Adam Bledsoe

Adam Bledsoe
Avera · Gastroenterology

MD

About

33
Publications
1,113
Reads
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152
Citations
Additional affiliations
July 2017 - July 2017
Mayo Clinic - Rochester
Position
  • Fellow

Publications

Publications (33)
Article
Eosinophilic esophagitis (EoE), gastritis (EG), and/or duodenitis (EoD) are associated with accumulation and activation of eosinophils and mast cells in the esophagus, stomach, and/or duodenum, respectively. Lirentelimab (AK002), an antibody against siglec-8, depletes eosinophils and inhibits mast cells. We performed an open-label extension (OLE) s...
Article
Full-text available
Objective The purpose of this article is to describe clinical and imaging characteristics of confirmed cases of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Methods Retrospective review of electronic medical records identified patients considered for a diagnosis CMUSE over 20-years in a single large tertiary center. Clinical data w...
Article
Full-text available
Background Certolizumab pegol (CZP) has been successfully used for the treatment of Crohn’s disease (CD); however, real-world data regarding the utility of CZP trough levels (CTL) are lacking. Aims To correlate CTL with CD outcomes and to determine frequency of CZP antibodies. Methods Retrospective evaluation of all CD patients on maintenance CZP...
Article
Background & aims: In celiac disease (CeD), gluten induces immune activation, leading to enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly(dl-lactide-co-glycolic acid) nanoparticles, is designed to induce gluten-specific tolerance. Methods: TAK-101 was evaluated in phase 1 dose escalation safety and phase 2a...
Article
Background Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare illness characterized by multiple strictures and shallow ulcers of the small bowel. Even though diagnostic criteria have been described, further ellucidation is needed on therapeutic interventions and potential discriminating factors between CMUSE and other more common...
Chapter
After excluding common causes of non-responsive celiac disease (NRCD), clinicians should suspect refractory celiac disease (RCD) and determine if a clonal or abnormal population of T-cells is evident in the duodenal mucosa. The presence of this aberrant T-cell population in the absence of lymphoma is diagnostic of type II RCD. This entity, which li...
Article
Objective: To evaluate micronutrient deficiencies in a contemporary cohort of adult patients with newly diagnosed celiac disease (CD). Patients and methods: This is a retrospective study of prospective adults newly diagnosed with CD from January 1, 2000, through October 31, 2014, at Mayo Clinic. Micronutrient data were collected for tissue trans...
Article
Full-text available
Background and aims: Inflammatory bowel diseases, principally Crohn's disease and ulcerative colitis, and celiac disease are among the most common immune-mediated gastrointestinal diseases. We aim to elucidate the clinical course and outcomes of patients with concomitant inflammatory bowel disease and celiac disease, a unique population that remai...
Article
Colon ischemia (CI) is an underrecognized entity associated with high morbidity and mortality. Establishing the diagnosis and initiating appropriate and timely treatment is critical for improving outcomes. Colon ischemia is a disease spectrum that requires a full understanding for recognition and treatment. This review outlines the full spectrum of...
Article
Post-weaning social isolation of rats is utilized as a model of early life stress. We have previously demonstrated that rats exposed to post-weaning social isolation exhibit greater anxiety-like behaviors as adults. Furthermore, these rats exhibit greater density of corticotropin-releasing factor (CRF) type 2 receptors in the dorsal raphe nucleus....

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