Aftab Ahmad

• M. Pharm, Ph.D.(Pharmaceutical Sciences)
• Associate Professor at King Abdulaziz University

Introduction: Miscarriage, an unfortunate outcome of pregnancy, presents significant challenges in reproductive health for individuals and families worldwide. This review highlights the importance of-Progesterone‖ ahormone vital for the maintenance of pregnancy, in miscarriage.Decreased progesterone levels are associated with increased myometrial c...

Ebola virus disease (EVD) is a rare, highly contagious and a deadly disease with a variable fatality rate ranging from 30% to 90%. Over the past two decades, Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo (DRC), and Uganda. The causative agents of the most EVD cases are three distinct species o...

Microorganisms produce diverse classes of metabolites under various physiological conditions. Many bacterial strains have been reported to carry out the process of desulfurization in a cost-effective manner by converting dibenzothiophene (DBT) into 2-hydroxybiphenyl (2-HBP) and then using the 2-HBP as a carbon source for growth and development. Key...

Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has b...

The current study was conducted to examine the possible advantages of Heydotis corymbosa (L.) Lam. extract nanogel as a perspective for enhanced permeation and extended skin deposition in psoriasis-like dermatitis. Optimised nanophytosomes (NPs) were embedded in a pluronic gel base to obtain nanogel and tested ex vivo (skin penetration and dermatok...

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ACh). This can cause a variety of cognitive and neurological problems, including Alzheimer’s disease. Taxifolin is a natural phytochemical generally found in yew tree bark and has significant pharmacol...

Globally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal therapies, precision medicine, and palliative care, and traditional therapies such as surgery, radiation therapy...

Metabolic syndrome (MetS) therapy with phytochemicals is an emerging field of study with therapeutic potential. Obesity, insulin resistance, high blood pressure, and abnormal lipid profiles are all components of metabolic syndrome, which is a major public health concern across the world. New research highlights the promise of phytochemicals found i...

With an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise. Every year, millions of animals are used for experimental testing during which these suffer from pain and are then eventually sacrificed. Besides bioethical issues,...

Acyclovir (ACV) is a promising candidate for drug repurposing because of its potential to provide an effective treatment for viral infections and non-viral diseases, such as cancer, for which limited treatment options exist. However, its poor physicochemical properties limit its application. This study aimed to formulate and evaluate an ACV-loaded...

Obesity is a major metabolic disorder in developed countries, with an increasing number of people affected globally. PPARγ is primarily expressed in adipose tissue with a lesser extent in other tissues. PPARγ is an important mediator in several metabolic processes such as insulin sensitivity and adipogenesis. Because of its critical role in these p...

Background: Hepatic fibrosis is a major health problem all over the world, and there is no effective treatment to cure it. Hence, the current study sought to assess the anti-fibrotic efficacy of apigenin against CCl4-induced hepatic fibrosis in mice. Methods: Forty-eight mice were put into six groups. G1: Normal Control, G2: CCl4 Control, G3: Si...

A pharmaceutical formulation with favorable pharmacokinetic parameters is more likely to be efficacious and safe to overcome the failures of the drug resulting from lack of efficacy, poor bioavailability, and toxicity. In this view, we aimed to evaluate the pharmacokinetic functionalities and safety margin of an optimized CS-SS nanoformulation (F40...

Objective: A significant global health issue that affects 25.5% of Saudi people is hypertension (HTN). According to international recommendations, most HTN patients require more than one therapy to reach their blood pressure targets (BP). Therefore, it would be preferable to utilize two medications from distinct classes separately or in a predeter...

Citation: Fule, R.; Kaleem, M.; Asar, T.O.; Rashid, M.A.; Shaik, R.A.; Eid, B.G.; Nasrullah, M.Z.; Ahmad, A.; Kazmi, I. Formulation, Optimization Abstract: Innovative drug delivery systems based on iron oxide nanoparticles (INPs) has generated a lot of interest worldwide and have prime biomedical benefits in anticancer therapy. There are still issu...

A series of benzimidazole-tethered pyrrolones and N-benzylpyrrolones were synthesized, charac­terized, and explored for their in vitro anti-proliferative activities. The cytotoxicity of the synthesized com­pounds was evaluated against three cancer cell lines, A549, MCF7, and DU145. (E)-5-(1H-Benzimidazol-2-yl)-3-(3,4,5-trimethoxbenzylidene)-1H-pyrr...

Triple-negative breast cancer is considered the most aggressive type of breast cancer among women and the lack of expressed receptors has made treatment options substantially limited. Recently, various types of nanoparticles have emerged as a therapeutic option against TNBC, to elevate the therapeutic efficacy of the existing chemotherapeutics. Amo...

Backgrounds Inter-individual variability in response to statin was mainly due to genetic differences. This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH)...

With a high prevalence globally, asthma is a severe hazard to human health, as well as an economic and social burden. There are now novel therapies available for asthma with the use of nanotechnology. Recent developments in nanoscience and medicine have encouraged the creation of inhalable nanomedicines that can enhance the efficacy, patient compli...

Objectives Tuberculosis is a chronic lung disease caused by Mycobacterium tuberculosis (MTB), whose thick cell envelope and drug metabolizing enzymes offering it multidrug resistance. Therefore, there is a need to identify new molecular targets, biologically active as well as clinically safe anti-MTB compounds from natural resources. Methods In th...

Anthocyanins are naturally occurring water-soluble flavonoids abundantly present in fruits and vegetables. They are polymethoxyderivatives of 2-phenyl-benzopyrylium or flavylium salts. Delphinidin (Dp) is a purple-colored plant pigment, which occurs in a variety of berries, eggplant, roselle, and wine. It is found in a variety of glycosidic forms r...

Colorectal cancer (CRC) is the third leading cause of death in men and the fourth in women worldwide and is characterized by deranged cellular energetics. Thymoquinone, an active component from Nigella sativa, has been extensively studied against cancer, however, its role in affecting deregulated cancer metabolism is largely unknown. Further, the p...

The development of resistance in microbes against antibiotics and limited choice for the use of chemical preservatives in food lead the urgent need to search for an alternative to antibiotics. The enzymes are catalytic proteins that catalyze digestion of bacterial cell walls and protein requirements for the survival of the cell. To study methyltran...

In the present study, a novel series of new furanone-based benzothiazole derivatives ( 4a-j ) were synthesized from 4-(benzo[ d ]thiazol-2-yl)-4-oxobutanoic acid ( 3 ) as potential anticancer agents. In vitro cytotoxicity against three human cancer cell lines (A549, MCF7, and DUI45) revealed substantial activity. Di-substituted compound, 4i emerged...

Pneumonia like the pandemic COVID-19 is a virus disease, first time came into light in December 2019 in the Wuhan city of China. As of today, more than two million deaths from more than 210 countries have been confirmed. This disease has modeled a great threat to human mental health, physical health, and forcefully stuck the routine life with psych...

Introduction: Current study was designed to evaluate the wound healing activity of a Saudi pomegranate peel extract on excision wound healing in experimentally induced diabetes in rats. Methodology: Animals were divided into three groups: diabetic excision wound with no treatment, diabetic excision wound with gel alone and diabetic excision wound w...

Background: Alström syndrome (AS) is a very rare childhood disorder characterized by cardiomyopathy, progressive hearing loss and blindness. Inherited genetic variants of ALMS1 gene are the known molecular cause of this disease. The objective of this study was to characterize the genetic basis and understand the genotype–phenotype relationship in S...

The 6-shogaol, is a flavanone type flavonoid that is abundant in citrus fruit and has a wide range of pharmacological effects. The present study attempted to evaluate the antiurolithic effect of 6-shogaol on ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. The efficacy of 6-shogaol 50mg/kg and 100mg/kg was...

During cancer, a major challenge faced by oncologists is the treatment of metastasis; a leading cause of cancer-related deaths around the world. Metastasis involves a highly ordered sequence of events starting with the detachment of tumor cells from the extracellular matrix (E.C.M.). In normal cells, detachment from E.C.M. triggers programmed cell...

Background Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition characterized by multiple psychological and physiological impairments in young children. According to the recent reports 1 out of every 58 newly born children is suffering from autism. The aetiology of disorder is complex and poorly understood, hindering the ad...

In the present work, a simple, rapid, reliable and accessible high-performance thin-layer chromatography (HPTLC) technique has been established for the concurrent quantification of plumbagin. The well-known medicinal plant, Plumbago zeylanica L., has been traditionally used to treat a variety of ailments in India and other countries. Chromatographi...

Aerogels are specialized highly porous and light nanostructures in which nearly 95% air is trapped by the replacement of solvent in the mesh of material. Biomedical application of aerogels have been well explored as antifungal, antibacterial, antiviral, biosensing and imaging agents, tissue engineering, diagnosis, and regenerative medicines. Differ...

Celiac disease (CeD) is a gastrointestinal autoimmune disorder, whose specific molecular basis is not yet fully interpreted. Therefore, in this study, we compared the global gene expression profile of duodenum tissues from CeD patients, both at the time of disease diagnosis and after two years of the gluten-free diet. A series of advanced systems b...

A series of benzimidazole‐derived–furanones (4a–l) were synthesized, characterized, and explored for their in vitro anticancer activities. The pharmacokinetic parameters assessed revealed that all the compounds followed the Lipinski's rule of five, making them potential drug candidates. Further, the results of anticancer activity revealed that (E)‐...

In this study, two series of imidazopyridine‐linked thiazolidinone rings (5a–h and 6a–h) constituting 16 new compounds were synthesized and tested for their antiproliferative activity against a panel of three human cancer cell lines, that is, MCF‐7 (human breast cancer), A549 (human lung cancer), and DU145 (human prostate cancer). Three compounds,...

Background and Objective: Nanoemulsions (NE) have been proved to enhance the bioavailability of the therapeutic agents with reduced side effects. The objective of the study was to evaluate the antitumor potential of Doxorubicin (Doxo) and Atorvastatin (ATR) combination, either loaded in nanoemulsions (Doxo-ATR-NE) or water (Doxo-ATR-Solution) again...

Background and Objective: Nanoemulsions (NE) have been proved to enhance the bioavailability of the therapeutic agents with reduced side effects. The objective of the study was to evaluate the antitumor potential of Doxorubicin (Doxo) and Atorvastatin (ATR) combination, either loaded in nanoemulsions (Doxo-ATR-NE) or water (Doxo-ATR-Solution) again...

Abstract: Background and Objective: Nanoemulsions (NE) have been proved to enhance the bioavailability of the therapeutic agents with reduced side effects. The objective of the study was to evaluate the antitumor potential of Doxorubicin (Doxo) and Atorvastatin (ATR) combination, either loaded in nanoemulsions (Doxo-ATR-NE) or water (Doxo-ATR-Solut...

Background Tridax procumbens(L.) leaves are traditionally used in wound healing by tribal people. The matured leaves are crushed to make a paste and applied on the surface of the wound. Purpose The aim of the present investigation was to evaluate the wound healing activity of ethanolic extract of Tridax procumbens (L.) (EETP) in streptozotocin ind...

Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. Rats were divided into six groups. All grou...

Resveratrol (RESV), an anticancer nutraceutical compound, is known to show poor bioavailability inside the human body. Therefore, this study has designed multiple chemical analogs of RESV compound for improving its pharmacokinetic as well as its anti-cancer properties. Initially, the drug likeliness and ADME-toxicity properties of these new chemica...

Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models. Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In orde...

Objective: To evaluate a novel polyherbal formulation (BSVT) containing the standardized extracts from the leaves of Boerhavia diffusa, Solidago virgaurea, Vitex negundo, and thymoquinone in CCl4 induced hepatorenal toxicity in rats. Methods: A total of 36 rats were divided into six groups including normal control, CCl4 (2 mL/kg, i.p.), CCl4 (2 mL/...

Background: Since ages lawsone, an orange‑colored dye from leaves of Lawsonia inermis is being used by women for self‑adornment and is also used in textile industries for dyeing reasons. Objective: Comparing traditional and modern extraction modes for extraction of lawsone from L. inermis leaves and simultaneous use of response surface methodology...

The aim of this study was to investigate the protective effect of a novel polyherbal formulation against cisplatin‐induced hepatorenal toxicity in six groups of rats. Group I: Normal control; Group II: cisplatin (5 mg/kg i.p.); Group III: cisplatin (5 mg/kg i.p.) + cystone (750 mg/kg p.o.); Group IV: cisplatin + Costus speciosus , Fumaria indica, C...

Nano metal organic frameworks (NMOFs) belong to the group of nanoporous materials. Over the decades, the conducted researches explored the area for the potential applications of NMOFs in areas like biomedical, chemical engineering and materials science. Recently, NMOFs have been explored for their potential use in cancer diagnosis and therapeutics....

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and occurs frequently in patients with liver cirrhosis. HCC is the leading cause of cancer-related mortality around the globe. Aim: This study assessed the effects of thiamin in the anticancer activity of methotrexate (MTX) in diethyl nitrosamine (DEN) induced hepato...

Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Na...

Treatment of diabetic patients with antioxidant, such as extra virgin olive oil (EVOO), may be beneficial in numerous debilitating complexities. This study was aimed at assessing the protective role of virgin olive oil in reducing hyperglycemia in streptozotocin- (STZ-) induced diabetic rats. Thirty-six healthy male Sprague-Dawley rats were divided...

HCC has been reported to be immensely occurring carcinoma worldwide. Recent days the mortality occurred due to liver cancer has also been found to be increased at an alarming speed affecting mostly the young patients. The aim of the current study was to decipher the role of calcium and vitamin K3 in the treatment of chemically induced hepatocarcino...

Background Ursolic acid (UA) is a promising molecule with anti-inflammatory, analgesic and potential anti-arthritic activity. Methods This study was undertaken to make formulation and evaluation of Ocimum sanctum L. leaf extract (OLE) loaded nano-structured lipid carriers (OLE-NLCs) for improved transdermal delivery of UA. Different surfactants, s...

Introduction The wound is defined as an injury of a living tissue, arose due to either an accidental injury like cut of the cells or skin or sometime, maybe broken the tissue, which may cause the anomalies in the cellular ability to exhibit the protective mechanism. Wound healing is process of regaining the integrity of cell structure and layers of...

Background Camel milk (CM) and Nigella sativa (NS) have been traditionally claimed to cure wide range of diseases and used as medicine in different part of world, particularly in Saudi Arabia. Several research studies have been published that proved beneficial effects of CM and NS. Objective This study was undertaken to investigate the antihepatot...

Purpose: To synthesize and evaluate the antimicrobial activity of silver nanoparticles (AgNPs) derived from a supercritical carbon dioxide extract of the fresh aerial parts of Phyllanthus niruri. Methods: The synthesis of AgNPs of a P. niruri extract was carried out in a microwave oven. The extraction was carried out using a supercritical fluid ext...

Background The prevalence of morbidity and mortality due to infections from parasitic worms and protozoa is on rise especially in third world countries. The situation is further worsened by drug resistant microbial pathogens. Objectives The antimicrobial and anthelmintic activities associated with substituted furfuraldehyde and 1,8-naphthyridine n...

Background: Metformin is the first-line oral anti-diabetic drug and Nigella sativa (NS) have been used as traditional medicine to cure/prevent a wide range of diseases in different part of the world, particularly in Saudi Arabia. Objective: To carry out the comparative biochemical and histopathological studies on the efficacy of metformin, Nigella...

Eslicarbazepine acetate (ESL) is a new, once daily, orally administered, third generation antiepileptic drug which is indicated in the treatment of partial-onset seizures. ESL is known to exert it’s anticonvulsant effect by blocking the voltage-gated sodium channels. Several clinical trials and pharmacological studies have revealed that seizure con...

In the present study, synthetic chalcones, flavanones and Schiff bases were prepared starting from paraceamol, and evaluated their anticipated anti-inflammatory activity. Chalcones were synthesized by reacting 3-acetyl-4-hydroxy acetanilide and aromatic aldehydes in alcoholic potassium hydroxide (KOH) solution under Claisen-Schmidt condensation con...

Objectives: To investigate the effect of coenzyme Q10 (CoQ10) on apoptotic myocardial cell death in rat model of heart ischemia and reperfusion I/R injury. Materials and methods: Eighteen rats (200-250 g) were divided into three groups of 6 rats in each. Group I (sham-operated control group): this is the control group. The animals received the s...

Based on the core structure of Felbinac drug, three series (4a-d, 5a-d and 6a-n) of five membered heterocyclic derivatives containing three heteroatoms were designed and synthesized starting from Felbinac. In the rational design of the target molecules, the biphenyl ring along with the methylene bridge of felbinac was retained while the carboxyl gr...

Objective: To evaluate the cardioprotective effect of Nigella sativa L. (N.?sativa) in isoproterenol-induced myocardial infarction (MI). Methods: Groups were treated with different doses of ethanol extract of N.?sativa (EENS) and N.?sativa oil alone and along with enalapril for 28 days. MI was induced by subcutaneous administration of isoproterenol...

Silver (Ag) nanoparticles are well established for its antibacterial activity. In this study, we demonstrate the antibacterial activity of the electrospun nanofiber mats coated with various ratios of Ag and ZnO nanoparticles and relate it with the hydrophilicity of the membrane imparted due to Ag nanoparticles. Electrospun nanofibers were prepared...

A number of pyridazinone derivatives bearing substituted benzylidene and heterocyclic/aromatic rings at 4th and 6th positions, respectively were synthesized in good to moderate yields and screened for antioxidant activity. Antioxidant activity of pyridazinone derivatives was evaluated by using several in vitro radical scavenging methods such as 1,1...

Background: Furanone and pyrrolone heterocyclic ring system represent important and interesting classes of bioactive compounds. Medicinal chemists use these heterocycyclic moieties as scaffolds in drug design and discovery. Methods: A series of 3-arylidene-5-(naphthalene-2-yl)-furan-2(3H)-ones (2a-j) were synthesized by incorporating pharmacopho...

Objectives: The study aimed to synthesize a mutual prodrug of norfloxacin and fenbufen with an objective of obtaining an effective and safer anti-inflammatory drug with useful antimicrobial actions. Methods: An amide-based mutual prodrug (NF-FN) was prepared following a single-step synthesis by condensing norfloxacin with fenbufen under appropriate...

Dronedarone, a benzofuran containing chemical compound, is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It is prescribed to the cardiovascular patients who have paroxysmal or persistent atrial fibrillation to lower the chances of hospitalization. Amiodarone, sotalol, procainamide dofetilide, quinidine, ibutili...

Background: Non steroidal anti-inflammatory drugs are the most widely prescribed drugs to manage pain and inflammatory conditions, but their long term use is associated with gastrointestinal toxicity. Objectives; The study aimed to synthesize an ester-based prodrug of a non steroidal anti-inflammatory agent, mefenamic acid in order to improve the...

A series of new 6-substituted-N-[3-{2-(substituted phenyl)-ethenyl} quinoxaline-2(1H)-ylidene]-1,3-benzothiazole-2-amine (4a-f) were designed and synthesized by condensing 2-amino-benzothiazole-6-sulfonic acid amide (1) with chalcones of quinoxaline-2-one (3a-f) in a hope to obtain promising and a new class of diuretic agents. Structures of all the...

p class="Abstract">The methanolic extract of Aegle marmelos leaves was evaluated against cisplatin-induced renal toxicity in rats. Rats were divided into 5 groups: Group 1 received normal saline (1 mL, p.o.) for 15 days; Group II received single dose of cisplatin (5 mg/kg, i.p.) on day 15 and normal saline (1 mL, p.o.) for 15 days; Group III, IV an...

The present research work involved synthesis of some novel pyridazine derivatives and evaluation of their analgesic and anti-inflammatory activities in experimental animals to obtain safer non-steroidal anti-inflammatory drugs (NSAIDs). Friedal craft acylation reaction of succinic anhydride with toluene in the presence of anhydrous aluminum chlorid...

Doxorubicin is a commonly used anticancer agent which may cause cardiac toxicity. Phoenix dactylofera (dates) was evaluated whether it reduces cardiac toxicity induced by doxorubicin in Wistar albino rats or not. The rats were divided into five groups (n=6). Group-1: Control; group-2: Disease control; Groups 3, 4 & 5: Therapeutic groups (Phoenix da...

In the past two decades, a shift in paradigm has been observed in the development of new drugs from the plants for the treatment of diseases. Many scientists are focusing on the evidence based use of medicinal plants to develop pharmacotherapy for various human ailments. An important medicinal plant that has caught the attention of researchers all...

Objective of the present study was to carry out the physicochemical and phytochemicals standardization of Lepidium sativum L seeds to establish the standard pharmacognostical parameters of this valuable medicinal plant. Many standardization parameters of Lepidium sativum were analyzed. Standard method was adopted for the preliminary phytochemicals...

Hepatocellular carcinoma (HCC) is the fifth and third most common cause of cancer-related deaths. Erythrosine, a commonly used coloring agent in tablet preparation was studied for its role when supplemented with sub necrotic dose of DENA (n-diethyl nitrosamine) to induced HCC in Wistar rats. Single dose of chemical carcinogen DENA with intraperiton...

Based on the heterocyclic core of bendamustine, four series (4a-g, 5a-f, 8a-b and 9a-b) of benzimidazole derivatives were designed and synthesized starting from 4-(1H-benzo[d]imidazol-2-yl)-4-oxobutanehydrazide. In the rational design of target molecules, the benzimidazole ring of bendamustine was retained and the bis-(chloroethyl) amine group (mec...

Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other...

Rosiglitazone, peroxisome proliferator-activated receptor-γ (PPARγ) ligand, is a clinically tested drug used in the treatment of diabetes. Several reports have proved that rosiglitazone involved in the regulation of glucose and lipid homeostasis, proliferation, inflammation and differentiation. The current study was confronted to exemplify the effe...

A series of pyrazolo-pyridazine derivatives (4a-j) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antimicrobial agents. In the first step, 6-substituted phenyl-2,3,4,5tetrahydropyridazin-3-one (2a,b) was prepared by reacting 4-(4-methylphenyl)-4-oxobutanoic acid (1a) and 4-(4chlorophenyl)-4-oxobuta...

Umbelliferone (7-hydroxycoumarin) possesses strong anti-inflammatory properties and free radical scavenging activity. The intent of the current study was to examine the renal protective efficacy of Umbelliferone β-D-galactopyranoside (UFG) against oxidative stress, inflammation and renal injury in Wistar rats, initiated by diethylinitrosamine (DEN)...

A small library of twenty-four quinoline based butenolides also known as furanones and their nitrogen analogues was prepared by using two different aroylpropionic acids, viz. 3-(2-naphthoyl)propionic acid (3) and 3-(biphenyl-4-yl)propionic acid (4), as starting materials. The 3-aroylpropionic acids were reacted with different 6-substituted-2-chloro...

A new series of N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides were synthesized with a new class of Schiff bases derived from the reaction of substituted phenyl-1-ketohydrazide 2 or 2-(4-chloro-3-methylaryloxy) acetohydrazide 3 with different 5-(substituted aryl)-2-furfuraldehyde (1a-k) to yield substituted N-({5-(substituted aryl)-fu...

The study aimed to evaluate the hepatoprotective potential of aqueous extract of Tamarindus indica fruit against combination of two antitubercular drugs viz. Isoniazid and Rifampicin induced hepatotoxicity in rats. In vitro antioxidant activity of aqueous extract of T. indica by DPPH-HPLC method was found to be 81.48%. Treatment with aqueous extrac...