Adenike Adeniji-Sofoluwe

University of Ibadan · Department of Radiology

Purpose To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women. Methods BC cases and matched controls were enrolled in three sub-Saharan African countries, Nigeria Cameroon, and Uganda, between 1998–2018. Multivariable logistic regression was used to test the association...

Background: Populations of African ancestry are underrepresented in global oncology clinical trials resulting in paucity of data on safety and efficacy of cancer medicines in vulnerable Black populations. The ARETTA clinical trial was initiated by the Nigerian Breast Cancer Study Team in partnership with the University of Chicago Comprehensive Canc...

Chest X-ray (CXR) characteristics of patients with drug-resistant tuberculosis (DR-TB) depend on a variety of factors, and therefore, identifying the influence of these factors on the appearance of DR-TB in chest X-rays can help physicians improve diagnosis and clinical suspicion. Our aim was to describe the CXR presentation of patients with DR-TB...

TPS622 Background: Breast cancer rates are increasing in Nigeria and across sub-Sahara Africa without the necessary infrastructure to manage the disease. Adequate clinical trial resources are needed to address the growing need for high quality, patient centered cancer care on the Continent. The ARETTA clinical trial was initiated by the Nigerian Br...

A preperitoneal abscess is an uncommon manifestation of extraperitoneal collection. We present a case of an anterior abdominal wall preperitoneal abscess in a 30-year-old Nigerian female with abdominal pain and purulent abdominal wall discharge ten days after an initial admission for spontaneous bacterial peritonitis. This report underscores the ro...

Background: Orbito-ocular diseases are a major public health issue, often causing visual impairment with serious socioeconomic implications on individual lives. Ocular ultrasonography is an invaluable diagnostic tool when clinical examination of the ocular fundus is difficult. Objectives: To describe the indications, sonographic findings, and co...

Background: There is both higher mortality and morbidity from cancer in low and medium income countries (LMICs) compared with high income countries (HICs). Clinical trial activities and development of more effective and less toxic therapies have led to significant improvements in morbidity and mortality from cancer in HICs. Unfortunately, clinical...

Introduction: Mammography is a major tool for the screening and diagnosis of breast cancer globally. Poor funding and lack of good public health education for mammography in resource-limited countries limit access to mammographic services. In these settings, patients bear the cost of breast cancer screening from out-of-pocket expenses. The aim of...

Background: There is both higher mortality and morbidity from cancer in low and medium income countries (LMICs) compared with high income countries (HICs). Clinical trial activities and development of more effective and less toxic therapies have led to significant improvements in morbidity and mortality from cancer in HICs. Unfortunately, clinical...

Background: There is both higher mortality and morbidity from cancer in low and medium income countries (LMICs) compared with high income countries (HICs). Clinical trial activities and development of more effective and less toxic therapies have led to significant improvements in morbidity and mortality from cancer in HICs. Unfortunately, clinical...

Introduction: Ectopic pregnancy in Sub-Saharan Africa has an incidence of 1%-5% of all deliveries and 5%-10% of all gynaecological admissions. The fallopian tube is the most common site of occurrence of an ectopic pregnancy and ruptured ectopic is the commonest variety seen in low resource settings. Materials and Method: This is a 2-year retrospect...

Purpose The increasing incidence of breast cancer during pregnancy and postpartum in Nigeria remains a source of concern and management dilemma. Integrating a screening program into existing antenatal and postnatal services might provide a real opportunity to promptly detect and plan treatment in low-income countries. The objective of this work was...

Background: Breast disorders cause great anxiety for women especially when they occur in pregnancy because breast cancer is the most common cause of cancer related deaths in women. Majority of the disorders are Benign Breast Diseases (BBD) with various degrees of associated breast cancer risks. With increasing breast cancer awareness in Nigeria, w...

Background: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. Methods: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were...

Background: Axillary lymph node (LN) status of patients with breast cancer is important in the surgical management. Sonographic evaluation of axillary LNs in newly diagnosed breast cancer is required to predict prognosis. Objective: The purpose of this study was to describe the morphologic features by sonographic evaluation of the cortices and s...

An unusual type of neurofibroma predominantly seen in children and young adults is diffuse neurofibroma. We present a 25-year-old female with recurring soft tissue masses in her right lower limb. MRI showed areas of T1 iso-intensity and T2 hyperintensity relative to skeletal muscle within the subcutaneous fat. These masses show marked enhancement p...

Introduction/Objectives: To assess the efficacy and correlation of MDCT scans in the clinical staging of patients with HNCs prior to therapeutic intervention. Methodology: Thirty-four HNCs were studied according to the 2005 WHO. Clinical AJCC 6th edition & radiological staging. Results: 14 Squamous Cell Carcinoma (SCC 41.2%) mean age 49.4 + 14.7 ye...

Cranialultrasoundisanexcellenttoolfor evaluating normal anatomy and pathological lesions of the brain in the paediatric age group. Itisthemostreadilyavailableandeasily repeatable technique for imaging the neonatal brain. This study aims to analyze data on cranial ultrasound scans performed over five years from January 2012 to December 2016. Materia...

Cranial ultrasound is an excellent tool for evaluating normal anatomy and pathological lesions of the brain in the paediatric age group. It is the most readily available and easily repeatable technique for imaging the neonatal brain. This study aims to analyze data on cranial ultrasound scans performed over five years from January 2012 to December...

Background: Breast cancer (BC) risk prediction models, such as the Gail model, have been developed and widely used to identify women at higher risk of having breast cancer in developed countries. However, no model exists for Black women of sub-Saharan Africa (SSA). Because African women have different risk profiles, it is of public health importanc...

Across race/ethnicities, breast cancer incidence and mortality rates markedly differ. Numerous studies have demonstrated that individuals of African ancestry acquire aggressive, early-onset breast cancers more frequently than other populations for reasons that remain unexplained. The sources of these disparities are complex, and a comprehensive cha...

Context: The incidence of breast cancer is increasing worldwide. In black women, breast cancer is associated with aggressive features and poor survival. Objective: Identification of risk factors such as early age of menarche, obesity and family history of breast cancer may permit preventive strategies. Study Design: A cross-sectional comparative st...

Background: The testes are responsible for the production of spermatozoa and testosterone in man. Reliable and accurate determination of testicular volume is of great potential benefit in evaluation of patients with a variety of disorders affecting testicular growth, development and function. Ultrasonography (USS) provides a good and reliable tool...

Breast cancer is the most common cancer among females in Nigeria. Bilateral breast cancer can occur synchronously or metachronously. We report three different cases of bilateral breast cancer in three female patients managed by the Ibadan Multidisciplinary Breast Tumour Board, domiciled at the University College Hospital (UCH), over a 3-year period...

Background: Early detection is an essential step in decreasing the mortality and morbidity of breast cancer. Mammography is a proven effective tool for early breast cancer detection. It has high sensitivity and specificity and remains the gold standard for breast cancer screening. This study aims at describing the findings at screening mammography...

BACKGROUND: Tru-cut needle biopsies form an integral part of Triple assessment of breast cancer and include clinical assessment, mammography and core needle biopsy. No study has been done to evaluate the validity of the procedure in our environment. This study was done to evaluate the validity of core needle biopsies in our centre.

Benign diseases are more common than malignant diseases in pregnant and lactating women. Fibroadenomas are the most commonly identified benign breast tumour in pregnant and lactating women. Pregnancy related breast cancer is defined as breast cancer that occurs during pregnancy or within 1 year of delivery. Its incidence is estimated at 1 in 3000 t...

Background: Adult colo-colonic intussusception is a rare abnormality and it may pose a diagnostic challenge. Objective: To report two cases of adult colo-colonic intussusception with benign lesion as the lead points. Methods: The Clinical records of the two patients containing the management details were retrieved and reviewed. Results: The...

Background: Early detection is an essential step in decreasing the mortality and morbidity of breast cancer. Mammography is a proven effective tool for early breast cancer detection. It has high sensitivity and specificity and remains the gold standard for breast cancer screening. This study aims at describing the findings at screening mammography...

Background/Aims: The purpose of this paper is to present the various types of calcifications seen on mammograms in Nigerian women in Ibadan. The study was to describe calcifications using the American College of Radiology Breast Imaging Reporting and Data System (ACR-BIRADS) classification, document the incidence of the various types of calcificati...

Background and Objectives: Ultrasound-guided core needle or tru-cut biopsy is a new concept in breast cancer diagnosis and treatment in developing countries, including Nigeria. A tru-cut biopsy is less invasive surgery, replacing diagnostic surgical biopsies in many institutions. It has a known sensitivity of 94-100%, whether performed with ultraso...

Background: The World Health Organization has projected that by the year 2020, head trauma from Road Traffic Crashes (RTCs) alone will be the 3 rd leading burden of diseases in developing countries. Computed tomography (CT) is the imaging modality of choice in acute traumatic head injury evaluation and provides an excellent guide to the care of the...

Background: Sonographic breast density pattern like mammography is dependent on the relative proportion of connective and glandular tissue. Breast density is a marker for breast cancer risk and has received wide spread interest in many countries in recent times. Aims and objectives: This paper aims at describing the sonographic breast pattern in...

An 80 year old clergy, presented with a 5-day history of left-sided chest pain which was non-radiating but had cough productive of white sputum. No history of haemoptysis, dyspnoea, orthopnoea or paroxysmal nocturnal dyspnoea was elicited. However, a history of smoking 2 cigarettes per day for 10 years was present. He is a known hypertensive on med...

Toxoplasmosis is one of the most common zoonoses worldwide caused by Toxoplasma gondii . Majority of T. gondii infections are asymptomatic or induce transitory and mild symptoms characterized by lymphadenopathy. Risk factors are immunosuppression and pregnancy. Human immunodeficiency virus (HIV) infected persons represent the group at highest risk...

Lymphatic filariasis caused by nematode parasite Wuchereria bancrofti and Brugia Malayi is endemic in the tropics. In Nigeria, 25% of the population is infected. Lymph edema and elephantiasis are the predominant manifestations. Its infrequent manifestation is in the breast. This paper discusses the epidemiology, reviews literature, imaging options...

Brain metastases (BM) occur in up to one-fifth of patients with metastatic breast cancer (MBC). Imaging plays a key role in diagnosis. The pattern and distribution of these changes are also crucial to their management. These patterns have not been fully studied in Nigerian women. Retrospective analysis of the findings on the cranial Computed Tomogr...

Background Mammography has been used in developed countries with considerable success but very little is known about this imaging modality in low resource settings. This study examined the level of awareness of mammography and determined factors influencing the level of awareness. Methods We conducted a hospital based cross sectional study to inve...

Mammographic breast density is dependent on the relative proportion of radiolucent fat and radio-dense connective and glandular tissue. This breast density is said to be a marker of risk for breast cancer and has received widespread interest in many countries in recent years. Aims and The main objective of this study is to estimate the prevalence o...

The authors report a case of recurrent intestinal obstruction due to complete transmural migration of a retained surgical sponge into the small intestine. A 41-year-old woman presented with recurrent episodes of intestinal obstruction following a previous laparotomy in a private hospital for some gynaecologic procedures. Relaparotomy revealed a mas...

Cerebral arteriovenous malformations (AVM) are rarely diagnosedand reported from our region of the world possibly due to the paucity (even unavailability) of the necessary imaging modalities especially digital subtraction angiography (DSA). In this report we present the CT features making for the confident diagnosis of a case of cerebral AVM, even...

Background: Ventricular size measurements aid early determination of deviation from normal and facilitate early intervention. This study seeks to establish normal ranges for measurements of intracranial ventricles in a term African population at birth and six weeks and define effects of modes of delivery and changes in anthropometry on the measurem...

Though the major target of the HIV-virus is the immune system, the frequency of abdominal disorders in HIV/AIDS patients has been reported to be second only to pulmonary disease. These abdominal manifestations may be on the increase as the use of antiretroviral therapy has increased life expectancy and improved quality of life. Ultrasonography is a...