Afrah Khairallah

Afrah Khairallah
Rhodes University | RU · Department of Biochemistry, Microbiology and Biotechnology

Doctor of Philosophy

About

6
Publications
2,144
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62
Citations
Introduction
Afrah Khairallah completed her PhD at the Research Unit in Bioinformatics (RUBi) hosted by Rhodes university, Department of Biochemistry and Microbiology. Afrah does research in Structural Bioinformatics and drug discovery.
Additional affiliations
March 2018 - October 2021
Rhodes University
Position
  • PhD
Education
February 2017 - February 2018
Rhodes University
Field of study
  • Bioinformatics

Publications

Publications (6)
Article
Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of GTP into dihydroneopterin triphosphate (DHNP). DHNP is the first intermediate of the folate de novo biosynthesis pathway in prokaryotic and lower eukaryotic microorganisms and the tetrahydrobiopterin (BH4) biosynthesis pathway in higher eukaryotes. The de novo folate b...
Article
Full-text available
Atovaquone (ATQ) is a drug used to prevent and treat malaria that functions by targeting the Plasmodium falciparum cytochrome b (PfCytb) protein. PfCytb catalyzes the transmembrane electron transfer (ET) pathway which maintains the mitochondrial membrane potential. The ubiquinol substrate binding site of the protein has heme bL, heme bH and iron-su...
Article
Full-text available
The de novo folate synthesis pathway is a well-established drug target in the treatment of many infectious diseases. Antimalarial antifolate drugs have proven to be effective against malaria, however, rapid drug resistance has emerged on the two primary targeted enzymes: dihydrofolate reductase and dihydroptoreate synthase. The need to identify alt...
Article
Full-text available
The folate biosynthesis pathway is an essential pathway for cell growth and survival. Folate derivatives serve as a source of the one-carbon units in several intracellular metabolic reactions. Rapidly dividing cells rely heavily on the availability of folate derivatives for their proliferation. As a result, drugs targeting this pathway have shown t...
Article
Full-text available
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins has attracted considerable attention in drug discovery due to the benefits and versatility of allosteric modulators in providing desirable selectivity against protein targets while minimizing toxicity and other side effects. The proliferation of novel...

Questions

Question (1)
Question
Hi all, " NW ALIGN "produces a histogram of the sequence alignment scores, can you explain why are the score presented as negative values

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