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Abdullahi Tunde Aborode

Abdullahi Tunde Aborode
Healthy Africans Platform · Research and Development

About

112
Publications
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434
Citations
Citations since 2016
112 Research Items
434 Citations
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Publications

Publications (112)
Article
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There is higher energy in the protein content than in other weaning foods; sorghum and millets are utilized as weaning food in Ethiopia, India, Tanzania, Uganda, and several other African countries. Traditional beverages and giant beers made from sorghum seeds have more nutrients than beers made using malt. The chemical composition and mycoflora of...
Preprint
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With a population of 1.3 billion people, of which 56% reside in rural settings, Africa seemed ill-prepared to handle the distribution of a COVID-19 vaccine. In addition, the capacity needed for a successful COVID-19 vaccination campaign in Africa surpassed the available resources in local and state health agencies. As a result, African governments...
Article
Full-text available
With a population of 1.3 billion people, of which 56% reside in rural settings, Africa seemed ill-prepared to handle the distribution of a COVID-19 vaccine. In addition, the capacity needed for a successful COVID19 vaccination campaign in Africa surpassed the available resources in local and state health agencies. As a result, African governments w...
Article
Full-text available
Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date, most FDA-approved tyrosine kinase (TK) inhibitors have been reported as dual inhibitors of EGFR an...
Article
COVID‐19 is an acute respiratory illness caused by Severe Acute Respiratory Syndrome‐Coronavirus 2 (SARS‐CoV‐2). The first case was reported in Africa on 14th February 2020 and has surged to 11 million as of July 2022, with 43% and 30% of cases in Southern and Northern Africa. Current epidemiological data demonstrate heterogeneity in transmission a...
Article
Introduction: Alzheimer's disease (AD) is a form of dementia which affects majority of the people. It is characterized by memory loss and other cognitive functions disabilities and is one of the most challenging neurodegenerative disorders to treat, because of its progressive nature. The disease affects millions of people all around the world, and...
Article
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There is an increase emergence of technologies in healthcare especially since the COVID-19 pandemic. In this paper, we discussed our perspective on how the Internet of Things (IoT), machine learning (ML), and blockchain technology contribute to Universal Health Coverage (UHC), especially in developing countries supported by current and robust resea...
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Africa experienced the third wave of the coronavirus disease in 2019, which caused an 18% rise in cases in most parts of the continent. As of January 2022, the region had an estimated 10.4 million cumulative cases and more than 233,000 deaths, which add up to the burden on the fragile healthcare system, which continues to face a shortage of staff a...
Article
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SARS-CoV-2 triggered a worldwide medical crisis, affecting the world’s social, emotional, physical, and economic equilibrium. However, treatment choices and targets for finding a solution to COVID-19’s threat are becoming limited. A viable approach to combating the threat of COVID-19 is by unraveling newer pharmacological and therapeutic targets pe...
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Background Malaria is a global infectious (vector-borne: Anopheles mosquitoes) disease which is a leading cause of morbidity and mortality in Sub-Saharan Africa (SSA). Among all its parasitic (protozoan: Plasmodium sp. ) variants, Plasmodium falciparum (PF) is the most virulent and responsible for above 90% of global malaria deaths hence making it...
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In the present work we reported the synthesis of Schiff bases from 4-phenoxy-5-sulfamoylbenzoic acid motif. The reaction was carried out by substitution of different aldehyde and ketones at sulfamoyl group of sulfamoylbenzoic acid. The generated substituted products (4a-4i) possessed potent structure activity relationship and exhibited drug like pr...
Article
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a respiratory pathogen with neuroinvasive potential. Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines such a...
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In Sub Saharan Africa, the morbidity and mortality rate from Non-Communicable diseases is increasing more than any place in the world. However, Sub Saharan Africa faces many challenges such as problems with financing, health system issues, contending interests from industry actors as well as low NCD awareness levels, which have impeded all efforts...
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Shortage of hospital bed capacity and overcrowding remains a significant problem in Nigeria's healthcare system. The problem is even more conspicuous in emergency units in various health institutions. Despite Nigeria's already high morbidity burden, overcrowding remains a problem in these parts. The problem of overcrowding in tertiary health instit...
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The crystal structure of N-((4-acetylphenyl)carbamothioyl)pivalamide (3) was synthesized by inert refluxing pivaloyl isothiocyanate (2) and 4-aminoacetophenone in dry acetone. The spectroscopic characterization (1H-NMR, 13CNMR, FT-IR) and single crystal assays determined the structure of synthesized compound (3). Systematic experimental and theoret...
Article
(1) Background: Achillea mellifolium belongs to a highly reputed family of medicinal plants, with plant extract being used as medicine in indigenous system. However, limited data is available regarding the exploitation of the medicinal potential of isolated pure compounds from this family; (2) Methods: A whole plant extract was partitioned into fra...
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Background The sheer quality of the female genital tract is not always respected at the time of childbirth because no protocol for the management of perineal tears exists in our services these days. The management remains dependent on a gynecologist and obstetrician. The study aimed to describe the characteristics of perineal tears. Methods Our cr...
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An estimated five billion people worldwide lack access to surgical care, while LMICs including African nations require an additional 143 million life-saving surgical procedures each year.African hospitals are under-resourced and understaffed, causing global attention to be focused on improving surgical access in the continent. The African continent...
Article
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Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multip...
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Compounds isolated from natural sources have been used for medicinal purposes for many centuries. Some metabolites of plants and microorganisms possess properties that would make them effective treatments against bacterial infection, inflammation, cancer, and an array of other medical conditions. In addition, natural compounds offer therapeutic app...
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Risks of heavy metal exposure from contaminated indoor dust constitute a major threat to human health. In this paper, heavy metals in deposited indoor dust samples from four tertiary institutions in Ondo State, Nigeria—Federal University of Technology, Akure; Federal College of Agriculture, Akure; Ondo State College of Health Science Technology, Ak...
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Ebola virus disease is one of the most serious and deadliest infectious diseases in the world with a sufficient number of recorded deaths. Since its discovery in 1976 until its last epidemic (14th), recorded and declared on April 23, 2022 by the National Minister of Public Health of the Democratic Republic of Congo and we have observed a succession...
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Introduction Syphilis is a treatable but highly contagious sexually transmitted disease (STI) that has a long history of infecting millions of people from diverse ethnicities and is mainly considered promiscuity. An uprise in syphilis cases is noted in the Coronavirus pandemic. This short communication discerns salient factors precipitating the syp...
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Children in detention in Africa are part of the vulnerable population exposed to the COVID-19 pandemic due to factors such as overcrowding, poor healthcare of inmates, and lousy state of the facilities. The number of children in detention was estimated to be about one million in 2010, and this has further increased threat to global health. The fall...
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The current study included density function theory calculations, molecular docking studies, SeeSAR analysis, molecular dynamics studies and assessments of the absorption, distribution, metabolism, excretion and toxicity properties (ADMET) of N-(4-acetyl-4,5-dihydro-5-(7,8,9-substituted-tetrazolo[1,5-a] acetamides of -quinolin-4-yl)-1,3,4-thiadiazol...
Article
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Malaria is one of the deadliest infectious diseases in Africa. Many measures have been taken over the past few years to reduce the burden of malaria on public health following the recommendation of WHO, still, malaria has continued to rake devastation in Africa. Combating malaria in Africa has grown into an international concern. The eradication of...
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Climate change and its reflection on tropical health in the Central African Republic (CAR) are primary indicators of how the CAR gives attention and concern to its environment. Climate change has a significant impact on the environment and consequently on humanity's survival. Different tropical diseases that stem from changes due to climate affect...
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Access to maternal health care is limited for women in Africa, while it remains a crucial determinant of maternal mortality and morbidity. The utilization of telemedicine and digital health can help remove barriers to access through economical and geographical convenience. In addition, feasible frameworks operating on themes such as technology, use...
Article
Introduction. - The economic crisis in Lebanon, a middle-income eastern Mediterranean country, has been threatening the health of the local population. This review will look at the impact of the economic crisis and Covid-19 on health and healthcare in the country, discussing food insecurity and water shortages, and the hospital crisis for what conc...
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The effect of COVID-19 is enormous, and high-risk COVID-19 case arises when underlying infections like diabetes, chronic obstructive pulmonary disease, heart failure, coronary artery disease, or cardiomyopathy are present, and an immunocompromised state such as Human Immunodeficiency Virus (HIV). People living with HIV(PLHIV) may be exposed to seve...
Article
Neglected Tropical Diseases (NTDs) are a group of twenty (20) chronic, communicable, infectious diseases endemic to the tropics and sub-tropics climate countries which are intimately associated with poverty, poor sanitation, limited clean water, and healthcare delivery; and dwellers live in proximity to pathogens and diseases vectors. The pathogens...
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Introduction Mixed connective tissue disease (MCTD) is a rare autoimmune condition characterized by Scleroderma, Polymyositis, and Systemic Lupus Erythematous (SLE). Though a possible relationship between COVID-19 and autoimmune diseases has been recently reported, its pathophysiological mechanism behind flares in Lupus Nephritis (LN), a complicati...
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Virus outbreaks have always been a cause of concern for public health. The recent reports of Nipah Virus cases amidst the COVID‐19 pandemic is alarming for India. With the pandemic impacting the world, healthcare systems are strained and focused on the strategies to curb the spread of the COVID‐19. However, the Nipah virus has high pathogenicity an...
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The first case of COVID-19 was identified in December 2019. In just two years, the pandemic has wreaked a lot of havoc across the globe. Various determining factors will decide the fate of a looming third wave in India. Although there is no direct evidence of a third wave, many metro cities in India have reported a surge of new cases despite mass v...
Preprint
Full-text available
SARS-CoV-2 triggers a worldwide medical crisis, affecting the world's social, emotional, physical, and economic equilibrium. However, treatment choices and targets for finding a solution to COVID-19's threat are becoming limiting. A viable approach to combating the threat of COVID-19 is to create pharmacological and therapeutic targets by uncoverin...
Preprint
Full-text available
Essential oils are important source of rich medicinal compounds. They are highly volatile, aromatic compounds from natural origins. The essential oils cause the hydrophobility of the bacteria cytoplasm, resulting to the cell wall degradation. The recent activity studies of Lantana camara have mapped out the need to investigate the antibacterial pot...
Article
COVID-19-related morbidity and mortality are significantly increased with increasing age and the presence of co-existing health conditions, such as cancer and cardiovascular disease. While most infected people recover, even very young and otherwise healthy patients may unpredictably succumb to this disease. COVID-19 is highly susceptible to Angiote...
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Prostate cancer (PCa) is the most common malignancy found in men and the second leading cause of cancer-related death worldwide. Castration-resistant prostate cancer (CRPC) is defined by PCa cells that stop responding to hormone therapy. Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) plays a critical role in the biosynthesis of androgens in...
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Reasons why some parts of Nigeria are not having an equitable supply of COVID vaccines along with some suggestions to tackle the situation.
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The plague has been wreaking havoc on people in Madagascar with the COVID-19 pandemic. Madagascar’s healthcare sector is striving to respond to COVID-19 in the face of a plague outbreak that has created a new strain on the country’s public health system. The goal and activities of the gradual epidemic of plague in Madagascar during COVID-19 are des...
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In February 2021, a new Ebola virus disease outbreak was confirmed amid the COVID-19 pandemic in the Democratic Republic of Congo. Although the country has successfully contained the outbreak amid its fight against the COVID-19 pandemic, the epidemiological situation is still concerning, primarily due to the risk of an increase in the number of COV...
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Levofloxacin (LEV) is an antibiotic that has a negative ecotoxicological effect. Its mitigation from the aqueous environment is achievable by adsorption. The aim of this paper was to review the removal of LEV from aqueous media via adsorption. The goal was to carefully study the trends of research findings by various authors over the past two decad...
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Coronavirus disease 2019 (COVID-19) and measles are major threats to the health and wellbeing of Africans. Measles is an endemic disease in Africa with a high mortality rate especially in children despite available vaccines. This letter aims to discuss the impact of the COVID-19 pandemic on prevention and management of measles in Africa. The emerge...
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COVID-19 has become a global public health obstacle. This disease has caused negligence on mental health institutions, decreased trust in the healthcare system and traditional and religious beliefs, and has created a widespread stigma on people living with mental health illness, specifically in Nigeria. The increase of COVID-19 cases that have exha...
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Medical education has undergone numerous reforms within the last century. Such reforms have produced numerous models of curricula across the world, which includes but is not limited to organ systems-based, problem based and traditional discipline based medical curricula. The system based of medical education in Nigeria need reform as different syst...
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Zika virus remains endemic and opportunistic of high transmission in the tropical region of Africa, and the repeated cases of the Zika virus in Africa made it public health emergency in 2016. Amidst the COVID-19 pandemic, the catastrophic cases of unknown and unreported deaths overwhelming the region of Africa could not give health attention to res...
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Self-medication is known as "the usage of drugs, herbs or home remedies on one's own initiative, or on the advice of another person, without consulting a doctor'. In Africa, self-medication has reached a critical stage, with people using and taking any drug regardless of how poisonous the material may be as long as unprofessional suggestions advoca...
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The political and military advance of the Taliban, reduced healthcare capacity, and imminent humanitarian crisis risk exacerbating an already very serious threat posed by COVID-19 in Afghanistan. The continued rise of COVID-19 cases in Afghanistan appears inevitable, but poor diagnostic capacity prevents accurate case measurement, while vaccine pro...
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Dengue fever (DF) is a significant public health problem in the African continent. The primary prevention strategy against the disease is vaccination and entomological control of vectors; however, implementing such a strategy in several countries in the continent is far below what is necessary to control the disease. The Coronavirus disease (COVID-...