Abir Tadmouri

Laboratoires Pierre Fabre · Real-World Evidence and data analytics

The aim of this study was to gain insights into the real-world experience of metastatic melanoma patients. Important Quality of life (QoL) aspects, specific disease burden and treatments experiences of melanoma patients have been investigated.

Approximately 8–10% of metastatic colorectal cancer (mCRC) tumours harbour BRAFV600E mutations. Eleven randomised controlled trials (RCTs) and 24 non-RCTs were identified. Seven studies evaluated BRAF inhibitors. Single-agent BRAF inhibitors had minimal efficacy, whereas BRAF inhibitor plus anti-EGFR therapy improved outcomes. In BEACON CRC, overal...

Introduction Les patients atteints d’un mélanome avancé sont fréquemment confrontés à des questions concernant leur maladie, leur traitement ou des signes et symptômes potentiels. Les stratégies visant à contrôler les symptômes consistent notamment à éduquer les patients et identifier les comportements à risque. Dans un contexte où le système de sa...

Background In COLUMBUS, treatment with encorafenib plus binimetinib in patients with advanced BRAF-mutant melanoma showed improved progression-free and overall survival with favourable tolerability compared to vemurafenib treatment. Here, results on health-related quality of life (HRQoL) are presented. Methods COLUMBUS was a two-part, open-label,...

Aims: Cost-effectiveness data on the remote monitoring (RM) of implantable cardioverter-defibrillators (ICDs) compared to the current standard of care (SC) remains limited. This meta-analysis was performed to assess the economic burden, and to develop an integrated economic model evaluating the efficiency of the RM strategy vs. SC in the context o...

Objective Recipients of allogeneic hematopoietic stem transplantation (allo‐HCT) with positive cytomegalovirus (CMV) serology are at increased risk of morbidity and mortality. The primary objective of this study was to assess the association between treated CMV infection and overall mortality within one year after allo‐HCT in adult CMV‐seropositive...

Recipients of allogeneic hematopoietic stem cell transplant (HSCT) who have positive cytomegalovirus (CMV) serology are at increased risk for morbidity and mortality after HSCT. However, the exact correlation between early CMV infection and post-HSCT outcomes, notably relapse, is still a source of conflicting data, especially in the era of viral su...

Immunoglobulin (Ig) therapy is used to treat a wide range of immunodeficiencies and autoimmune diseases; While, its clinical benefit has been demonstrated in several studies, Ig therapy is associated with a risk of systemic adverse effects. As such, Onset of renal impairment, including acute renal failure, osmotic nephrosis and renal insufficiency,...

We reviewed the efficacy of SCIg administration in terms of muscle strength maintenance and patient satisfaction comparing with IVIg in the treatment of auto-immune neuromuscular diseases. A systematic review was conducted, and identified studies from databases (PUBMED, EMBASE, EBSCO, Web of Science and Google Scholar) which were analyzed. The meth...

Aims: Although left ventricular assist devices (LVADs) are currently approved for coverage and reimbursement in France, no French cost-effectiveness (CE) data are available to support this decision. This study aimed at estimating the CE of LVAD compared with medical management in the French health system. Methods and results: Individual patient...

Appendix S1. Main hospitalisation categories following the LVAD index hospitalization, using the DRG system (n = 5146).

Appendix S2. Survival curve ‐ Survival with a VAD; Survival curve ‐ Survival after heart transplant; Survival curve – Time to heart transplant; Costs (€) after VAD transplantation (n = 508).

Table S1. Clinical characteristics and clinical outcomes of the 14 patients having received LVAD in Hopital Marie Lannelongue.

Appendix S3. Survival curve ‐ Survival with a VAD; Survival curve ‐ Survival after heart transplant ; Survival curve – Time to heart transplant; Costs (€) after VAD transplantation (n = 508).

Background Antisynthetase syndrome is a rare and debilitating multiorgan disease characterized by inflammatory myopathy, interstitial lung disease, cutaneous involvement, and frequent chronic inflammation of the joints. Standard treatments include corticosteroids and immunosuppressants. In some cases, treatment resistance may develop. Administratio...

International Journal of Pharmaceutics. 2016. Volume 511, Issue 2, Pages 1146-1147 INTRODUCTION: Acceptability of medicines for paediatric use is critical to ensure treatment success. Our research program aims to develop a tool that should participate to the acceptability assessment standardization during the paediatric formulation development. P...

Disease stratification, using phenotypic characterization performed either by hypothesis- or data-driven methods, was developed to improve clinical decisions. However, cluster analysis has not been used for allergic rhinitis. To define clusters in allergic rhinitis and to compare them with ARIA (Allergic Rhinitis and Its Impact on Asthma), a hypoth...

Context: Patients with gastrointestinal cancer are at high risk for deterioration of nutrition. Home parenteral nutrition (HPN) could improve nutritional status and quality of life (QoL). Objectives: The purpose of this study was 1) to evaluate the impact of HPN on QoL, 2) to assess changes in nutritional status, and 3) to assess proxy perceptio...

Nucleus tractus solitarius (NTS) is the integrative sensory relay of autonomic functions in the brainstem. To explore the nonneuronal cellular basis of central chemosensitivity during the first 24 hr of ventilatory acclimatization to hypoxia (VHA), we have investigated glial activation markers in the NTS. Conscious mice (C57/BL6) were placed in a h...

Résumé Introduction La dénutrition est un facteur de mauvais pronostic, impactant la qualité de vie (QdV) des patients cancéreux. Notre objectif était d’évaluer l’impact de la nutrition parentérale à domicile (NPAD) sur la QdV des patients âgés, dénutris et atteints d’un cancer. Patients et méthodes Cette étude observationnelle prospective réalis...

Malnutrition is a predictor of poor outcomes in patients with cancer. Little is known about the benefit of nutritional support in these patients. The purpose of this study was to assess the impact of home parenteral nutrition (HPN) on quality of life (Qol) in cancer patients. We performed an observational prospective study to determine the impact o...

Calcium current through voltage-gated calcium channels (VGCC) controls gene expression. Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription. Electrical activity induces Cacnb4 association to Ppp2r5d, a regulatory subunit of PP2A phosphatase, followed by (i) nuclear tr...

High voltage-activated (HVA) calcium channels are hetero-multimeric complexes that translate electrical signals into Ca2+ influx, a secondary messenger that mediates essential neuronal processes such as neurotransmitter release and neuronal excitability. HVA calcium channels are composed of four subunits: Cavα1 subunit, the pore forming of the chan...

Direct regulation of N-type calcium channels by G-proteins is essential to control neuronal excitability and neurotransmitter release. Binding of the G(betagamma) dimer directly onto the channel is characterized by a marked current inhibition ("ON" effect), whereas the pore opening- and time-dependent dissociation of this complex from the channel p...

Les canaux calciques neuronaux activés par la dépolarisation membranaire contrôlent diverses fonctions cellulaires telles que l'excitabilité neuronale et la transmission synaptique. Les canaux calciques sont formés d'une sous-unité principale Cav associée à 3 sous-unités régulatrices (b, a2d et g). La sous-unité auxiliaire Cavb joue un rôle crucial...

An increase in intracellular Ca2+ due to voltage-gated Ca2+ (CaV) channel opening represents an important trigger for a number of second-messenger-mediated effects ranging from neurotransmitter release to gene activation. Ca2+ entry occurs through the principal pore-forming protein but several ancillary subunits are known to more precisely tune ion...

Maurocalcine (MCa) is a 33-amino acid residue peptide toxin initially isolated from the scorpion Scorpio maurus maurus. Its structural and functional features make it resembling many Cell Penetrating Peptides. In particular, MCa exhibits a characteristic positively charged face that may interact with membrane lipids. External application of MCa is...