien...

Plastic compounds have been used for several decades to generate anatomical constructs for the training of new surgeons and medical students alike. The present study seeks to highlight the advantages and disadvantages of two different plastic compounds (Technovit 7143 and Epoxi BIODUR?E12) used to create corrosion casts of the vascular branching pa...

The liver segmentation is mainly determined by the intraparenchymatous distribution of the vascular and ductal hepatic elements; from this, the hepatic portal vein (HPV), is the most important afferent element. The lateral branches (LBrs) are serving left lateral division (LLD) of the liver and present a moderate morphological variability. On a tot...

On a total of 150 renal corrosion casts were examined the posterior branch and the artery of renal posterior segment. For the origin of the posterior branch, there have been highlighted three morphological types, namely: Type I, bifurcation in anterior and posterior branches (92.67% of cases); Type II, trifurcation in anterior, posterior and superi...

The elements of afferent pedicle of the liver have a segmental distribution to the liver parenchyma. Divergence part of the hepatic portal vein is the main element of intraparenchymatous spatial distribution vasculo-ductal systems. On 500 divergence (intraparenchimal) portions of of hepatic portal vein (125 pieces of liver corrosion casts, 125 ultr...

A comparative analysis of the origin and number of the arterial sources of the two poles of the renal artery was performed on 100 corrosion pieces and 50 dissection pieces. The renal artery trunk developed two branches (anterior and posterior) in 86.7% of cases, three branches (anterior, posterior and superior/inferior) in 10.7% of cases, and four...

Breast lymph drainage is complex. In case of breast cancer, the primary tumour drains into the first regional lymph node, the so called sentinel lymph node (SLN), which captures disseminated tumoral cells. In case of breast cancer, SLN biopsy evaluates node status, axillary stage of the disease. The study lot consisted of 45 female patients with ma...

The group of small hepatic veins form the lower group of hepatic veins ‐ participating in the venous drainage (VD) of the caudate lobe (CL) ‐ and the lower portions of right and left hepatic lobes. VDCL was examined by a number of 150 hepatic corrosion casts; the pieces were made by injecting plastic mass in the vascularductal elements of the liver...

Right renal ectopia with malrotation was seen on a CT angiography in a 64-year-old male patient. Bilateral triple renal arteries were also revealed: one main (superior) renal artery and two accessory arteries (middle and inferior), all originating in the abdominal aorta. The renal arteries are disposed symmetrically. The main arteries and the acces...

Terminologia Anatomica (1998) homologates the caudate branches (CBr) of the portal hepatic vein (PHV) originating from the transverse portion of the left branch of the PHV. Our previous papers described the presence of CBr originating from other segments of the PHV. We analyzed the types of spatial distribution of CBr of the PHV according to their...

Terminologia Anatomica (1998) homologates 2 arteries of the caudate lobe (CLA): right (RCLA) and left (LCLA), each originating from the homonym branch of the proper hepatic artery (PHA) (right branch ‐ RBr; left branch ‐ LBr). Our previous work evidenced variability both in origin and in number of CLA. We analyzed on 150 corrosion casts the types o...

Terminologia Anatomica (1998) homologates 2 ducts of caudate lobe (CLD): right (RCLD) and left (LCLD), each originating from the homonym hepatic duct (right ‐ RHD and left ‐ LHD). Our previous work evidenced variability both in origin and in number of the CLD. We analyzed on 150 hepatic corrosion casts the types of spatial distribution of CLD accor...

The necessity to perform complex surgical reconstructions at calf level represented a booster for surgical anatomy studies. The term of angiozome includes all the anatomical structures vascularized by a source artery. We studied the muscular teritory of the posterior tibial artery angiozome on 60 anatomical dissection casts and also on 10 lower leg...

According to Terminologia Anatomica, the portal hepatic vein (PHV) trunk bifurcates into the right branch and the left branch in the vicinity of the hepatic hillum. The caudate branches start from the transverse portion of the left branch. We studied the branching modalities of the PHV trunk and the morphological aspect of its branches at hillum le...

La veine porte hépatique (VPH) est considérée comme l’un des éléments vasculaires dont le mode de ramification intra-parenchymateuse est le plus constant. La branche antérieure (BA) se distribue au parenchyme de la division droite du parenchyme hépatique par deux branches segmentaires (segments V et VIII). Sur un matériel d’étude représenté par 155...

Selon la Terminologia Anatomica (1998), la veine porte hépatique (VPH) se ramifie dans la portion supérieure du pédicule hépatique en une branche droite (BrD) et une branche gauche (BrG). La BrD donne naissance aux branches antérieure (BrA) et postérieure (BrP). La BrG présente une portion transversale d’où naissent les branches caudées et une port...

Les branches médiales (BM) naissent de la portion ombilicale de la branche gauche (BG) de la veine porte hépatique (VPH). Elles vascularisent la division médiale gauche (DMG) du parenchyme hépatique. La segmentation de cette région du foie a été très étudiée dans la littérature anatomo-chirurgicale. Ainsi, le nombre de segments (S) de la DMG varie...

Le foie de type dorso-pétal est caractérisé par un lobe gauche de dimension plus grande, présentant une antéversion plus basse (voire même une rétroversion) et une surface de contact hépato-diaphragmatique plus petite. Selon le développement quantitatif des affluents d’origine (la veine antérieure gauche), la veine hépatique moyenne (VHM) peut être...

Dans la littérature anatomique, on considère que, de toutes les artères de l’organisme, les artères rénales sont celles qui présentent la plus remarquable variabilité morphologique. Les plus importants aspects de variabilité se rapportent au nombre et à la distribution intra-parenchymateuse des branches artérielles. D’un nombre total de 225 pièces...

Le système de drainage veineux du parenchyme rénal est constitué par la succession de six ordres de collecteurs veineux, les derniers étant représentés par des troncs veineux antérieurs et postérieurs (situés respectivement en avant et en arrière du pelvis rénal) ; de leur union naît la veine rénale. D’un matériel d’étude représenté par 200 pièces...