Adela Isvoranu

• PhD Psychology
• Assistant Professor at National University of Singapore

Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the present study was to use the novel n...

Post-traumatic stress disorder (PTSD) researchers have increasingly used psychological network models to investigate PTSD symptom interactions, as well as to identify central driver symptoms. It is unclear, however, how generalizable such results are. We have developed a meta-analytic framework for aggregating network studies while taking between-s...

The Gaussian Graphical Model (GGM) has recently grown popular in psychological research, with a large body of estimation methods being proposed and discussed across various fields of study, and several algorithms being identified and recommend as applicable to psychological datasets. Such high-dimensional model estimation, however, is not trivial,...

Network approaches to psychopathology have become increasingly common in mental health research, with many theoretical and methodological developments quickly gaining traction. This article illustrates contemporary practices in applying network analytical tools, bridging the gap between network concepts and their empirical applications. We explain...

Over the past decade, longitudinal network analyses have gained significant traction in psychological science. These approaches, applied to intensive time-series or panel data, require a high level of flexibility and involve numerous modeling decisions, which can introduce considerable degrees of freedom into the process. Despite their growing use...

Purpose Recent research has sought to study how the overlapping features of extant cognitive vulnerabilities might serve as a general risk factor for internalizing psychopathology. However, it is not clear how this purportedly transdiagnostic core vulnerability is associated with internalizing psychopathology at the symptom level. Using a newly dev...

Background New mothers and fathers are at risk of developing postnatal depressive problems. To understand how postnatal depressive symptoms unfold over time, analyses at the within-person level are necessary. Inspecting postnatal depressive problems at the symptom level provides a novel perspective, ultimately offering insight into which symptoms c...

Importance Studies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed li...

Background The link between trauma exposure and psychotic disorders is well-established. Further, specific types of trauma may be associated with specific psychotic symptoms. Network analysis is an approach that can advance our understanding of the associations across trauma types and psychotic symptoms. Methods We conducted a network analysis wit...

Background: Recent research has sought to study how the overlapping features of extant cognitive vulnerabilities might serve as a general risk factor for internalizing psychopathology. However, it is not clear how this purportedly transdiagnostic core vulnerability is associated with internalizing psychopathology at the symptom level. Using a newly...

Objective: Polygenic risk score (PRS) studies commonly employ a disorder-level approach to phenotyping, implicitly considering psychiatric disorders as homogenous constructs. However, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms can shed a...

In recent years, network models have become increasingly popular in the field of psychology. Such comparably novel statistical techniques require specific guidelines to make them accessible to the research community. So far, researchers have provided tutorials guiding how network analysis can be applied to psychological data. However, there is curr...

Background and hypothesis: Recovery from psychosis is a complex phenomenon determined by an array of variables mutually impacting each other in a manner that is not fully understood. The aim of this study is to perform an approximated replication of a previous network analysis study investigating how different clinical aspects-covering psychopatho...

The Gaussian graphical model (GGM) has recently grown popular in psychological research, with a large body of estimation methods being proposed and discussed across various fields of study, and several algorithms being identified and recommend as applicable to psychological data sets. Such high-dimensional model estimation, however, is not trivial,...

Posttraumatic stress disorder (PTSD) researchers have increasingly used psychological network models to investigate PTSD symptom interactions, as well as to identify central driver symptoms. It is unclear, however, how generalizable such results are. We have developed a meta-analytic framework for aggregating network studies while taking between-st...

In recent years, network analysis has been applied to identify and analyse patterns of statistical association in multivariate psychological data. In these approaches, network nodes represent variables in a data set, and edges represent pairwise conditional associations between variables in the data, while conditioning on the remaining variables. T...

Psychotic and autistic symptoms are related to social functioning in individuals with psychotic disorders (PD). The present study used a network approach to (1) evaluate the interactions between autistic symptoms, psychotic symptoms, and social functioning, and (2) investigate whether relations are similar in individuals with and without PD. We est...

A growing number of publications focus on estimating Gaussian graphical models (GGM, networks of partial correlation coefficients). At the same time, generalizibility and replicability of these highly parameterized models are debated, and sample sizes typically found in datasets may not be sufficient for estimating the underlying network structure....

The comorbidity of personality disorders and mental disorders is commonly understood through three types of theoretical models: either a) personality disorders precede mental disorders, b) mental disorders precede personality disorders, c) mental disorders and personality disorders share common etiological grounds. Although these hypotheses differ...

In the current study, we aimed to investigate the network structure of COVID-19 symptoms and its related psychiatric symptoms, using a network approach. Specifically, we examined how COVID-19 symptoms relate to psychiatric symptoms and highlighted potential pathways between COVID-19 severity and psychiatric symptoms. With a sample of six hundred se...

Background Understanding complex associations between psychopathology and chronic illness is instrumental in facilitating both research and treatment progress. The current study is the first and only network-based study to provide such an encompassing view of unique associations between a multitude of mental and physical health-related domains. Me...

Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has...

Statistical network models describing multivariate dependency structures in psychological data have gained increasing popularity. Such comparably novel statistical techniques require specific guidelines to make them accessible to the research community. In this literature, researchers have previously provided tutorials guiding the estimation of net...

Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this...

In the current study, we aimed to investigate the network structure of COVID-19 symptoms and its related psychiatric symptoms, using a network approach. Specifically, we examined how COVID-19 symptoms relate to psychiatric symptoms and highlighted potential pathways between COVID-19 severity and psychiatric symptoms. With a sample of six hundred se...

Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the r...

A growing number of publications focuses on estimating Gaussian graphical models (GGMs, networks of partial correlation coefficients). At the same time, generalizibility and replicability of these highly parameterized models are debated, and sample sizes typically found in datasets may not be sufficient for estimating the underlying network structu...

Students' relationships with peers and teachers strongly influence their motivation to engage in learning activities. Ethnic minority students, however, are often victimized in schools, and their educational achievement lags behind that of their majority group counterparts. The aim of the present study was to explore teachers' multicultural approac...

Background Psychosis spectrum disorder is a heterogeneous, multifactorial clinical phenotype, known to have a high heritability, only a minor portion of which can be explained by molecular measures of genetic variation. This study proposes that the identification of genetic variation underlying psychotic disorder may have suffered due to issues in...

Students' relationships with peers and teachers strongly influence their motivation to engage in learning activities. Ethnic minority students, however, are often victimized in schools, and their educational achievement lags behind that of their majority group counterparts. The aim of the present study was to explore teachers' multicultural approac...

Background One of the oldest and most influential theories of psychosis formation states that delusions arise in an attempt to explain unusual experiences, including perceptual aberrations. The White Noise Task by Galdos et al (2011) was developed as an experimental task to assess the tendency to attribute meaning to random perceptual stimuli: spee...

Background Disorders within the psychosis spectrum are highly heterogeneous and multifactorial (Weinberger & Harrison, 2010). However, in spite of decades of research, causes of psychosis are still uncertain (e.g., Tandon et al., 2008). In an attempt to overcome these shortcomings, recent years have seen a rise in the modeling of psychotic disorder...

Elucidating schizotypal traits is important if we are to understand the various manifestations of psychosis spectrum liability and to reliably identify individuals at high risk for psychosis. The present study examined the network structures of (1) 9 schizotypal personality domains and (2) 74 individual schizotypal items, and (3) explored whether n...

Recent literature has introduced (a) the network perspective to psychology and (b) collection of time series data to capture symptom fluctuations and other time varying factors in daily life. Combining these trends allows for the estimation of intraindividual network structures. We argue that these networks can be directly applied in clinical resea...

Students who have better relationships with their peers and teachers are more likely to be motivated to engage in learning activities. The aim of the present study was to introduce the application of a novel methodological approach in order to explore plausible mechanisms with which teachers’ perceived approach to multiculturalism influences studen...

Recent literature has introduced (1) the network perspective to psychology, and (2) collection of time-series data in order to capture symptom fluctuations and other time varying factors in daily life. Combining these trends allows for the estimation of intra-individual network structures. We argue that these networks can be directly applied in cli...

Recent literature has introduced (1) the network perspective to psychology, and (2) collection of time-series data in order to capture symptom fluctuations and other time varying factors in daily life. Combining these trends allows for the estimation of intra-individual network structures. We argue that these networks can be directly applied in cli...

Disorders within the psychosis spectrum are highly heterogeneous and multifactorial [1,2]. Despite intensive research over the past century, the causes and pathogenesis of psychosis are still unclear, and no genetic marker has been consistently linked to developing a psychotic disorder [3–5]. In recent years, in an attempt to overcome this conundru...

Current diagnostic systems mainly focus on symptoms needed to classify patients with a specific mental disorder and do not take into account the variation in co-occurring symptoms and the interaction between the symptoms themselves. The innovative network approach aims to further our understanding of mental disorders by focusing on meaningful conne...

Recent literature has introduced (1) the network perspective to psychology, and (2) collection of time-series data in order to capture symptom fluctuations and other time varying factors in daily life. Combining these trends allows for the estimation of intra-individual network structures. We argue that these networks can be directly applied in cli...

Research Master Poster Conference 2016

The spectrum of psychotic disorder represents a multifactorial and heterogeneous condition and is thought to result from a complex interplay between genetic and environmental factors. In the current paper, we analyze this interplay using network analysis, which has been recently proposed as a novel psychometric framework for the study of mental dis...

Poster