Adam SchullerColorado State University | CSU · Department of Environmental & Radiological Health Sciences
Doctor of Philosophy
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Citations since 2017
10 Research Items
Interests include: environmental neurotoxicology, toxicoepigenetics, reproductive toxicology. Currently studying wildfire smoke exposure in this context.
January 2020 - present
- Research Assistant
- Investigate the relationship between environmental woodsmoke, epigenetic modifications, and Alzheimer's disease. Specifically interested in effects of DNA methylation on neuroinflammation and contributions to amyloid beta and tau pathologies.
November 2018 - July 2019
The University of Akron
- Research Assistant
- Involved in ongoing work regarding effects of chronic opioid use on cortical bone remodeling in a rabbit model.
January 2016 - May 2017
- Research Assistant
- Assisted with projects characterizing cytokine profiles in AD and glaucoma mouse models. Visualized neuro-pathology using fluorescence microscopy and immunohistochemistry. Quantified protein using ProteinSimple Wes platform.
Woodsmoke poses a significant health risk as a growing component of ambient air pollution in the United States. While there is a long history of association between woodsmoke exposure and diseases of the respiratory, circulatory, and cardiovascular systems, recent evidence has linked woodsmoke exposure to cognitive dysfunction, including Alzheimer’...
Wildfires are now a common feature of the western US, increasing in both intensity and number of acres burned over the last three decades. The effects of this changing wildfire and smoke landscape are a critical public and occupational health issue. While respiratory morbidity due to smoke exposure is a priority, evaluating the molecular underpinni...
Wildfire events are increasing across the globe. The smoke generated as a result of this changing fire landscape is potentially more toxic than air pollution from other ambient sources, according to recent studies. This is especially concerning for populations of humans or animals that live downwind of areas that burn frequently, given that ambient...
Background: Visual disturbances often precede cognitive dysfunction in patients with Alzheimer's disease (AD) and may coincide with early accumulation of amyloid-β (Aβ) protein in the retina. These findings have inspired critical research on in vivo ophthalmic Aβ imaging for disease biomarker detection but have not fully answered mechanistic quest...
Learning Overview: Attendees of this presentation will be introduced to novel histological data from a longitudinal live animal experiment documenting the effects of chronic opioid exposure on cortical bone remodeling. The ultimate goal is to describe how opioid agonists, particularly morphine sulphate and fentanyl, affect microscopic structures of...
Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need to establish an animal model system to evaluate the effects of opioids on bone remodeling. Rabbits have been employed as model organisms in orthopedic research as they exhibit well-defined cortical bone remodeling similar to humans. Existing r...
Learning Overview: The goal of this presentation is to introduce a novel longitudinal model for studying the effects of prolonged opioid exposure on cortical bone remodeling in an animal—the rabbit—that remodels its cortical bone in a manner comparable to humans. The ultimate goal is to describe how analgesic drugs, particularly morphine and fentan...
Learning Overview: The goals of this presentation are to: (1) describe the longitudinal effects of systemic opioids, particularly fentanyl and morphine sulfate, on behavioral and physiologic parameters; and (2) demonstrate the long-term use of transdermal fentanyl patches in the management of analgesia in a rabbit model system. Impact on the Foren...
In the Htau model of Alzheimer’s disease (AD), one which expresses neurofibrillary tangle (NFT) pathology, a bone mineral density (BMD) deficit has been observed. This phenotype has been correlated with significant loss of tryptophan hydroxylase (TPH) positive cells in the dorsal raphe nucleus (DRN), a region known to play a role in bone modulation...