Afsaneh Sadre Momtaz

Afsaneh Sadre Momtaz
North Carolina Agricultural and Technical State University | NC A&T · Joint School of Nanoscience and Nanoengineering-Department of Nanoengineering

Doctor of Philosophy

About

6
Publications
1,608
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109
Citations

Publications

Publications (6)
Article
Full-text available
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on host cells to initiate molecular events, resulting in intracellular release of the viral genome. Therefore, antagonists of this interaction could allow a modality for therapeutic intervention. Peptides can inhibit the S-RBD:ACE2 interaction by interacting with the pr...
Conference Paper
Background Tumor growth depends on pro-angiogenic vascular endothelial growth factors (VEGF-A/-B) via binding to VEGF receptors (VEGFR1 and VEGFR2) that are biomarkers of tumor angiogenesis. Importantly, interfering with this interaction by small molecules impairs tumor growth and angiogenesis. Methods A novel peptide (known as VGB3) was synthesiz...
Article
Full-text available
Insert abstract text here. RGD peptides represent the most outstanding recognition motif involved in cell adhesion and binds to αvβ3 integrin that has been targeted for cancer therapy. Various RGD-containing peptides and peptidomimetics have been designed and synthesized to selectively inhibit this integrin. In this study, the synthesis of RGD base...
Article
Full-text available
ABSTRACT Background: Vascular endothelial growth factor (VEGF) A and B are endothelial cell mitogens whose ligation to VEGFR1/VEGFR2 drives tumor angiogenesis and metastasis, and epithelial-mesenchymal transition (EMT). Blockade of these signaling axes could be obtained by disturbing the interactions between VEGFA and/or VEGFB with VEGFR1 and/or VE...
Article
Background: Neutralization of vascular endothelial growth factor receptor 1 (VEGFR1) and/or VEGFR2 is a widely used means of inhibiting tumor angiogenesis. Methods: Based on the complex X-ray structures of VEGFA/VEGFR1, VEGFA/VEGFR2, and VEGFB/VEGFR1, a peptide (referred to as VGB) was designed to simultaneously bind to VEGFR1 and VEGFR2, and bindi...

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