Abdur Rauf

Abdur Rauf
University of Swabi · Department of Chemistry

Doctor of Philosophy
Phytochemistry, Pharmacology

About

607
Publications
221,645
Reads
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8,123
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Introduction
Abdur Rauf, Ph.D., is an Assistant Professor in the Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Pakistan. His research work focuses on Medicinal Chemistry, Nanotechnology, and Pharmacology. He is the author and co-author of more than 350 research papers published in peer-reviewed journals (Impact factor = 1410.94). He has won the Young Scientist Award from the Directorate of Science and Technology, and the Research Productivity award from the Pakistan Science Foundation.
Additional affiliations
November 2016 - January 2017
University of Swabi
Position
  • Head of Department
July 2015 - August 2016
University of Swabi
Position
  • Assistant Professor of Organic Chemistry
July 2015 - November 2016
University of Swabi
Position
  • Assistant Professor (HOD)
Education
August 2010 - August 2011
Pakistan Council of Scientific and Industrial Research
Field of study
  • Phytochemical screening of plants belong to KPK.
November 2007 - November 2009
Independent Researcher
Independent Researcher
Field of study
  • Isolation, biological activity
September 2007 - September 2011
Independent Researcher
Independent Researcher
Field of study
  • isolation

Publications

Publications (607)
Article
One of the leading global causes of death is cancer; even though several treatment methods have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones are a type of quinone that is found in nature and has vital biological roles. These chemicals have anticancer (antineoplastic), analgesic, anti-inflammatory, antimalar...
Article
Full-text available
A group of bioactive, isoprenoid pigments known as carotenoids is mostly present in fruits and vegetables. Carotenoids are essential for the prevention of physiological issues, which makes maintaining excellent health easier. They are effective functional ingredients with potent health-promoting properties that are widely present in our food and li...
Article
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Pistacia integerrima Stew ex Brandis is a valued medicinal plant used for curing various diseases such as diarrhea, fever, liver disorder, pain, asthma, and inflammation. The aim of this study was the isolation of bioactive leishmanicidal agents from the methanolic extract. The methanolic extract led to the isolation of flavonoids 3,5,7,4/-tetrahyd...
Article
Full-text available
Nanoscale engineering is one of the innovative approaches to heal multitudes of ailments, such as varieties of malignancies, neurological problems, and infectious illnesses. Therapeutics for neurodegenerative diseases (NDs) may be modified in aspect because of their ability to stimulate physiological response while limiting negative consequences by...
Article
The Himalayan region supports a wide diversity of flora and fauna; hence it is home to many natural resources. Despite this, the people living here are struggling for essential needs such as food and nutrition. However, in Himalayan region, wild plants and their fruits contribute significantly to the livelihood of local people and communities. Seve...
Article
Full-text available
The current study aimed to assess the pharmacological potential of Justicia adhatoda by evaluating the presence of biologically active compounds using the gas chromatography–mass spectrometry approach and to undertake biological activities for the effectiveness of the present compounds using standard tests. A total of 21 compounds were identified i...
Article
Full-text available
The galls of Pistacia integerrima are used in folk medicine for curing diabetes. The main aim of this study was the purification of flavonoids from galls of P. integerrima. The methanolic extract was subjected to column chromatographic analysis which afforded six flavonoids, namely, 3,5,7,4 ′ -tetrahydroxy-flavanone (1), naringenin (2), 3,5,4 ′ -tr...
Article
Full-text available
Cancer is commonly thought to be the product of irregular cell division. According to the World Health Organization (WHO), cancer is the major cause of death globally. Nature offers an abundant supply of bioactive compounds with high therapeutic efficacy. Anticancer effects have been studied in a variety of phytochemicals found in nature. When Food...
Article
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Colon cancer affects both men and women and is the world's second most significant cause of cancer-related mortality. Colon cancer death rates have risen worldwide due to the current food habit and lifestyle, which include a lot of meat, alcohol, and not enough physical exercise. As a result, novel, less harmful pharmacological treatments for colon...
Article
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key contributor to the carcinogenesis process and have therefore been implicated in several aspects of tumorigenesis, including cell differentiation, proliferation, invasion, angiogenesis, apoptosis, and metastasis. This pathway offers multiple molecular targets th...
Article
Background Thiosemicarbazones are an important class of synthetic organic compounds exhibiting promising biological activities; antiviral, antibacterial, antitubercular, antiprotozoal, antimalarial, antifungal, enzyme inhibitory and antitumor. Different α-(N)-heterocyclic thiosemicarbazones are potent inhibitor of ribonucleotide reductase enzyme th...
Chapter
Environmental Microbiology: Advanced Research and Multidisciplinary Applications focus on the current research on microorganisms in the environment. Contributions in the volume cover several aspects of applied microbial research, basic research on microbial ecology and molecular genetics. The reader will find a collection of topics with theoretical...
Chapter
Environmental Microbiology: Advanced Research and Multidisciplinary Applications focus on the current research on microorganisms in the environment. Contributions in the volume cover several aspects of applied microbial research, basic research on microbial ecology and molecular genetics. The reader will find a collection of topics with theoretical...
Article
SARS-CoV-2 was first discovered in Wuhan in late 2019 and has since spread over the world, resulting in the present epidemic. Because targeted therapeutics are unavailable, scientists have the opportunity to discover new drugs or vaccines to counter COVID-19, and a number of synthetic bioactive compounds are now being tested in clinical studies. Du...
Article
Currently, available therapeutic medications are both costly as well as not entirely promising in terms of potency. So, new candidates from natural resources are of research interest to find new alternative therapeutics. A well known combination is a β-sitosterol, a plant derived nutrient with anticancer properties against breast, prostate, colon,...
Article
Full-text available
The galls of Pistacia integerrima are used in folk medicine for curing diabetes. The main aim of this study was the purification of flavonoids from galls of P. integerrima. The methanolic extract was subjected to column chromatographic analysis which afforded six flavonoids, namely, 3,5,7,4′-tetrahydroxy-flavanone (1), naringenin (2), 3,5,4′-trihyd...
Article
Full-text available
Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples of brain disorders that have no cure. Besides, there is a huge demand for drugs that can cure th...
Conference Paper
Recently reported dimeric naphthoquinones (1-3), were isolated from chloroform fraction of Diospyros lotus roots. The chemical structures of isolated compounds were identified by using advanced NMR analysis. The pure constituents (1-3) were evaluated for their inhibitory enzyme activities such as urease, carbonic anhydrase, and α-chymotrypsin inhib...
Article
Full-text available
The sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms. Consequently, marine organisms have piqued the interest of scientists as an abundant source of natural resources with unique structural features and fascinating biological activities. Marine macrolide is a top-class natural product wit...
Article
Once the World Health Organization (WHO) declared the COVID-19 (Coronavirus Infectious Disease-19) outbreak to be pandemic, massive efforts have been launched by researchers around the globe to combat this emerging infectious disease. Strategies that must be investigated such as expanding testing capabilities, developing effective medicines, as wel...
Article
Full-text available
Background: Penicillium produces a wide range of structurally diverse metabolites with significant pharmacological impacts in medicine and agriculture. For the first time, a complete metabolome of Penicillium claviforme (P. claviforme) (FBP-DNA-1205) was studied alongside pharmacological research in this study. Methods: The metabolic profile of P....
Preprint
A ten-step bio-inspired enantioselective synthesis of peshawaraquinone, an uncommon and complex naphthoquinone mero-terpenoid is described. Key to the success of this synthetic pathway is a well-tuned HFIP-promoted metal-free allylation was developed to coupling lawsone with allylic alcohols, together with an usual organo-catalyzed [3+2] cycloaddit...
Article
Pistacia integerrima galls are traditionally applied for the treatment of various diseases pathological conditions and diseases. The aim of the present study was to explore the phytochemical and pharmacological importance of galls of Pistacia integerrima. The phytochemical study of the galls of Pistacia integerrima led to the purification of flavon...
Article
Full-text available
In the era of acquired microbial resistance (AMR), resulting in the ineffectiveness of antibiotics is of keen interest for researchers in current scenarios. Ten novel metal complexes of gemifloxacin have been synthesized by reacting it with essential and trace elements in a 2:1 ratio predetermined conducto-metrically. As these metals are either pre...
Article
In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journ...
Article
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Green silver nanoparticles (AgNPs) and crude ethanolic, methanolic, aqueous, and acetonic extracts from leaves of Agave americana, Mentha spicata, and Mangifera indica were scrutinized for possible antineoplastic and cytotoxic efficacy. In this study, all the synthesized AgNPs were characterized using UV-Vis spectroscopy, X-ray diffraction, SEM (sc...
Article
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Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and moiety of gamma-pirone, dense with a two-benzene ring structured, distributed widely in nature. Naturally occurring xanthones are found in micro-organisms and higher plants as secondary metabolites also in fungi and lichens. Compounds of the family C...
Article
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Rhazya stricta is a well-known medicinal plant and source of numerous potential secondary metabolites including steroids, alkaloids, tannins etc. R. stricta possess multi-medical applications and used for curing of various diseases such as inflammation, diabetes, sore throat, infectious, helminthiasis, arthritis and cancer. The current investigatio...
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There is increasing use of natural products including medicinal plants, phytopharmaceuticals, nutraceuticals, vitamins, and nutritional supplements for different health purposes worldwide
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The second wave of coronavirus disease 2019 (COVID-19) caused severe infections with high mortality. An increase in the cases of COVID-19-associated mucormycosis (CAM) was reported predominantly in India. Commonly present in immunocompromised individuals, mucormycosis is often a life-threatening condition. Confounding factors and molecular mechanis...
Article
Tomatoes (Solanum lycopersicum) are of great significance in terms of the worldwide consumption of nutritional diets. More than half of the production is sold as fresh products, while the whole fruit is still typically processed into various products, including canned tomatoes, paste, juice, and puree. Tomatoes are rich in phenolic compounds, which...
Article
Full-text available
Ficus benghalensis (Moraceae) is widely found in Asian Countries and has been traditionally prescribed owing to its analgesic, anti-inflammatory, and muscle relaxation properties. Purposely, in this study, phytochemical composition and isolation of fixed oil from F. benghalensis were comprehended for the first time. The fatty acids were isolated fr...
Article
Objective: Pleural effusion often occurs after CABG. Usually, this effusion is slight and asymptomatic. There is also high symptomatic effusion, but in a small percentage of patients. Pleural effusion after CABG may be associated with significant morbidity and prolonged hospital stay. Early diagnosis and treatment can reduce morbidity of patients a...
Article
Background and Aim: Cardiovascular diseases (CVDs) are the chronic non-communicable diseases and leading cause of mortality due to various risk factors such as diabetes, tobacco usage, hypertension, obesity, dyslipidemia, and physical inactivity. The incidence of CVDS is rising rapidly due to these risk factors. These risk factors track at differen...
Article
Fruits contain enormous source of vitamins that provides energy to the human body. These are also affluent in essential and vital vitamins, minerals, fiber, and health-promoting components, which has led to an increase in fruit consumption in recent years. Though fruit consumption has expanded considerably in recent years, the use of synthetic chem...
Article
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The main aim of this research was to explore Parthenium hysterophorus Linn phytochemically and pharmacologically. Phytochemical screening is important for the isolation of active compounds before bulk extraction. The crude extracts and their fractions were screened for enzyme (urease, α-glycosidase, and phosphodiesterase) inhibition assays, in vivo...
Article
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Purpose: The research study was prototyped to assess pharmacological activities (antimicrobial, anti-oxidant, phytotoxic and haemagglutination) of Agave americana, Mentha spicata and Mangifera indica leaves extracts. The positive outcomes of the study can aid in formulations of novel therapeutic opportunities by using natural, eco-friendly, and eco...
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Lettuce is one of the most famous leafy vegetables worldwide with lots of applications from food to other specific uses. There are different types in the lettuce group for consumers to choose from. Additionally, lettuce is an excellent source of bioactive compounds such as polyphenols, carotenoids, and chlorophyll with related health benefits. At t...
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The scientific community is endowed with the essential biogenic, eco-benign, and cost-effective synthesis of gold nanoparticles (AuNPs) of least explored Trillium govanianum methanolic extract. The study involved T. govanianum selection based on its tremendous therapeutic properties. These AuNPs were characterised by UV–visible spectroscope, atomic...
Article
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Diabetes mellitus (DM) is a metabolic syndrome. Diabetes has become more common in recent years. Chemically generated drugs are used to lessen the effects of DM and its following repercussions due to unpleasant side effects such as weight gain, gastrointestinal issues, and heart failure. On the other hand, medicinal plants could be a good source of...
Chapter
Legumes are grown in more than 120 countries across all the continents. 90% of the global production of legume are produced in small group of countries such as India, Turkey, Pakistan, Bangladesh, Nepal, Iran, Mexico, Myanmar, Ethiopia, Australia, Spain, Canada, Syria, Morocco and Egypt. Legume are vegetarian sources of proteins and are an integral...
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Hyperlipidemia, the most common form of dyslipidemia, is the main source of cardiovascular disorders, characterized by elevated level of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) with high-density lipoprotein cholesterol (HDL-C) in peripheral blood. It is caused by a defect in lipid metabolism in the...
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Congress grass (Parthenium hysterophorus L., family Asteraceae) is found generally in agricultural and vacant lands across the globe. This study investigated the fatty acids and elemental profiles of different parts including roots, stem and leaves of P. hysterophorus in the response to seasonal variation. The elemental analysis and fatty acid were...
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Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important startin...
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The family Lamiaceae contains several plants used in traditional medicine to fight against different diseases. Salvia verbenaca L. (S. verbenaca) is one of the Lamiaceae species distributed around the Mediterranean regions. This plant exhibits different bioactive properties, including antibacterial, anticancer, antioxidant, antileishmanial, antidia...
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Micromeria biflora, a traditional medicinal plant, is extensively used for treating various painful conditions, such as nose bleeds, wounds, and sinusitis. A phytochemical investigation of the chloroform fraction of Micromeria biflora led to the isolation of salicylalazine. Salicylalazine was assessed in vivo for analgesia, muscle relaxation, sedat...
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Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes. Entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivati...
Article
Coronavirus disease 2019 (Covid-19) is a primary respiratory disease with an alarming impact on citizens worldwide. Triggered by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Covid-19 may present with a variety of neurological symptoms, including headache, changes in consciousness and seizure/convulsion. SARS-CoV-2 has neuroinv...
Chapter
Global climate changes such as increasing CO2 levels, temperature increases, drought, etc., have been shown to adversely affect agricultural products. Weeds can be seen as a major problem because they seem to fight at the expense of the crop for resources such as light, water, and nutrients. Weed species are commonly favored in crops that are more...
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Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are e...
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Juglans regia L. are nutritious fruit bearing plants mostly found in Northern areas of Pakistan. The population of walnuts was explored from district Dir and Swat Khyber Pakhtunkhwa, Pakistan for their geographical, climatic and chemical divergence. The geographical differences such as altitude, latitude and longitude whereas climatic differences...