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January 2013 - present
January 2009 - present
January 2008 - present
Publications
Publications (101)
The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic synd...
Background
Adequate nutrition and regular physical activity (PA) are key elements in healthy aging. In France, behavioural interventions promoting healthy eating and PA in older adults consist mainly in collective workshops organised by pension and health insurance funds. After analyzing pre-existing workshops, we designed the co-constructed projec...
Background
Diet and physical activity are key components of healthy aging. Current interventions that promote healthy eating and physical activity among the elderly have limitations and evidence of French interventions’ effectiveness is lacking. We aim to assess (i) the effectiveness of a combined diet/physical activity intervention (the “ALAPAGE”...
Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with...
Background:
The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks.
Methods:
A total of 91 patients with MS (MS; 39 men, 52 women)...
Aim
The study investigated changes in microvascular perfusion during post-exercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity.
Methods
Skin blood perfusion was assessed in each group using laser doppler flowmetry and laser speckle contrast imaging before and...
Background and Aim
Childhood obesity is associated with vitamin D (VD) deficiency and vascular dysfunction. Considering evidence indicates that VD may improve vascular function, this study, for the first time, assessed the effect of VD supplementation on microvascular reactivity in obese adolescents (OA).
Methods and Results
This randomized contro...
Postural changes induce arteriolar vasoconstriction in response to an increase in venous pressure in the limbs known as the venoarteriolar reflex (VAR). Previous studies reported that skin blood perfusion is impaired during the VAR in persons with type 2 diabetes mellitus (T2DM) with or without peripheral neuropathy, compared to control subjects. T...
Introduction et but de l’étude
Accompagner les seniors pour vieillir en bonne santé est primordial, à la fois pour la qualité de vie des seniors mais aussi pour limiter les coûts sociétaux de la perte d’autonomie. La recherche interventionnelle ALAPAGE vise à concevoir et à évaluer une intervention à destination des seniors basée sur des ateliers c...
Background and Aims
Epidemiological studies show that obese adolescents are candidates to suffer cardiovascular pathologies in adulthood. In order to detect subfractions with diagnostic value for future cardiovascular disorders, we analysed the complete lipoprotein profile of severely obese adolescents.
Methods and Results
Twenty eight obese adole...
Introduction
Cardiac Autonomic Neuropathy (CAN) is a common underdiagnosed complication of type 2 diabetes (DT2). Heart Rate Variability (HRV) at rest, in the time and frequency-domain, has been shown to effectively diagnose CAN. Post-exercise recovery period is associated with changes in parasympathetic and sympathetic control, allowing potential...
Introduction
Microcirculation dysfunction is common in type 2 diabetes (DT2) and plays a crucial role in diabetic neuropathy (NP) development. Some microcirculatory vasomotor changes are altered in DT2 with NP. Acute exercise is known to induce a skin vasodilatory response dependent in part on endothelial and neurogenic factors. In this way, we hyp...
Objectives:
This study was performed to evaluate the long-term maintenance of nutritional changes promoted during an intensive initial intervention to induce body weight loss. The ability of these changes to predict long-term health outcomes was also examined.
Methods:
Nutritional variables, body composition, and metabolic markers collected in t...
Recording oscillations in cutaneous blood perfusion using laser Doppler flowmetry (LDF) is of common use in clinical research, due, mainly, to its non-invasive nature. Detailed information about the vascular tone in different frequency bands and the related physiologic compartment can be inferred from wavelet analysis (WA) of an LDF signal. However...
L’activité physique adaptée (APA) se définit comme une activité physique ou sportive adaptée aux capacités de personnes à besoins spécifiques : atteintes de maladies chroniques, vieillissantes, en situation de handicap ou vulnérables. Elle mobilise des connaissances scientifiques pluridisciplinaires pour évaluer les ressources et les besoins des in...
Introduction et but de l’étude
Une alimentation adéquate et une activité physique régulière sont des éléments clés du vieillissement en bonne santé. Depuis 2016, un partenariat est engagé en PACA entre chercheurs et acteurs clés de la prévention en nutrition destinée aux seniors (Carsat Sud-Est, Mutualité Française Sud, Pôle Infos Seniors Marseille...
Introduction et but de l’étude
L’activité physique dans la prise en charge du diabète de type 2 (DT2) est un élément fondamental pour lutter contre la maladie et ses complications cardiovasculaires et dégénératives, influençant fortement la qualité de vie du patient. L’objectif a été d’établir des recommandations dans le cadre de la procédure d’exp...
Obesity in children is associated with vitamin D (VD) deficiency and cardiometabolic abnormalities. To analyze the effects of VD supplementation in adolescents with obesity enrolled in a weight-loss program. Adolescents with obesity (n=26) and with normal weight (n=23; controls) were matched for age, sex, and puberty stage. The obesity group follow...
Oxidative stress-related inflammation is known to play a vital role in obesity-associated cardiovascular disease, contributing to the early stages of the pathology as well as during its development. Therefore, it is of great interest to understand how obesity-induced stress modulates antioxidant enzyme activity during puberty. To this end, 27 sever...
The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic ex...
Ce document présente la synthèse et les recommandations issues
des travaux du groupe d’experts réunis par l’Inserm dans le cadre
de la procédure d’expertise collective (voir annexe) pour
répondre à la demande du Ministère chargé des sports concernant
la prévention et le traitement des maladies chroniques par
l’activité physique1.
Ce travail s’appui...
Objective: The prevalence of type 2 diabetes (T2D) is rapidly increasing in Sub-Saharan Africa, where sickle-cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of developin...
Objective:
To determine which modality of exercise program (endurance and/or resistance dominance) is the most effective for improving vascular function in the micro- and macrocirculation in metabolic syndrome (MetS).
Methods:
Sixty-two MetS patients were enrolled in a 6-month lifestyle intervention program based on diet and exercise training. E...
The optimal exercise modality for the improvement of health-related parameters and microvascular function in obese adolescents is not yet fully understood. Therefore, this study aimed to 1) compare the microvascular phenotype of obese and normal-weight adolescents; and 2) to determine the effects of a lifestyle intervention including three months o...
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eight...
Objectives:
To demonstrate that lifestyle modifications will reduce the cost of routine medications in individuals with type 2 diabetes (T2D), through a mechanism involving glycaemic control.
Design:
A within-trial cost-medication analysis with a 1-year time horizon.
Setting:
Controlled environment within the spa resort of Chatel-Guyon, France...
Aims:
To analyse the effects of different modalities of exercise training on heart rate variability (HRV) in individuals with metabolic syndrome (MetS).
Methods and results:
Eighty MetS participants (aged 50-70 years) were housed and managed in an inpatient medical centre for 21 days, including weekends. Physical activity and food intake/diet we...
Introduction et but de l’étude
Les adolescents obèses ont non seulement une insulinorésistance associée à une dysfonction vasculaire mais aussi un déficit en vitamine D dont le rôle dans la régulation du métabolisme phosphocalcique est bien établi. Par ailleurs, il existe une association inverse forte entre taux de vitamine D et risque cardiovascul...
Aims:
The purpose of our study was to determine the effect of lifestyle intervention on left ventricular (LV) regional myocardial function in patients with metabolic syndrome (MetS) and investigate the relationships of the changes in myocardial function to changes in epicardial adipose tissue (EAT), inflammatory profile and MetS components.
Metho...
Dietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results of clinical studies on patients with MetS involving the chronic supplementation of a polyphenol-rich diet, foods, extracts or with single phenolics on the features of MetS (obesity, dysli...
Background:
Weight loss is a public health concern in obesity-related diseases such as metabolic syndrome (MetS). However, restrictive diets might induce bone loss. The nature of exercise and whether exercise with weight loss programs can protect against potential bone mass deficits remains unclear. Moreover, compliance is essential in interventio...
Overconsumption of sugary drinks has recently been implicated in the pathogenesis of cardiovascular disease. Our objective was to elucidate acute hemodynamic and nitric oxide (NO)- related micro- and macrovascular responses to the ingestion of a commercial sugary drink containing sucrose or tap water with or without sucrose at a similar concentrati...
The first objective of this study was to demonstrate differences within endothelial-dependent and endothelial-independent vasoreactivity in macro- and microcirculation beds among patients with metabolic syndrome (MetS) with and without type 2 diabetes mellitus (T2D) compared with healthy counterparts. The second objective was to determine relations...
Background:
While aerobic exercise training may decrease arterial stiffness, the impact of combined aerobic and resistance training is unclear. Therefore, the aim of this study was to systematically review and quantify the effect of combined aerobic and resistance training on arterial stiffness, as determined by arterial pulse wave velocity (PWV),...
Context and objective:
This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Seventeen SOA (body mass index z-score = 4.22...
Context and objective:
Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were...
Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle inter...
We aimed to comprehensively evaluate lipoprotein profile including lipid particle size following a lifestyle intervention in metabolic syndrome (MetS) volunteers and to assess the associations between lipoprotein subfractions and carotid-intima-media-thickness (CIMT) – a surrogate indicator of atherogenesis.
100 participants (50–70 years) from the...
and Objective
Controversy exists as to whether aerobic exercise training decreases arterial stiffness in obese subjects. The aim of this study was to systematically review and quantify the effect of aerobic exercise training on arterial stiffness in obese populations.MethodsMEDLINE, Cochrane, Scopus, and Web of Science were searched up until May 20...
Controversy exists as to whether aerobic exercise training decreases arterial stiffness in obese subjects. The aim of this study was to systematically review and quantify the effect of aerobic exercise training on arterial stiffness in obese populations.
MEDLINE, Cochrane, Scopus, and Web of Science were searched up until May 2013 for trials assess...
Introduction
Les bénéfices d’une activité physique régulière sont bien connus non seulement en terme de prévention du diabète de type 2 (DT2) mais également dans la prise en charge globale de la pathologie. Le réentraînement à l’effort standardisé engendre des améliorations du profil métabolique et de la capacité physique fonctionnelle (CPF) chez l...
With its increasing prevalence, obesity represents a major public health issue. Obesity, particularly visceral obesity, is associated with endothelial dysfunction mainly via decreased nitric oxide (NO) bioavailability, resulting from decreased expression of endothelial NO synthase (eNOS), loss of eNOS activity, and accelerated NO degradation by rad...
Objective:
The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocard...
The presence of left ventricular (LV) dyssynchrony in individuals with metabolic syndrome (MetS), a predictor of type 2 diabetes (T2D), lacks clarity. We compared LV dyssynchrony in MetS individuals with and without T2D, and healthy control subjects using speckle-tracking imaging echocardiography. Ninety-two MetS participants (64 without, 28 with T...
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus (T2DM) subjects. The aim of this study was to systematically review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects. MEDLINE, Cochrane, Scop...
Objective:
Recent findings indicated silent incipient myocardial dysfunction in juvenile obesity despite normal global cardiac function. The present study investigated whether lifestyle intervention is able to favorably impact these obesity-related myocardial abnormalities and whether improvements are related to changes in insulin resistance and c...
By means of flowmotion analysis, it is mainly accepted that, in normal conditions, insulin specifically increases the activity of microvascular smooth muscle. The objective of this study was to compare this effect in severely obese and normal-weight adolescents. Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotio...
Controversy exists among trials assessing whether exercise can improve arterial function in type 2 diabetes mellitus (T2DM) subjects. Therefore the aim of this study was to systematically review and quantify the effects of exercise on arterial function in T2DM subjects.
MEDLINE, Cochrane, Scopus and Web of Science were searched up until January 201...
In type 2 diabetes, in contrast to the well-documented endothelial dysfunction, studies assessing vascular smooth muscle (VSM) function have yielded discrepant results over the last two decades. We therefore sought to determine whether or not VSM function is impaired in individuals with type 2 diabetes.
We conducted a systematic search of MEDLINE,...
Severe obesity is one of the fastest growing obesity categories in childhood [1], and has been related to vascular stiffness in central elastic arteries [2]. However, recent reports have shown a preserved arterial compliance in obese adolescents compared to their normal-weight counterparts [3–5], thus suggesting that the mechanisms relating obesity...
The prevalence of severe obesity is increasing worldwide in adolescents. Whether it is associated with functional myocardial abnormalities remains largely unknown, potentially because of its frequent association with other cardiovascular risk factors and also use of insensitive techniques to detect subclinical changes in myocardial function. We use...
Introduction: The main risk of morbi-mortality in subjects suffering from metabolic syndrome (MS) is cardiovascular. It is mainly associated with elevated LDL-cholesterol (LDL-c). Electrophoresis of LDL-c screens subfractions numbered 1- 7. Among them, the subfractions 3-7 are specifically atherogenic. Diet and exercise improve this atherogenic pro...
With an increasing prevalence, pediatric obesity is often a prelude to adulthood obesity, and represents a major public health issue. Comorbidities are very common and severe in obese adults, justifying the search for earlier markers or risk factors for cardiovascular diseases in obese children. Endothelial dysfunction has been found to be present...
Eur J Clin Invest 2011; 41 (11): 1149–1163
The aim of this study was to evaluate the impact of a low-intensity training program on subclinical cardiac dysfunction and on dyssynchrony in moderately obese middle aged men. Ten obese and 14 age-matched normal-weight men (BMI: 33.6 ± 1.0 and 24.2 ± 0.5 kg/m(2)) were included. Obese men participated in an 8-week low-intensity training program wit...
Although increased blood flow (BF) in exercising muscles is thought to be impaired in obese subjects and may contribute to physical inactivity, data are scarce in this regard and the involvement of endothelium dysfunction remains partly hypothetical.
A total of 16 middle-aged obese men (body mass index, BMI ≥ 30 kg m(-2)) and 16 normal-weight men (...
The purpose of the study was to evaluate the dynamics of diastolic and systolic function from rest to maximal exercise using conventional echocardiography and tissue Doppler imaging (TDI) in obese prepubertal boys compared to age-matched lean controls. Eighteen obese (10 with first degree obesity and 8 with second degree obesity according to French...
Obese children exhibit vascular disorders at rest depending on their pubertal status, degree of obesity, and level of insulin resistance. However, data regarding their vascular function during exercise remain scarce. The aims of the present study were to evaluate vascular morphology and function at rest, and lower limb blood flow during exercise, i...
Resting and exercise cardiac function, skeletal muscle oxygenation and whole-body aerobic exercise capacities were evaluated prospectively in cardiac symptom-free HIV men receiving antiretroviral therapies and in healthy controls matched for age, physical activity, smoking and body surface area. HIV patients showed resting cardiac dysfunction, alte...
Although cardiotoxic effects of highly active antiretroviral therapy (HAART) are a growing concern, there is a lack of prospective studies of subclinical involvement of the heart in human immunodeficiency virus (HIV)-infected patients. This study evaluated noninvasively cardiac morphologic characteristics and function in HIV-positive (HIV(+)) men r...
The effect of body posture (e.g., gravity) on circulatory responses to exercise remains to be clarified. This study was designed to examine cardiovascular dynamics during prone swim bench exercise in age-group swimmers and to compare these responses to those of matched non-athletic children. Fourteen trained swimmers (mean age 11.3+/-0.5 years) per...
Pulse wave velocity measurement is used as an index of arterial stiffness. The purpose was to evaluate the reproducibility of pulse wave velocity measurement at rest, during exercise and recovery from exercise, using an automated device. Twelve healthy young adults (mean age 22.0 +/- 3.1 yrs) underwent an upright submaximal cycle test on two separa...
Little attention has been paid to children with respect to factors controlling maximal oxygen uptake (V.O (2max)). This study was therefore specifically designed to examine the potential relationships between cardiac size, diastolic function and O (2) carrying capacity with maximal aerobic capacity. Specifically, body size indices (body surface are...
In children, there is very limited evidence focusing on the beneficial effect of exercise training on heart rate variability (HRV) during childhood. Despite the fact that more and more children are engaged in intensive training programs, the question arises if such intensive training involves deleterious effects on the cardiac autonomic nervous sys...
Unlabelled:
Cardiovascular adaptations to training may include changes in arterial distensibility, although studies involving sick and healthy individuals have yielded contradictory results. Moreover, despite the fact that endurance training frequently begins in childhood, its influence on arterial distensibility is less well characterised in chil...
To determine the relative contribution of the gender difference in body composition, blood hemoglobin concentration, and cardiac dimension and function at rest and exercise of the gender difference in maximal oxygen uptake (O(2)max) in 10- to 12-year-old children.
Thirty-five healthy children (17 girls and 18 boys; mean +/- SD age, 10.5 +/- 0.4 yea...