Adela Banciu

• Researcher at University of Bucharest

This research activity proposes to produce composite hydrogel–bioactive glass. The primary purpose of this research is to develop and optimize 3D-printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The bioglass, a bioactive material known for its bone-bonding ability (SiO2–P2O5–CaO–Na2O), co-doped with euro...

The proposal of this research activity is to produce composite hydrogel-bioactive glass. The primary purpose of this research is to develop and optimize 3D printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The bioglass, a bioactive material known for its bone-bonding ability (SiO2–P2O5–CaO–Na2O), co-doped...

Bacterial cellulose (BC) is a polysaccharide produced by Gram-positive and Gram-negative bacteria with a strictly aerobic metabolism, having a huge number of significant applications in the biomedical field. This study investigates the development of bacterial cellulose (BC)-based composite systems that incorporate cerium dioxide nanoparticles (CeO...

Resistance to chemotherapy is a problem of major social and economic importance, when looking at factors like the decrease in life expectancy, the associated therapeutic costs, and a significant number of cancers that resist current chemotherapy. The development of chemotherapeutics for all theoretically possible tumor variants is an approach that...

Cellular asymmetry is an important element of efficiency in the compartmentalization of intracellular chemical reactions that ensure efficient tissue function. Improving the current 3D printing methods by using cellular asymmetry is essential in producing complex tissues and organs such as the liver. The use of cell spots containing at least two ce...

The skin is a complex and selective system from the perspective of permeability to substances from the external environment. Microemulsion systems have demonstrated a high performance in encapsulating, protecting and transporting active substances through the skin. Due to the low viscosity of microemulsion systems and the importance of a texture th...

Genipin crosslinked composite blends of fish gelatin/kappa-carrageenan (fG/κC) with different concentrations of graphene oxide (GO) for osteochondral substitutes were prepared by a simple solution-blending method. The resulting structures were examined by micro-computer tomography, swelling studies, enzymatic degradations, compressions tests, MTT,...

Bacterial cellulose (BC) is a unique microbial biopolymer with a huge number of significant applications in the biomedical field, including bone tissue engineering. The present study proposes to obtain and characterize BC hybrid composites with calcium phosphate as biocompatible and bioactive membranes for bone tissue engineering. BC precursor memb...

In this study a microemulsion assisted sol-gel method was used to synthesise mesoporous bioactive glass nanoparticles (MBGNs) in the SiO2-B2O3-CaO-MgO-ZnO system, followed by calcination at 600̊C/3 h. The obtained MBGNs showed a typical borosilicate glass structure with similar spherical shape and nanometric dimension. Also, they exhibited high spe...

This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illust...

Background: Faecal microbiota transplant (FMT) is a highly effective therapy for recurrent Clostridioides difficile infection (rCDI) with cure rates ranging between 85 and 92%. The FMT role for primary Clostridioides difficile infection (CDI) has yet to be settled because of limited data and small-sample studies presented in the current literature...

Background: Urinary tract infections (UTIs) are considered common facilitating factors, along with other infections, in triggering febrile seizures (FS). The main purpose of our study was to identify specific inflammatory patterns of UTI cases from other infections in a specific cluster, using a combination of inflammatory biomarkers to differentia...

The purpose of this study resides in the design and deposition of several types of bioactive interfaces with complex composition, targeting a superior osseointegration of bone implants. The experimental approach is framed by two oxide systems, SiO2‒CaO‒P2O5‒ZnO‒MgO and SiO2‒CaO‒P2O5‒ZnO‒SrO, while the percentage values were established as optimised...

In this work, composite fibers connected in three-dimensional porous scaffolds were fabricated by electrospinning, starting from polycaprolactone and inorganic powders synthesized by the sol-gel method. The aim was to obtain materials dedicated to the field of bone regeneration, with controllable properties of bioresorbability and bioactivity. The...

This work aims the obtaining of composite scaffolds based on polycaprolactone fibres loaded with inorganic powders, hydroxyapatite or/and barium titanate, through the electrospinning technique, as well as their characterization both from physicochemical point of view and biological side in order to establish the potential of such materials for inte...

This work aims the obtaining of composite scaffolds based on polycaprolactone fibres loaded with inorganic powders, hydroxyapatite or/and barium titanate, through the electrospinning technique, as well as their characterization both from physicochemical point of view and biological side in order to establish the potential of such materials for inte...

The neuron-specific Elav-like Hu RNA-binding proteins were described to play an important role in neuronal differentiation and plasticity by ensuring the post-transcriptional control of RNAs encoding for various proteins. Although Elav-like Hu proteins alterations were reported in diabetes or neuropathy, little is known about the regulation of neur...

A main challenge for optical graphene-based biosensors detecting nucleic acid is the selection of key parameters e.g. graphenic chemical structure, nanomaterial dispersion, ionic strength, and appropriate molecular interaction mechanisms. Herein we study interactions between a fluorescein-labelled DNA (FAM-DNA) probe and target single-stranded comp...

Voltage-gated calcium channels and estrogen receptors are essential players in uterine physiology, and their association with different calcium signaling pathways contributes to healthy and pathological conditions of the uterine myometrium. Among the properties of the various cell subtypes present in human uterine myometrium, there is increasing ev...

Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain endothelium is lacking. Here, w...

Myocardial infarction (MI) is a disorder that lowers the lifespan and quality of life. Reperfusion treatment as early as possible is the most effective solution, with an increased focus on post-MI medication. In the recovery process after MI, telocytes (TCs) appear to play an important role, which develops a large number of questions awaiting answe...

In this review, we describe the current knowledge on calcium signaling pathways in interstitial cells with a special focus on interstitial cells of Cajal (ICCs), interstitial Cajal-like cells (ICLCs), and telocytes. In detail, we present the generation of Ca²⁺ oscillations, the inositol triphosphate (IP3)/Ca²⁺ signaling pathway and modulation exert...

Telocytes (TCs) are interstitial cells described in multiple structures, including the gastrointestinal tract, respiratory tract, urinary tract, uterus, and heart. Several studies have indicated the possibility that TCs are involved in the pacemaker potential in these organs. It is supposed that TCs are interacting with the neighboring muscular cel...

Telocytes (TCs), located ubiquitously in the internal organs of vertebrates, are a heterogeneous, recently described, cell population of the stromal space. Characterized by lengthy cytoplasmic extensions that can reach tens of microns and are called telopodes (Tps), TCs are difficult to see using conventional microscopes. It was the electron micros...

Acid sensing ion channels (ASICs) are widely expressed in the body and represent good sensors for detecting protons. The pH drop in the nervous system is equivalent to ischemia and acidosis and ASICs are very good detectors in discriminating slight changes in acidity. ASICs are important pharmacological targets being involved in a variety of pathop...

The aim of the study was to determine the students' expectations before and after MSc and teachers' perception of the educational process from the perspective of developing employment opportunities. Questionnaires were applied to master students and teachers from the Faculty of Biology. For master students, the results pointed out a statistically s...

It was organized a non-formal course with the objectives to increase the capacity to develop research projects, understanding and critical interpretation of scientific articles, changing their ideas into research projects, in order to fulfill the need of students to be involved in research. Together with students from Faculty of Medicine and Facult...

Recently, telocytes (TCs) were described as a new cell type in the interstitial space of many organs, including myometrium. TCs are cells with very long, distinctive extensions named telopodes (Tps). It is suggested that TCs play a major role in intercellular signaling, as well as in morphogenesis, especially in morphogenetic bioelectrical signalin...

Telocytes (TCs) are a brand-new cell type frequently observed in the interstitial space of many organs (see www.telocytes.com ). TCs are defined by very long (tens of micrometers) and slender prolongations named telopodes. At their level, dilations-called podoms (~300 nm), alternate with podomers (80-100 nm). TCs were identified in a myometrial int...

Background. Newly described telocytes (TCs) are a novel cell type in the interstitial space of human myometrium. TCs are characterized by very long and distinctive prolongations named telopodes (Tps). It was suggested that TCs could influence the contractile activity of myometrial smooth muscle cells (SMCs). Therefore, our aim was an in vitro elect...

Telocytes (TCs) are a brand-new cell type frequently observed in the interstitial space of many organs (see www.telocytes.com). TCs are defined by very long (tens of μm) and thin prolongations named telopodes. Dilations, called podoms (~300 nm) alternate with podomers (80-100 nm). The mechanisms of telopodes’ elongation and ramification is not know...

Diabetic neuropathy is the most common complication of diabetes. Classical clinical tests (e.g. glycohemoglobin test, fasting plasma glucose test and oral glucose tolerance test) fail to diagnose early diabetes / diabetic neuropathy. New markers from basic research should be also included in the standard screening of the patients with high genetica...