Adrian Ivanoiu

Adrian Ivanoiu
Université Catholique de Louvain - UCLouvain | UCLouvain · Institute of Neuroscience

About

116
Publications
17,431
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5,294
Citations
Citations since 2016
46 Research Items
3296 Citations
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20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600

Publications

Publications (116)
Article
Background Diagnosis of neurodegenerative diseases can raise difficulties among immigrant patients due to language, educational or sociocultural differences with natives. CSF biomarkers of Alzheimer’s disease are useful tools to early diagnose neurodegeneration. Yet very few studies have investigated differences of those biomarkers between immigran...
Article
Background/purpose: Brain function changes with Alzheimer's disease (AD) progression. Evaluating those changes longitudinally is important to understand the complex relationships between brain pathologies and cognition. We aimed (1) to identify longitudinal changes in functional connectivity in patients with mild cognitive impairment (MCI) charact...
Article
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. Objective:...
Article
The integrity of face identity recognition (FIR) in prodromal Alzheimer’s disease (prAD) is inconsistent in the literature, and the cognitive processes underpinning a potential impairment remain elusive. The concepts of pattern separation (PS) and pattern completion (PC) offer an interesting insight in this respect, since efficient FIR implies that...
Article
Magnetic resonance imaging (MRI) has become important in the diagnostic work‐up of neurodegenerative diseases. icobrain dm, a CE‐labeled and FDA‐cleared automatic tool for brain volumetry using clinical MRI scans, has shown great potential in differentiating cognitively healthy controls (HC) from Alzheimer’s disease (AD) dementia (ADD) patients in...
Article
MK‐6240 is a promising second‐generation tau‐positron emission tomography (PET) tracer for evaluation of cerebral tauopathy in patients with and without cognitive impairment. To further validate the use of MK‐6240 in Memory Clinics, we aimed to evaluate the association between MK‐6240 PET results and well‐validated cerebrospinal fluid (CSF) tau and...
Article
Few resting‐state functional magnetic resonance imaging (rs‐fMRI) studies were carried out in patients with mild cognitive impairment (MCI). Most were cross‐sectional and brought conflicting results with both decrease and increase of rs‐fMRI connectivity reported. We used a recently developed atlas of resting‐state networks specific for late adulth...
Article
Full-text available
Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive saccades and eye re-acceleration in anticipation of a target re-appearance. While the neural pathways involved are not fully understood, it is known that the frontal lobe plays an important ro...
Article
Full-text available
Background: Magnetic resonance imaging (MRI) has become important in the diagnostic work-up of neurodegenerative diseases. icobrain dm, a CE-labeled and FDA-cleared automated brain volumetry software, has shown potential in differentiating cognitively healthy controls (HC) from Alzheimer's disease (AD) dementia (ADD) patients in selected research...
Article
Full-text available
Background Evidence of immune-mediated neurological syndromes associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is limited. We therefore investigated clinical, serological and CSF features of coronavirus disease 2019 (COVID-19) patients with neurological manifestations. Methods Consecutive COVID-19 patients wi...
Article
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Objective: Alzheimer's disease (AD) begins with subtle memory decline, years before dementia onset. The presence of subjective memory complaints (SMC) has been proposed as a marker of preclinical AD. However, recent evidence has demonstrated early and progressive loss of awareness of memory difficulties in non-demented older adults harboring AD pat...
Article
Full-text available
Purpose: To evaluate cerebral amyloid-β(Aβ) pathology in older adults with cognitive complaints, visual assessment of PET images is approved as the routine method for image interpretation. In research studies however, Aβ-PET semi-quantitative measures are associated with greater risk of progression to dementia; but until recently, these measures l...
Article
There is an unmet need for an accurate, non‐invasive biomarker test for the diagnosis of early Alzheimer’s disease (AD). To identify new biomarkers, we focused on long non‐coding RNAs (lncRNAs) as they are tissue‐ specific to identify lncRNA panel candidates for diagnostic of early Alzheimer’s disease (AD) and other dementia types. We performed a s...
Article
A number of biomarkers have shown utility for predicting cognitive decline and conversion from mild cognitive impairment (MCI) to dementia. However, few studies have investigated the effectiveness of biomarkers combinations and their individual contributions for predicting rate of memory decline. This study evaluated the utility of several imaging...
Article
Patients with mild cognitive impairment (MCI) are at‐risk of progression to Alzheimer’s dementia (AD), particularly if they have elevated amyloid (Aβ), the hallmark pathology of AD. However, a proportion of Aβ‐negative MCI also progress to dementia in clinical practice. We sought to investigate (1) whether subthreshold Aβ load, brain metabolism, or...
Article
Alzheimer's disease (AD) begins with subtle memory decline, years before dementia onset. The presence of subjective memory complaints (SMC) has been proposed as a marker of preclinical AD. However, recent evidence has demonstrated early and progressive loss of awareness of memory difficulties in non‐demented older adults harboring AD pathology. We...
Article
Full-text available
Neuropsychological testing is difficult in allochthonous older individuals due to language, sociocultural, and educational differences with autochthones. Using biomarkers could help making early diagnosis of neurodegeneration in this population, but so far very few studies have investigated biomarker differences between allochthones and autochthone...
Article
Early diagnosis of Alzheimer's disease (with the announcement of the diagnosis). The number of patients consulting to find out if they have Alzheimer's disease continues to grow. Reasons to consult most often include anxiety about being affected by this disease, confidence in medical and therapeutic advances relayed in the media and the desire to p...
Article
Neurological involvement of sarcoidosis is a rare condition, and its occurrence in the context of transplantation is exceptional. Moreover, treatment can be challenging. We report the unusual case of a patient transplanted with a kidney for end-stage renal disease secondary to sarcoidosis who experienced a neurological recurrence of the disease und...
Article
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Background: Cerebrospinal fluid (CSF) biomarkers are increasingly used to diagnose Alzheimer's disease (AD). However, important methodological and technical remain regarding measurement variability between kit providers and users. We compared the Lumipulse fully automated assays with the manual INNOTEST assays (both from Fujirebio Europe NV, Gent,...
Article
Importance Positron emission tomography (PET) imaging now allows in vivo visualization of both neuropathologic hallmarks of Alzheimer disease (AD): amyloid-β (Aβ) plaques and tau neurofibrillary tangles. Observing their progressive accumulation in the brains of clinically normal older adults is critically important to understand the pathophysiologi...
Article
Background: Palliative care and Advance Care Planning (ACP) are increasingly recommended for an optimal management of late-stage dementia. In Belgium, euthanasia has been decriminalized in 2002 for patients who are "mentally competent" (interpreted as non-demented). It has been suggested that advance directives for euthanasia (ADE) should be made...
Article
Background: There is an unmet need for an accurate, non-invasive and non-costly biomarker test for the diagnosis of Alzheimer’s disease (AD). The objectives of the ADDIA study are a) the proof-of-performance of two cellular biomarkers, β-amyloid peptide and a kinase, detected in blood cells using specific fluorescent probes, and b) the validation o...
Article
Introduction: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Methods: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Gener...
Article
Full-text available
Background: Magnetic resonance imaging (MRI) acquisition/processing techniques assess brain volumes to explore neurodegeneration in Alzheimer's disease (AD). Objective: We examined the clinical utility of MSmetrix and investigated if automated MRI volumes could discriminate between groups covering the AD continuum and could be used as a predicto...
Article
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Importance Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers...
Article
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We previously reported a GRN null mutation, originating from a common founder, in multiple Belgian families with frontotemporal dementia (FTD). Here, we used data of a 10-year follow-up study to describe in detail the clinical heterogeneity observed in this extended founder pedigree. We identified 85 patients and 40 unaffected mutation carriers, be...
Article
Introduction: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Methods: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Ge...
Article
Full-text available
We investigated the genetic role of sortilin (SORT1) in frontotemporal dementia (FTD). SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited FTD. In Belgian cohorts of 636 FTD patients and 1,066 unaffected control individuals, we identified five patient-only non-synonymous rare variant...
Article
The current study examines the hypothesis that differential aphasia may be due to a problem with language control rather than with language-specific impairment and how this is related to non-linguistic cognitive control abilities. To this end, we report a case study of an L2 dominant French-English bilingual aphasia patient with larger impairments...
Article
Full-text available
Importance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-β...
Article
Full-text available
Alzheimer’s disease (AD) is a highly prevalent condition and its prevalence is expected to further increase due to the aging of the general population. It is obvious that the diagnosis of AD has implications for driving. Finally, driving discussions are also emotionally charged because driving is associated with independence and personal identity....
Data
Supp. Figure S1. Western blot analysis of all identified single amino acid deletions and missense mutations overexpressed in HEK293T cells. TBK1 plasmids containing a missense mutation or a single‐amino acid deletion were transiently transfected in HEK293T cells. The p.Ser172Ala mutant (kinase dead, KD), generating a TBK1 protein lacking kinase act...
Article
Importance: Patients carrying a C9orf72 repeat expansion leading to frontotemporal dementia and/or amyotrophic lateral sclerosis have highly variable ages at onset of disease, suggesting the presence of modifying factors. Objective: To provide clinical-based evidence for disease anticipation in families carrying a C9orf72 repeat expansion by ana...
Article
Movement disorders following heart surgery are very unusual. Post-pump chorea is mainly a pediatric complication of heart surgery, typically manifesting after a latent period of normality and is usually related with long extracorporeal circulation time and deep hypothermia. We report a 73-year-old woman, without risk factors predisposing to paroxys...
Article
Objectives: Relatively few studies have investigated relationships between performance on clinical memory measures and indexes of underlying neuropathology related to Alzheimer's disease (AD). This study investigated predictive relationships between Free and Cued Selective Reminding Test (FCSRT) cue efficiency (CE) and free-recall (FR) measures an...
Article
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Efficient social interactions require taking into account other people’s mental states such as their beliefs, intentions or emotions. Recent studies have shown that in some social situations at least, we do spontaneously take into account others’ mental states. The extent to which we have dedicated brain areas for such spontaneous perspective takin...
Article
Background: Patients with mild cognitive impairment (MCI) are at risk for Alzheimer's dementia but the presence of amyloid (Aβ) strongly increases this risk. In clinical settings, when Aβ status is not available, different neurodegenerative markers are used to characterize MCI. The accuracy of these markers to discriminate between Aβ-and Aβ+ MCI i...
Article
Full-text available
TAR DNA-binding protein 43 (TDP-43) inclusions are pathological hallmarks of patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Loss of TDP-43 in zebrafish engenders a severe muscle and vascular phenotype with a concomitant elevation of filamin C (FLNC) levels, an observation confirmed in the frontal cor...
Article
Full-text available
Pathological expansion of a G4C2 repeat, located in the 5' regulatory region of C9orf72, is the most common genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). C9orf72 patients have highly variable onset ages suggesting the presence of modifying factors and/or anticipation. We studied 72 Belgian index...
Article
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We present the effects of Targretin® (bexarotene) on cognition and biomarkers in a patient with mild Alzheimer's disease (AD). Targretin® is a Retinoic X Receptor (RXR) agonist shown to improve synaptic and cognitive functions in animal models of AD by increasing neuronal cholesterol efflux. After 6 months of treatment with Targretin® 300 mg/day, m...
Article
The purpose of this study was to investigate associative learning effects in patients with prodromal Alzheimer’s disease (prAD) by referring to the Temporal Context Model (TCM; Howard, Jing, Rao, Provyn, & Datey, 2009), in an attempt to enhance the understanding of their associative memory impairment. TCM explains fundamental effects described in c...
Article
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Background: Olfactory dysfunction is associated with Alzheimer's disease (AD), and already present at pre-dementia stage. Objectives: Based on the assumption that early neurodegeneration in AD is asymmetrical and that olfactory input is primarily processed in the ipsilateral hemisphere, we assessed whether unirhinal psychophysical and electrophy...
Article
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Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. To use individual participant data meta-analysis to estimate th...
Article
Full-text available
We conducted a survey regarding the medical care of patients with dementia in expert settings in Belgium. Open, unrestricted and motivated answers were centralized, blindly interpreted and structured into categories. The report of the results was then submitted to the participants in subsequent plenary meetings and through email. Fourteen experts r...
Article
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Among legislative criteria granting the right to practice euthanasia or assisted suicide, there are systematically four major elements. Precisely, any request must be voluntary, persistent, to be well thought and well informed. Such euthanasia raises numerous difficult questions in case of dementia. It also justifies thinking about possibilities th...
Article
Full-text available
Background: New diagnostic criteria for predemential Alzheimer's disease (AD) advocate the use of biomarkers. However, the benefit of using biomarkers has not been clearly demonstrated in clinical practice. Objective: To investigate whether a combination of biomarkers may be helpful in classifying a population of non-demented patients attending...
Article
We report here the case of a 56-year-old man with well-documented cardiac light chain amyloidosis successfully imaged with F-flutemetamol PET/CT in 2011. A matched pair healthy volunteer was imaged in the same conditions, and no specific heart uptake could be detected. The present report suggests the potential benefit of this new pharmaceutical in...
Article
Full-text available
Adequate nutrition plays an important role in the maintenance of cognitive function, particularly during aging. Malnutrition is amongst the risk factors for developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). Epidemiological studies have associated deficiencies in some nutrients with a higher risk of cognitive dysfunction and/o...
Article
Full-text available
The temporal poles (TPs) are among the brain regions that are often considered as the brain network sustaining our ability to understand other people's mental states or "Theory of Mind" (ToM). However, so far the functional role of the left and right TPs in ToM is still debated, and it is even not clear yet whether these regions are necessary for T...
Article
BACKGROUND AND PURPOSE: Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage. We postulated that some hippocampus subfields are specifically atrophic in aMCI and that measuring hippocampus subfields volumes will improve sensitivity of MR imaging to detect...
Article
Full-text available
Objective: To characterize patients with frontotemporal lobar degeneration (FTLD) with a repeat expansion mutation in the gene C9orf72, and to determine whether there are differences in the clinical presentation compared with FTLD carriers of a mutation in GRN or MAPT or with patients with FTLD without mutation. Design: Patient series. Setting: D...
Article
Anticipatory eye movements are often evoked by the temporal expectation of an upcoming event. Temporal expectation is based on implicit timing about when a future event could occur. Implicit timing emerges from observed temporal regularities in a changing stimulus without any voluntary estimate of elapsed time, unlike explicit timing. The neural ba...
Article
(18)F-flutemetamol is a positron emission tomography (PET) tracer for in vivo amyloid imaging. The ability to classify amyloid scans in a binary manner as 'normal' versus 'Alzheimer-like', is of high clinical relevance. We evaluated whether a supervised machine learning technique, support vector machines (SVM), can replicate the assignments made by...
Article
Full-text available
Prediction is essential for motor function in everyday life. For instance, predictive mechanisms improve the perception of a moving target by increasing eye speed anticipatively, thus reducing motion blur on the retina. Subregions of the frontal lobes play a key role in eye movements in general and in smooth pursuit in particular but their precise...
Article
Increased sensitivity to proactive (PI) and retroactive (RI) interference has been observed in amnestic mild cognitive impairment (aMCI). PI and RI are often explained as being the result of a response competition mechanism. However, patients with aMCI are supposed to suffer mostly from encoding deficits. We hypothesized that in aMCI interference m...
Conference Paper
Background / Purpose: Neuroimaging studies have shown that the temporal poles (TPs) are part of the neural network activated when participants reason about other people’s mental states, irrespective of the nature (verbal or non-verbal) of the reasoning context and whatever the type of mental state inferred. However, there is so far no clear neuro...
Article
Care plans are intended to improve the independence and functioning of patients with cognitive dysfunction and support the caregivers involved. They are an integral part of the Belgian reimbursement procedure for cholinesterase inhibitors. This nationwide, multicenter, observational study examined the content and implementation of the care plan alo...
Article
Full-text available
TheRI-48 cued recall test was devised to discriminate between healthy elderly and patients with mild cognitive impairment who are at risk of developing Alzheimer's disease (AD). However, no long-term follow-up studies have been conducted using this test. We analyzed the predictive power of the RI-48 test for determining the patients who will conver...
Article
Full-text available
Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage. We postulated that some hippocampus subfields are specifically atrophic in aMCI and that measuring hippocampus subfield volumes will improve sensitivity of MR imaging to detect aMCI. We evaluated episo...
Article
Previous functional MRI studies have shown increased hippocampus activation in response to item encoding in amnestic mild cognitive impairment (aMCI). Recent behavioral studies suggested that associative memory could be more impaired than item memory in aMCI. So far, associative encoding has not been evaluated separately from item encoding in funct...
Article
In the present study, we report on the performance of a patient with probable Alzheimer's disease (AD) who made a lot of verbal code intrusions during the production of Arabic numerals. For instance, she wrote 3 mille instead of 3000 [trois mille] or 15ZE instead of 15 [quinze]. These errors of shift towards the unintended code are typical in cases...