Abdur Rahman Ansari

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• Doctor of Philosophy
• Professor (Assistant) at University of Veterinary and Animal Sciences

Endotoxin or lipopolysaccharide (LPS) exposure can cause injury to the respiratory airways and in response, the respiratory epithelia express toll like receptors (TLRs) in many species. However, its role in the innate immunity in the avian respiratory system is poorly understood. The aim of the present study was to evaluate the effects of LPS on th...

Background Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes during TLR4 signaling under LPS stress in acute liver injury is poorly understood in avian species. The present investigation was ther...

The present work aimed at assessing passive, innate, and acquired immunity in piglets from sows supplemented with either organic or inorganic selenium (Se). A total of 12 multiparous pregnant sows were randomly allocated to three groups: selenium-deficient, corn and soy–based diet base diet (BD), 0.3 mg Se/kg as hydroxy-selenomethionine (OH-SeMet),...

Visfatin is involved in the body’s inflammation and immune response. Inflammation could promote, while visfatin may directly or indirectly mitigate the effects of apoptosis and autophagy. Whether visfatin lessens the detrimental effects of lipopolysaccharide (LPS)-induced mouse acute lung injury (ALI) is poorly understood yet. Therefore, in the cur...

The thymus is a lobulated unique lymphoid immune organ that plays a critical role in the selection, development, proliferation, and differentiation of T cells. The thymus of developing chickens undergoes continued morphological alterations; however, the biomolecular and transcriptional dynamics of the postnatal thymus in avian species is not clear...

Background At an early age, chickens commonly exhibit a rise in the average daily gain, which declines as they age. Further studies indicated that the decrease in chicken growth performance at a later age is closely associated with an age-related decline in Lactobacillus abundance in the small intestines. Whether inhibiting the age-related decline...

Enzymes being biological catalysts play a pivotal role in accelerating the chemical reaction. The rise in environmental pollution due to the use of hazardous chemicals in textiles leads to environmental unsustainability affecting the ecosystem. Replacement of these chemicals with biocatalysts that are biodegradable, reliable, stable, environment-fr...

Plastics derived from fossil fuels are an important part of modern life and it is the most commonly used material in every industrial sector. The use of plastics is increasing day by day and its degradation has become a great challenge. Moreover, non-degradable plastic polymers tend to accumulate as waste in the environment posing a major ecologica...

Cecal microbiota plays an essential role in chicken health. However, its contribution to fat metabolism, particularly in abdominal fat deposition, which is a severe problem in the poultry industry, is still unclear. Here, chickens at 1, 4, and 12 months of age with significantly (p < 0.05) higher and lower abdominal fat deposition were selected to...

Animals and poultry produce a significant amount of waste or by-products on a global scale. They are currently underutilized in high-value applications or used to produce relatively low-value goods like animal feed and pet food. The disposal of some animal by-products poses a significant environmental risk since they cannot be used to produce food...

Rising demand of diesel fuel of this high-traffic world compels us to produce more and more fuel which is not eco-friendly practice, so another way to achieve our goal safely is to produce biodiesel which is not only an alternative but also an excellent substitute. In other words, production of conventional diesel severely affects the environment a...

The present project was designed to study and compare different parameters of the forelimb and hind limb bones in juvenile, adult male and female rose-ringed parakeet in breeding and non-breeding seasons. For morphometric measurement, the forelimb and hind limb bones of juvenile and adult parrots (male = 9, female= 9) were collected in breeding and...

The present project was designed to study and compare different parameters of the forelimb and hind limb bones in juvenile, adult male and female rose-ringed parakeet in breeding and non-breeding seasons. For morphometric measurement, the forelimb and hind limb bones of juvenile and adult parrots (male = 9, female= 9) were collected in breeding and...

Visfatin, a multifunctional adipocytokine, is particularly important in the regulation of apoptosis and inflammation through an unidentified mechanism. Clarifying the control mechanisms of visfatin on inflammation and apoptosis in RAW264.7 cells and mice immunological organs was the goal of the current investigation. In order to create a pathophysi...

In several countries, organic or municipal solid wastes, such as cattle and buffalo manure, have become a serious political and environmental issue owing to organic waste incineration and garbage disposal. To overcome this problem, biogas production from manure, a green treatment that both contributes to the availability of sustainable energy and a...

Background Intestinal inflammation is prevalent in chicken, which results in decreased growth performance and considerable economic losses. Accumulated findings established the close relationship between gut microbiota and chicken growth performance. However, whether gut microbiota impacts chicken growth performance by lessening intestinal inflamma...

Background: Rapidly developed broilers are often accompanied by excessive fat deposition and markedly decreased feed utilization, which is a severe problem in the poultry industry. Recent studies established that gut microbiota significantly alters chicken fat deposition. However, what kind of cecal bacteria can regulate fat deposition and how they...

Streptococcus suis (S. suis) is an important zoonotic pathogen threatening the global pig farming industry. It causes respiratory and digestive tract infections simultaneously in pigs. The balanced gut microbiota not only affects the local mucosal immune response but also involves the regulation of the immune status of the distant lung tissues that...

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease caused by PRRS virus (PRRSV), characterized by sow reproductive failure and respiratory symptoms in pigs of all ages. PRRSV mainly causes severe lung damage by invading alveolar macrophages. Visfatin is closely related to acute lung injury, immune response and infla...

Visfatin is a multifunctional protein involved in inflammatory immune stress. The aim of current study was to explore the role of visfatin in lipopolysaccharide (LPS)-induced intestinal mucosal inflammation and to confirm its cellular effect in inflammatory immune response through silencing of Toll-like receptors (TLRs). We divided Kunming mice int...

It has been established that gut microbiota influences chicken growth performance and fat metabolism. However, whether gut microbiota affects chicken growth performance by regulating fat metabolism remains unclear. Therefore, seven‐week‐old chickens with high or low body weight were used in the present study. There were significant differences in b...

The present study aimed to explore the effects of supplemental boron on osteogenesis of tibia and to investigate the possible relationship between additional boron and the expression of bone morphogenetic protein-2 (BMP-2) in tibia of ostrich chicks. Therefore, forty-eight African ostrich chicks (15 days old) were supplemented with 0 mg/L, 40 mg/L,...

This chapter reviews the current knowledge about production and characterization of biogas as a sustainable energy source. Technology for biogas production is well established and principally employed for the generation of sustainable electricity from different feedstock as well as for the environment-friendly disposal of organic waste. Biogas, the...

Zoonoses include infectious diseases, usually transmitted between domestic or wild animals and humans. Rabies is a fatal neurological zoonotic disease caused by Lyssavirus, a bullet shaped virus affecting the central nervous system (CNS). About 55,000-60,000 individuals die of rabies annually around the world. Rabies is certainly the infection with...

In poultry industry, male chickens have a better growth performance than female ones under the same genetic background and diet. Emerging evidences proposed an important role of intestinal microbiota in chicken's growth performance. This study aimed to determine gut microbiota related gender based differences in the growth performance of chickens....

In order to obtain the porcine recombinant visfatin protein with high expression and low endotoxin content, the current study aims to express and verify the biological activity of the purified porcine recombinant visfatin protein. Firstly, four different expression strains were successfully constructed. Then they were simultaneously induced at 37℃...

The purpose of the present study is to determine if visfatin is involved in inflammation or apoptosis induced by LPS in rat. Forty Wistar rats were divided into four groups: saline group, LPS group, visfatin group and Visfatin+LPS co-stimulated group. Spleen samples from each group of rats were collected for study. The spleen structure was examined...

Background A growing body of evidences suggest critical role of the chicken gut microbiota in growth performance and fat metabolism. However, the underlying mechanism by which the gut microbiota affects chicken growth performance by regulating fat metabolism remains unclear. The purpose of current study was to compare cecal microbial communities be...

Visfatin acts as a significant regulator of inflammatory cytokines. However, the immunological response and therapeutic effects of visfatin under bacterial stress in murine lung tissue are still not clear. To investigate the role of visfatin on lipopolysaccharide (LPS)-induced acute lung injury (ALI), thirty Kunming mice were divided into Saline, L...

This study focusses on antibacterial properties and wound healing potential of curcumin cross-linked with chitosan-PVA membranes. The crude curcumin was extracted from the rhizome of (Curcumin longa) and chitosan-PVA 80 was also prepared separately. The synergistic potential 10, 20 and 30 mg of curcumin alone and in combination with chitosan-PVA wa...

Despite functionally different, both immune and reproductive systems communicate through an intricate signaling network. The reproductive organs may be affected by several sexually transmitted diseases however the activation of immune system may elicit a variety of reproductive challenges faced by dairy animals. Toll-like receptors (TLRs) activate...

Consequently, increasing demand and consumption of nonrenewable energy sources worldwide faces three crucial problems: high fuel prices, climatic changes, and pollution. This energy is basically used up by the automobiles, industries, and power generation sectors and is depleting gradually. Due to these reasons, the world is switching toward ecofue...

Toll like receptor 4 (TLR4), eosinophils and mast cells play significant role in host immunity during several pathogenic infections. However in vivo tissue expression of TLR4 and distribution pattern of eosinophils and mast cells in chicken bursa of Fabricius (BF) during Salmonella enterica serovar Typhimurium (STm) infection is poorly studied. The...

Glycoprotein B (gB), C (gC) and D (gD) of herpes simplex virus are implicated in virus adsorption and penetration. The gB, gC and gD are glycoproteins for different processes of virus binding and attachment to the host cells. Moreover, their expression is necessary and sufficient to induce cell fusion in the absence of other glycoproteins. Egress o...

Toll-like receptors (TLRs) identify the pathogen associated molecular patterns (PAMPs) and turn on the host immune responses upon breaching the natural barriers for instance intestinal mucosa or the skin by the pathogenic microbes. Each type of TLR induce unique expression pattern and target genes with respect to specific ligand. The expression and...

Spleen is one of the crucial sites for cellular and humoral immunity but it easily damaged during pathogenic infections resulting in immunosuppression. The current study was therefore performed to explore the mechanism of acute spleen injury induced by salmonella lipopolysaccharide (LPS) in young chicks. Healthy one-day-old Cobb strain broiler chic...

We investigated the mechanisms that induce atrophy of the chicken bursa of Fabricius (BF) upon lipopolysaccharide (LPS) treatment in young chicks. LPS treatment resulted in ~36% decrease in bursal weight within 36 h (P < 0.01). Histological analysis showed infiltration of eosinophilic heterophils and nucleated oval shaped RBCs in or near blood vess...

Acute thymic involution (ATI) is usually regarded as a virulence trait. It is caused by several infectious agents (bacteria, viruses, parasites, fungi) and other factors, including stress, pregnancy, malnutrition and chemotherapy. However, the complex mechanisms that operate during ATI differ substantially from each other depending on the causative...

The bursa of Fabricius is an immune organ unique to birds and possesses a specialized micro-environment that supports the differentiation of B cells and production of antibodies but, it can be damaged by lipopolysaccharide (LPS) derived from Salmonella typhimurium, one of the most deleterious food-borne pathogens. However, its mechanism of action a...

This study was undertaken to determine if visfatin is involved in the inflammation or apoptosis introduced by LPS in rats. Forty 8-week old Wistar rats were divided into four groups (n = 10 in each group) and injected with saline, visfatin, LPS and visfatin+LPS co-stimulated via caudal vein. The duodenum, jejunum and ileum were harvested from all t...

Haemonchus contortus is a blood sucking gastrointestinal (GI) parasite that causes heavy production losses in small ruminants due to their poor immune response and rapid development of anthelmentic resistance. Identifying genes involving in immune related pathways against GI nematode infection will assist in better responding and curing the ill eff...

Haemonchus contortus is a blood sucking gastrointestinal (GI) parasite that causes heavy production losses in small ruminants due to their poor immune response and rapid development of anthelmentic resistance. Identifying genes involving in immune related pathways against GI nematode infection will assist in better responding and curing the ill eff...

Boron is an essential trace element which plays an important role in process of metabolism and the function of the tissues. However, the effects of boron on the intestinal cells in African ostrich chicks are poorly reported. Therefore, this study was designed to investigate the role of boron on proliferation and apoptosis of the intestinal cells. A...

Background Thymus is the crucial site for T cell development and once believed to be immune privileged. Recently, thymus has gained special attention as it is commonly targeted by infectious agents which may cause pathogenic tolerance and subsequent immunosuppression. Results We analyzed thymic responses to the challenge with Salmonella typhimuriu...

Objective Identification of the candidate genes that play key roles in phenotypic variations can provide new information about evolution and positive selection. Interleukin (IL)-32 is involved in many biological processes, however, its role for the immune response against various diseases in mammals is poorly understood. Therefore, the current inve...

Toll-like receptor 4 (TLR4) plays a significant role in modulation of immunological tolerance in reproductive tract of human female. To better understand the functions of TLR4 in establishing and maintaining the pregnancy in pigs, this study was performed to investigate the cellular expression and distribution patterns of TLR4 in the uterus of preg...

Visfatin is an adipocytokine displaying multiple functional properties, which plays a role in the regulation of cell apoptosis and inflammation by an as yet unidentified mechanism. The aim of the present study was to determine if visfatin is involved in apoptosis pathway induced by LPS in rat Mesenteric lymph nodes (MLNs). Experimental rats were di...

The purpose of the present study is to determine if visfatin is involved in inflammation or apoptosis induced by LPS in rat. Forty Wistar rats were divided into four groups: saline group, LPS group, visfatin group and Visfatin+LPS co-stimulated group. Spleen samples from each group of rats were collected for study. The spleen structure was examined...

Agri cultural and animal husbandry college of Tibet university，lizhi， P. R. China;8 College of Agroforestry Engineering and planning, Nematode contagion is a core impediment to the profitable dairy production for livestock farms. Gastrointestinal (GI) parasitism causes weight loss and low milk production, along with h igh mortality in sheep and goa...

Nematode contagion is a core impediment to the profitable dairy production for livestock farms. Gastrointestinal (GI) parasitism causes weight loss and low milk production, along with high mortality in sheep and goat. The current intensive anthelmintics therapies to control parasitic burden resulted in the appearance of drug resistant parasitic str...

Previous studies revealed that thymus is a targeted immune organ in malnutrition, and high-boron stress is harmful for immune organs. African ostrich is the living fossil of ancient birds and the food animals in modern life. There is no report about the effect of boron intake on thymus of ostrich. The purpose of present study was to evaluate the ef...

Toll-like receptors (TLRs) play crucial roles in innate and adaptive immune responses to invading pathogens. TLR4 is responsible for the recognition of bacterial lipopolysaccharide (LPS) in different parts of central nervous system of many vertebrates. To better understand the functions of TLR4 in cerebellum of chicken, present study was designed t...

Foxn1 is essential for thymus development. The relationship between boric acid and thymus development, optimal dose of boric acid in ostrich diets, and the effects of boric acid on the expression of Foxn1 were investigated in the present study. Thirty healthy ostriches were randomly divided into six groups: Group I, II, III, IV, V, VI, and suppleme...

Bubaline paratuberculosis is a chronic, debilitating disease that has been implicated in causing reduced milk yield and poor carcass quality in affected animals. The objective of the current study was to depict the histopathological manifestations of paratuberculosis in subclinically infected Nili-Ravi buffaloes. For this purpose a total of 53 slau...

Bubaline paratuberculosis is a chronic, debilitating disease that has been implicated in causing reduced milk yield and poor carcass quality in affected animals. The objective of the current study was to depict the histopathological manifestations of paratuberculosis in subclinically infected Nili-Ravi buffaloes. For this purpose a total of 53 slau...

The purpose of the present study is to determine if visfatin is involved in inflammation or apoptosis induced by LPS in rat. Forty Wistar rats were divided into four groups: saline group, LPS group, visfatin group and Visfatin + LPS co-stimulated group. Spleen samples from each group of rats were collected for study. The spleen structure was examin...

Toll-like receptor 4 (TLR4) has been suggested to play a regulatory role in immune cell development; however, studies regarding the role of TLR4 in the development of the chick thymus are scarce. In this study, we investigated the distribution and expression pattern of TLR4 in normal chick thymi at different stages of development, in order to bette...

Paratuberculosis is chronic enteritis of the domestic ruminants caused by Mycobacterium avium subsp. paratuberculosis. Post-mortem examination of twelve naturally infected (displaying disease associated gut lesions) adult buffaloes was performed to accomplish explorative histopathology. Tissue samples were collected specifically from the small inte...

This study was conducted on ten Nili-Ravi buffaloes to elucidate the influence of season on the morphometric values of corpus luteum and ovary through ultrasonography in spring (February to April) and dry hot (May to June) seasons on alternate days during the entire length of estrous cycle in the same animals. A total of 10 ml of blood sample was t...