Adrian Curtin

Adrian Curtin
Drexel University | DU · School of Biomedical Engineering, Science and Health Systems

PhD Biomedical Engineering

About

48
Publications
8,115
Reads
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721
Citations
Additional affiliations
March 2020 - present
Drexel University
Position
  • PostDoc Position
August 2014 - March 2020
Shanghai Jiao Tong University
Position
  • PhD Student
December 2012 - January 2020
Drexel University
Position
  • PhD Student

Publications

Publications (48)
Article
Full-text available
Endoscopic procedures performed in the United States routinely involve the use of conscious sedation as standard of care. The use of sedation reduces patient discomfort and anxiety while improving the technical quality of the procedure, and as a result, over 98% of clinicians have adopted the practice. The tremendous benefits of sedation are offset...
Article
Full-text available
Background: The capacity for TMS to elicit neural activity and manipulate cortical excitability has created significant expectation regarding its use in both cognitive and clinical neuroscience. However, the absence of an ability to quantify stimulation effects, particularly outside of the motor cortex, has led clinicians and researchers to pair no...
Article
Full-text available
Neuroergonomics is an emerging field that investigates the human brain in relation to behavioral performance in natural environments and everyday settings. Functional near‐infrared spectroscopy (fNIRS), a noninvasive brain‐monitoring technology that relies on optical techniques to detect changes of cortical hemodynamic responses to human perceptual...
Conference Paper
Automated spoken language interfaces have seen a remarkable proliferation in recent years, integrating with automotive, household, industrial, and mobile platforms to shape the way in which we interact with our devices. While the use of an auxiliary auditory information stream has the potential to decrease interference and prevent disengagement fro...
Article
Recent evidence highlights the role of the cerebellum-cerebral loop in the pathophysiology of schizophrenia (SZ). Electroconvulsive therapy (ECT) is clinically applied to augment the effect of antipsychotic drugs. The study aims to address whether the cerebellum-cerebral loop is involved in the mechanisms of ECT's augmentation effect. Forty-two SZ...
Article
Full-text available
Objective Women’s experiences of sexual violence can be not only psychologically and physically traumatizing but may also have lasting effects on brain functions, including cognitive control relating to the inhibition and processing of emotion. Thus, the purpose of this pilot study is to explore underlying neural correlates of sexual violence’s imp...
Conference Paper
Full-text available
Latent Dirichlet Allocation (LDA) and Sentiment Analysis have become prominent tools in natural language processing applications for both research and industry. While LDA is a generative probabilistic modeling methodology that is widely used in Topic Modeling to extract underlying themes and topics from a collection of words, Sentiment Analysis is...
Conference Paper
Full-text available
Video games provide a high-octane competitive sports platform where players with diverse skills engage in tasks that require precise control of cognitive skills and emotional responses. Electrodermal activity (EDA) is a portable, non-invasive, and wearable physiological activity sensing modality that captures correlates of emotional responses. In t...
Chapter
The performance of a team is tightly connected to how well its members communicate and collaborate while working towards shared objectives, a process known as group cognition. In competitive team sports, strategic and efficient coordination between team members often makes the difference between success and failure. Professional e-sport gaming, in...
Chapter
Mental workload assessment is a core element of designing complex high-precision human machine interfaces with industrial and medical applications, from aviation to robotic neurosurgery. High accuracy and continuous mental state decoding play an essential role for keeping the operator’s mental workload on a moderate level to prevent cognitive tunne...
Article
Full-text available
Advances in neuroimaging have promised the development of specific and objective biomarkers for the diagnosis and treatment of psychiatric disorders. Recently, functional near-infrared spectroscopy (fNIRS) has been used during cognitive tasks to measure cortical dysfunction associated with mental illnesses such as Schizophrenia (SCH), Major-Depress...
Article
Autism spectrum disorder (ASD) encompasses a wide range of impairments in reciprocal social and communicative skills. Mirror neurons, which are concentered in the Inferior Parietal Lobule (IPL) play an integral role in sensory-motor processing of social interactions and are thought to be functionally impaired in ASD. We implemented high frequency R...
Article
Background: Electroconvulsive therapy (ECT) has been shown to be effective in schizophrenia (SZ), particularly in drug-refractory cases or when rapid symptom relief is needed. However, its precise mechanisms of action remain largely unclear. To clarify the mechanisms underlying modified electroconvulsive therapy (mECT) for SZ, we conducted a longi...
Chapter
Full-text available
The result of training to improve in a given skill is most often demonstrated by an increase in the relevant performance measures. However, a complementary and at times more informative measure is the mental workload imposed on the performer when doing the task. While a number of varied methods exist for measuring workload, we have chosen to explor...
Conference Paper
A familiar construct in everyday life is the use of past performance to predict future performance of individuals such as human operators. Here, we propose that brain activity measured during cognitive task execution can be used for prediction of future performance of the same individual on the same task. We recorded multimodal wearable neuroimagin...
Article
Full-text available
Control of attention is thought to be specifically impaired in schizophrenia due to abnormal function in the prefrontal cortex (PFC). The PFC plays a critical role in the identification of relevant stimuli and the development of appropriate biases for the identified signals, including selection of an appropriate attentional ‘zoom’. We examined how...
Data
Detailed list of stimulation parameters and qualitative results for all studies investigating the effects of stimulation on task.
Data
Detailed list of stimulation parameters and qualitative results for all studies investigating stimulation at rest.
Chapter
A Brain-computer Interface (BCI) is a system that interprets specific patterns in human brain activity, such as the intention to perform motor functions, in order to generate a signal which can be used for communication or control. Functional near infrared spectroscopy (fNIRS) is an emerging optical neuroimaging technique which is a relatively new...
Chapter
Full-text available
The finite nature of human cognitive capacity demands an efficient relationship between invested mental effort and task performance. As a result, the process of learning can be partially viewed as the acquisition of knowledge and formulation of strategies which attempt to reduce relative cognitive demands and increase overall mental efficiency, the...
Article
Background: Electroconvulsive therapy (ECT) is often considered as an augmentation of antipsychotic treatment for schizophrenia in drug-refractory cases. However, the mechanisms underlying the observed therapeutic effects are still not understood. Objective: We aimed to investigate changes in whole brain grey matter volume (GMV) before and after mo...
Article
Abnormal auditory steady state response (ASSR) is a typical finding among schizophrenia patients, which is thought to directly reflect deficient gamma band oscillations in the brain. However, whether these ASSR alterations are state dependent, e.g. during eye-open or eye-closed conditions, has not yet been carefully elucidated in schizophrenia. Our...
Article
Full-text available
Transcranial magnetic stimulation (TMS) is a noninvasive method used to excite or inhibit cortical activity for experimental, diagnostic, and therapeutic interventions. However, nonmotor regions of the brain targeted in TMS therapies, such as the dorsolateral prefrontal cortex (DLPFC), offer no extrinsic response to stimulation, resulting in a need...
Article
Full-text available
Depressed patients have a demonstrated cognitive bias in emotional information processing. However, it is unknown how early perceptual processing is modulated by emotional stimuli in depression. To examine this question, we studied 22 depressed patients and 22 healthy controls performing a cued target-response task with emotional facial expression...
Article
Full-text available
The Parallel Robotics Inspired Goniometer (PRIGo) is a novel compact and high-precision goniometer providing an alternative to (mini-)kappa, traditional three-circle goniometers and Eulerian cradles used for sample reorientation in macromolecular crystallography. Based on a combination of serial and parallel kinematics, PRIGo emulates an arc. It is...
Article
Full-text available
A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source. Building upon and critically extending previous developments realised for the high-resolution endstations of the two undulator beamlines X06SA and X10SA, as well as the super-bend dipole beamline X06DA,...
Conference Paper
Full-text available
Synthetic speech has a growing role in human computer interaction and automated systems with the emergence of ubiquitous computing such as smart phones, car multimedia control and navigation systems. Cognitive processing costs associated with comprehension of synthetic speech relative to comprehension of natural speech have been demonstrated with b...
Conference Paper
Full-text available
Next generation brain computer interfaces (BCI) are expected to provide robust and continuous control mechanism. In this study, we assessed integration of optical brain imaging (fNIR: functional near infrared spectroscopy) to a P300-BCI for improving BCI usability by monitoring cognitive workload and performance. fNIR is a safe and wearable neuroim...
Conference Paper
Full-text available
The role of practice is crucial in the skill acquisition process and for assessments of learning. In this study, we used a portable neuroimaging technique, functional near infrared (fNIR) spectroscopy for monitoring prefrontal cortex activation during learning of spatial navigation tasks throughout 11 days of training and testing. Two different tas...
Thesis
Endoscopic procedures performed in the United States routinely involve the use of conscious sedation as standard of care. The use of sedation reduces patient discomfort and anxiety while improving the technical quality of the procedure, and as a result, over 98% of clinicians have adopted the practice. The tremendous benefits of sedation are offset...
Article
Full-text available
In this study, a Brain Computer Interface (BCI) based on the P300 oddball paradigm has been developed for spatial navigation control in virtual environments. Functionality and efficacy of the system were analyzed with results from nine healthy volunteers. Each participant was asked to gaze at an individual target in a 3×3 P300 matrix containing dif...
Article
Full-text available
Brain-computer interface (BCI) provides patients suffering from severe neuromuscular disorders an alternative way of interacting with the outside world. The P300-based BCI is among the most popular paradigms in the field and most current versions operate in synchronous mode and assume participant engagement throughout operation. In this study, we d...
Conference Paper
Full-text available
The efficiency and safety of many complex human-machine systems such as Unmanned Aerial Vehicle (UAV) are closely related to the cognitive workload and situational awareness of their operators. Subjective operator reports, physiological and behavioral measures are not reliably sensitive for monitoring cognitive overload. Drexel's Optical Brain Imag...
Conference Paper
Full-text available
An accurate assessment of mental workload and expertise level would help improve operational safety and efficacy of human computer interaction for aerospace applications. The current study utilized functional near-infrared spectroscopy (fNIR) to investigate the relationship of the hemodynamic response in the anterior prefrontal cortex to changes in...
Article
Full-text available
MazeSuite is a complete toolset to prepare, present and analyze navigational and spatial experiments1. MazeSuite can be used to design and edit adapted virtual 3D environments, track a participants' behavioral performance within the virtual environment and synchronize with external devices for physiological and neuroimaging measures, including elec...

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Project (1)
Project
Cognitive Dysmetria is an integrative theory to account for the diverse symptoms observed in schizophrenia wherein dysfunction of cortical-thalamo-cerebellar (CTC) circuitry can produce in humans a difficulty in prioritizing, processing, coordinating, and responding to information. This study extends the use of CTC connectivity from resting-state fMRI data to investigate distinctive functional connectivity (FC) patterns across patients with schizophrenia, bipolar, and attention deficit disorder as well as healthy volunteers. We investigated connectivity across 188 cortical, thalamic, subcortical, and cerebellar regions of interest (ROI) in 135 subjects. Consistent with cerebellar roles in cognition, we found similar decreases in FC in non-motor cerebellar, language/auditory, and salience networks in all three psychiatric cohorts compared to psychotypical subjects.