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Abimbola Oluseyi Ogunsola

Abimbola Oluseyi Ogunsola
Babcock University, Ilisan-Remo, Ogun State, Nigeria

PhD / FMLSCN
Preclinical research in developmental origin of health and diseases

About

47
Publications
7,157
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50
Citations
Introduction
I am working on unravelling the mechanisms underlying fetal programming of metabolic disorders in the offspring of diabetic mothers and other intrauterine adverse environmental influences. The development of novel intervention strategies to alleviate the consequences of fetal programming is the ultimate goal.
Additional affiliations
February 2013 - present
Babcock University, Ilisan-Remo, Ogun State, Nigeria
Position
  • Lecturer
January 2013 - December 2016
Babcock University
Position
  • Lecturer
July 2008 - November 2012
College of Medicine, University of Lagos
Position
  • Research Officer
Education
January 2011 - December 2012
Lagos University Teaching Hospital
Field of study
  • Medical Laboratory Science (Haematology)
January 2010 - November 2018
University of Lagos
Field of study
  • Physiology
January 2007 - December 2008
Lagos University Teaching Hospital
Field of study
  • Medical Laboratory Science (Haematology)

Publications

Publications (47)
Preprint
Full-text available
To test the hypothesis that maternal undernutrition exerts a greater effect on offspring metabolic function compared to maternal overnutrition, female rats (n=10 per group) were subjected to a high calorie diet or 50 % global nutrient restriction relative to control rats on standard rat chow, for 8 weeks prior to pregnancy and during pregnancy. Bir...
Article
Full-text available
Objective: This study aimed to evaluate effects of quail and chicken eggs on fasting blood glucose level, insulin level and lipid profile in male rats fed high fructose diet. Methods: Forty-eight male Sprague-Dawley rats were divided into six groups i.e. Control + Distilled water, Control + Quail, Control + Chicken, High Fructose Diet + Distilled w...
Article
Full-text available
Background: Maternal diabetes is known to impair placental function; however, its effect on placental expression of progesterone/oestrogen receptors and role of the placenta in foetal programming has not been well documented. The study assessed serum progesterone and oestradiol levels, placental morphology, placental progesterone and oestrogen rece...
Article
Full-text available
The continuous rise in the prevalence of obesity around the world has been linked to dietary behaviours. But there are also views on how female labour participation and their income levels affect the prevalence of obesity among women, which vary across countries. The relationship between female labour force participation and income level against th...
Article
Background Genistein was reported to adversely influence fetal development although this is yet to be fully understood as a mechanism. Methods In this study, pregnant rats were divided into control (Cont.) and genistein force-fed (2-mg/kg and 4-mg/kg) groups. Each group was divided further into five subgroups: GD-0, GD-6, GD-13, GD-18, and GD-20 b...
Article
Full-text available
Objectives. We aimed to evaluate the effects of a single (acute) and repeated (chronic) exposure to forced-swimming stressor on glucose tolerance, insulin sensitivity, lipid profile and glycogen content in male rats. Methods. Thirty adult male Sprague-Dawley rats (12 weeks old) were divided randomly into five groups: control group, single exposure...
Article
A major challenge in diabetic disease is the systemic glucose handling mechanisms with little effort directed at it in the recent past. Spondias mombin is a flowering plant of the anacardiacae family that has been credited with anti-diabetic properties. This study evaluated the anti-diabetic activity of S. mombin, its effects on glucose transporter...
Article
Full-text available
Moringa oleifera has become a very popular plant due to its widely acclaimed nutritional and phytomedicinal values. The leaves, seed, pods and flowers are consumed and used as ingredients and spices, while concoctions are also made from them. The leaves and flowers may also be consumed as vegetables. There are however, concerns about the effects of...
Article
Full-text available
This is an exploratory study that utilizes the sustainable development framework as the basis of its argument. From the deterioration of health which the Niger Delta region has experienced over the years, to the socio-economic consequences of oil spills and degradation of its environment, we find from literature review that in the face of policy fa...
Article
Full-text available
Throughout history, humanity has been at crossroads on the issue of healthcare delivery. This applies to both developed and developing nations, and more recently, in countries like the United States, United Kingdom and South Africa, faced with challenges in their citizens’ access to healthcare services. Much recent research and discussion have focu...
Article
Full-text available
While socio-economic status (SES) and lifestyle have been isolatedly considered as key social factors affecting the prevalence of metabolic disorders like Type II diabetes mellitus, there had not been clear-cut analysis of the simultaneous relationship and impact of the two as diabetes risk factors. SES such as income, education, housing, access to...
Article
Full-text available
Diets laden with salt and refined sugar have been implicated in the pathogenesis of diabetes and hypertension. However, few studies have investigated the impact of such diets on reproductive functions, hence, the present study. Male Sprague–Dawley rats (100–120 g, n = 24) were randomly divided into four groups designated control (standard chow), su...
Article
Full-text available
Humans have numerous forms of diversity ranging from the very fundamental form of gender to inter-and intra-populations forms of diversity. Several methods have been established for identifications of humans; very importantly, gender and dermatoglyphic features, especially thumbprints. Handedness has also been shown to vary among humans. There is h...
Article
Full-text available
Exposure to a compromised intra uterine environment has been known to alter fetal growth and metabolic processes with long term consequences for health. Maternal nutrition prior to and during gestation plays a role in fetal programming, however the mechanisms underlying these changes have not been fully elucidated. This study was designed to evalua...
Article
Full-text available
1 Department of Anatomy, Ben Carson Sr. School of Medicine, Babcock University, Nigeria. 2. Hematology Department, Ben Carson Sr. College of Medicine, Babcock University, Nigeria * Email Address for Correspondence/ Adresse de courriel pour la correspondance: olaowolabi001@yahoo .com Accepted/Accepté: February 2014 Full Citation: Owolabi JO,...
Conference Paper
Transforming Growth Factors (TGF β) inhibin and activin are involved in regulation of pituitary gonadotrophin secretion however precise implications of this involvement in female diabetic and insulin resistant rats is less understood. Female Sprague-Dawley rats aged 6 weeks were divided into 3 groups. Control; Streptozotocin (STZ) group received si...
Article
Full-text available
In this paper, we report the results of histological and histochemical studies to differentiate between normal-term and growth-retarded placentas. His-tology was based on Gordon and Sweet, while histochemistry was c a r r i e d o u t b y l o c a l i z i n g G-6-PDH and LDH in the placentas. Thirty (30) placentas, 15 normal-term and 15 growth-retard...
Article
Full-text available
This study compares the pathophysiology of normal and growth retarded human placental tissues. Female patients were recruited from the Antenatal Clinic of Dolu Specialist Hospital, Mafoluku, Oshodi, Lagos, between 2008 and 2012. A total of 48 normal term placentas and 15 placentas of known IUGR cases were used for this study. IUGR cases were confir...
Article
Several groups in recent times have related the pathogenesis of renal haemodynamic changes in diabetes and most of the experimental diabetic conditions studied so far were carried out using streptozotocin injection only. The aim of the present study was to examine the effects of streptozotocin, fructose and sucrose induced insulin resistance on pla...
Article
Full-text available
Aim: The aim of this study is to determine the glycemic pattern of pregnant Nigerian women. Setting: A tertiary Prenatal Diagnosis and Therapy Centre and Dept of Obstetrics and Gynecology of the University of Lagos, Nigeria. Methods and Material: Between May 2002 and March 2010, Nine hundred and forty four (944) healthy pregnant women of which were...
Article
Full-text available
Virgin female Sprague-Dawley rats aged 6 weeks, weighing 110-120 g were randomly divided into 2 groups. Group 1 served as control group and was fed with normal rat chow. Group 2 served as Chronic fructose group and was fed ad libitum on a special diet containing 25% fructose mixed with 75% normal rat chow weight/weight for 4 weeks and continued til...
Article
In a total n = 102 women with normal pregnancies and deliveries, the rate of waveform notching in the uteroplacental flow velocity pattern was investigated. Notching appeared to be significantly more frequent in the uterine than in the accurate artery. This was unilateral and mainly affected in placenta- concentrated sites. Bilateral notching or no...
Article
Plasma magnesium was assayed in n = 6 normal insulin dependent diabetic pregnant Nigerian women longitudinally during pregnancy using atomic absorption spectrophotometer (AAS). Plasma magnesium concentration (mean standard deviation) was significantly lower in the diabetic patients compared with healthy women.
Article
Objectives: To establish a reference range of thyroid binding globulin (TBG) values in normal fetuses and their mothers during pregnancy in Nigerian women. Methods: Cross sectional analysis of blood samples collected from n=65 fetal cord samples between 13 and 40 weeks of gestation, and n=68 maternal blood samples between 12 and 40 weeks were perf...
Article
Objective: To investigate and establish a reference range of human Hepatocyte growth Factor (hHGF) in normal pregnancies, EPH-Gestosis and HELLP Syndrome Pregnancies in Nigerian Women. Methods: Retrospective analysis of blood samples collected from the following groups of patients n = 15 non pregnant women, pregnant women: early n = 15 (10 – 14 we...
Article
Diabetes in pregnancy is known to be associated with increased occurrence of both fetal and maternal adverse events. Glucose and HbA1C are established tools in the assessment of glycemic control. Although HbA1C reference intervals are well established for the general population, reference intervals for pregnant women are not clearly defined. Objec...
Article
One of the most prevalent disorders of man is the dietary deficiency of iron and the resulting anaemia. Measurement of ferritin is useful in determining changes in body iron store, early detection of iron deficiency anaemia, and for monitoring the iron status of pregnant women. Objectives: To evaluate the ferritin level in maternal and cord blood a...
Article
Objective: To investigate changes in amniotic fluid insulin in normal pregnancies compared with pathological pregnancies in Nigerian women. Method: Insulin concentrations were measured using ELISA Kits (Diagnostic Automation Inc., USA) in amniotic fluid of n = 20 normal pregnant women, n = 17 women with intrauterine death and n = 9 women with anen...
Article
Objective: To investigate if markers for activation of the immune system are present in patients with preeclampsia by assessing maternal plasma and amniotic fluid for Tumor necrosis factor-α and Interleukin 1 Study design: n = 30 women with severe pre-eclampsia composed the study group (Group A). An antepartum comparison group was composed of healt...
Article
Background: Auto-immune diseases are the third leading cause of morbidity and mortality in the industrialized world, only surpassed by cancer and heart disease. Autoimmune processes and mechanisms are considered as contributing factors in some cases of unexplained infertility in both men and women. Antinuclear antibodies (ANAs) are venerable biomar...
Article
Background: It is estimated that 10-20 % of couples attending fertility clinics have unexplained infertility. The investigations of causes of infertility and fetal loss are beginning to deal increasingly with immunological factors, and in particular, with the autoimmunity. Objectives: The aim of the study is to evaluate the prevalence of anticardio...
Article
Objective: To establish a reference range of insulin growth factor1 (IGF-I) in normal fetuses and to assess whether intrauterine growth retardation is associated with increased or decreased IGF- I levels. Method: Retrospective analysis of blood samples collected from n= 45 fetuses who underwent blood sampling at 18 - 38 weeks gestation was perform...
Article
OBJECTIVE: To determine the breast milk content of zinc and copper and the effect of lactation on them in the first six months of lactation. DESIGN: A cross sectional study. SETTINGS: Prenatal Diagnosis and Therapy Centre in a tertiary Hospital in Lagos. MATERIAL AND METHODS: Breast milk levels of copper and zinc were assessed in 120 healthy lact...
Article
Epidermal growth factor (EGF) is a polypeptide that elicits mitogenic response in several tissues. An elevation of the amniotic fluid levels of this factor has been reported recently during labour suggesting a role in human parturition. To confirm the previous report, we examine in amniotic fluids the epidermal growth factor in samples collected in...

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Projects (5)
Project
Implement a new crossed algorithm using a CloudSim 3.0.3 toolkit that would reduce power consumption of data centers drastically.