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Abubakr El-Mahmoudy

Abubakr El-Mahmoudy
Benha University Faculty of Veterinary Medicine · Department of Pharmacology

Professor Doctor of Pharmacology. MSc, PhD Pharmacology & MSc Clinical Chemistry

About

50
Publications
9,880
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599
Citations
Introduction
Abubakr El-Mahmoudy currently works as a Professor at the Department of Pharmacology, Benha University Faculty of Veterinary Medicine. El-Mahmoudy does research in Pharmacology and Clinical Chemistry.
Additional affiliations
July 1993 - September 2015
Benha University Faculty of Veterinary Medicine
Position
  • Professor (Associate)

Publications

Publications (50)
Article
Full-text available
Hepatic injury is a worldwide health problem. This study aimed to evaluate the possible hepatoprotective potential of Artichoke (Cynara scolymus) extract (CSE) in albino rats using the thioacetamide (TAA) a model of liver injury. Acclimatized 42 rats were divided randomly into seven groups, each consists of six rats, and subjected to different trea...
Article
Full-text available
Drug-induced hepatotoxicity is a frequent cause of liver injury worldwide. The present study was designed to evaluate the possible hepato-protective potential Agaricus bisporus extract (ABE; a type of mushrooms) in albino rats using Carbon tetrachloride (CCl4)-model of liver injury. Forty-two albino rats were utilized in this experiment arranged ra...
Article
Full-text available
Background: Drug-induced reproductive organs toxicities is an important aetiology in investigation of male infertility. The aim is to study levofloxacin effect on male reproductive system in comparison to ciprofloxacin.Methods: Twenty-five male wister rats weighted 230±20 gm and aged 8 weeks were randomly divided into five groups of five. The first...
Article
Full-text available
Background: Many drugs are implicated in male infertility and screening for medication history is an important for diagnosis and treatment of the problem. The aim is to study amikacin effect on male reproductive system in comparison to gentamicin.Methods: Twenty-five male wister rats weighted 220±20 gm and aged 8 weeks were randomly divided into fi...
Article
Full-text available
The aim of the present study was to elucidate the possible biochemical changes in lipid metabolism and organ function after treatment with sildenafil in normal and hyperlipidemic albino rats. Albino rats were grouped into seven groups (n=10/group) with blood sampling on days 30, 45 and 60 of the experiment for biochemical analysis. Group-i and-ii w...
Article
Full-text available
The present study was designed to look at the hematological disorders in gentamicin nephrotoxicity model, as kidney is considered as one of the hemopoietic organs. In a previous study, novel and classical kidney injury biomarkers were utilized to evaluate the nephroprotective potential of Carica papaya leaf extract (CPLE) in the same model in albin...
Article
Full-text available
Objective: This study was designed to evaluate hematological disorders and the orchestrating roles of hepcidin and IL-6 in rat models of thioacetamide (TAA) and carbon tetrachloride (CCl4) hepatotoxicity. Methods: Rats were intraperitoneally injected with TAA (10 mg/100 g rat weight dissolved in isosaline) or CCl4 (100 μL/100 g rat weight dilute...
Article
Full-text available
This study was designed to provide laboratory evidence supporting the hematopoietic effect of Beta vulgaris (beet) leaf aqueous extract in phenylhydrazine-induced anemia model in albino rats. Extraction of the leaves/stalks was done by maceration in 30% hydro-ethanol for 48 h. An intraperitoneal injection of 20 mg/kg phenylhydrazine was applied for...
Article
Full-text available
This study has aimed at utilization of novel and classical kidney function biomarkers to evaluate the nephroprotective potential of Carica papaya leaf extract (CPLE) in gentamicin nephrotoxicity model. The used classical biomarkers were urea and creatinine; while the new biomarkers were Kidney injury molecule-1 (KIM-1) and Clusterin. Forty-five mal...
Article
Full-text available
Punica granatum flower and leaf were extracted with hydromethanol 50% and evaluated for antioxidant activity using phosophomolybdenum, DPPH, reducing power, and⁻OH-scavenging assays; and for anti-inflammatory activity using HRBC-MS assay. Both extracts exhibited antioxidant activities indicated by DPPH decolorization and⁻OH-scavenging and increased...
Article
The effects of repeated oral administration of clarithromycin (7.5 mg/Kg B.W., daily for 5 consecutive days) on blood parameters, clinico-chemical parameters and vital organ histology were evaluated in Ross broiler chickens. Twelve clinically healthy birds have been used in a parallel study design, where they have been randomly divided into two gro...
Article
Clinicochemical, haematological and histopathological alterations were demonstrated in broiler chickens following repeated oral bolus administration of two different enrofloxacin generic preparations, formulated as 10% oral solutions, given at a dose regimen of 10 mg/Kg body weight for 5 consecutive days. The two tested preparations were Enrol® (Me...
Article
Full-text available
The pharmacokinetics and absolute bioavailabilities of two generics of enrofloxacin (ENRO) 10% oral solution formulation at a dose of 10 mg/Kg body weight were compared after single intracrop (i.c.) bolus administrations in reference to single intravenous (i.v.) standard ENRO administration in broilers using a randomized parallel design. The two te...
Article
Full-text available
The pharmacokinetics of lornoxicam (a non-steroidal anti-inflammatory drug) at a dose of 0.4 mg/Kg body weight was evaluated after single intravenous (i.v.) and intramuscular (i.m.) bolus administrations in rabbits. An HPLC assay using pure lornoxicam base as a standard was used to measure its concentrations in plasma at prefixed time points up to...
Article
Full-text available
The pharmacokinetics of clarithromycin at a dose of 7.5 mg/kg body weight was evaluated after single intravenous (i.v.) and intracrop (i.c.) bolus administrations in broilers. An HPLC assay using pure clarithromycin base as a standard was used to measure its concentrations in plasma. Following an i.v. bolus injection, the plasma concentration-time...
Article
Full-text available
The object of this study was to evaluate the safety and meat quality criteria in broilers following intramuscular injection of boldenone. Twenty-four broiler chicks, divided into two groups, were used in the present study. Boldenone was injected intramuscularly at a single-dose level of 5 mg/kg body weight into 12 broiler chicks at 2 weeks old; the...
Article
Full-text available
Background: Tilmicosin is a macrolide antibiotic used mainly for controlling respiratory infections in animals. Tilmicosin therapy, like that with other macrolide members, may be associated with various adverse effects on different organ functions that remain a controversial matter. Therefore, the object of the present study was to investigate the...
Article
Full-text available
The aim of the present study was to assess the analgesic activity of the macrolide antibiotic tilmicosin at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, against chemical- and thermal-induced acute pains, using acetic acid-induced writhing, formalin-induced pain, hot-plate, and tail-flick models in mice. Tilmicosin showed a dose-de...
Article
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The deleterious effects of the residues of antibacterial drugs have been considered as one of the most serious problems in the world on the basis of their importance in both veterinary and human fields. Therefore, the present study was planned out to evaluate the residual levels of oxytetracycline in camel tissues in Tripoli area in Libya. Forty sa...
Article
Full-text available
We investigated the effect of the probiotic Lactobacillus acidophilus on acute phase parameters in infected animals and to evaluate its possible use as alternative to replace the classical anti-inflammatory drugs as a trial to avoid the side effect of these drugs and its disadvantages. Forty albino rats were divided into four groups, group A was gi...
Article
Full-text available
Background: To shed some light on full characterization and utilization of non-steroidal anti-inflammatory drugs (NSAIDs) in veterinary medicine, this study, therefore, was designed to clarify the pharmacological effects of two NSAIDs (one selective, that is meloxicam, and the other is non-selective, that is piroxicam) on intestinal contractility o...
Article
Full-text available
This study aimed to investigate the effect of mannan-oligosaccharide (MOS) on the lipogram and selected organ functions in hyperlipidemic rats. Animals were subjected to different treatments for 60 days. Balanced basal diet was supplied to control rats; saturated high fat-and/or MOS-contained diets were supplied to tested rats. Sera were collected...
Article
Full-text available
The aim of the present study was to investigate the mechanisms by which Hibiscus sabdarifa petal extract produces its well-established antihypertensive activity, from both pharmacological and biochemical aspects of view. Pharmacologically, the aqueous extract exhibited a hypotensive effect when injected intravenously (femoral vein) in anesthetized...
Article
Full-text available
Background: This study was designed to identify the active contents of Citrullus colocynthis plant and to examine their teratogenicity in rats. The fruit pulp of the poisonous plant was collected randomly from Suq-Alkhamis district, Tripoli, Libya. Methods: The glucoside colocynthin was isolated by lead acetate method while the alkaloids and saponi...
Article
The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken were used, the first two groups received 100 mg/kg and 200 m...
Article
Full-text available
The aim of the present study was to elucidate the possible biochemical alterations in lipid metabolic profile and organ function profiles that may result from continuous treatment with the drug, sildenafil in normal and hyperlipidemic rats. Blood samples were taken for biochemical analysis on days 30, 45 and 60 of the experiment. Sildenafil (5.625...
Article
Full-text available
The relationship between ATP-induced membrane potential and contraction was inestigated in the smooth muscle of chicken anterior mesenteric artery using micro-electrode and tension recording techniques respectively. Application of ATP to en-dothelium-denuded arterial preparations developed concentration-dependent, slow depolarization which started...
Article
Full-text available
The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken were used, the first two groups received 100 mg/kg and 200 m...
Article
Full-text available
The object of the present study was to assess the possible alterations in blood of sheep that may occur following intramuscular injection of tobramycin. Tobramycin was injected to 10 sheep at a dosage regimen of 5 mg/kg of body weight for 5 successive days. Two types of blood samples (with and without EDTA as an anticoagulant) were collected from t...
Article
Full-text available
Rotavirus non-structural protein (NSP) 4 can induce aqueous secretion in the gastrointestinal tract of neonatal mice through activation of an age- and Ca(2+)-dependent plasma membrane anion permeability. Accumulating evidence suggests that nitric oxide (NO) plays a role in the modulation of aqueous secretion and the barrier function of intestinal c...
Article
Electrical field stimulation (EFS) induces frequency-dependent contractions of the longitudinal muscle of isolated quail rectum which were sensitive to tetrodotoxin. The aim of the present study was to investigate whether purinergic neurons are implicated in the response to nerve stimulation. The shape of the EFS-induced contractile response was di...
Article
The neurotransmitter(s) that generate the inhibitory junctional potential (IJP) in the circular muscle of hamster distal colon and their mechanisms have not been elucidated. The aim of the present study, therefore, was to determine the contributing roles of the non-adrenergic, non-cholinergic (NANC) inhibitory transmitter(s) including nitric oxide...
Article
Full-text available
The object of the present study was to clarify the neurotransmitter(s) controlling membrane responses to electrical field stimulation (EFS) in the circular smooth muscle cells of first-order branches of chicken anterior mesenteric artery. EFS (five pulses at 20 Hz, 1 ms) evoked a hyperpolarization of amplitude −21.6±1.2 mV, total duration 21.8±1.2...
Article
Full-text available
Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF) as a model for type II DM and...
Article
The object of the present study was to clarify the neurotransmitters controlling membrane responses to electrical field stimulation (EFS) in the longitudinal smooth muscle cells of the chicken anterior mesenteric artery. EFS (5 pulses at 20Hz) evoked a depolarization of amplitude 19.7 ± 2.1 mV, total duration 29.6 ± 3.1 s and latency 413.0 ± 67.8 m...
Article
Full-text available
Nitric oxide (NO) is involved in the destruction of beta-cells during the development of type I diabetes mellitus (DM). We demonstrated the possibility of rescuing beta-cells by intervention with thymoquinone (TQ) using streptozotocin (STZ) rat diabetic model. The hyperglycemic and hypoinsulinemic responses to STZ were significantly abrogated in ra...
Article
Full-text available
Neurogenic ATP and nitric oxide (NO) may play important roles in the physiological control of gastrointestinal motility. However, the interplay between purinergic and nitrergic neurons in mediating the inhibitory neurotransmission remains uncertain. This study investigated whether neurogenic NO modulates the purinergic transmission to circular smoo...
Article
The interaction between the endothelium and purinergic perivascular nerves was investigated by measuring the changes in amplitude of excitatory junction potential (EJP) of smooth muscle cells in hamster mesenteric arteries (100-350 microm). Uridin-5'-triphosphate (UTP) (100 microM) applied to endothelium-intact preparations evoked a hyperpolarizati...
Article
The objective of the present study was to determine the immunomodulatory role of thymoquinone (TQ) regarding its effect on the production of nitric oxide (NO) by rat peritoneal macrophages. Under certain conditions, macrophagesand certain other cells can produce high concentrations of NO from its precursor L-arginine via inducible nitricoxide synth...
Article
Full-text available
Regulation of vasoactive intestinal peptide (VIP) release by nitric oxide (NO) was investigated in the hamster jejunum. Electrical field stimulation and applied NO (3-100 microM) evoked biphasic hyperpolarizations consisting of an initial transient hyperpolarizing component followed by a second more slowly developing component (late component). The...

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