
Abeer A KassemPharos University in Alexandria | PUA · Faculty of Pharmacy
Abeer A Kassem
Associate Professor of Pharmaceutics and Pharmaceutical Technology
About
27
Publications
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Introduction
Abeer A Kassem Associate Professor, currently works at the Department of Pharmaceutics and Pharmaceutical Technology,, Faculty of Pharmacy, PUA, Alexandria, Egypt.
Skills and Expertise
Additional affiliations
November 2019 - present
September 2007 - September 2014
September 1990 - September 2007
Publications
Publications (27)
Gastroretentive Levofloxacin (LVF) floating mini-tablets for the eradication of Helicobacter pylori (H. pylori) were prepared using the matrix forming polymer hydroxypropyl methylcellulose (HPMC K100M), alone or with Carbopol 940P in different ratios by wet granulation technique. Buoyancy of mini-tablets was achieved by addition of an effervescent...
Abstract Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of chitosan-alginate and chitosan-pectin polyelectrolyte complex (PEC) films as drug release regulators for tetracycline HCl (Tc) to...
Abstract Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA using proniosome as a n...
Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections th...
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D receptor binding pocket, located transmemberanous. This work aimed at preparing transdermal ZOL-nanoformulation (niosomes) to surpass these limitations and to explore...
Background
Development of multidrug resistance in Uropathogenic Escherichia coli (UPEC) makes treatment of Urinary Tract Infections (UTIs) a major challenge. This study was conducted to investigate the effect of trans-resveratrol (t-RSV) at a subinhibitory concentration (sub-MIC-t-RSV) on phenotypic and genotypic expression of virulence factors of...
The antihyperglycemic effect of Plicosepalus acaciae (P. acaciae) extract was proven, but it still needs to be formulated into a suitable dosage form. We aimed at preparing an oral stabilized SLNs for P. acaciae with high payload, to be used as powder for reconstitution, filled into capsule or compressed into tablet. SLNs were prepared by emulsion...
There has been an increasing demand for the development of nanocarriers targeting multiple diseases with a broad range of properties. Due to their tiny size, giant surface area and feasible targetability, nanocarriers have optimized efficacy, decreased side effects and improved stability over conventional drug dosage forms. There are diverse types...
Background:
Lipid based nanocarriers have gained recently enormous interest for pharmaceutical application. They have the potential to provide controlled drug release and to target the drug to a specific area. In addition, lipid based nanocarriers can improve the bioavailability of drugs suffering from high hepatic first-pass metabolism, by enhanc...
Objective: Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient’s pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study wa...
Objective: Development of sublingual fast dissolving lyophilized almotriptan tablets, to enhance its pre-gastric absorption and so alleviating the gastrointestinal dysmotility that is commonly associated with migraines.
Methods: Primary almotriptan lyophilized tablets (Alm-lyotab), were prepared using polyvinyl alcohol (PVA), polyvinyl pyrrolidon...
Background : Recent studies suggest that metformin (MF) is osteogenic.
Aim: The assessment of the effect of a muco-adhesive, multiple layer film of MF in intra-pocket application in
non-surgical management of moderate –severe chronic periodontitis.
Materials and Methods: The study included 20 patients with moderate –severe chronic periodontitis. Sc...
Introduction:
Periodontal disease broadly defines group of conditions in which the supportive structure of the tooth (periodontium) is destroyed. Recent studies suggested that the anti-diabetic drug metformin hydrochloride (MF) has an osteogenic effect and is beneficial for the management of periodontitis.
Objective:
Development of strong mucoad...
Background:
The use of triptans in the treatment of migraine was a breakthrough. Their selective agonistic action at serotonin (5-hydroxytryptamine) receptors has provided insights into the pathophysiology of migraine and represented a significant advance in migraine pharmacotherapy. Sumatriptan was the first synthesized triptan available for clin...
Abstract: Helicobacter pylori (H. pylori) is a worldwide infection that affects millions of people. Some people develop only minor
symptoms or even no symptoms at all, whereas others complain of terrible stomach and chest pain, diarrhea, bloating, nausea,
vomiting, heartburn, headaches, depression, anxiety and rashes. H. pylori can be eradicated by...
Helicobacter pylori (H. pylori) is a worldwide infection that affects millions of people. Some people develop only minor
symptoms or even no symptoms at all, whereas others complain of terrible stomach and chest pain, diarrhea, bloating, nausea,
vomiting, heartburn, headaches, depression, anxiety and rashes. H. pylori can be eradicated by using con...
Periodontitis is a multifactorial infection associated with a variable bacterial pattern. The treatment focuses mainly on the reduction of the total bacterial count. Local delivery of antimicrobials has been investigated as an adjunct to conventional therapy. Tetracycline was proved to inhibit collagenases and was thus proposed to be useful in trea...
Periodontitis is a multifactorial infection associated with a variable bacterial pattern. The treatment focuses mainly on the reduction of the total bacterial count. Local delivery of antimicrobials has been investigated as an adjunct to conventional therapy. Tetracycline was proved to inhibit collagenases and was thus proposed to be useful in trea...
Resveratrol (Res), a polyphenolic phytoalexin, had showna promising therapeutic efficacy towards treatment of periodontal disease in vitro. This work aims to develop Res microbeads with strong mucoadhesion using thiolated alginate (TA) for local treatment of periodontal pockets. TA was synthesized by conjugating sodium alginate (A) with thioglycoli...
The study demonstrates the feasibility of prolonging gastric residence time and release rate of metronidazole (Mz) by preparing floating raft system (FRS) using ion-sensitive in situ gel forming polymers. FRSs contained 3, 4, 5 and 0.5, 0.75, 1% w/v sodium alginate (Alg) and gellan gum (G), respectively, 0.25% w/v sodium citrate and calcium carbona...
In situ gelling formulations allow easy application to the target area. Gelation is induced by physiological stimuli at the site of application where the formula attains semisolid properties and exerts sustained drug release. In situ gelling formulations containing either 3% meloxicam (Mx) or 2% minocycline HCl (MH) were prepared for local applicat...