Abu Shara Shamsur Rouf

University of Dhaka · Department of Pharmaceutical Technology

Osimertinib is a newly approved treatment line for the non-small cell lung carcinoma actively caused by mutation in EGFR and T790M. The present study was targeted to originate a validated method for the qualification as well as quantification of osimertinib through RP-HPLC in bulk and its pharmaceutical formulation. The mobile phase, 65% triethylam...

Hair loss in adult men albeit common, can cause emotional distress. Many people with hair fall issues try chemical-based treatments that may lead to health complications and allergic reactions. Cosmetics using natural ingredients derived from plants have fewer side effects compared to synthetic alternatives. The study aimed to formulate herbal hair...

Energy drinks and mango juice are popular beverages. Apart from the natural ingredients and some additives present in these drinks, sugar is an important component of both. It has been established that, other than providing sweetness, sugars are potent to bring about health consequences for their consumers. Sweeteners, both artificial (aspartame, s...

To combat the SARS-CoV-2 addition of molnupiravir into the current therapeutic regimen has added new hopes. But currently, not so many analytical methods are available for analyzing molnupiravir. The current study aimed at developing a suitable and efficient RP-UHPLC method for molnupiravir capitalizing full factorial design. The optimized method i...

Ledipasvir, belonging to the BCS class II, is a directly acting anti-viral agent used to treat Hepatitis C virus infections. Due to poor water solubility and oral bioavailability, developing an effective delivery system for this drug has been an enormously challenging issue for the formulators. Moreover, suitable dosage forms for pediatric and geri...

Being the de facto primary healthcare contacts in rural Bangladesh, retail pharmacy shops (RPSs) influence the medication usage by the people. Therefore, identifying dispensing activities of RPSs can be a key indicator of medicine use. The aim of the current study is to explore the drug dispensing practice of retail pharmacists in the rural areas o...

Inadequate resources and a fragmented healthcare system in Bangladesh lead to the practice of almost non-reporting of adverse drug reactions (ADR). Pharmacists may offer service in this regard to strengthen pharmacovigilance if given the appropriate opportunity. To evaluate their preparedness, the current cross-sectional study aims to assess the kn...

A well-defined and strictly controlled dissolution rate plays vital role in optimization of sustained release dosage form. For this purpose, a computer optimized technique, based on a response surface methodology (RSM) utilizing a quadratic equation and factorial design has been widely used for designing and optimization of different pharmaceutical...

Emergence of antiviral drug resistance in influenza virus remains a major public health concern worldwide. Nowadays, different herbs receive renewed attention because of their enormous antiviral potential. In this study, we investigated the antiviral activity of Camellia sinensis, Persicaria hydropiper, Persicaria orientale, Persicaria lapathifolia...

The current study aimed at developing and optimizing a prompt, simple and efficient RP-UHPLC method based on Quality by Design (QbD) for analyzing mesalamine. Experimental design for developing the method was performed capitalizing a 32 full factorial design in Design Expert® software (Version 12, Stat-Ease Inc., USA) where the percentage of methan...

The intent of the research work was to develop and validate a simple, selective and precise reversed phase ultra-high performance liquid chromatography (RP-UHPLC) method for the determination of ledipasvir. A forced degradation study was performed as per International Conference on Harmonisation (ICH) guidelines Q1A (R2) and Q1B. Ledipasvir was fou...

This study was aimed to investigate the degradation behavior and physicochemical stability of desvenlafaxine using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) system. The chromatogram was developed on Eclipse XDB-C8 column (150 x 4.6 mm, 5μm). The eluents were monitored through a photo diode array plus (PDA+) detector at...

The study aimed to develop and evaluate an immediate-release tablet dosage form of Linagliptin. Different concentrations (ranges 5-10%) of super-disintegrants, Croscarmellose sodium (CCS), and Sodium starch glycolate (SSG) were used to prepare nine tablet dosage forms (F1 to F9) through the direct compression method. The compatibility of the formul...

Worldwide more than 180 million people get infected by chronic Hepatitis C Virus (HCV) and around 700,000 people pass away every year due to HCV related problems. Sofosbuvir and Ribavirin are prescribed as combined medication for the management of HCV infection globally. Therefore, optimization of a pharmaceutical dosage form containing Sofosbuvir...

Cancer is accountable for the demise of numerous lives worldwide annually. In this research a derivative of lumichrome, 5,10-dihydro-7,8-dimethyl alloxazine was assessed for its anticancer property through docking study. It was appraised after performing molecular docking study of the 5,10-dihydro-7,8-dimethyl alloxazine, there was a strong interac...

The extent of tobacco cultivation remains substantially high in Bangladesh, which is the 12th largest tobacco producer in the world. Using data from a household survey of current, former, and never tobacco farmers, based on a multi-stage stratified sampling design with a mix of purposive and random sampling of households, this study estimated the f...

A well-established drug used in the management of inflammatory bowel disease is 5-aminosalicylic acid (e.g. Mesalazine or Mesalamine). For the treatment of mild to moderate flares of ulcerative colitis and Crohn’s disease, Mesalazine has been used as the first line drug in both western and Asian countries due to its superiority over other drugs in...

The aim of this study was to investigate whether fruit juices available in markets of Bangladesh contain any preservative. A specific RP-HPLC method was developed, validated and applied to identify and quantify preservatives including benzoic acid, sorbic acid, methyl paraben and propyl paraben simultaneously in 50 different products. These additiv...

In Bangladesh, tuberculosis (TB) is a key public health concern. In this study, we assessed knowledge, attitudes, and perceptions toward TB among the general population. A cross-sectional mixed methods study was conducted between March and August 2014, in which a total of 400 adults were interviewed at Dhaka city in Bangladesh. The overall knowledg...

In the current years, a lot of research works have been continued in the quest to find a desired drug delivery system within the human body. Among different drug delivery systems, nanobots have become much popular due to its capability to perform different tasks like actuating, sensing, signaling, information processing and intelligence at nanoscal...

A validated reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the determination of Milnacipran hydrochloride in pharmaceutical preparations. Shimadzu HPLC containing SPD-20Av uv-visible detector, SIL 20 AC HT manual injector, LC-20 AT binary pump with software LC solution of version 1.2 was e...

This research was aimed to establish a versatile, sensitive, rapid and validated RP-HPLC method to analyze linagliptin in bulk as well as in pharmaceutical dosage forms. Liquid chromatography was performed on HPLC system and 20μl of samples were injected into a C18 column (150 x 4.6 mm i.d., 5μm particle size) and the eluents were monitored through...

Mikania cordata is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh. In the present study, essential oil (12.5, 25 and 50 mg/kg) and two extracts, viz., chloroform and ethyl acetate extracts (200, 400, 800 mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by acetic acid-induced writhing and ho...

p>A novel reversed phase ultra-high performance liquid chromatographic (RP-UHPLC) method was developed for the estimation of sitagliptin in pharmaceutical dosage form. Separation was done by a X-bridge C18 column (4.6 i.d.× 150 mm, 5 μm particle size) with a flow rate of 1 ml/min using phosphate buffer (pH 6) and acetonitrile (70:30, v/v) as mobile...

Mikania cordata is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh. In the present study, essential oil (12.5, 25 and 50 mg/kg) and two extracts, viz., chloroform and ethyl acetate extracts (200, 400, 800 mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by acetic acid-induced writhing and ho...

p>A series of 2-substituted-5-methylbenzimidazole derivatives ( 3a-e ) were synthesized by reacting 4-methyl-1,2-phenylenediamine ( 1 ) with a number of p -substituted benzaldehydes ( 2a-e ) in moderate yields (25.51- 40.21%). The synthesized compounds ( 3a-e) were characterized by spectroscopic data and were evaluated for antioxidant activity usin...

p>The objective of the present study was to design and evaluate once daily sustained release tablet of carvedilol, using two molecular weight grades of hydrophilic polymers (methocel® K4M CR and methocel^®K15M CR) as release retarding materials. Two sets of formulations were prepared, where first set of four formulations (F1- F4) containe...

p>This study was aimed to develop a simple, sensitive and rapid procedure for the analysis of clarithromycin in pure as well as in matrix tablet dosage form by using RP-HPLC method. The chromatographic separation was achieved by a reversed phase C₁₈ column (150 mm length × 4.6 mm i.d., 5 μm particle size) in an isocratic mode with mobile...

p>The present work describes a quality by design (QbD)-based rapid, simple, precise and robust RPUHPLC method for the routine analysis of vildagliptin in bulk drug and in pharmaceutical dosage forms. Chromatographic separation was achieved by a X-bridge C18 column with isocratic elution of mobile phase containing mixture of phosphate buffer (pH 6.8...

p> Objective: This study was conducted to synthesise some 2-substituted-5-nitro benzimidazole derivatives to evaluate their antioxidant activity. Methods: The titled compounds were synthesised by sodium metabisulfite mediated reaction of 4-nitro-1, 2-phenylenediamine with a number of para -substituted benzaldehydes. The antioxidant activity was ev...

Highly nutritious dairy products are ingested regularly by all ages of population. Adulteration of dairy products to enhance the inherent stability and acceptability to common consumers by different harmful and toxic ingredients like formalin, an unpermitted preservative, has been a burning issue in Bangladesh over the last few years. The aim of th...

Background The aim of this current study was to investigate the presence and to determine the contents of caffeine, preservatives and antioxidants in dairy products available in Bangladesh, one of the alarming countries in terms of food security. As high as 41 marketed dairy products, of both locally and internationally manufactured, were collected...

p>This study describes a validated assay method to determine caffeine, benzoic acid, methylparaben, propylparaben, butylparaben, butylatedhydroxyanisole, and butylatedhydroxytoluene simultaneously by reversed phase high performance liquid chromatographic (HPLC) method. The separation of compounds was achieved on a C18 column in a gradient of aceton...

p>The main objective of the study was to formulate fast dissolving tablets of allopurinol to achieve better dissolution rate and further improving the bioavailability to provide a quick onset of action. Nine formulations of fast dissolving tablets of allopurinol were prepared by direct compression technique using croscarmellose sodium (Group A), so...

Freeze dried aqueous crude extracts of three traditionally used botanicals Moringa oleifera, Cucumis sativus and Carica papaya were subject to antioxidant potential test by two widely used methods-reducing power assay & DPPH free radical scavenging activity test along with the estimation of total phenolic and total flavonoid content. Brine shrimp l...

The present study reveals an improved method for the evaluation of Adhatoda vasica extract by quantitation of major metabolite vasicine. The plant powder was extracted with methanol and evaporated in vaccuo to obtain an oily residue. The residue was diluted with aqueous solution of citric acid (1%) and was further extracted with chloroform. The pre...

ABSTRACT In present study an attempt was made to formulate and to evaluate the sustain release Carvedilol matrix tablets by using METHOCEL K100LV CR, METHOCEL K100M CR and Xanthum Gum polymer. The tablets were prepared by direct compression method. The granules were evaluated by angle of repose, bulk density, tapped density and compressibility inde...

The ethyl acetate extracts of Drynaria quercifolia tubers and leaves were studied for their chemical and biological potentialities. The tuber extract was enriched with more reducing power compared to the leaf extract. But, the phenolic content was higher in the leaf extract compared to the tuber extracts. However, both the extracts were comparably...

Controlled release tablet matrix of theophylline was prepared with kollidon SR, a spray dried powder grade polymer (polyvinyl acetate and povidone based matrix rate retarding hydrophobic materials) by utilizing direct compression technique. Different proportion of kollidon SR was used to develop the matrix builder in the five proposed formulations...

Aims: To develop and validate two assay methods for the determination of total and free formaldehyde content in cosmetics by Colorimetric and High Performance Liquid Chromatographic (HPLC) methods, respectively. Study Design: Colorimetric and HPLC methods. Place and Duration of Study: Department of Pharmaceutical Technology, Faculty of Pharmacy, Un...

The purpose of this study was to develop and validate a stability indicating reversed phase HPLC test method to determine the content of drug substance and its organic impurities of Salmeterol Xinafoate (SX) in Inhaler dosage form. Chromatographic separation of SX and its known impurities were successfully achieved on a stainless still column packe...

In the present study, an attempt has been taken to evaluate the effect of sodium lauryl sulphate (SLS) and glyceryl mono stearate (GMS) as solubility enhancers on the release profile of a poorly soluble drug, carbamazepine. Matrix tablets of carbamazepine were prepared by wet granulation technique using hydrophilic polymers (10% of Methocel K15 MCR...

In this study essential oil composition, antioxidant and cytotoxic properties of the flowers of Alstonia scholaris (L.) R. Br. were investigated. The chemical composition of the oil was analyzed by GC-MS. The antioxidant potential was evaluated using two separate methods, inhibition of free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and superoxi...

In this study essential oil composition, antioxidant and cytotoxic properties of the flowers of Alstonia scholaris (L.) R. Br. were investigated. The chemical composition of the oil was analyzed by GC-MS. The antioxidant potential was evaluated using two separate methods, inhibition of free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and superoxi...

ABSTRACT: In the present study, an attempt has been taken to evaluate the effect of sodium lauryl sulphate (SLS) and glyceryl mono stearate (GMS) as solubility enhancers on the release profile of a poorly soluble drug, carbamazepine. Matrix tablets of carbamazepine were prepared by wet granulation technique using hydrophilic polymers (10% of Methoc...

The aim of this work was to develop and statistically optimize nitroglycerin matrix tablets for sustained release application by response surface methodology based on 32 full factorial design utilizing a polynomial equation. The tablets were manufactured using direct compression technology with 2% w/w nitroglycerin in lactose as the active ingredie...

Medicinal plants constitute an important component of flora and are widely distributed in Bangladesh. The pharmacological evaluation of substances from plants is an established method for the identification of lead compounds which shows the way to the development of novel and safe medicinal agents. Based on the ethnopharmacological literature two w...

The aim of the study was to develop sustained release matrix tablet of Losartan potassium and to evaluate its efficacy in reducing hypertension. In this experiment, sustained release matrix tablets were prepared by direct compression method and Methocel K4M CR and Methocel K100M CR were used as polymer. The evaluation involves three stages: the mic...

A simple, precise, accurate, rapid and reproducible RP-HPLC method has been developed for the determination of Nitazoxanide in powder for suspension dosage form. Chromatography was carried out on an ODS C18 column (250 x 4.6 mm x 5 µm length), using a mixture of acetonitrile and 0.005 mol L-1 tetra n-butyl ammonium hydrogen sulphate (54:46 v/v) as...

This paper describes degradations of aceclofenac (ACF) in tablet dosage form under different International Conference on Harmonization (ICH) prescribed stress conditions (thermal, acid degradation, base degradation, oxidation and photolysis), and establishments of a simple, rapid and precise stability-indicating reversed-phase HPLC assay method. Ch...

A number of indanyl tetrazolederivatives namely 5-(6′-chloroindan-1′-yl)tetrazole (CIT), 5-(6′-bromoindan-1′-yl)tetrazole (BIT), 5-(6′-chloroindan-1′-yl)methyltetrazole (CIMT), 5-(6′-bromoindan-1′-yl)methyltetrazole (BIMT) were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour...

A precise, sensitive and versatile reversed-phase HPLC method was developed that allowed the separation and simultaneous determination of caffeine, benzoic acid, methyl paraben, propyl paraben, butyl paraben, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The separations were achieved by using a gradient flow rate of acetonitril...

This research work has been carried out to detect the presence of and if present, to quantify caffeine, preservatives and antioxidants in dairy products using reversed phase High Performance Liquid Chromatography (HPLC) method. Three different analytical methods were used to evaluate the content of caffeine, five preservatives namely benzoic acid,...

Traditional medicines derived from medicinal plants are used by about 60% of the world‟s population. Various types of macroscopic, microscopic, physical, chemical and microbiological analyses are recommended for quality control of herbal medicines by several regulatory authorities. Adhatoda vasica L. contains vasicine which acts as a. The present s...

Aims: To develop and validate two assay methods for the determination of total and free formaldehyde content in cosmetics by Colorimetric and High Performance Liquid Chromatographic (HPLC) methods, respectively. Study Design: Colorimetric and HPLC methods. Place and Duration of Study: Department of Pharmaceutical Technology, Faculty of Pharmacy, U...