Abhishek De

• MD FAGE SCE-Dermatology FRCP-Edin
• Professor (Associate) at Calcutta National Medical College

Elevated Cytokine Levels and Their Correlation with Disease Activity in Chronic Spontaneous Urticaria: A Detailed Analysis in the Indian Demographic Authors: Dr. Abhishek De, Disha Chakraborty, Professor Kiran Godse Affiliation Department of Dermatology, DY Patil University, Navi Mumbai. Abstract Background: While the inflammatory impact of cyt...

Objectives: Atopic dermatitis (AD) and contact dermatitis (CD) have a complicated and debatable correlation. A large number of studies have suggested that AD patients have a higher prevalence of contact allergy than non-AD patients. In this study, we aimed to compare the prevalence and patterns of CD in AD and non-AD patients using patch testing. W...

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that profoundly affects quality of life, particularly in patients with moderate-to-severe disease that is refractory to conventional treatments. Cyclosporine is a cornerstone of systemic therapy for severe AD; however, its long-term use is hindered by toxicity, and effective alternative...

Background: Atopic dermatitis (AD) is a chronic relapsing inflammatory disease that impacts the quality of life of affected individuals as well as their families. Its pathogenesis involves impaired skin barrier function and immune dysregulation. Moisturizers are used in AD management as they help in repairing the skin barrier. Objective: The object...

Foreword Dr. Christian Vestergaard MD.PhD.DMSc. Clinical Chairprofessor Department of Dermatology Aarhus University Hospital Aarhus, Denmark Atopic dermatitis is one of the most common inflammatory skin conditions, affecting not only children but also adults. While its pathogenesis remains incompletely understood, both environmental and genetic f...

• Expert contributions: Authored by over 30 experts with extensive experience in psoriasis, including members of SIG Psoriasis, ensuring comprehensive and authoritative content • Comprehensive coverage: Addresses all aspects of psoriasis, from the latest concepts in etiopathogenesis to emerging therapies, newer molecules, and future directions in r...

Introduction Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses. Aims and Objectives To observe various morph...

Dupilumab is the first US FDA-approved biologic for moderate to severe atopic dermatitis (AD) in adults and children of age more than six months. It is a fully monoclonal antibody that inhibits interleukin (IL)-4 and IL-13 signal transmission. The initial product monograph mentioned major side effects like hypersensitivity reactions and eye problem...

A boy of 11 years, born of a consanguineous marriage, presented with silvery gray hair, which he has had since birth, along with insidious onset hyperpigmentation all over the body for the past 10 years. Similar changes were found in his maternal uncle. On cutaneous examination, diffuse hyper-pigmentation was seen on the face, trunk, and lower limb...

33rd EADV Congress, Amsterdam

Abstract Background Studies revealed patients with chronic spontaneous urticaria (CSU) had lower vitamin D3 levels. Some studies indicated that high-dose vitamin D3 supplementation for 4-12 weeks may reduce disease activity. However, the results of different trials were inconsistent and there is a paucity of well-designed clinical trials especially...

This book reviews the most fascinating research articles on urticaria from the past 12 months, offering valuable insights and updates in the field.

The human skin is a crucial organ that reflects a variety of endocrine diseases as the interactions of the endocrine and integumentary systems are reflected there. Dysregulation of endocrine hormones results in the appearance of clinically significant cutaneous lesions, which can be recognized by clinicians and hence serve as markers of endocrinopa...

Background Atopic dermatitis (AD) has a complex etiology that includes Th2 polarization, which is accompanied by the cytokines IL4, IL-5, IL-13, and IL-31, as well as Th17 and Th22, and in chronic lesions, Th1 cells. Tofacitinib inhibits Th1-, Th2-, and Th17-associated cytokines by selectively blocking JAK1 and JAK3 receptors. We conducted a multic...

Background Chronic spontaneous urticaria (CSU) is a distressing skin condition characterized by the recurrent appearance of itchy hives. A subset of CSU patients remains resistant to conventional treatment with high-dose antihistamines. Tofacitinib, a Janus kinase inhibitor, has shown promise in various inflammatory skin diseases. We aimed to evalu...

Background Psoriasis (PS), vitiligo (VT), and Pityriasis rosea (PR) are chronic skin diseases often occurring as a consequence of exaggerated immune responses. These skin manifestations can be triggered as a result of the molecular mimicry between viral protein (s) and host protein (s), which could generate auto-antibodies. In addition, it can be h...

The remarkable characteristics of stem cells (SCs), particularly their potency, capacity for self-renewal, and clonality, are well known. In recent years, there have been notable advancements in the field of cell therapy. Due to its distinctive qualities and versatility, this innovative therapy is already turning into a potentially helpful remedy f...

Preface It is with great pleasure and deep gratitude that I write this preface for our book titled "Urticaria," published by GJS Publications Pvt. Ltd. This book is the culmination of extensive research, collaboration, and dedication, and if brings together a series of intriguing and insightful cases of urticaria that we believe will provide valuab...

Simulium dermatitis following blackfly bites in Northeastern India: a case report Within the diverse Simulidae family, key genera such as Simu-lium, Prosimulium, and Gigantodax stand out for their medical significance. These typically small black flies range from 1 to 5 mm and feature distinctive traits like prominent eyes and 11-segmented antennae...

Introduction. In India, the SARS-CoV-2 Delta wave (2020–2021) faded away with the advent of the Omicron variants (2021–present). Dengue incidences were observed to be less in Southeast Asia during the active years of the pandemic (2020–2021). However, dengue virus type 3 (DV3) cases were increasingly reported in this region (including India) concur...

Abstract COVID‐19 tended to be less aggressive in dengue endemic regions. Conversely, dengue cases plummeted in dengue endemic zones during the active years of the pandemic (2020–2021). We and others have demonstrated serological cross‐ reactivity between these two viruses of different families. We further demonstrated that COVID‐19 serum samples t...

The nose is a common site for many dermatological disorders and even skin cancers. Herein, we report a case of an elderly man who presented with papular lesions on his nose. A 64-year-old man presented with a cluster of four to five skin-colored papules on his nose for the last two years which were gradually increasing in size. He also had rhinophy...

Pattern recognition receptors (PRRs), which are found in microorganisms but not in hosts, allow Leprae bacilli to be recognized as foreign. Several kinds of pattern recognition receptors, such as toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-1-like receptors (RLRs), are present in the innate immune system. Sen and Baltimore (1986) d...

Introduction The treatment options for chronic spontaneous urticaria (CSU) primarily include second generation non-sedative antihistamine (SGAHs). Bilastine is a newer, nonsedating SGAH approved for urticaria in February 2019 by the Drugs Controller General of India. Its major advantages are in terms of superior efficacy, lack of drug interactions...

Psoriasis is a chronic inflammatory skin condition affecting millions of individuals worldwide. Over the years, various treatment modalities have been explored to alleviate the symptoms and improve the quality of life for patients with psoriasis. Among these treatment options, lasers and lights have emerged as promising non-invasive approaches with...

Exposure to external environmental stimuli can lead to skin aging, pigmentation, hair loss, and various immune-mediated as well as connective tissue diseases. Although conventional treatments are routinely used and favoured, they fail to achieve an adequate balance between clinical and cosmetic outcomes. Exosomes are vesicles with a lipid bilayer r...

This book is an exclusive guide focusing on the use of biologics, biosimilars and targeted immunotherapies It covers every biologics from in details: history, classification and nomenclature of biologics followed by the investigations, monitoring, adverse effects and contraindications of using biologics Covers all molecules which are presently used...

Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by intense itching, eczema, and sleep disturbances. While traditional therapies like topical corticosteroids and calcineurin inhibitors provide some relief, they often lead to side effects and lack long-term efficacy. Recent breakthroughs in biologics and small molecule th...

Background Fixed drug reaction (FDE) is characterized by the development of well-circumscribed, round, erythematous macules and plaques on cutaneous or mucosal surface following ingestion of the offending drug. Aim and Objectives To study the etiological agents responsible for FDE and to study the clinical patterns of FDE due to different drugs....

Background Adverse drug reactions (ADRs) are major problems in the drug therapy. Cutaneous adverse drug reactions (CADRs) are the most common ADRs. The pattern of CADRs differs among various drugs. Aims To record various morphological patterns of CADRs and their causal relationships among patients attending in a tertiary care centre. Materials an...

Objectives Managing mild-to-moderate atopic dermatitis (AD) often necessitates topical therapies, and one such recently introduced option is crisaborole ointment. This study sets out to assess the efficacy and safety of crisaborole ointment in pediatric cases of AD over four weeks. Material and Methods Nineteen children between 2 and 16 years old...

We conducted a cross sectional institutional study to compare the serum levels of vitamin D in CSU patients with healthy controls and to assess the correlation between the disease severity and vitamin D deficiency. We also tried to evaluate the effect of vitamin D supplementation to the standard dose of levocetirizine in CSU patients with low serum...

Atopic dermatitis is a chronic inflammatory dermatological condition associated with intense pruritus seen in all age groups and ethnic diversities. It can have a significant impact on the quality of life. The options for treatment include skincare, topical therapies, systemic therapies, and phototherapy. Treatment of atopic dermatitis may be assoc...

Background Although second-generation antihistamines (SGAHs) are recommended as first-line drugs in chronic spontaneous urticaria (CSU), symptom relief has been reported in <50% of patients at licensed doses and up to fourfold dosing is recommended for these patients. Bilastine (SGAH), at licensed doses and higher doses, is efficacious in CSU. Howe...

Introduction Leprae bacilli are identified as foreign by pattern recognition receptors (PRRs) present in the microbes but absent in the host. The Nucleotide oligomerization domain (NOD)-like receptor (NLR) family comprises the nucleotide-binding oligomerisation domain (NOD1 and NOD2) proteins, which are two well-known PRRs. The objectives of this s...

Topical calcineurin inhibitors (TCIs) and topical corticosteroids (TCS) are the mainstays of flare management for atopic eczema or atopic dermatitis (AD). Tacrolimus (an immunomodulator), belongs to the class of calcineurin inhibitors, with promising efficacy in AD. We performed this systematic review to obtain an up-to-date coverage map of control...

Alopecia is a highly prevalent condition worldwide including in India. There are different types of alopecia with differing etiology, presentation, and hence treatment. Androgenetic alopecia represents the most common form of hair loss affecting male as well as female population termed as male and female pattern hair loss, respectively. Several tre...

Atopic dermatitis is among the cutaneous inflammatory disorders whose pathophysiology is thought to be influenced by the JAK-STAT intracellular signalling system. The effectiveness of systemic and topical Janus kinase (JAK) inhibitors in the treatment of atopic dermatitis has been shown in clinical trials and case studies. At present, oral abrociti...

Background The pathogenesis of chronic spontaneous urticaria (CSU) is poorly understood, with limited treatment options. An increase in IL-4, IL-5, and IFN-gamma in the cytokine profile suggests a mixed Th 1/Th2 response in CU. IL-6 trans-signaling and elevated IL-17 of the Th17 pathway are critically involved in the initiation and promotion of in...

Background Obesity is considered one of the risk factors for dermatophytosis and warrants systemic therapy. Itraconazole is the most commonly used antifungal, but owing to pharmacokinetic challenges, super-bioavailable itraconazole (SITZ) was approved globally, recently. For the management of dermatophytosis in obese patients, there are mixed opini...

Bilastine is a newer second-generation anti-histamine. Our trial results suggest that antihistamines have a unique mechanism of action by reducing systemic autoimmunity in chronic spontaneous urticaria patients by decreasing the level of pro-inflammatory cytokines, IL-6, IL-17. We chose Bilastine as it is much less sedating than other SGAHs.

Due to the lack of reliable biomarkers, patient-reported outcome measures (PROMs) have a crucial role in assessing and monitoring the progression of chronic urticaria (CU) and angioedema (AE). PROMs are described as “any report coming directly from subjects without interpretation of the physician or others about how they function overall or feel in...

Introduction Itraconazole follows non-linear pharmacokinetics and hence is recommended once daily, but in real-world practice, is commonly prescribed as twice daily. Hence, this study aimed to evaluate the efficacy and safety of super-bioavailable-itraconazole-130 mg (SB-130) and conventional-itraconazole-200 mg (CITZ-200) once daily compared with...