Adham Elshahabi

Adham Elshahabi
Universitätsklinikum Tübingen · Division of Neurology with a main focus on epileptology

MBBCh, MSc

About

18
Publications
1,742
Reads
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265
Citations
Citations since 2017
13 Research Items
237 Citations
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Education
October 2012 - October 2016
University of Tuebingen
Field of study
  • Neuroscience
September 2010 - September 2012
Università degli Studi di Trento
Field of study
  • Cognitive Neuroscience
September 2003 - February 2010
Zagazig University
Field of study
  • Human Medicine

Publications

Publications (18)
Article
Full-text available
Idiopathic/genetic generalized epilepsy (IGE/GGE) is characterized by seizures, which start and rapidly engage widely distributed networks, and result in symptoms such as absences, generalized myoclonic and primary generalized tonic-clonic seizures. Although routine magnetic resonance imaging is apparently normal, many studies have reported structu...
Article
Dynamic causal modelling (DCM) is a method to non-invasively assess effective connectivity between brain regions. 'Musicogenic epilepsy' is a rare reflex epilepsy syndrome in which seizures can be elicited by musical stimuli and thus represents a unique possibility to investigate complex human brain networks and test connectivity analysis tools. We...
Article
Full-text available
Electroencephalography (EEG) and magnetoencephalography (MEG) are widely used to localize brain activity and their spatial resolutions have been compared in several publications. While most clinical studies demonstrated higher accuracy of MEG source localization, simulation studies suggested a more accurate EEG than MEG localization for the same nu...
Article
Purpose: To assess the impact of colored noise on statistics in event-related functional MRI (fMRI) (visual stimulation using checkerboards) acquired by simultaneous multislice imaging enabling repetition times (TRs) between 2.64 to 0.26 s. Methods: T-values within the visual cortex obtained with analysis tools that assume a first-order autoregr...
Article
Full-text available
Objective: Genetic generalized epilepsy is characterized by aberrant neuronal dynamics and subtle structural alterations. We evaluated whether a combination of magnetic and electrical neuronal signals and cortical thickness would provide complementary information about network pathology in GGE. We also investigated if these imaging phenotypes were...
Article
Full-text available
Objective To assess whether neuronal signals in patients with genetic generalized epilepsy (GGE) are heritable, we examined magnetoencephalography (MEG) resting-state recordings in patients and their healthy siblings. Methods In a prospective, cross-sectional design, we investigated source-reconstructed power and functional connectivity in patient...
Article
Full-text available
Conscious perception of the emotional valence of faces has been proposed to involve top-down and bottom-up information processing. Yet, the underlying neuronal mechanisms of these two processes and the implementation of their cooperation is still unclear. We hypothesized that the key substrates enabling conscious perception are differential partici...
Article
Full-text available
Epilepsy is one of the most prevalent neurological diseases with a high morbidity. Accumulating evidence has shown that epilepsy is an archetypical neural network disorder. Here we developed a non-invasive cortical functional connectivity analysis based on magnetoencephalography (MEG) to assess commonalities and differences in the network phenotype...
Data
Figure S2. Mean BOLD time courses during GSWDs in the 3 investigated networks and the thalamus.
Data
Table S2. DCM F values (i.e., negative log‐evidence) for each model at single subject and group level.
Data
Figure S1. Activation pattern of BOLD signal changes preceding and following GSWDs in all patients. Activations are depicted in yellow and deactivations in blue (p < 0.05, corrected at cluster level).
Data
Table S1. GLM analysis on single‐subject level depicting activations (+) and deactivations (−) for each subject (N = 12) at 16, 12, 8, 4, and 0 s before and 4 s after GSWD onset.
Preprint
Conscious perception of emotional valence of faces has been proposed to involve top-down and bottom-up information processing. Yet, the underlying neuronal mechanisms of these two processes and the implementation of their cooperation is still unclear. We hypothesized that the networks activated during the interaction of top-down and bottom-up proce...
Article
Full-text available
Objective Genetic generalized epilepsies (GGE) are characterized by generalized spike‐wave discharges (GSWD) in electroencephalography (EEG) recordings without underlying structural brain lesions. The origin of the epileptic activity remains unclear, although several studies have reported involvement of thalamus and default mode network (DMN). The...
Article
Full-text available
The human brain is known to contain several functional networks that interact dynamically. Therefore, it is desirable to analyze the temporal features of these networks by dynamic functional connectivity (dFC). A sliding window approach was used in an event-related fMRI (visual stimulation using checkerboards) to assess the impact of repetition tim...

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