Adam A. Bailey

Adam A. Bailey
Translational Gastroenterology Unit · Oxford University Hospitals NHS Foundation Trust

MBChB

About

71
Publications
5,050
Reads
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1,417
Citations
Introduction
Adam Bailey currently works in the Translational Gastroenterology Unit at the John Radcliffe Hospital, Oxford University Hospitals NHS Trust.
Additional affiliations
August 2008 - present
Oxford University Hospitals NHS Trust
Position
  • Consultant Gastroenterologist
January 2005 - December 2007
Westmead Hospital
Position
  • Endoscopy Fellow

Publications

Publications (71)
Article
Inadvertent injection of contrast agent into the pancreatic duct is believed to be an important contributor to pancreatitis occurring after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis, PEP). Our aim was to examine whether primary deep biliary cannulation with a guide wire is associated with a lower rate of PEP than conven...
Article
In the absence of precut needle-knife sphincterotomy (NKS), failure of biliary cannulation may occur in up to 10% of cases. There are few prospective evaluations of the safety and efficacy of NKS, and studies of its early use in difficult cannulation have been inconclusive. Whether precut NKS after failure of primary biliary cannulation is independ...
Article
The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers. Review of prospectively collected data from 416 CEs identified 27 tumors in 26 patients. Clinical parameters, tumor histology, and follow-up are reported. Twenty-seven tumors...
Article
Full-text available
Patients with Barrett's high-grade dysplasia (HGD) or early esophageal adenocarcinoma (EAC) that is shown on biopsy alone continue to undergo esophagectomy without more definitive histological staging. Endoscopic resection (ER) may provide more accurate histological grading and local tumor (T) staging, definitive therapy, and complete Barrett's exc...
Article
Transfusion thresholds for acute upper gastrointestinal bleeding are controversial. So far, only three small, underpowered studies and one single-centre trial have been done. Findings from the single-centre trial showed reduced mortality with restrictive red blood cell (RBC) transfusion. We aimed to assess whether a multicentre, cluster randomised...
Article
Full-text available
Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis (PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and cl...
Article
Full-text available
Barrett’s oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett’s oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Here we investigate the cellular complexity of Barrett’s o...
Preprint
Full-text available
Barretts esophagus is a precursor of esophageal adenocarcinoma. In this common condition, squamous epithelium in the esophagus is replaced by columnar epithelium in response to acid reflux. Barretts esophagus is highly heterogeneous and its relationships to normal tissues are unclear. We investigated the cellular complexity of Barretts esophagus an...
Article
Full-text available
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1 was identified in a patient with ulcerative colitis-like VEOIBD. Exome screening of 1,878 pediatric patients identified fu...
Conference Paper
Introduction Barrett’s oesophagus ć–ćassociated dysplasia and neoplasia in early stages can be treated endoscopically, but accurate assessment before intervention is challenging. This study aimed to investigate the diagnostic accuracy of pre-resection biopsies in patients who undergo endoscopic mucosal resection (EMR) for dysplasia or...
Article
Full-text available
Background and aims: Radical endoscopic excision of Barrett’s epithelium performing 4 – 6 endoscopic resections during the same endoscopic session results in complete Barrett’s eradication but has a high stricture rate (40 – 80 %). Therefore radiofrequency ablation is preferred after endoscopic mucosal resection (EMR) of visible nodules. We investi...
Article
Introduction Radical endoscopic ablation of Barrett’s epithelium performing 4–6 endoscopic resections during the same endoscopic session has been shown to result in complete Barrett’s ablation but has a high stricture rate (40–80%). Therefore radiofrequency ablation is preferred for the ablation of Barrett’s epithelium after endoscopic mucosal rese...
Article
Endoscopic mucosal resection (EMR) has become the standard treatment for early oesophageal neoplasia. The mucosal defect caused by EMR usually takes several weeks to heal. Despite guidelines on high-risk endoscopic procedures in patients on anticoagulation, evidence is lacking whether EMR is safe in such patients. We investigated the immediate and...
Article
Introduction High grade dysplasia (HGD) is often reported after Seattle protocol biopsies have been taken or the exact position of a targeted lesion within a Barrett’s segment has not been precisely documented. We investigated how often the histology of subsequent endoscopic resection agreed with the initial biopsy of HGD. Method We searched our pr...
Article
Full-text available
Objectives: Data on costs associated with acute upper gastrointestinal bleeding (AUGIB) are scarce. We provide estimates of UK healthcare costs, indirect costs and health-related quality of life (HRQoL) for patients presenting to hospital with AUGIB. Setting: Six UK university hospitals with >20 AUGIB admissions per month, >400 adult beds, 24 h...
Article
Full-text available
Aim: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation. Methods: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting...
Article
Background Proximal esophageal heterotopic gastric mucosa or so-called inlet patch in the cervical oesophagus is easily missed on endoscopic examination because of its localisation, usually just below the upper oesophageal sphincter. We evaluated the clinical use of narrow band imaging for detection of inlet patches. Methods In this prospective, c...
Article
Introduction Radical endoscopic ablation of Barrett’s epithelium performing 4–6 endoscopic resections during the same endoscopic session has been shown to result in complete Barrett’s ablation but has a high stricture rate (48–88%).1–3 Therefore radiofrequency ablation is preferred for the ablation of Barrett’s epithelium after endoscopic mucosal r...
Article
Full-text available
Background and aim: Postpolypectomy haemorrhage (PPH) is a known adverse event that can occur following polypectomy, occurring in 0.3-6.1% of cases. Previous meta-analysis has included small polyps, which are less likely to bleed, and less amenable to some methods of mechanical haemostasis. No comprehensive cost-benefit analysis of this topic is a...
Article
Full-text available
There is a 10% shortfall in the number of proximal colorectal cancer cases detected by the UK Bowel Cancer Screening Programme and the actual number of UK-registered proximal colorectal cancers. Sessile serrated adenomas/polyps (SSA/P) are common premalignant lesions in the proximal colon and are notoriously difficult to spot endoscopically. Missed...
Article
Introduction Endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA) is now considered standard for treatment of high grade dysplasia (HGD) and intramucosal cancer in Barrett’s oesophagus (BE). Complete ablation of the Barrett’s epithelium is recommended to reduce the risk of metachronous neoplasia. However, RFA is an expensive...
Article
Full-text available
Introduction The serrated pathway of colorectal carcinogenesis is a distinct and important pathway leading to CpG island methylated phenotype (CIMP) carcinomas. These lesions are over-represented in interval cancers and may explain the failure to prevent right-sided cancer with colonoscopy. Hyperplastic polyps (HPs) in the left colon rarely transfo...
Article
Introduction Ectopic gastric mucosa in the cervical oesophagus (inlet patch) is easily missed on endoscopic examination because of its localization, usually just below the upper oesophageal sphincter. In some individuals, an inlet patch might cause symptoms such as dysphagia, globus sensation, odynophagia or coughing. We prospectively investigated...
Article
Full-text available
Acute upper gastrointestinal bleeding (AUGIB) is the commonest reason for hospitalization with hemorrhage in the UK and the leading indication for transfusion of red blood cells (RBCs). Observational studies suggest an association between more liberal RBC transfusion and adverse patient outcomes, and a recent randomised trial reported increased fur...
Article
Full-text available
Aim An audit of serrated polyps diagnosed over a 4-year period: 2009 to 2012 was undertaken to ascertain the reporting trends of sessile serrated polyps (SSP). Methods All right sided hyperplastic polyps (HP) proximal to the splenic flexure and all polyps designated SSP were retrieved from the study period. Three pathologists blinded to the origina...
Article
Introduction Endoscopic mucosal resection (EMR) has become an established treatment modality in the managment of patients with high grade dysplastic lesions and intramucosal cancer in Barrett oesophagus. The mucosal defect caused by the endoscopic resection usually takes several weeks to heal. There is no data whether this procedure is also safe fo...
Article
Full-text available
Extracorporeal shock wave lithotripsy (ESWL) of pancreatic duct stones followed by ERCP with mechanical clearance of the pancreatic duct and subsequent stenting is an established treatment option for chronic calcific pancreatitis. To test the efficacy of a modified transportable mini-lithotripter for ESWL of pancreatic duct stones. Prospective sing...
Article
Full-text available
IntroductionPrecut sphincterotomy facilitates selective bile duct access during endoscopic retrograde choliangiopancreaticography (ERCP) in patients in whom conventional cannulation has failed. However, it is associated with a higher complication rate and does not always facilitate successful initial cannulation. If biliary cannulation is not succe...
Article
Full-text available
IntroductionCorrect staging is essential in selecting patients with early oesophageal neoplasia for endoscopic therapy. We prospectively investigated the diagnostic value of endoscopic ultrasound (EUS) in predicting submucosal infiltration in early Barrett neoplasia.Methods Patients with histologically proven high grade dysplasia or intramucosal ca...
Article
Recurrent stent obstruction necessitating reintervention is problematic and incompletely understood. The aim of the present study was to identify factor(s) predisposing to reintervention. Retrospective review of patients (n = 117) referred to a single major endoscopic referral centre for palliative enteral stenting from 1999 to 2006. Twelve were ex...
Article
Introduction: Extracorporeal shock wave lithotripsy (ESWL) of pancreatic duct stones, followed by endoscopic retrograde cholangio-pancreaticography (ERCP) with mechanical clearance of the pancreatic duct, and subsequent stenting is an established treatment option in patients with chronic calcifying pancreatitis. Aim: To test the efficacy of a modif...
Article
Small flat nonpolypoid lesions of the colorectum can be technically difficult to target and completely remove; techniques such as hot biopsy forceps electrocauterization are associated with serositis, delayed bleeding, and perforation. This study aimed to describe a novel technique for the removal of such lesions and demonstrate its safety and effi...
Article
EMR is a viable alternative to surgery for removal of large mucosal neoplastic lesions of the entire GI tract. Few studies have, however, been published on the safety, efficacy, and technical aspects of EMR in the duodenum. Our purpose was to evaluate the efficacy and safety of EMR of large (>15 mm) duodenal adenomas. Retrospective evaluation of a...
Article
BACKGROUND AND STUDY AIMS: Inadvertent injection of contrast agent into the pancreatic duct is believed to be an important contributor to pancreatitis occurring after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis, PEP). Our aim was to examine whether primary deep biliary cannulation with a guide wire is associated with a lo...

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