Adeleye Ademola Olutayo

Adeleye Ademola Olutayo
Federal University Oye-Ekiti · Pharmaceutics and Pharmaceutical Technology

Ph.D, PGDE

About

33
Publications
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Introduction
Olutayo Adeleye currently works as a Lecturer in the department of Pharmaceutics and Pharmaceutical Technology, Federal University Oye Ekiti, Ekiti State, Nigeria.

Publications

Publications (33)
Article
Full-text available
Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were eva...
Article
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Background: Diabetes mellitus has become an increase concern in the world. People especially in poor communities have been using medicinal plants to treat diabetes and its complications. Much work has been done to find scientific evidences to support the use of medicinal plants thus ethylacetate extract of Combretum platypterum was investigated for...
Article
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Objectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with aqueous and methanol extract of Ehretia cymosa le...
Article
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Objectives The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) as a suspending agent in metronidazole suspension. Methods and Materials Metronidazole suspension was formulated with mucilage (0.1%, 0.5%, 1%, and 2% w /v) from P. biglobosa seeds as the suspending agent. Similar suspensions of metronidazole that conta...
Article
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The hand is an easy agent for the spread and transmission of pathogens and community-acquired infections. This study aims at evaluating the antimicrobial activity of Strombosia grandifolia hand sanitizer compared with a commercially available alcohol-based hand sanitizer. Water, methanol, and ethyl acetate extract from the leaf of Strombosia grandi...
Article
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In the quest for natural biodegradable, non-toxic polymers for use as excipients in pharmaceutical formulations, mucilage of Basella alba L (BAM) stem was isolated and evaluated as a suspending agent in metronidazole suspensions at different concentrations (0.5% - 2% w/v) in comparison to tragacanth (TCG) and gelatin gums (GLT). The micromeritic pr...
Article
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Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available in nature. The most common source of commercial microcrystalline cellulose is fibrous wood pulp. Cellulose and its derivatives have found wide commercial applications in the pharmaceutical, cosmetic, food, paper, textile, and engineering industries. Thi...
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Medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and in the Middle East use herbal medicine for disease management such as SARS caused by coronavirus. Infection from coronavirus is initiated by entry of the virus into a susceptible host cell. The two human coronaviruses of public health...
Article
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Background: Silver nanoparticles (SNP) are the most preferred and most often used metallic nanoparticles in biomedical studies. However, there are only few studies on its application in topical drug delivery design. Objectives: This study was carried out to design topical ointments containing n-hexane and methanol Ehretia cymosa leaf extracts media...
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Background Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it. Main text The deadly coronavirus disease 2019 (COVID-19) caused by a novel coronavirus known as...
Article
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Objectives: Oral hygiene, an integral part of the body's general well-being, should be maintained to prevent dental problems. This study was conducted to incorporate the ethanol extract of Massularia acuminata twigs in a formulation of herbal toothpaste and evaluate its antibacterial activity compared with a commercially available herbal toothpast...
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The aim of the work was to characterize chitosan extracted from snail shell and evaluate its use as a disintegrant and binder in metronidazole tablet formulation in comparison with standard chitosan (SC). The mechanical properties were assessed using crushing strength and friability, while the release properties were assessed using disintegration a...
Article
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Objective : Maize plants have been genetically engineered to produce genotypes with agriculturally desirable traits such as high starch content, pest resistance and increased nutritional value. Maize starch has been widely used as an excipient in pharmaceutical formulations. This study aims to produce sustained release ibuprofen tablets using starc...
Article
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Objective(s): To synthesize silver nanoparticle (SNP) using an extract of the leaf of Ehretia cymosa as a reducing and stabilizing agent and to apply it as an anti-inflammatory agent in medicated ointment formulation. Materials and methods: The leaf of Ehretia cymosa was extracted with absolute ethanol and the phytochemical constituents were examin...
Article
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Background and Aims: Mouthwashes are oral home care product used to treat mouth infections and to maintain satisfactory oral hygiene. The use of effective mouthwash is a reasonable means to prevent dental caries and oro-dental infections. The aim of this study was to evaluate the antimicrobial potential of Distemonanthus benthamianus chewing stick...
Article
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Among several forms of metallic nanoparticles used in biomedical applications, AgNPs are the most fascinating and widely used. Therefore, this study was carried out to evaluate the anti-inflammatory activity of Ehretia cymosa-AgNPs cream. Different extracts of the plant (methanol, ME; n-hexane, NE; ethylacetate, EE) were used to synthesize AgNPs, w...
Article
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Background: Oral films are gaining popularity and acceptance as new drug delivery systems, because of ease of administration and better patient compliance. However, most raw materials used in developing countries are imported and expensive. Therefore, there is need to develop local and naturally occurring raw materials as excipients. Objective: Thi...
Article
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Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipi-ents. Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses, such as compression pressure, thus imposing changes in the properties of these materials. Variations in the compres...
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Background: Solid dosage forms, especially tablets are the commonest product lines in pharmaceuucal industries. This study was therefore conducted to assess the in-vitro bioequivalence of five brands of paracetamol (500mg) tablets manufactured in South West Nigeria to ascertain its quality.
Article
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Background: Creams are semi-solid topical products which are intended to be applied to the skin or mucous membrane. Herbal medicated creams are used for various therapeutic purposes. The antimicrobial properties of Andrographis paniculata leaves have been studied by various researchers. Objectives: The objective of this study is to formulate and ev...
Article
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Drugs are exposed to some conditions which are inevitable in the shelf-life of those drugs. Such conditions are met during drug distribution to the point of consumption. If stability of a drug product is not maintained throughout its shelf-life, quality, safety, potency and efficacy will be compromised. This study aimed to investigate the effect of...
Article
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Polymers have gained tremendous popularity in the production of pharmaceutical products due to their various applications in drug delivery. The aim of this study was to evaluate and compare the effect of xanthan gum, a natural polymer and hydroxyl propyl methyl cellulose, a semi-synthetic polymer on the mechanical and release properties of metronid...
Article
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The aim of this study was to evaluate and compare the compactibility, mechanical and release properties of tramadol tablets prepared by direct compression using cissus gum, a naturally occurring plant polymer as directly compressible excipient in comparison with xanthan gum. Compactibility was measured by Heckle, mechanical properties by tensile st...
Article
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Background: Starches provide a means of drug delivery via the oral route. Objectives: The aim is to develop oral dissolving films of Naproxen from binary mixtures of starches obtained from Ofada rice (Oryzaglaberrima) and Bambara groundnut (Vigna subterranean), and Carbomer, a synthetic polymer. Methods: Starches were extracted from the grains of O...
Article
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The aim of this study was to evaluate the compaction characteristics of cissus gum extracted with two different solvents (acetone and water) as binder in direct compression tablet formulations in comparison with xanthan and sodium carboxymethylcellulose (SCMC). 400 mg of each of the adhesives was compressed into a compact on a hydraulic single pres...
Article
Full-text available
The aim of this study was to evaluate the compaction characteristics of cissus gum extracted with two different solvents (acetone and water) as binder in direct compression tablet formulations in comparison with xanthan and sodium carboxymethylcellulose (SCMC). 400 mg of each of the adhesives was compressed into a compact on a hydraulic single pres...
Article
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Drug delivery to the proper site of action in the body is greatly influenced by the excipients used and some processing variables such as changes in compression force. The aim of this investigation was to study the influence of changes in compression forces during tablet manufacturing on the mechanical and release properties of Tramadol matrix tabl...
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Background: the use of natural excipients and their semi synthetic derivatives in drug delivery continues to be an area of active research.
Article
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Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics. To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matr...
Article
The paper present a study regarding the binding properties of Cissus gum, obtained from Cissus populnea (Vitaceae), in paracetamol tablet formulations in comparison with official gelatin. Compressional properties were analyzed using density measurements and compression equations of Heckel. The mechanical properties of the tablets were assessed usin...
Article
Full-text available
The quantitative effects of a new gum, used as a binder, on the mechanical and release properties of paracetamol tablet formulations were analyzed in a 2 3 full factorial experiment. Cissus gum extracted from Cissus populnea Guill. & Perr. (Vitaceae) was compared with official gelatin. The individual and interaction effects of type of binder, conce...

Questions

Question (1)
Question
I actually want to know if pilot plant scale-up takes place after FDA has approved a New Drug Application (NDA) or it is done during the clinical trial stages.

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