Adriana M Kakehasi

Adriana M Kakehasi
Federal University of Minas Gerais | UFMG · Departamento de Aparelho Locomotor

MD, PhD

About

250
Publications
22,624
Reads
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1,561
Citations
Additional affiliations
January 2008 - May 2010
Santa Casa de Belo Horizonte
Position
  • Rheumatologist
May 2010 - present
Federal University of Minas Gerais
Position
  • Professor (Associate)

Publications

Publications (250)
Article
Full-text available
Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus in a multicenter cohort design. Methods: Data for this analysis were obtained from the Study of Safety, Effectiveness and Duration of Immunity after Vaccination against SARS-CoV-2 in Patients with Immune-Mediated Inflamm...
Article
Full-text available
Objectives To compare the impact of COVID-19 on the clinical status and psychological distress of patients with immune-mediated rheumatic disease (IMRD) caused by SARS-CoV-2 infection with that of noninfected IMRD controls during a 6-month follow-up period. Methods The ReumaCoV Brazil is a longitudinal study designed to follow IMRD patients for 6...
Article
Adipose tissue stores energy in fat-rich adipocytes, which can produce and release several adipokines and modulate body metabolism. Exercise may induce adipokine production in adipocytes; however, the relationship between the two remains unclear. Few studies have shown the relationship between adipokines and strength training. Thus, we aimed to eva...
Preprint
Objective: To evaluate the humoral response to and effectiveness of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus in a multicenter cohort design. Methods: Data for this analysis were obtained from the Study of Safety, Effectiveness and Duration of Immunity after Vaccination against SARS-CoV-2 in Patients with Immune-Mediated...
Article
Full-text available
Background SARS-CoV-2 infection has become a major international issue, not only from a medical point of view, but also social, economic and political. Most of the available information comes from the United States, Europe, and China, where the population and the socioeconomic status are very different from Latin American countries. This study eval...
Article
Full-text available
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough COVID-19 occurring in IMRD patients participating in the SAFER-study, a Brazilian multicentric cohort evaluating the safety, effectiveness,...
Article
Full-text available
Background Patient management in rheumatoid arthritis (RA) has evolved to a “treat-to-target” (T2T) approach, which entails intensive treatment and regular follow-up with the goal of achieving low levels of disease activity or clinical remission. Even though a T2T approach is endorsed by professional organizations and yields superior outcomes, its...
Article
Full-text available
Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have asse...
Preprint
Full-text available
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune mediated rheumatic disesases (IMRD) patients are scarce. This study describes breakthrough COVID-19 among IMRD patients participating of SAFER-study, a Brazilian multicentric cohort evaluating safety, effectiveness and immunogen...
Preprint
Full-text available
Objectives To compare the impact of COVID-19 on the clinical status and psychological distress of patients with immune-mediated rheumatic disease (IMRD) caused by SARS-CoV-2 infection with that of noninfected IMRD controls during a 6-month follow-up period. Methods The ReumaCoV Brazil is a longitudinal study designed to follow IMRD patients for 6...
Article
Background/Objective To assess safety/efficacy of tofacitinib and tumor necrosis factor inhibitors (TNFi) in patients from Latin America (LATAM) in ORAL Surveillance. Methods In ORAL Surveillance, 4362 patients with rheumatoid arthritis aged ≥50 years with ≥1 additional cardiovascular risk factor received tofacitinib 5 or 10 mg twice daily or TNFi...
Conference Paper
Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Individuals with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with comorbidities. In late 2022, the SARS-CoV-2 omicron B...
Conference Paper
Background Patients with immune-mediated rheumatic diseases (IMRD) undergoing immunosuppressive treatment are at greater risk of infection. Infectious are one of the main causes of death in this group of patients. Although vaccination impacts in reducing the incidence of infections, the vaccine coverage of the general population in Brazil has been...
Conference Paper
Background Breakthrough COVID-19 infections occurring in fully vaccinated people have been described. There is particular concern about the effectiveness of vaccination in patients with immune-mediated rheumatic diseases (IMRD). Data on the characteristics and prognosis of breakthrough COVID-19 among IMRD patients are scarce. Objectives To describ...
Conference Paper
Background Host, viral and environmental factors have been associated with severe clinical outcome of COVID-19. A large body of accumulating evidence supports the idea that age, ethnicity, sex, comorbidities, immunological history, viral factors and low socioeconomic status (SES) are risk factors for severe COVID-19 outcomes. Studies addressing the...
Conference Paper
Background Telomeres are protein complexes located at the top of each arm of chromosomes, essential for maintaining the stability of the genome. Telomere shortening is found in physiological aging and senescence-related to systemic lupus erythematosus (SLE). Objectives To compare the relative telomere length (TL) in patients with SLE and controls...
Conference Paper
Background The efficacy of the COVID-19 vaccine in patients with autoimmune diseases (AID) depends on the underlying disease, the type of immunosuppression and the vaccine regimens administered. However, there are few studies evaluating immunogenicity according to immunosuppressive drugs and different COVID-19 vaccine platforms in a large cohort of...
Conference Paper
Background The combinations of methotrexate (MTX) with sulfasalazine (SSZ), leflunomide (LEF) or cyclosporine (CsA), combined or not with antimalarials, have been used in the treatment of rheumatoid arthritis (RA) and have demonstrated safety and efficacy comparable to the combination of methotrexate with biologic agents [1]. However, among patient...
Conference Paper
Full-text available
Background Antimalarials (AM) have been traditionally associated with increased risk of ocular adverse events, specially reversible vortex keratopathy and irreversible retinal toxicity (1). Despite the drug-related adverse events, the anti-inflammatory effects of AM in rheumatoid arthritis (RA) could potentially aid to prevent or reduce the intensi...
Article
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Background Monoclonal antibodies have proven efficacy in the management of several conditions and infliximab (IFX) is one of the most important drugs of the class. Some recent data have shown low rates of both persistence and adherence to several available biologics. Objective The objective of this study was to describe adherence and persistence r...
Preprint
Full-text available
Objectives: To compare the impact of COVID-19 on clinical status and psychological condition in patients with immune-mediated rheumatic diseases (IMRD) infected by SARS-CoV-2 with IMRD controls not infected, during a 6-month follow-up. Methods: The ReumaCoV Brasil is a longitudinal study designed to follow-up IMRD patients for 6 months after COVID-...
Article
Background There is neither a gold standard definition nor a universal consensus to diagnose sarcopenia in patients with chronic hepatitis C. Thus, we aimed to compare the prevalence of sarcopenia and the agreement and discrepancies between European Working Group on Sarcopenia in Older People (EWGSOP1), EWGSOP2, and Foundation for the National Inst...
Article
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This article aims to describe malignancies in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), or non-radiographic axial spondyloarthritis (nr-axSpA) treated with upadacitinib (UPA) or active comparators. This integrated safety analysis includes data from 11 phase 3 UPA trials across RA (6 trials), Ps...
Article
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Objective: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population. Methods: Data from 3 national registries, SAR-COVID (Argen...
Preprint
Full-text available
BACKGROUND Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with comorbidities associated. However, few studies in the li...
Article
Full-text available
Background: Although biosimilar uptake has increased (at a variable pace) in many countries, there have been recent concerns about the long-term sustainability of biosimilar markets. The aim of this manuscript is to assess the sustainability of policies across the biosimilar life cycle in selected countries with a view to propose recommendations fo...
Article
Adipose tissue is specialized cells that produce and release adipokines. Exercise may modulate adipokine production in adipocytes. The aim of this longitudinal study was to evaluate the acute and chronic effects of strength training (ST) on plasma levels of adiponectin, leptin, and resistin. Twelve untrained young male participants (23.42±2.67 year...
Article
Background Systemic lupus erythematosus (SLE) is an autoimmune disease, which presents an immune disorder that leads to the production of autoantibodies with potential involvement of multiple organs. Infections are one of the most frequent causes of hospitalization and death in lupus patients, and SARS-CoV-2 infection has been a global threat since...
Article
Full-text available
Background The ChAdOx1, Coronavac, BNT162B2 and Janssen vaccines are available for the primary and booster immunization of immunosuppressed patients. However, there are few studies in the literature that assess the immunogenicity and safety of the different platforms COVID-19 vaccines in patients with autoimmune diseases (AID). Objectives The pres...
Article
Full-text available
Background Antimalarials (AM) have been related to a lower risk and severity of infections in systemic lupus erythematosus [1], but in rheumatoid arthritis (RA) the results are not unanimously favorable to a possible protective effect exerted by AM [2,3]. In our recent study of RA patients treated with biologic disease modifying anti-rheumatic drug...
Article
Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with comorbidities associated. However, few studies in the li...
Article
Full-text available
Background The COVID-19 pandemic has brought uncertainties to rheumatology practice, mainly related to the possibility of triggering disease activity after infection in immune mediated rheumatic diseases (IMRD). To date, there are few data in the literature specifically evaluating this issue. Objectives Evaluate the disease activity in IMRD patien...
Article
Full-text available
Background Golimumab and certolizumab were the last original anti-TNF agents approved in Brazil for the treatment rheumatoid arthritis (RA). Recent studies indicate that certolizumab is associated with higher risk of infections [1] and golimumab with better drug survival compared to the other anti-TNF agents [2], although they have not been compare...
Article
Full-text available
Background Some individuals may have persistent symptoms after COVID-19, a new condition known as long COVID-19. However, these complaints can be misunderstood with disease activity in patients with immune-mediated rheumatic diseases (IMRD), especially fatigue and mental distress. Objectives To evaluate fatigue, depression, anxiety, and stress in...
Article
Objectives To test the association of use of antimalarials with the overall safety of treatment in rheumatoid arthritis (RA) patients receiving one or multiple courses of biologic (b-) DMARDs or a Janus kinase inhibitor (JAKi). Methods BiobadaBrasil is a multicentric registry-based cohort study of Brazilian patients with rheumatic diseases startin...
Article
Background/Aims For patients with RA who are refractory to biologic disease-modifying antirheumatic drugs (bDMARDs), such as tumor necrosis factor inhibitors (TNFis), optimal disease control is less likely to be achieved with subsequent therapy. In line with recommendations from EULAR and ACR, switching to a treatment with a different mechanism of...
Article
Full-text available
Introduction/objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by ongoing inflammation and degradation of synovial joints. The oral JAK inhibitor, upadacitinib, is approved for RA. We conducted an integrated safety analysis of upadacitinib 15 mg once daily (QD) in patients from Latin America (LATAM) versus the res...
Article
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Background Fibroblast-like synoviocytes (FLS) play a prominent role in rheumatoid synovitis and degradation of the extracellular matrix through the production of inflammatory cytokines and metalloproteinases (MMPs). Since animal models are frequently used for elucidating the disease mechanism and therapeutic development, it is relevant to study the...
Article
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Objective To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods A task force was constituted by 24 rheumatologists (panel members), with...
Article
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Background Rheumatoid arthritis (RA) generates an inflammatory profile that predisposes to total and visceral fatty accumulation and reduced fat free mass (FFM). This metabolic disorder contributes to poor functionality, increased cardiovascular risk and higher mortality. This study aimed to address a systematic review with meta-analysis to determi...
Article
Full-text available
Objectives To evaluate the disease activity before and after COVID-19 and risk factors associated with outcomes, including hospitalization, intensive care unit (ICU) admission, mechanical ventilation (MV) and death in patients with spondylarthritis (SpA). Methods ReumaCoV Brazil is a multicenter prospective cohort of immune-mediated rheumatic dise...
Article
During the COVID-19 pandemic, undergraduate medical students (UMS) exposed to isolation, social distancing and complete or partial face-to-face educational activities interruption may present increased stress, depression and anxiety. This study was undertaken to evaluate if, during isolation, UMS involved in online group activities as investigators...
Article
Full-text available
Objectives: To evaluate factors associated with COVID-19 severity outcomes in patients with systemic lupus erythematosus (SLE). Methods: This was a cross-sectional analysis of baseline data of a prospective, multi-stage cohort study-"The ReumaCoV Brazil"-designed to monitor patients with immune-mediated rheumatologic disease (IMRD) during the SA...
Article
Background Knowledge on the status of gender equity in academic and clinical rheumatology in Brazil is scarce. Here, we aimed to create a scenario of work possibilities, academic development, and social issues among Brazilian rheumatologists. Methods This cross-sectional study was done using a web-based survey conducted among members of the Brazil...
Article
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Background: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple joints. It is associated with psoriasis and treated with synthetic and biologic drugs. Objective: The objective of this study was to assess the outcomes of patients who received biologic therapy with tumor necrosis factor (TNF) inhibitors in terms of ef...
Article
Full-text available
Objective: this study evaluated the biological therapy effects on disease activity, functionality, quality of life, drug survival, and safety of patients with psoriatic arthritis naïve and experienced in biological therapy. Methods: a oneyear prospective observational study was performed. The outcomes assessed were drug survival, disease activity,...
Article
Full-text available
Background: The coronavirus disease 2019 (COVID-19) pandemic has brought additional burden to patients living with immune-mediated rheumatic diseases (IMRDs), especially at the beginning of 2020, for which information for this population is lacking. Methods: COnVIDa is a cross-sectional study on patients with IMRD from all regions of Brazil who...
Article
Full-text available
Background Patients with autoimmune inflammatory diseases (AID) have been prioritized for urgent vaccination to mitigate COVID-19 risk. However, few studies in the literature assessed the immunogenicity and safety of the COVID-19 vaccine in patients with AID. Objectives In this context, the present study aims to evaluate the immunogenicity and saf...
Article
Full-text available
Background The effect of age on persistence and safety of treatment with biologic disease modifying anti-rheumatic drugs (bDMARDs) in rheumatoid arthritis has been a subject to research interest. Two recently published studies did not observe significantly different survival of treatment with bDMARDs among older age (≥ 65 years) individuals (1,2);...
Article
Full-text available
Background The SARS-CoV-2 virus has caused a worldwide health crisis. Patients with inflammatory arthritis are at higher risk of hospitalization and death by COVID-19 due to comorbidities or immunosuppressive treatments. Vaccination is one the most important strategies to control the pandemic. Objectives To evaluate the incident cases of SARS-CoV-...
Article
Full-text available
Background Antimalarials (AM) are frequently part of the initial scheme of conventional synthetic DMARDs in the treatment of rheumatoid arthritis (RA), and have been associated with lower incidence of diabetes and better lipid profile in these patients (1). However, the role of AM in schemes involving biologic (b-) or targeted synthetic (ts-) DMARD...
Article
Background For patients with RA who are refractory to biologic DMARDs (bDMARDs), such as tumor necrosis factor inhibitors (TNFis), optimal disease control is less likely to be achieved with subsequent therapy. ¹ In line with recommendations from EULAR and ACR, switching to a treatment with a different mechanism of action is appropriate for these pa...