Agata Kurzyk

Maria Sklodowska Curie National Research Institute of Oncology · Department of Cancer Biology

Nanohydroxyapatite (nanoHAP) is widely used in bone regeneration, but there is a need to enhance its properties to provide stimuli for cell commitment and osteoconduction. This study examines the effect of calcination at 1200 °C on the physicochemical and biological properties of nanoHAP doped with magnesium (Mg²⁺), strontium (Sr²⁺), and zinc (Zn²⁺...

The study examines the effect of calcination at a temperature of 1200°C on the physicochemical and biological properties of nanohydroxyapatite (nanoHAP) substituted with magnesium (Mg ²⁺ ), strontium (Sr ²⁺ ), and zinc (Zn ²⁺ ). The materials were characterized by Fourier-transform spectroscopy, X-ray diffraction (XRD), scanning electron microscopy...

Hepatocellular carcinoma (HCC) is one of the most threatening tumours in the world today. Pharmacological treatments for HCC mainly rely on protein kinase inhibitors, such as sorafenib and regorafenib. Even so, these approaches exhibit side effects and acquired drug resistance, which is an obstacle to HCC treatment. We have previously shown that se...

Evaluation of mesenchymal stem cell seeding efficiency in three-dimensional (3D) scaffolds is a critical step for constructing a potent and useful tissue engineering product for regenerative medicine. To determine the quantity of cells seeded on a scaffold, their condition and viability, and/or to confirm cell adhesion to the scaffold surface, a nu...

Background: Vascularization is important for the clinical application of tissue engineered products. Both adipose-derived stem cells (ASCs) and surgical prefabrication can be used to induce angiogenesis in scaffolds. Our aim was to compare the angiogenic potential of ASC-seeded scaffolds combined with scaffold prefabrication with that of non-seede...

The purpose of the current study was to evaluate the usefulness of adipose-derived stem cells (ASCs) for bone injury therapy. Lipoaspirates were collected from the abdomen regions of 17 healthy female donors (mean age 49 ± 6 years) using Coleman technique or Body-jet liposuction. In the present study, the primary objective was the in vitro characte...

Adipose tissue yields adult adipose stem cells (ASCs) in large quantities via less-invasive methods. These cells are of interest owing to their modulating properties and paracrine activities, which can be harnessed in regenerative medicine. Many studies on the use of rat fat tissue in an autologous animal model have been conducted; however, the dif...

Angiogenesis is the formation of new blood vessels from existing vessels. This process occurs via budding endothelial cells in postnatal period, which is essential to many physiological phenomena (e.g. wound healing, formation of the placenta) and pathological ones such as cancer, ischemic diseases, and chronic inflammation. Various mechanisms of t...

Artykuł otrzymano 25 sierpnia 2014 r. Artykuł zaakceptowano 5 listopada 2014 r. Słowa kluczowe: angiogeneza, śródbłonek, czynnik proangiogenny, czynnik antyan-giogenny, antyangiogenna terapia, nowo-twór, komórki macierzyste Wykaz skrótów: AML (ang. acute myelo-id leukemia) — ostra białaczka szpikowa; FGF (ang. fibroblast growth factor) — czyn-nik w...

The multipotential progenitor cells called ,Mesenchymal Stem Cells" (MSC) are capable of differrentiation at least into bone, cartilage, and adipose tissues. The commonly recognized role of these cells is the formation of connective tissue which participates in formation of every organ. The progeny of MSC produces also the hematopoietic microenviro...

High light induces the production of cysteine and glutathione (GSH) as part of the oxidative stress response triggered by reactive oxygen species. Cysteine is produced in a two-step process, in which serine acetyltransferase (SAT) catalyses the first reaction. In Arabidopsis thaliana cyclophilin CYP20-3 was reported to promote plastidic SAT1 activi...

Glioblastoma multiforme is the most common type of primary brain tumor in adults. WWOX is a tumor suppressor gene involved in carcinogenesis and cancer progression in many different neoplasms. Reduced WWOX expression is associated with more aggressive phenotype and poor patient outcome in several cancers. We investigated alternations of WWOX expres...

Glioblastoma multiforme is the most common type of primary brain tumor in adults. WWOX is a tumor suppressor gene involved in carcinogenesis and cancer progression in many different neoplasms. Reduced WWOX expression is associated with more aggressive phenotype and poor patient outcome in several cancers. We investigated alternations of WWOX expres...