Abduzhappar Gaipov

Abduzhappar Gaipov
Nazarbayev University | NU · School of Medicine

Doctor of Medicine

About

305
Publications
122,350
Reads
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7,593
Citations
Additional affiliations
January 2019 - present
Nazarbayev University
Position
  • Professor (Assistant)
January 2017 - July 2018
University of Tennessee Health Science Center
Position
  • PostDoc Position
Description
  • CKD clinical and epidemiological research methodology
September 2015 - September 2018
Astana Medical University
Position
  • Lecturer
Description
  • Medical Education Program for internship students (Module Nephrology) –164/3 (hours/weeks)
Education
January 2017 - July 2018
University of Tennessee Health Science Center
Field of study
  • ISN Research Fellowship and Post Doctoral Fellow
May 2015 - April 2016
ISN-ANIO CNC Program
Field of study
  • Renal Pathology Course
February 2015 - January 2016
ERA-EDTA Young Nephrology Platform
Field of study
  • Advisory Program

Publications

Publications (305)
Article
Full-text available
Background Endometriosis is a condition affecting reproductive-age women and associated with dysmenorrhea, pelvic organs dysfunction, pelvic pain, and infertility. The real epidemiology of endometriosis remains underestimated. No data are available on prevalence of endometriosis in Kazakhstan. Therefore, the aim of this was to investigate the epide...
Article
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Chronic kidney disease (CKD) is a progressive condition characterized by declining renal function, with limited biomarkers to predict its progression. The early identification of prognostic biomarkers is crucial for improving patient care and therapeutic strategies. This follow-up study investigated urinary proteomics and clinical outcomes in 18 CK...
Article
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b>Background and objective: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major contributors to chronic viral hepatitis (CVH), leading to significant global health mortality. This study aims to predict the one-year mortality in patients with CVH using their demographics and health records. Methods: Clinical data from 82,700 CVH patients d...
Article
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Background As set out in Sustainable Development Goal 3.3, the target date for ending the HIV epidemic as a public health threat is 2030. Therefore, there is a crucial need to evaluate current epidemiological trends and monitor global progress towards HIV incidence and mortality reduction goals. In this analysis, we assess the current burden of HIV...
Article
Full-text available
Background Central Asia is known to face various ecological challenges that constitutes major risk factors for Parkinson’s disease (PD). This study examines the burden of PD in Central Asia, a region where data on neurological disorders is notably sparse. Methods Building on the latest Global Burden of Disease Study (GBD 2021), this study investig...
Article
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We sought to assess cardiac magnetic resonance derived left ventricular hemodynamic forces (HDF) in athletes compared to patients with hypertension. Sixty athletes and 48 hypertensive patients were studied. HDF were measured during the entire cardiac cycle, the systolic phase, suction, early LV filling, and atrial thrust. Statistical comparisons we...
Article
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Background Cancer remains a leading cause of death both globally and in Kazakhstan, making it crucial to track its mortality trends. This study aimed to investigate cancer mortality trends from 2014 to 2022 in Kazakhstan. Methods This study utilized data from Kazakhstan’s Unified National Electronic Health System to perform descriptive data analys...
Article
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Tuberculosis (TB) is a highly contagious disease that remains a global concern affecting numerous countries. Kazakhstan has been facing considerable challenges in TB prevention and treatment for decades. This study aims to understand TB transmission dynamics by developing and comparing statistical and deterministic models: Seasonal Autoregressive I...
Article
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b>Aim : This paper examines the predictors of all-cause mortality among hospitalized HIV-positive patients in Kazakhstan. Material and methods : The study uses baseline data from patient hospital discharge records derived from the Unified Electronic Healthcare System of Kazakhstan (UNEHS) between 2014 and 2019. Artificial intelligence technology wa...
Article
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Peripheral artery disease (PAD) is a global health concern associated with arterial narrowing or blockage, leading to significant morbidity and mortality. The aim of this study is to assess the disease burden and trends in mortality utilizing nationwide administrative health data. This retrospective study utilized data from the Unified National Ele...
Article
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In this work, Brillouin light-scattering spectroscopy and optical backscattering reflectometry (OBR) using Mg–silica-NP-doped distributed sensing fibers were employed for monitoring local GHz visco-elastic properties and surface temperature, respectively, during laser driven heating and ablation of chicken tissues. The spatial temperature distribut...
Article
Full-text available
Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. We estimated incidence, prevalence, death, and disability-adjusted life-year (...
Article
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Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disabilit...
Article
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Chronic kidney disease (CKD) presents a significant global health challenge, often progressing to end-stage renal disease (ESRD) necessitating renal replacement therapy (RRT). Late referral (LR) to nephrologists before RRT initiation is linked with adverse outcomes. However, data on CKD diagnosis and survival post-RRT initiation in Kazakhstan remai...
Preprint
Full-text available
By assessing left ventricular hemodynamic forces (HDF) during different phases of the cardiac cycle, we aimed to provide insights into the cardiac adaptations in athletes as compared to patients with hypertension. Sixty athletes and 48 hypertensive patients were studied using cardiac magnetic resonance. HDF were measured during the entire cardiac c...
Article
Full-text available
Cardiovascular kidney metabolic (CKM) syndrome represents a complex interplay of cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic comorbidities, posing a significant public health challenge. Gender exerts a critical influence on CKM syndrome, affecting the disease severity and onset through intricate interactions involving...
Article
Background: Since late 2019, chronic renal disease, which complicates COVID-19 infection, has affected millions globally. Aim: To find key findings, prognosis, associated factors, outcomes, gaps, and recommendations related to COVID-19 in individuals with CKD. Methdology: A narrative review using keywords (COVID-19 OR SARS-CoV-2 OR 2019-nCoV Infect...
Article
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Aim: to determine the rate of mortality of cases with chronic kidney disease and its risk factors admitted to hospital with COVID-19 in Almaty City, Kazakhstan. Methods: Patients with coronavirus infections who were hospitalized at a hospital in the Kazakhstani Almaty region from June 2020 until June 2022 are included in the retrospective analysis....
Poster
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Cohort consisted of 8,660 children with ASD, 6,834 (78.9%) were males and 6,384 (73.7%) were urban residents. The mean age at diagnosis was 6.0±2.2 years. The majority of hospitalizations were due to psychiatric/neuropsychiatric cause (73%). Number of hospitalized children with ASD increased from 305 to 1053 patients from 2014 to 2021. Median follo...
Article
Full-text available
Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its related complications. Kidneys excrete hundreds of individual proteins, some with a potential impact on CKD progression or as a marker of the disease. However, the available data on specific urinary proteins and their relationship with CKD severity rema...
Article
Full-text available
The aim of this study was to investigate the epidemiology of congenital heart disease (CHD) in Kazakhstan, using the data from the Unified National Electronic Healthcare System (UNEHS) for the period of 2014-2021. This retrospective cohort study included all patients diagnosed with CHD in Kazakhstan and registered in the UNEHS between January 2014...
Article
Background and Aims The toxic effects of filtered proteins on the tubules cause a more rapid progression of disease in individuals with higher levels of proteinuria, suggesting the presence of “high-risk candidate” proteins that could contribute to CKD progression. In our previous cross-sectional proteomic study, vitamin D-binding protein (VTDB) sh...
Article
Background and Aims Proteinuria is the one of the main cause of kidney failure progression. There is inadequate data about protein components in urine and CKD severity. Our recent urinary proteomics study demonstrated the higher expression of CD44 in the urine proteome of healthy participants compared to CKD patients, arguing the protective role of...
Article
Full-text available
The coronavirus pandemic of 2019 has become a global health problem. This article presents an analysis of the scientific literature focusing on the pathogenetic and clinical parallels between the kidneys and SARS-CoV-2, as well as the state of kidney health in patients who have recovered from treatment. The goal is to analyze the effects of COVID-1...
Article
Objective Kidney transplantation is the gold standard therapeutic alternative for patients with end‐stage renal disease; nevertheless, it is not without potential complications leading to considerable morbidity and mortality such as post‐transplant diabetes mellitus (PTDM). This narrative review aims to comprehensively evaluate PTDM in terms of its...
Article
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This scoping review addresses the transformation and development of new healthcare systems in nine countries —Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Turkmenistan, and Uzbekistan over the period following the collapse of the Soviet Union from 1991 to the present. This assessment focuses on maternal and child health...
Article
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While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including hemoglobin A1c (HbA1c), t...
Article
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Background Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to...
Article
Full-text available
Background: Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to...
Article
Full-text available
According to the Global Burden of Disease (GBD) study, chronic kidney disease (CKD) was prevalent in 697.5 million individuals worldwide in 2017. By 2040, it is anticipated that CKD will rank as the fifth most common cause of death. This study aims to examine the epidemiology of CKD in Kazakhstan and to project future trends in CKD prevalence and m...
Article
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Background Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of D...
Article
b>Brief Description: The investigation of glomerular disease prevalence is vital for comprehending chronic kidney disease development, particularly in regions like Kazakhstan and Central Asia, where confirming data is lacking. This study focuses on the epidemiology of glomerular diseases, utilizing registered cases of glomerular diseases in the nat...
Article
Renal injury is among the leading causes of morbidity and mortality, however, there are no reliable indicators for determining the likelihood of developing CKD, CKD progression or AKI events. Vascular growth factors called angiopoietins have a role in endothelial function, vascular remodeling, tissue stabilization and inflammation, and have been im...
Article
Full-text available
We aimed to describe incidence and all-cause mortality of hematological pediatric malignancies (leukemia and lymphomas) in Kazakhstan based on nationwide large-scale healthcare data from the Unified National Electronic Healthcare System (UNEHS) for the 2014–2021 year period. The cohort included data of patients less than 18 years old with the diagn...
Article
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b>Aim : The aim is to clarify the prevalence of nonadherence to antidiabetic therapies among type 2 diabetes mellitus (T2DM) patients and identify its causes. Methods : A three-part questionnaire (general background, Knowledge-Attitude-Practice section, and non-adherence reasons) was developed. In total 324 diabetic patients were surveyed via telep...
Article
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https://pubmed.ncbi.nlm.nih.gov/38092509/#full-view-affiliation-41
Article
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Background Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiography, including Doppler (flow Doppler and Doppler myocardial imaging) and speckle-tracking, along with cardiac magnetic resonance,...
Article
Full-text available
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is a multinational collaborative research study with >10,000 collaborators around the world. GBD generates a time series of summary measures of health, including prevalence, cause-specific mortality (CSMR), years of life lost (YLLs), years lived with disability (YLDs), and disabi...
Article
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The purpose of this review is to describe the impact of endurance and strength physical training on the cardiovascular system by reviewing the molecular signaling pathways, which plays a key role in different muscle adaptations, and the cardiac changes in terms of metabolic and cardiac remodeling, and hemodynamics. In response to endurance-exercise...
Article
Full-text available
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The seasonal autoregressive integrated moving average (SARIMA) model is widely used for forecasting infectious disease incidence, including TB. However, there is a lack of comprehensive research on TB epidemiology and predictions for the future in Kazakhstan. Therefore, this s...
Article
Full-text available
Background Heart failure (HF) affected 64.3 million people worldwide and contributed to 9.9 million years lived with disability globally in 2017. Despite its global relevance, there is a lack of comprehensive statistics on the prevalence, incidence, and burden of HF in developing Central Asian countries. This study aims to fill the gap and present...
Article
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Objectives This study aims to estimate tuberculosis (TB) incidence, mortality rates and survival HRs in Kazakhstan, using large-scale administrative health data records during 2014–2019. Design A retrospective cohort study. Settings Data for patients with TB in Kazakhstan during 2014–2019, reported in the Unified National Electronic Healthcare Sy...
Poster
Full-text available
Cohort included data of patients less than 18 years old with the diagnosis of hematological malignancies registered in the UNEHS for the period of 2014-2019 years. Descriptive statistics were conducted to indicate socio-demographic characteristics of the cohort. Incidence, prevalence, all-cause mortality were calculated per 100 000 population. Cox...
Article
Proteinuria is a well-established biomarker of chronic kidney disease and a risk predictor of associated disease outcomes. Proteinuria is also a driver of chronic kidney disease progression toward end-stage kidney disease. Toxic effects of filtered proteins on proximal tubular epithelial cells enhance tubular atrophy and interstitial fibrosis. The...
Article
Full-text available
The epidemiology of type 1 diabetes mellitus (T1DM) in children aged 0-17 in Kazakhstan was explored using aggregated large-scale healthcare data from the unified national electronic health system (UNEHS) in 2014-2021. Incidence, period prevalence, and mortality rates per 100,000 population at risk were calculated. Cox proportional hazards regressi...
Article
Aim: To perform a meta-analysis to quantify the effect of tirzepatide on blood pressure and lipids. Methods: PubMed, Ovid/Medline, Web of Science, Scopus, Cochrane Library and CINAHL databases were screened and the randomized controlled trials evaluating the effects of tirzepatide on either blood pressure or lipid profiles were included. Result...
Article
Full-text available
Introduction Spontaneous pregnancy loss (SPL) is a common health problem that affects 1:10 of childbearing women, and is linked with physical and psychological complications. As the number of nationwide studies on the incidence of SPL is few, especially from middle-income countries, in this study we investigated the epidemiology, complications and...
Article
Full-text available
b>Purpose: Assessment of public knowledge of chronic kidney disease (CKD) is an essential step in development of CKD prevention and screening programs. Our aim was to estimate the level of public CKD knowledge and its predictors in the former Soviet Union countries using a validated questionnaire. Materials and methods: This cross-sectional survey...
Article
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Background: Cardiovascular diseases contribute to premature mortality globally, resulting in substantial social and economic burdens. The Global Burden of Disease (GBD) Study reported that in 2019 alone, heart attack and strokes accounted for the deaths of 18.6 million individuals. Ischemic heart diseases, including acute myocardial infarction (AMI...
Article
Full-text available
Background Although meningitis is largely preventable, it still causes hundreds of thousands of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030, and assessing trends in the global meningitis burden can help track progress and identify gaps in achieving these goals. Using data from the Global Burden of Diseases,...
Article
Full-text available
Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Metho...
Article
Full-text available
Background: Although meningitis is largely preventable, it still causes hundreds of thousands of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030, and assessing trends in the global meningitis burden can help track progress and identify gaps in achieving these goals. Using data from the Global Burden of Diseases...