Adam Li

• Doctor of Philosophy
• Postdoctoral Fellow at Columbia University

Objective Whereas a scalp electroencephalogram (EEG) is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates of epilepsy are 20% to 30%. We aim to demonstrate how network properties in EEG reco...

Objective: While scalp EEG is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates of epilepsy are 20-30%. We aim to demonstrate how analyzing network properties in EEG recordings can be used t...

Causal inference studies whether the presence of a variable influences an observed outcome. As measured by quantities such as the "average treatment effect," this paradigm is employed across numerous biological fields, from vaccine and drug development to policy interventions. Unfortunately, the majority of these methods are often limited to univar...

Over the past 10 years, the drive to improve outcomes from epilepsy surgery has stimulated widespread interest in methods to quantitatively guide epilepsy surgery from intracranial EEG (iEEG). Many patients fail to achieve seizure freedom, in part due to the challenges in subjective iEEG interpretation. To address this clinical need, quantitative i...

Over 15 million epilepsy patients worldwide have drug-resistant epilepsy. Successful surgery is a standard of care treatment but can only be achieved through complete resection or disconnection of the epileptogenic zone, the brain region(s) where seizures originate. Surgical success rates vary between 20% and 80%, because no clinically validated bi...

Approximately 30% of patients with epilepsy do not respond to anti-epileptogenic drugs. Surgical removal of the epileptogenic zone (EZ), the brain regions where the seizures originate and spread, can be a possible therapy for these patients, but localizing the EZ is challenging due to a variety of clinical factors. High-frequency oscillations (HFOs...

Over 15 million epilepsy patients worldwide do not respond to drugs and require surgical treatment. Successful surgical treatment requires complete removal, or disconnection of the epileptogenic zone (EZ), but without a prospective biomarker of the EZ, surgical success rates vary between 30%-70%. Neural fragility is a model recently proposed to loc...

Over 15 million epilepsy patients worldwide have medically refractory epilepsy (MRE), i.e., they do not respond to anti-epileptic drugs. Successful surgery is a hopeful alternative for seizure freedom but can only be achieved through complete resection or disconnection of the epileptogenic zone (EZ), the brain region(s) where seizures originate. Un...

Over 15 million patients with epilepsy worldwide do not respond to drugs. Successful surgical treatment requires complete removal or disconnection of the seizure onset zone (SOZ), brain region(s) where seizures originate. Unfortunately, surgical success rates vary between 30 and 70% because no clinically validated biological marker of the SOZ exist...

Over 15 million patients with epilepsy worldwide do not respond to medical therapy and may benefit from surgical treatment. In cases of focal epilepsy, surgical treatment requires complete removal or disconnection of the epileptogenic zone (EZ). However, despite detailed multimodal pre-operative assessment, surgical success rates vary and may be as...

For epileptic patients requiring resective surgery, a modality called stereo-electroencephalography (SEEG) may be used to monitor the patient's brain signals to help identify epileptogenic regions that generate and propagate seizures. SEEG involves the insertion of multiple depth electrodes into the patient's brain, each with 10 or more recording c...

Epilepsy affects over 50 million people worldwide and 30% of patients' seizures are medically refractory. The process of localizing and removing the epileptogenic zone is error-prone and ill-posed in part because we do not understand how epilepsy manifests. It has recently been proposed that the epileptic cortex is fragile in the sense that seizure...

Introduction: For patients with medically-refractory temporal-lobe epilepsy (mrTLE), the most effective treatment remains resection of the epileptogenic zone (EZ) via anterior temporal lobectomy (ATL). Successful outcomes require accurate identification and resection of the EZ. We compared the results of a network fragility algorithm applied to ele...

A bstract Over 15 million epilepsy patients worldwide do not respond to drugs. Successful surgical treatment requires complete removal, or disconnection of the seizure onset zone (SOZ), brain region(s) where seizures originate. Unfortunately, surgical success rates vary between 30%-70% because no clinically validated biological marker of the SOZ ex...

Cortical stimulation mapping (CSM) is a common clinical procedure for mapping eloquent cortex in epilepsy patients. Electrical responses to the stimulation, or after-discharges (ADs), that occur in response to stimulation can point to unstable regions of cortex that are more prone to spontaneous seizures. Clinicians are interested in identifying re...

Seizures in patients with medically refractory epilepsy (MRE) cannot be controlled with drugs. For focal MRE, seizures originate in the epileptogenic zone (EZ), which is the minimum amount of cortex that must be treated to be seizure free. Localizing the EZ is often a laborious process wherein clinicians first inspect scalp EEG recordings during se...

Seizures in patients with medically refractory epilepsy (MRE) epilepsy cannot be controlled with drugs. For focal MRE, seizures originate in the epileptogenic zone (EZ), which is the minimum amount of cortex that must be treated to be seizure free. Localizing the EZ is often a laborious process wherein clinicians first inspect scalp EEG recordings...

Introduction Bilateral mesial temporal epilepsy (Bi-mTLE) can be seen in up to 39% of patients with mTLE (Aghakhani et al., 2014). Up to 77% of Bi-mTLE patients ultimately undergo surgery, yet only 25% of these resected patients obtain an outcome of Engel Class I (Aghakhani Y et al., 2014). A network-based algorithm, EZTrack, has been developed to...

Treatment of medically intractable focal epilepsy (MIFE) by surgical resection of the epileptogenic zone (EZ) is often effective provided the EZ can be reliably identified. Even with the use of invasive recordings, the clinical differentiation between the EZ and normal brain areas can be quite challenging, mainly in patients without MRI detectable...

Treatment of medically intractable focal epilepsy (MIFE) by surgical resection of the epileptogenic zone (EZ) is often effective provided the EZ can be reliably identified. Even with the use of invasive recordings, the clinical differentiation between the EZ and normal brain areas can be quite challenging, mainly in patients without MRI detectable...

Epilepsy affects around 50 million people worldwide. Over 30% of patients are drug-resistant where the only treatment may be surgical resection of the epileptogenic zone (EZ), the region of the brain that generates seizures. Identification of the EZ is often based on invasive EEG recordings. As such, surgical outcome relies heavily on precise and d...

Electrocorticography (ECoG) and stereotactic electroencephalography (SEEG) are popular tools for studying neural mechanisms governing behavior and neural disorders, such as epilepsy. In particular, clinicians are interested in identifying brain regions that start seizures, i.e., the epileptogenic zone (EZ) from such invasive recordings. Currently,...