Abolanle . A. A Kayode

Abolanle . A. A Kayode
Babcock University · Department of Biochemistry

BSc MSc. PhD
Anti-ulcer, Anti-viral and Anti-cancer Activities of Medicinal Plants

About

58
Publications
32,400
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466
Citations
Citations since 2016
46 Research Items
333 Citations
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
2016201720182019202020212022010203040506070
Additional affiliations
January 2018 - March 2018
Nelson Mandela University
Position
  • Graduate Scholar
Description
  • Spectroscopy Cytometry
February 2009 - October 2018
Bells University of Technology
Position
  • Lecturer
Education
September 2011 - June 2019
University of Ibadan
Field of study
  • Phytochemistry

Publications

Publications (58)
Chapter
Cancer as a disease has been a remarkable scourge and over the past years, advances have been made in understanding the molecular basis of carcinogenesis and combating this disease. The common traits exhibited by cancer have been individually studied to figure out its mode of action and its mechanism of survival even in the most austere conditions....
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Neurodegenerative diseases (NDs) have over the years become a growing cause for concern and it is increasingly becoming a major health problem associated with impairment, ageing of the brain and other neuropathological conditions. These include Parkinson’s disease, Dementia, Huntington’s disease, Alzheimer disease, and Depression. Due to increas...
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This study was designed to determine the effect of chronic oral exposure of overdose of cough syrups containing codeine (CSC) and dextromethorphan (DXM) on the rate of deoxyribonucleic acid (DNA) fragmentation in the liver and brain of Wistar rats. Forty-five rats divided into 9 groups of 5 rats were used. Groups 1, 2, 3, and 4 were treated with 0....
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Cancer as a disease has been a remarkable scourge and over the past years, advances have been made in understanding the molecular basis of carcinogenesis and combating this disease. The common traits exhibited by cancer have been individually studied to figure out its mode of action and its mechanism of survival even in the most austere conditions....
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Full-text available
Cancer is characterized by the development of cells that are unlike normal cells and they divide rapidly and also corrupt and destroy normal tissues in the body. Cancer cells possess the ability to spread through the body and cause damage. Cancer is caused by the mutation of DNA. The estimate of cancer cases worldwide as of 202 has risen to 19.3 mi...
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Vegan diet (VD) is a diet that consists of only plant based foods. This diet completely excludes all animal products; meat, fish, poultry and also food gotten from milk, oil and honey. Vegan diet differs from vegetarian diet, although they are similar; some vegetarian include egg (ovo vegetarians), milk from animals (lacto vegetarians) or fish (pes...
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Background: Ketogenic diet (KD) is a beneficial nutritional plan consisting of low carbohydrate, high fat, and moderate protein levels and aids in amelioration of some metabolic disorders. The objective of this study is to develop a ketogenic diet model using cheap and readily available fiber sources. METHODS: Cabbage head and coconut fruits were o...
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The leaf pulp of Carpobrotus edulis has antibacterial, antifungal, and tissue regeneration abilities. Chromium is a ubiquitous contaminant that has raised a major concern due to its level of toxicity. This study investigated the therapeutic role of leaf pulp of Carpobrotus edulis on chromium VI-induced toxicity in male Wistar rats. Thirty rats were...
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This study investigates the antidiabetic effect of a ketogenic diet (KD) on sucrose-induced insulin resistance in the fruit fly model. The fruit flies were divided and grouped into four: Group A, B, C, and D, representing the control, high-sucrose diet (HSD), KD, and HSD + KD, respectively. The administration of the various treatments to the groups...
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This study determines the contraceptive activity of Allium sativa (Garlic) and Allium cepa (Onion) juices on reproductive output and development of Drosophila melanogaster. The fruit flies were divided and grouped into 5, group A serves as the control, group B serves as the onion group, group C serves as the garlic group, group D serves as the onio...
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BACKGROUND AND OBJECTIVE: Ketogenic diet (KGD) is a low-carbohydrate, high-fat and average protein dietary formulation, which has been reported with the ability to ameliorate several metabolic diseases, especially those under the direct influence of hormonal disruptions. Monosodium glutamate (MSG) had been found to induce uterine fibroids in labora...
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Objectives This study investigates the impact of a repeated oral exposure to two cough syrups containing codeine and dextromethorphan (DXM) on male Wistar rats. Methods We divided 35 rats into seven groups of five rats each. Group A was given 0.5 ml of distilled water, Groups B, C, and D were given 0.1, 0.2 and 0.4 ml/kg body weight (b. w) of coug...
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Citation: Omowumi T Kayode., et al. "Testicular Dysfunction Biomarkers in Reproductive Biochemistry Research". EC Gynaecology 9.12 (2020): 50-55. Abstract Keywords: Testicular Dysfunction Biomarkers; Hormones; Semen; Fertility Biomarkers in biological research are key molecules that give important information about the state of an organ, tissue, or...
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Medicinal plants have posed as natural resources of compounds with pharmacological and nutritional properties aiding humans to prevent and treat diseases. These plants also have therapeutic properties and exert beneficial pharmacological effect on man and animal as curative medicine. Thus, necessitating the need to select some plants such as: Turme...
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Background and Objective: Imported chicken meat is smuggled into the country through the porous borders of Idiroko road which leads into Ota, Ogun State and sold to retailers in the open market. This study was carried out to assess and compare the nutritional composition and safety profile of the imported frozen, exotic commercial and indigenous ch...
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Lycopene is a phytochemical that is present at high concentration in fruits and vegetables such as tomato, guava, watermelon, spinach, carrot, beetroot, and red grapefruit. Lycopene, just like some members of the carotenoids family, has proven to be of high medicinal, scientific, pharmaceutical, and commercial value. These features of lycopene can...
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Lycopene is an extensively studied phytochemical that belongs to the hydrocarbon class of the carotenoid family. In 1876, a red-colored pigment in tomato was discovered by Millardet. Later on, this red-colored pigment became known as “lycopene,” a name that was given by Schunck. Lycopene is also known as carotene present in fruits and vegetables of...
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Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history,...
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Purpose Benign prostatic hyperplasia (BPH) is a urological disease characterized by proliferation of the stromal and epithelial cells of the prostate of older men. Ketogenic diet (KD) is a high fat, moderate protein and low carbohydrate diet which acts on metabolic systems through hormonal modulation and simulation amongst other mechanisms. This st...
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Cushing's syndrome is a hormonal disorder that affects multiple systems of the body. It is caused by excessive cortisol production. Cortisol is the hormone produced by adrenal gland. Its secretions varies with circadian rhythm and its peak can be seen in the morning, however, during night it is produced in very low quantity. The pituitary gland is...
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We review the basic clinical manifestation, diagnosis and management of brain tumor. Google search was done by using different terms associated with brain tumor and different databases were used, such as Google Scholar, Cochrane Database, and Science Direct etc. In spite of the fact that clinical manifestations fl uctuate on the basis of category,...
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The inhibition of acetylcholinesterase (AChE), an enzyme that catalyzes acetylcholine hydrolysis in the treatment of Alzheimer disease (AD) will increase the levels of acetylcholine in the brain, thus improving cholinergic functions in AD patients. Natural therapies including herbs and medicinal plants are being used in the treatment of memory defi...
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There is an increasing interest in bioactive carbohydrates due to their numerous biological applications. Bioactive carbohydrates can be obtained from innumerable plants, animals and microorganisms, many of which have immense potential for use as ingredients in food and pharmaceutical products. Extensive studies have been carried out in various res...
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Background: Ketogenic diets (KD) consist of high fat, moderate protein and low carbohydrates. Aim: This review explores the effect of ketogenic diet and its mechanism of actions in disease management. Methods: Recent information on ketogenic diets and disease management were retrieved from academic journals using scientific search engines and popul...
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Securidaca longepedunculata (SL) and Luffa cylindrica (LC) leaf extracts have been shown to exhibit significant antiulcer effect on ethanol-induced gastric lesions. This study examined the antiulcerogenic effect of chromatographic fractions of ethyl acetate extracts of the selected plants. The ethyl acetate extracts of (SL) and (LC) were fractionat...
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Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged bio...
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Malaria infection is a public health problem of global concerns. Malaria is an endemic disease in major areas of Africa and some part of America and Asia. Typical symptoms of malaria include headaches, fever, vomiting, rigors, chills and tiredness while severe malaria could lead to seizures, coma, severe anaemia, respiratory distress, convulsions,...
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Papalanto, Ogun State is one of the locations where sugar cane (Saccharium offinarium) is grown and largely cultivated in Nigeria. Mineral compositions of the sugarcane juice in this area is not yet reported. Therefore, this study was carried out to determine the mineral content of the sugarcane cultivars in Papalanto, Ogun state, Nigeria. The resu...
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ABSTRACT: Ginger (Zinger officinale Roscoe, Zingiberaceae) is mainly consumed as food condiments globally. It is one of the most widely used natural products. Ginger has long been used as an important ingredient in cooking and traditional herbal Medicine. It contains many bioactive constituents, which have notable pharmacological and physiological...
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This study describes the qualitative phytochemical screening, antimicrobial and GC-MS analyses of the crude methanol extract of the stem and roots parts of Bidens pilosa partitioned between methanol, dichloromethane, ethyl acetate and hexane solvents. Phytochemical analysis indicated the presence of cardiac glycosides, terpenoids, flavonoids and al...
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Background: Alcoholic bitters have been acclaimed to boost sexual function and fertility in animals but there is no reported scientific evidence that evaluated its effects on the normal functioning of the testes. This study was therefore conducted to assess the effect of some alcoholic bitters on testicular function indices of male Wistar rats. Met...
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Securidaca longepedunculata (SL) and Luffa cylindrica (LC) are medicinal plants commonly used in combination with other recipes in the treatment of many ailments in traditional medicine among the Yoruba ethnic group in Nigeria. In our recent survey, the two plants were among the most frequently mentioned plants for the treatment of gastric ulcer in...
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Full-text available
Securidaca longepedunculata (SL) and Luffa cylindrica (LC) are medicinal plants commonly used in combination with other recipes in the treatment of many ailments in traditional medicine among the Yoruba ethnic group in Nigeria. In our recent survey, the two plants were among the most frequently mentioned plants for the treatment of gastric ulcer in...
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Full-text available
There has been high incidence of malaria and typhoid co-infection in Nigeria lately but no documented study has really considered its impact on the biochemical status of the patients. The aim of this study was to investigate the effect of malaria and malaria-typhoid co-infection on some hematological and biochemical parameters in infected patients....
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In this study, we report the quantification of the concentrations of Cd, Pb and As in borehole, well, stream and rain water sources in Ota and some major towns in Ogun State, Nigeria. The pH ranges from 4.8 to 6.98, 5.40 to 7.86 and 6.99 to 8.20 in boreholes, well and rain respectively. Lead was not detected at all in the drinking water sources in...
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Local production of ash-derived alkali was assessed in this review. Detailed information on local production of ash-derived alkali is rare in literature. Hence, the technologies, materials, probable criteria for selection of materials, processes, use, limitations, problems and areas needing further research in the local production of alkali were as...
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Several medicinal uses of the fluted pumpkin (Telfairia occidentalis) in traditional medicine have been documented. Although, many of these claims are yet to be validated by scientific researchers, a review of some investigated therapeutic activities of the plant are highlighted in this article. Experimental works done on Telfairia occidentalis esp...
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The composition and chemistry of ash and potash from various plant materials were assessed. Sequel to unavailability of vital information on the composition and chemistry of ash and potash is the production of potash of low quality, especially by local producers, as well as wrong determination or identification and quantification of components of p...
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Potash alkali and metal contents of ashes obtained from peels of six varieties of Nigeria Musa species were investigated. The varieties of Musa species – Musa paradisiaca (plantain), Musa 'Gross Michel' (Igbo banana), M.sapientum L. (paranta), Musa 'Wild Banana' (omini), Musa 'Red' (sweet banana), and Musa 'Fugamo' (somupeke), were investigated. Th...
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It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in...
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Comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfailiria occidentalis leaves, in treatment of Protein Energy Malnutrition (PEM) induced liver damage. PEM ratz were produced by feeding weanling rats a protein deficients diet (2% protein) for 28 days and then divided into four dietary treatment gr...
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The effect of two extracts of Parquetina nigrescens on mucosal antioxidants defense system in ethanol-induced ulcer in rats was studied. Activities of superoxide dismutase (SOD), catalase (CAT) and levels of reduced glutathione (GSH) were determined in the gastric mucosa and liver of normal and experimental groups of rats. The rats were pretreated...

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Projects (2)
Archived project
Project
To gather relevant information in all areas of drug discovery research into resourceful books that will be useful to everyone. E-mail: egbunachukwuebuka@gmail.com Some Books of the project: Elsevier Series on Drug Discovery Updates (Book proposals are being accepted). https://www.elsevier.com/search-results?labels=books&book-series=Drug%20Discovery%20Update Coronavirus Drug Discovery (Vol 1-3) https://www.elsevier.com/books/coronavirus-drug-discovery/egbuna/978-0-323-85156-5 https://www.elsevier.com/books/coronavirus-drug-discovery/egbuna/978-0-323-95574-4 https://www.elsevier.com/books/coronavirus-drug-discovery/egbuna/978-0-323-95578-2 Application of Nanotechnology in Food Science, Processing and Packaging https://link.springer.com/book/10.1007/978-3-030-98820-3 Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches https://www.elsevier.com/books/computer-aided-drug-design-cadd-from-ligand-based-methods-to-structure-based-approaches/rudrapal/978-0-323-90608-1 Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses https://www.sciencedirect.com/book/9780128215562/phytochemistry-the-military-and-health Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations https://link.springer.com/book/10.1007/978-3-030-42319-3 Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes https://link.springer.com/book/10.1007/978-3-030-72999-8 Analytical Techniques in Biosciences (Published) https://www.elsevier.com/books/analytical-techniques-in-biosciences/egbuna/978-0-12-822654-4 Neglected Tropical Diseases and Phytochemicals in Drug Discovery (John Wiley & Sons Canada, Limited, 2020; ISBN: 1119616603, 9781119616603) https://www.wiley.com/en-us/Neglected+Tropical+Diseases+and+Phytochemicals+in+Drug+Discovery-p-9781119616603 Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine (Elsevier, ISBN: 9780128202852; October, 2020) https://www.elsevier.com/books/preparation-of-phytopharmaceuticals-for-the-management-of-disorders/egbuna/978-0-12-820284-5 Drug Development for Cancer and Diabetes: A Path To 2030 (AAP/CRC Press Taylor & Francis, published). https://www.routledge.com/Drug-Development-for-Cancer-and-Diabetes-A-Path-to-2030/Saravanan-Egbuna-Averal-Kannan-Elavarasi-Bahadur/p/book/9781771888608 Phytochemicals as Lead Compounds for New Drug Discovery (Elsevier, ISBN: 9780128178904) https://www.elsevier.com/books/phytochemicals-as-lead-compounds-for-new-drug-discovery/egbuna/978-0-12-817890-4 Natural Remedies for Pest, Disease and Weed Control (Elsevier, ISBN: 9780128193051) https://www.elsevier.com/books/natural-remedies-for-pest-disease-and-weed-control/egbuna/978-0-12-819304-4 Phytochemistry: in vitro and in silico updates (Springer Nature, ISBN: 9780128193051). https://www.springer.com/us/book/9789811369193 Phytochemistry, Vol 1: Fundamentals, Modern Techniques, and Application (Published on the 14th Dec., 2018). https://www.crcpress.com/Phytochemistry-Volume-1-Fundamentals-Modern-Techniques-and-Applications/Egbuna-Chinenye-Ifemeje-Chidi-Udedi-Kumar/p/book/9781771887595 Phytochemistry, Vol 2: Pharmacognosy, Nanomedicine, and Contemporary Issues (Published on the 14th Dec., 2018). https://www.crcpress.com/Phytochemistry-Volume-2-Pharmacognosy-Nanomedicine-and-Contemporary/Egbuna-Kumar-Chinenye-Ifemeje-Vikas-Kurhekar/p/book/9781771887601 Phytochemistry, Vol 3: Marine, Industrial, and Advances (Published on the 14th Dec., 2018). https://www.crcpress.com/Phytochemistry-Volume-3-Marine-Sources-Industrial-Applications-and-Recent/Egbuna-Chinenye-Ifemeje-Kumar-Sharif/p/book/9781771887618 I will also welcome partnerships from similar projects, departments, faculties and universities. Please contact me through egbunachukwuebuka@gmail.com; Phone: +2347039618485