Affiong Iyire

• BPharm, MSc, PhD, PgCE, FHEA
• Lecturer at Aston University

Quality by Design (QbD), a current trend employed to develop and optimise various critical pharmaceutical processes, is a systematic approach based on the ethos that quality should be designed into the product itself, not just end tested after manufacture. The present work details a step-wise application of QbD principles to optimise process parame...

The formulation and delivery of macromolecules through the oral route pose considerable challenges due to factors such as large molecular weight, pH sensitivity, and limited formulation approaches. This challenge is compounded if the drug is poorly permeable, necessitating innovative drug delivery strategies. Vancomycin, a widely prescribed glycope...

Fixed dose combinations (FDCs) incorporating two or three medicines in a single inhaler have been created to enhance patient compliance and hence clinical outcomes. However, the development of dry powder inhalers (DPIs), particularly for FDCs, faces challenges pertinent to formulation uniformity and reproducibility. Therefore, this project aimed to...

Background Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need for several applications due to rapid drainage away via the nasolacrimal duct, especially for e...

Purpose Phoenix dactylifera extracts have shown efficacy as antioxidants and antibacterials for the treatment of lung diseases; however, the choice of route of administration remains a problem. The use of natural antibacterial remedies for the management of cystic fibrosis (CF) is promising due to recurring bacterial resistance to current antibioti...

Background: The advent of the COVID-19 pandemic caused a rapid increase in demand for healthcare services over a prolonged period, and the hospital emergency preparedness system has been essential. Therefore, this study aimed to explore Jordanian hospitals' response to emergency situations and examine the underlying role and effect of accreditatio...

During the global COVID-19 pandemic, hospitals faced tremendous pressure to cope with the emergency preparedness situations needed to cater for the influx of patients while maintaining their essential services. This study aimed to assess the level of readiness of hospitals in Jordan to respond to the COVID-19 pandemic using the WHO hospital readine...

With the increase in respiratory conditions including lung cancer post covid-19 pandemic, drug-loaded nanoparticulate dry powder inhalers (DPIs) can facilitate targeted lung delivery as a patient-friendly, non-invasive method. The aim of this work was to synthesise and optimise iron oxide nanoparticles (IONPs) containing dactinomycin as a model dru...

Niosomes are increasingly explored for enhancing drug penetration and retention in ocular tissues for both posterior and anterior eye delivery. They have been employed in encapsulating both hydrophilic and hydrophobic drugs, but their use is still plagued with challenges of stability and poor entrapment efficiency particularly with hydrophilic drug...

Children have often been treated as small adults in relation to drug formulation, but research has now shown this not to be the case. Therefore, there is a push from regulatory bodies to provide drug formulations specifically tailored towards the needs of this fragmented population. Orally dissolving films (ODFs) have been identified as an emerging...

Niosomes are emerging drug delivery systems that maintain the drug targeting advantages of liposomes, while overcoming the problems of low drug encapsulation and instabilities usually associated with liposomes. The purpose of this study was to systematically develop and characterise the physicochemical and biological toxicological properties of pre...

Orally dissolving films (ODFs) have received much attention as potential oral drug delivery systems for paediatric and geriatric patients, particularly those suffering from dysphagia. With their unique properties and advantages, the technology offers improved patient compliance and wider acceptability, eliminates the fear of choking, enables ease o...

HPLC methods for insulin in official monographs require extended runtimes and elevated temperatures. Inter-laboratory reproducibility of HPLC methods obtained from published literature is an on-going challenge, moreso for peptides. This paper serves as a step-by step guide to troubleshoot and establish a validated HPLC method for insulin at room te...

This chapter explores the feasibility of formulating drugs as multiparticulates for children. The paediatric population is diverse and ranges from preterm infants to teenagers between 16 and 18 years of age. Salient physiological differences exist within this population as compared with adults which translate to significant changes in pharmacokinet...

Scientific Reports 6: Article number: 32498; published online: 01 September 2016; updated: 14 October 2016

The aim of this work was to investigate alternative safe and effective permeation enhancers for buccal peptide delivery. Basic amino acids improved insulin solubility in water while 200 and 400 μg/mL lysine significantly increased insulin solubility in HBSS. Permeability data showed a significant improvement in insulin permeation especially for 10...

The acceleration of solid dosage form product development can be facilitated by the inclusion of excipients that exhibit poly-/ multi-functionality with reduction of the time invested in multiple excipient optimizations. Because active pharmaceutical ingredients (APIs) and tablet excipients present diverse densification behaviours upon compaction,...

Despite advances in drug delivery via novel routes of administration, the oral route still holds high appeal because of its lower cost, ease of administration and patient acceptance/ compliance. However, setbacks of this route including drug degradation in the gastro-intestinal tract (GIT) and first-pass metabolism in the liver leading to low bioav...

Short residence time in the mouth due to saliva scavenging and accidental swallowing, decreases the possibility of epigastric (buccal/ sublingual) absorption and is one of the shortcomings of conventional orally disintegrating tablets (ODTs)1. It has been hypothesized that inclusion of multifunctional excipients possessing mucoadhesive properties,...

The successful development of c ompressed ODTs utilises low compression force s to create a porous structure whereby excipients are added to enhance wicking/swelling action or p rovide strength to the fragile tablet framework. In this work, a systematic investigation comparing materials from two different categories was employed to understand their...