Adam N Perry

Adam N Perry
University of Texas at El Paso | UTEP · Department of Biological Sciences

PhD

About

19
Publications
2,206
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
750
Citations
Additional affiliations
October 2015 - present
University of Texas at El Paso
Position
  • Research Assistant Professor
October 2014 - September 2015
University of Texas at El Paso
Position
  • Research Associate
July 2009 - July 2014
University of Michigan
Position
  • Research Associate

Publications

Publications (19)
Article
Full-text available
Formation of long-term pair-bonds is a complex process, involving multiple neural circuits and is context- and experience-dependent. While laboratory studies using prairie voles have identified the involvement of several neural mechanisms, efforts to translate these findings into predictable field outcomes have been inconsistent at best. Here we te...
Article
Social housing has been shown to attenuate the motivation for cocaine in female, but not male rats. Here we investigate the potential mechanisms mediating the effect of social housing on the response to methamphetamine (METH). Female rats were individually or socially (pair) housed. The dopamine (DA) response to an acute METH infusion (0.3 mg/kg, i...
Article
Psychostimulant abuse is associated with a variety of impairments in social functioning, including an increased frequency of depression and aggression and deficits in social cognition. Psychostimulants reduce social investigation in rats and mice; however, it is less clear how other forms of social behavior (e.g., prosocial behavior) are affected....
Chapter
Women exhibit more rapid escalation of drug taking than men. In females, estradiol enhances acquisition of drug taking and motivation for drugs of abuse. Experiments from the Becker laboratory have demonstrated that estradiol enhances stimulated dopamine release in the dorsolateral striatum (DLS) but not the nucleus accumbens (NAc.). When behaviors...
Article
Chronic stressors are generally considered to disrupt reproduction and inhibit mating. Here we test the hypothesis that a chronic stressor, specifically social isolation, can facilitate adaptive changes that enhance/accelerate reproductive effort. In general, monogamous species display high levels of prosociality, delayed sexual maturation, and gre...
Article
Sex- and species-specific patterns of estrogen receptor (ER)-α expression are established early in development, which may contribute to sexual differentiation of behavior and determine male social organization. The current study investigated the effects of ERα and ERβ activation during the second postnatal week on subsequent alloparental behavior a...
Article
Full-text available
Cocaine dependence is characterized by compulsive drug taking and reduced involvement in social, occupational or recreational activities. Unraveling the diverse mechanisms contributing to the loss of interest in these "non-drug" pursuits is essential for understanding the neurobiology of addiction and could provide additional targets for treating a...
Article
Full-text available
Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their preference for cocaine over palatable food rewards. To validate the choice self-administration paradigm a...
Article
Estradiol is thought to play a critical role in the increased vulnerability to psychostimulant abuse in women. Sex differences in the ability of estradiol to influence cocaine self-administration in adult rats has been hypothesized to depend upon pubertal estradiol exposure. The current study investigated whether the presence of gonadal hormones du...
Article
Female rats exhibit greater intake and motivation to self-administer cocaine. In females but not males, isolation by itself is a stressor, which could lead to increased drug intake. Therefore, we hypothesized that social housing would buffer against stress and reduce the motivation to self-administer cocaine primarily in females. Male and female Sp...
Article
Full-text available
Following reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal striatum, where 17β-estradiol...
Article
Full-text available
High- versus low-novelty exploration predicts a variety of behavioral differences. For example, rats selectively bred for high-novelty exploration (bred-high responders, bHR) exhibit exaggerated aggression, impulsivity, and proclivity to addictive behaviors compared with low-novelty reactive rats (bred-low responders, bLRs), which are characterized...
Article
Full-text available
In this review we propose that there are sex differences in how men and women enter onto the path that can lead to addiction. Males are more likely than females to engage in risky behaviors that include experimenting with drugs of abuse, and in susceptible individuals, they are drawn into the spiral that can eventually lead to addiction. Women and...
Article
Sex steroids play a significant role in organizing male social behavior, which is associated with low levels of pro-social behavior and high levels of aggression. However, the role of steroids in organizing behavior in highly social males is unclear. The authors tested the hypothesis that low levels of sex steroids facilitate the expression of pro-...
Article
In most species, the effects of oxytocin (OT) on female reproductive behavior are dependent upon estrogen, which increases both OT and OT receptor expression. It is also becoming apparent that OT neurotransmission can influence estrogen signaling, especially during development, as neonatal OT manipulations in prairie voles alter ERalpha expression...
Article
Full-text available
Studies using estrogen receptor alpha (ERalpha) knock-out mice indicate that ERalpha masculinizes male behavior. Recent studies of ERalpha and male prosocial behavior have shown an inverse relationship between ERalpha expression in regions of the brain that regulate social behavior, including the medial amygdala (MeA), and the expression of male pr...
Article
Oxytocin (OT) has been implicated in reproductive functions, induction of maternal behavior as well as endocrine and neuroendocrine regulation of the cardiovascular system. Here we demonstrate that neonatal manipulation of OT can modulate the mRNAs expression for OT receptor (OTR), atrial natriuretic peptide (ANP), endothelial nitric oxide synthase...
Article
The optimal regulation of vertebrate sexual development and reproductive function involves integration of internal physiological signals, indicative of an individual's sexual status and capability for reproduction, with signals from the external environment. While these environmental cues are diverse, and oftentimes species-specific, the induction...
Article
Thesis (M.S.)--Arizona State University, 2001. Includes bibliographical references (leaves [55]-59).

Network

Cited By