Agnes Llamasares Castillo

Agnes Llamasares Castillo
University of Santo Tomas | UST · Department of Pharmacy

PhD Pharmacy

About

41
Publications
19,521
Reads
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179
Citations
Additional affiliations
June 2014 - June 2016
University of Santo Tomas
Position
  • Professor (Assistant)
June 2014 - June 2016
University of Santo Tomas
Position
  • Resident Researcher
June 2006 - June 2016
University of Santo Tomas
Position
  • Professor (Assistant)

Publications

Publications (41)
Article
Background: Breast cancer is currently the world's most predominant malignancy. In cancer progression, angiogenesis is a requirement for tumor growth and metastasis.Alpinumisoflavone (AIF), a bioactive isoflavonoid, exhibited good binding affinity with the angiogenesis pathway's druggable target through molecular docking. Objectives: To confirm...
Article
Full-text available
Fullerene molecules are composed of carbon in the form of a hollow sphere, tube, or ellipsoid. Since their discovery in 1985, they have gained a lot of attention in many science fields. The unique carbon cage structure of fullerene provides immense scope for derivatization, rendering potential for various industrial applications. Thus, the prospect...
Article
Full-text available
Context: Hyperuricemia is a metabolic syndrome characterized by a high serum uric acid level with an increased risk of gout, diabetes, cardiovascular and renal disease. Allopurinol is a widely known xanthine oxidase inhibitor that lowers serum uric acid production. Documented adverse effects of the drug raise the need for a natural alternative for...
Article
Full-text available
Purpose: The purpose of this study was to evaluate the intraocular pressure (IOP) reduction efficiency of hyaluronic acid-chitosan-latanoprost link nanoparticle (HA-CS-latanoprost link NP) formulated eye drops. Methods: The IOP reduction study was performed in 24 normotensive albino rabbits. The test animals were randomized and grouped according...
Article
Full-text available
Cardiovascular disease (CVD) is the number one cause of death worldwide. This condition resulted in huge research on CVD increasing the need for animal models suitable for in vivo research. Daphnia and zebrafish are good animal models for cardiovascular research due to their relative body transparency and easy culture property. Several methods have...
Article
Full-text available
Introduction: Cancer is considered as one of the deadliest human diseases today. Angiogenesis, the propagation of new blood vessels from pre-existing vasculature, is a critical step in the progression of cancer as it is essential in the growth and metastasis of tumors. Hence, suppression of angiogenesis is a promising approach in cancer therapy. Sy...
Preprint
Full-text available
Cardiovascular disease (CVD) is the number one cause of death worldwide. This condition resulted in huge research on CVD increasing the need for animal models suitable for the in vivo research. Daphnia and Zebrafish are good animal models for cardiovascular research due to their relative body transparency and easy culture property. Several methods...
Preprint
Full-text available
Fullerene molecules are composed of carbon in forms of a hollow sphere, ellipsoid, or tube. Fullerenes have attracted considerable attention in different fields of science since their discovery in 1985. The unique carbon cage structure of fullerene provides immense scope for derivatization, rendering potential for various industrial applications. T...
Article
Full-text available
Simple Summary: With the advantages of easy culture, body transparency, and high sensitivity to chemical pollution, water fleas have been recognized as a good model for ecotoxicity studies. In this paper, we established ImageJ-based methods to measure cardiovascular performance by evaluating the heart rate and blood flow velocity in three water fle...
Article
Full-text available
The heart is the most important muscular organ of the cardiovascular system, which pumps blood and circulates, supplying oxygen and nutrients to peripheral tissues. Zebrafish have been widely explored in cardiotoxicity research. For example, the zebrafish embryo has been used as a human heart model due to its body transparency, surviving several da...
Article
The Pandanus tectorius methanolic (PTM) and P. tectorius aqueous (PTA) extracts were investigated for their potential in vivo anti-inflammatory activity using carrageenan-induced rat paw edema. Parameters including paw thickness measurement, histopathological, and immunohistochemical cyclooxygenase (COX)-2 expression analyses were measured and anal...
Article
Full-text available
Background Cancer is a very serious public health problem ranking as the second leading cause of death worldwide. Angiogenesis plays a vital role as a prerequisite for tumor growth and metastasis and is indispensable in the further stage advancement of cancer. Objective Targeting several enzymes and receptors in angiogenesis’ signal transduction p...
Article
Full-text available
Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate mucoadhesive buccal tablet using Mefenamic acid and compatible excipients, and to evaluate the product using quality control tests and in vitro tests. The ingredients were subjecte...
Article
Mupirocin is a promising broad -spectrum antibiotic that is effective in treating MRSA infections. However, due to its rapid elimination and hydrolysis following injection and high protein binding, current therapeutic use is limited to topical administration. Nanotechnology -driven innovations provide hope for patients and practitioners in overcomi...
Article
Mupirocin is a promising broad-spectrum antibiotic that is effective in treating MRSA infections. However, due to its rapid elimination and hydrolysis following injection and high protein binding, current therapeutic use is limited to topical administration. Nanotechnology-driven innovations provide hope for patients and practitioners in overcoming...
Article
Full-text available
Context: The prevalence of alopecia around the world is high and awareness continuously increased due to social stigma. There are limited commercially-available medications for the management of different forms of baldness, most of which are prohibitively expensive and presents with various adverse effects. Aims: To evaluate the flavonoid-rich eth...
Article
Full-text available
Tinospora sinensis, a Philippine medicinal plant with reported anti-inflammatory activity, is traditionally used for wounds and scabies. Tinospora extract could exhibit activity against allergen-induced contact dermatitis which is characterized by itching with erythema and vesicles. To explore the effectivity of the Tinospora extracts in contact hy...
Presentation
Syzygium lineatum or “lubeg” is a popular nutraceutical plant in the Apayao region known for its traditional antioxidant and cancer-healing properties. In this study, a bioassay-guided approach was undertaken to investigate the anti-cancer principles from lubeg. Thus, crude extraction of the air-dried leaves followed by fractionation afforded three...
Article
Full-text available
Tinospora sinensis, a Philippine medicinal plant with reported anti-inflammatory activity, is traditionally used for wounds and scabies. Tinospora extract could exhibit activity against allergen-induced contact dermatitis which is characterized by itching with erythema and vesicles. To explore the effectivity of the Tinospora extracts in contact hy...
Presentation
Citrus essential oil loaded niosomes: its formulation, characterization and cytotoxicity activity
Presentation
Tinospora Lotion and stem extracts as remedy for ski diseases
Article
Full-text available
Objective: To investigate and characterize the chemical composition of the different crude extracts from the leaves of Broussonetia luzonica (Blanco) (Moraceae) (B. luzonica), an endemic plant in the Philippines. Methods: The air dried leaves were powdered and subjected to selective sequential extraction using solvents of increasing polarity throug...
Poster
Dementia is the decline in memory or thinking skills which is caused by progressive brain cell death. Mussaenda philippica A. Rich leaf extracts were used to determine its effects on the memory and brain tissues of Sprague-Dawley rats. Prior to the determination of the anti-dementia property of Mussaenda philippica A. Rich, the antioxidant property...
Article
Full-text available
Introduction: Broussonetia luzonica (Moraceae) Blanco is an edible and endemic plant in the Philippines. Other species of the plant are used traditionally in Chinese medicine to treat impotency and eye disorders and was proven to have anticancer potential. To date, there are no published scientific evidences yet to prove the cytotoxicity against he...
Article
Durio zibethinus L. (Malvaceae) also known as “Durian” in the Philippines is an evergreen tropical tree found mainly in the regions of Mindanao and Sulu. One-fourth of the fruits' mass is composed of seeds which is usually discarded [1]. This study aimed to determine the binding efficacy of extracted Puyat variety of Durian seed gum in Paracetamol...
Conference Paper
Full-text available
Cancer has always been one of the most prevalent diseases worldwide. According to the International Agency of Research of Cancer (2012), there are an estimated 14.1 million new cancer cases, and 8.2 million cancer-related deaths. T. foetidissima is a native plant species from the Philippines. This research aims to provide significant information re...
Poster
Full-text available
There were no significant changes observed in the lotion samples after 30 days which indicates physical compatibility of titanium dioxide with Tinospora extract and excipients. The mean tensile strength of the controlled incision [F=0.683, p=0.524] and the treated incision with Tinospora lotion [F=1.134, p=0.354] showed no significant difference. H...
Article
Full-text available
Free radicals injure the cells and damage the DNA that may cause diseases such as cancer, which has been found to cause 22% of all non-communicable diseases in 2012. Antioxidants take part in the prevention of cellular damage caused by oxidative stress. Plants with components such as alkaloids and flavonoids have been proven to exhibit antioxidant...
Article
Full-text available
Epilepsy is the most widespread neurological problem and is manifested in erratic and periodic disturbance of neurologic activity called seizures. A preclinical study was performed to investigate the anticonvulsant activity of the aqueous seed fraction of Cassia fistula Linn. in ICR Swiss albino mice using Maximal Electroshock-induced (MES) and Str...
Article
Full-text available
Bacterial biofilm formation can cause serious problems in clinical and industrial settings, which drives the development or screening of biofilm inhibitors. Pseudomonas aeruginosa is a well-known pathogen that exhibit biofilm formation through quorum-sensing, which is a bacterial cell-to-cell communication that regulates the production of many viru...
Article
Full-text available
Scabies is a contagious, parasitic skin infestation caused by Sarcoptes scabiei mite, which has the ability to regulate the host's inflammatory and immune responses. It is a serious community health problem in many less-developed countries. A randomized, controlled, parallel, pilot clinical study was performed to investigate the immunomodulatory ef...
Article
Full-text available
To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion. A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed...

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Projects

Projects (6)
Project
The primary objective is to evaluate whether the ethanolic leaf and most active sub-extracts of Alpinia elegans (C.Presl) K. Schum. possess chondroprotective activity. This will be assessed using MIA-induced Osteoarthritis Rat Model through possible modulation of oxidative stress, IL-1β, TNF- α, MMP-13 and MMP3
Project
The researcher's primary objective is to evaluate whether the ethanolic leaf and most active sub-extracts of Alpinia elegans (C.Presl) K. Schum. possess chondroprotective activity. Specifically, this study aims (1) to evaluate the acute oral toxicity of the leaf extract in experimental animals, (2) to determine its chondroprotective activity, superoxide dismutase (SOD), MMP13 and MMP3, Tumor Necrosis Factor alpha (TNF- α) and Interleukin1β will be measured using ELISA Kits while Catalase (CAT) will be assessed using Catalase activity Assay Kit (3) Histological analysis of the rat cartilage will be done specifically to determine articular cartilage injuries, cellular abnormalities and proteoglycan loss.