Afolarin Amodu

Albert Einstein College of Medicine | AECOM · Nephrology

Background: Biomarkers for non-invasive assessment of histopathology and prognosis are needed in patients with kidney disease. Methods: Using a proteomics assay, we measured a multi-marker panel of 225 circulating plasma proteins in a prospective cohort study of 549 individuals with biopsy-confirmed kidney diseases and semi-quantitative assessment...

Rationale & Objective Although kidney biopsy is a useful tool, nephrologists approach biopsies inconsistently for reasons incompletely understood, including lack of established clinical guidelines. We examined contemporary clinical decision-making patterns among nephrologists in the decision to perform native kidney biopsy. Study Design Qualitativ...

Background: Biomarkers for non-invasive assessment of histopathology and prognosis are needed in patients with kidney disease. Methods: Using a proteomics assay, we measured a multi-marker panel of 225 circulating plasma proteins in a prospective cohort study of 549 individuals with biopsy-confirmed kidney diseases and semi-quantitative assessment...

Background The major risk of kidney biopsy is severe bleeding. Numerous risk factors for bleeding after biopsy have been reported, but findings have been inconsistent. Methods We retrospectively reviewed medical records of adult patients enrolled in a native kidney biopsy cohort study to identify major bleeding events (red blood cell [RBC] transfu...

[This corrects the article DOI: 10.1371/journal.pone.0194697.].

Background The level of body-mass index (BMI) associated with the lowest risk of death remains unclear. Although differences in muscle mass limit the utility of BMI as a measure of adiposity, no study has directly examined the effect of muscle mass on the BMI-mortality relationship. Methods Body composition was measured by dual-energy x-ray absorp...

Causal mediation analysis. (DOCX)

Association of BMI with all-cause mortality modeled as a restricted cubic spline for all women (upper panel) and for women with preserved muscle mass (lower panel). The shaded area represents the 95% confidence interval. (DOCX)

Association of BMI with all-cause mortality without and with adjustment for appendicular skeletal muscle mass index among participants who did not report unintentional weight loss in the previous 12 months (n = 10,867). Error bars represent 95% confidence intervals. (DOCX)

Association of BMI with all-cause mortality without and with adjustment for appendicular skeletal muscle mass index among Americans younger than 60 years of age (n = 7,395). Error bars represent 95% confidence intervals. (DOCX)

Risk of mortality by BMI category and muscle mass status among participants who did not report unintentional weight loss in the previous 12 months (n = 10,867). Bars indicate prevalence of low muscle mass in each BMI category. (DOCX)

Associations with all-cause mortality in the full cohort and in sensitivity analyses. (DOCX)

Causal diagram depicting relationship of BMI, muscle mass, and mortality. (PPTX)

Association of BMI with all-cause mortality modeled as a restricted cubic spline for all men (upper panel) and for men with preserved muscle mass (lower panel). The shaded area represents the 95% confidence interval. (DOCX)

Association of BMI with all-cause mortality without and with adjustment for appendicular skeletal muscle mass index among Americans 60 years of age and older (n = 4,292). Error bars represent 95% confidence intervals. (DOCX)

Difference in body-mass index per 5% higher total body fat percentage. (DOCX)

Risk of all-cause mortality by BMI category and muscle mass status, without and with adjustment for waist circumference (n = 11,392). Error bars represent 95% confidence intervals. (DOCX)

Risk of mortality by BMI category and muscle mass status after excluding participants who died within the first 2 years of follow-up (n = 11,395). Bars indicate prevalence of low muscle mass in each BMI category. (DOCX)

Association of BMI with all-cause mortality without and with adjustment for appendicular skeletal muscle mass index after excluding participants with a diagnosis of diabetes mellitus, congestive heart failure, a history cancer (other than non-melanoma skin cancer), or an estimated glomerular filtration rate <30 mL/min/1.73m2 (n = 8,802). Error bars...

Association of BMI with all-cause mortality without and with adjustment for appendicular skeletal muscle mass index after excluding participants who died within the first 2 years of follow-up (n = 11,395). Error bars represent 95% confidence intervals. (DOCX)

Risk of mortality by BMI category and muscle mass status after excluding participants with a diagnosis of diabetes mellitus, congestive heart failure, a history cancer (other than non-melanoma skin cancer), or an estimated glomerular filtration rate <30 mL/min/1.73m2 (n = 8,802). Bars indicate prevalence of low muscle mass in each BMI category. (DO...

Hematuria is a common finding in renal cell carcinoma, and persistent hematuria, even in those receiving anticoagulation, warrants workup. We present a case of a patient with persistent hematuria who was found to have a renal mass that was not evident on renal ultrasound and computed tomography of the abdomen and pelvis but was seen on magnetic res...

Background The prevalence of diverticulosis is increasing with 5-10% of patients developing diverticulitis and 5-15% developing symptomatic bleeding. Diverticulitis can result in abscess, perforation, fistula, or obstruction. Bleeding has combined morbidity and mortality rates of 10-20%. The purpose of this study was to compare diverticulitis-relat...

In predialysis chronic kidney disease (CKD), the association of muscle mass with mortality is poorly defined, and no study has examined outcomes related to the co-occurrence of low muscle mass and excess adiposity (sarcopenic obesity). Methods: We examined abnormalities of muscle and fat mass in adult participants of the National Health and Nutriti...

Association of body composition categories with all-cause mortality through 2011 in 11,616 participants of NHANES 1999–2004 stratified by race/ethnicity.

Association of body composition categories with all-cause mortality in 1930 participants of NHANES 1999–2004 matched on age, sex, and race/ethnicity.

Association of sarcopenia with all-cause mortality through 2011 in 11,191 participants of NHANES 1999–2004 after excluding mortality in the first 24 months.

Association of body composition categories with all-cause mortality through 2011 in 11,191 participants of NHANES 1999–2004 after excluding mortality in the first 24 months.

Association of continuous ASMI and %TBF with all-cause mortality through 2011 by eGFR status in 11,616 participants of NHANES 1999–2004.

Association of covariates with all-cause mortality through 2011 in 11,616 participants of NHANES 1999–2004.

Association of sarcopenia with all-cause mortality through 2011 in 3949 participants of NHANES 1999–2004 using cystatin C to determine eGFR.

Association of body composition categories with all-cause mortality through 2011 in 3949 participants of NHANES 1999–2004 using cystatin C to determine eGFR.

Metabolic acidosis is common among persons with chronic kidney disease due to an inability to excrete the daily acid load. A more subtle or low-grade acidosis also occurs in otherwise healthy individuals due to the effects of aging and the high acid-forming potential of the Western diet. This has numerous sequelae, including effects on skeletal mus...

Greater dietary acid has been associated with lower serum bicarbonate levels in patients with CKD. Whether this association extends to the general population and if it is modified by age are unknown. This study examined the association of the dietary acid load, estimated by net endogenous acid production, with serum bicarbonate levels in adult part...