Abeer Mohamed Elsayed

Cairo University | CU · Department of Pharmacognosy

Antimicrobial potential of Citrus medica var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle and Limonia acidissima L. fruits and leaves extracts CMF, CML, LAF and LAL, respectively were evaluated. Gas chromatography-mass spectrometry (GC-MS) analysis for lipoidal matters revealed a high percentage of non-oxygenated compounds. Phytol was the m...

The aim of the present study is to explore the potential anticancer effect of the cardenolide; acovenoside A against non-small cell lung cancer (NSCLC), understand its molecular mechanism in inducing apoptosis and show the effect of its combination with carboplatin and taxol. MTT assay showed that the combination of acovenoside A with taxol and car...

A comprehensive study of leaves, flowers, fruits, bark, and seeds' extracts of Gmelina arborea Roxb was performed for first time to investigate their anti-inflammatory, anti-Alzheimer, and antidiabetic activities. A thorough comparative phytochemical investigation of the five organs was performed using Tandem ESI-LC-MS. The biological investigation...

Barley (Hordeum vulgare L.) is one of the world’s oldest cereal crops. There is considerable interest in barley’s potential usage in human diets. Barley is rich in bioactive metabolites such as high content of β-glucan, fiber, and vitamin E. It is also well-known as a rich source of phytochemical derivatives, namely, phenolic acids, flavonols, chal...

Mosquitoes and mosquito-borne infectious diseases are a global challenge, especially with increased resistance to synthetic insecticides. The foregoing study aimed to utilize the essential oil of leaves of Citrus sinensis var. Valencia as a cheap, safe, eco-friendly (green), and effective alternative to chemical insecticides. Essential oil samples...

Mosquitoes are unquestionably the most medic arthropod vectors of disease. Culex pipiens, usually defined as a common house mosquito, is a well-known carrier of several virus diseases. Crude ethanol extracts of different organs of Agratum houstonianum are tested with Culex pipiens Linnaeus (Diptera: Culicidae) to determine their larvicidal, antifee...

Fruits of Citrus sinensis L. Osbeck var. Valencia contain hesperidin as a major flavanone glycoside. Hesperidin (H) was isolated from the peels of Valencia orange and formulated as hexosomal nanodispersions (F1) adopting the hot emulsification method. The antimycobacterial activity(anti-TB) was evaluated through a microplate Alamar blue (MABA) assa...

Ferula tingitana L. has been reported for abortive and\or menstruation inducing properties. However, its contraceptive effect has never been deliberately evaluated. Furthermore, no inclusive chemical profiling of its extract was recorded. Many Ferula species were known for their effects on the oestrogenic rhythm. During our drug discovery from natu...

Compared to its leaf, few studies have been reported on the seeds of Moringa oleifera Lam. Metabolites profiling analysis of M. oleifera seed methanolic extract (ME) and its fixed oil (MO) was attempted via LC/MS and GC/MS. LC/MS analysis of M. oleifera seeds annotated 84 peaks of which glucosinolates and their corresponding acetyl isomers were abu...

2022): UPLC-MS/MS and GC-MS based metabolites profiling of Moringa oleifera seed with its anti-Helicobacterpylori and anti-inflammatory activities, Natural Product Research, ABSTRACT Compared to its leaf, few studies have been reported on the seeds of Moringa oleifera Lam. Metabolites profiling analysis of M. oleifera seed methanolic extract (ME) a...

Abstract The chemical composition of fruits and leaves derived oil of Citrus medica var. sarcodactylis Swingle (CMF&CML) and leaves of Limonia acidissima L. (LAL), Rutaceae were analyzed by gas chromatography-mass spectroscopy (GC-MS). Twenty-one components accounting for (98.51%) were identified in CMF oil. While in leaves oil, fourteen components...

Neglected tropical diseases (NTDs) such as leishmaniasis, filariasis, trypanosomiasis, and schistosomiasis have claimed the lives of over one billion people, mainly affecting the less privileged in Africa and Asia. In the face of the fact that obtainable actions for these ailments are of limited effectiveness and often highly toxic, there has been...

Objective: Scaevola taccada. (Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. It is used in folk medicine for diversity of ailments. This study aims to investigate the major phytoconstituents and biological activities of the leaves of S. taccada (Gaertn.) Roxb. Methods: In vitro biological examination viz. antimicrobial, cytotoxi...

Objective: To shed light on Scaevola taccada (Gaertn.) Roxb. which is widely dispersed all along the coasts of Africa. Conventionally, different parts of S.taccada were useful for treatment of a diversity of ailments. Methods: In-vitro biological examination viz. antimicrobial, cytotoxic and antioxidant activities of the ethanol soluble of the leav...

Identification criteria and quality control of Scaevola taccada (Gaertn.) Roxb. cultivated in Egypt were scanty. The present study aims to appraise characters of S.taccada grown in Egypt, as a traditional medicinal plant. A detailed botanical study of leaf, stem, and flower of S. taccada were investigated to find out their characters in entire and...

Objectives: Scaevola taccada. (Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. It is used in folk medicine for diversity of ailments. This study aims to investigate the major phytoconstituents and biological activities of the leaves of S. taccada (Gaertn.) Roxb. Methods: In-vitro biological examination viz. antimicrobial, cytotox...

Lycopene is a phytochemical that is present at high concentration in fruits and vegetables such as tomato, guava, watermelon, spinach, carrot, beetroot, and red grapefruit. Lycopene, just like some members of the carotenoids family, has proven to be of high medicinal, scientific, pharmaceutical, and commercial value. These features of lycopene can...

Lycopene is an extensively studied phytochemical that belongs to the hydrocarbon class of the carotenoid family. In 1876, a red-colored pigment in tomato was discovered by Millardet. Later on, this red-colored pigment became known as “lycopene,” a name that was given by Schunck. Lycopene is also known as carotene present in fruits and vegetables of...

Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history,...

Abstract Few studies thoroughly investigated different Yucca species introduced to Egypt. As a part of our ongoing investigation of the Yucca species; Yucca aloifolia and its variety Yucca aloifolia variegata, Yucca filamentosa, and Yucca elephantipes (Asparagaceae) were extensively subjected to phytochemical and antimicrobial investigation. Yucca...

As ongoing investigation of Huernia saudi-arabica D.V.Field (Asclepiadaceae), a new steroidal pregnane glycoside (Huernioside A) was isolated from dichloromethane fraction (DCM); it was identified as 3β, 11, 14β, 20(R)-tetrahydroxy-pregna-5,9(11)-diene-3-O-β-D-thevetopyranosyl-(1-4)-β-D-cymaropyranoside(HCP) through analysis of 1D, 2D NMR besides E...

The essential oils of Ageratum houstonianum Mill grown in Egypt were obtained and studied for the first time. The essential oils of leaves (0.1 % v/w) and flowers (0.06 % v/w) of A. houstonianum Mill. (Asteraceae) were comparatively analyzed by GC/MS using non polar column Rtx-5MS. A total of 11-32 components were identified, 7 being common in both...

Development of a novel agent for control of schistosomiasis is a mandate. In-vitro anti-schistosomal activity of the aerial parts of Huernia saudi-arabica were examined. Chromatographic investigations of the ethanol extract (EE) were afforded three compounds. Pregnane glycoside (CI) 12-β-p-hydroxy-benzoyl-20-O-acetyl-boucerin-3-O-β-D-glucopyranosyl...

Background: Genus Senecio is known by its phenolic constituents, terpenoids, essential oil (EO), and pyrrolizidine alkaloids. No previous reports could be traced about the phytochemical study of Senecio acaulis. Objectives: To investigate the chemical composition and biological potentiality of EO of S. acaulis aerial parts and to study the phytocon...

Background: Flaxseed is a highly important industrial and medicinal plant worldwide. Objective: To use inter simple sequence repeat (ISSR) technique for making unique fingerprint for the four newly produced genotypes of flax in Egypt. Materials and Methods: The genetic diversity among four promising Egyptian flax (Linum usitatissimum L.) genotypes...

Chemical profile analyses of Artichoke edible parts (fleshy receptacle, inner bracts) as well as roots are compared with the commercially usable leaf extract using HPLC-DAD-ESI-MS via chlorogenic acid as a marker. Overall polyphenolic constituents demonstrated by means of LC/MS profiling. The nutritional values and inulin contents of different asse...

The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar G...

Yucca aloifolia, Y. aloifolia variegata, Y. elephantipes and Y. filamentosa were investigated. DNA sequencing was performed for the four plants and a genomic DNA fingerprint was obtained and provided. The cytotoxic activities against four human cancer cell lines were investigated. The ethanolic extracts of leaves of Y. aloifolia variegata prevailed...

Criteria for identification and quality control of Artemisia monosperma Del., grown in Libya were scanty. Indigenous browse species are considered as useful sources of animal feeds. This prompted the exploration of the nutritional value of the plant. Macro- and micro-minerals were determined. Total carbohydrate, lipid and protein content were estim...

We investigated the cytotoxic potential of the cardenolide glycoside acovenoside A against non-small-cell lung cancer cells. Lung cancer is the leading cause of cancer-related mortality and the second most common cancer diagnosed. Epidemiological studies revealed a direct correlation between the regular administration of cardiac glycosides and a lo...

Flaxseed ( Linum usitatissimum L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressa...

Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana, and to throw light on antimicro...

Background: From the bioactivity stand point Artemisia monosperma Del. is reputed to have antispasmodic and anthelmintic properties. Various types of secondary metabolites were reported in A. monosperma plants from different localities. Objective: The current study was planned aiming to investigate the influence of stage of development on the compo...

A possible way to valorize citrus peel (P) and seed(S), which are wastes of the juice extraction industry, is to use them as natural bionematicides. However, information on the limonoids as well as polyphenolics contents of the peel and seeds of Citrus aurantium var. deliciosa were limited. In the present study, methanolic extracts of the peel and...

Crepis senecioides is one of the endemic plant species found in Libya. The ethanol extract (E) of the flowers was partitioned on silica gel column with dichloromethane affording four compounds. Their structures were elucidated by the physicochemical and spectral data as germanicol acetate (1), 3`,3``butyl, 8`,8``carboxy) di-octyl phethalate (2), ta...

The genus Aloe comprises over 400 species of flowering succulent plants. Aloe leaves are used in the treatment of asthma, gastrointestinal ulcers, cardiovascular disease, tumors, burns, and diabetes. They are rich in anthraquinones, such as aloin, aloe-emodin, chrysophanol, aloinoside A, and aloinoside B. The various species of Aloe show chemical a...

The current study aimed to investigate the protective effect of the cardenolide glycoside acovenoside A (AcoA) against doxorubicin-induced cardiotoxicity in mice. AcoA was isolated from the pericarps of Acokanthera oppositifolia to chemical homogeneity and characterized by means of 1D and 2D nuclear magnetic resonance spectroscopy. AcoA exhibited r...

Phytochemical investigation of the crude ethanol extract of the leaves of Schinus polygamus(Cav.) Cabrera (Anacardiaceae) result in isolation of eight compounds identified as triterpenoids, lupeol-3-βeta-acetate(I), βeta-sitosterol (II), lupeol(III). In addition to the polyphenols, gallic acid (IV), methyl gallate(V), quercetin-3-α-O-rhamnoside(VI)...

As a part of ongoing investigation of Acokanthera oppositifolia (Lam.) Codd., four compounds were isolated from its seeds, a new compound; lup-20(29)-en-3β-O-(3'-β-hydroxy) palmitate (1), three known compounds; a triterpene; lupeol (2), a cardiac glycoside; acovenoside A (3) and a sterol; β-sitosterol (4). Their structures were investigated using 1...

Many of the health benefits associated with Aloe species have been attributed to the polysaccharides contained in the gel of the leaves. The aim of this study was to investigate the chemical composition as well as the biological evaluation of polysaccharides isolated from the leaves of eight different Aloe species, A.vera(A1), A.arborescens (A2), A...

Genus Aloe, Xanthorrhoeaceae, is well distributed all over Egypt, and many species have been used as medicinal plants; mainly reported to prevent cardiovascular diseases, cancer and diabetes. This study attempts to analyze the secondary metabolites in the methanol extract of the leaves of eight Aloe species; A. vera (L.) Burm. f., A. arborescens Mi...

Ethanolic extract of the aerial parts of Haplophyllum tuberculatum demonstrated an efficient anti-fungal activity against Aspergillus fumigates, Geotricum candidum and Syncephalastrum racemosum with (MIC 0.49, 0.12 and 1.95 µg/ml). It also presented 75% potency as antibacterial agent on Staphylococcus aureus and Escherichia coli (MIC 1.95 and 15.63...

Background: Haplophyllum tuberculatum is a plant belongs to family rutacee. It is rich in volatile oils, fixed oils, alkaloids, and furanocoumarins. It is well known for the huge number of folkloric uses in middle east. Objective: The aim of this study is to establish the chemical composition of the essential oils of Libyan H. tuberculatum and to i...

Cell suspension cultures are now recognized as important model for studying natural products biosynthesis and functional genomics. Nevertheless, very few studies of metabolic comparisons between cell cultures (callus) and original plants have been reported, even though the biological identity of cultured cells with the normally grown plant is of gr...

The study evaluated the efficacy of methanolic extracts of Ruta chalepensis L. (Rutaceae), Withania somnifera (L.) Dunal (Solanaceae), Cleome paradoxa (B. Br.) (Capparaceae) and Heliotropium longiflorum (Hochst & Steud. ex A. DC.) Jaub. & Spach (Boraginaceae) aerial parts against Culex pipiens larvae. Different concentrations (100-500ppm) of the me...

This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE). The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups. GI: included 25 patients who had HE and were treated with la...

The study evaluated the efficacy of methanolic extracts of Ruta chalepensis (Rutaceae), Withania somnifera (Solanaceae), Cleome paradoxa (Capparaceae) and Heliotropium longiflorum (Boraginaceae) aerial parts against Culex pipiens larvae. Different concentrations (100-500 ppm) of the methanolic extracts of the plants were tested towards larval morta...

The leaf ethanol extract of Harpephyllum caffrum Bernh. has evidenced medicinal value due to its hepatoprotective activity. It demonstrated inhibitory effects on test standard microbes approximated to 40% the potency of ofloxacin and fluconazole. The same extract evidenced in vitro cytotoxicity on human cell lines, liver carcinoma HEPG2, larynx car...