Abdullah Emre Yildirim

• Professor (Assistant) at Gaziantep University

Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagno...

Background/Aims Pancreatic steatosis (PS) is a pathology associated with metabolic syndrome (MS), endocrin and exocrine disfunctions of the pancreas, and fatty liver. The data on the frequency of PS are very limited. We aimed to evaluate the frequency of PS detected by transabdominal ultrasonography (TAU) in gastroenterology clinics located in diff...

Background and Aim The aims of the present study were to evaluate the real-life efficacy and tolerability of glecaprevir (GLE)/pibrentasvir (PIB) in the treatment of patients with chronic hepatitis C (CHC). Materials and Methods Between May 2019 and May 2022, 686 patients with CHC, treated with GLE/PIB combination from 21 participating centers in...

Background: The present study aimed to evaluate the effects of fermented oligosaccharide, disaccharide, monosaccharide and polyols (FODMAP) diet therapy and probiotics on irritable bowel syndrome (IBS) symptoms, quality of life and depression in women diagnosed with IBS. Methods: For the study, 52 female IBS patients between the ages of 20 and 5...

Background: Cirrhosis, the end result of liver injury, has high mortality globally. The effect of country-level income on mortality from cirrhosis is unclear. We aimed to assess predictors of death in inpatients with cirrhosis using a global consortium focusing on cirrhosis-related and access-related variables. Methods: In this prospective obser...

Objective: Sarcopenia is one of the most significant contributors to morbidity in patients with chronic liver disease. Serum myokines are potential biomarkers for detecting early sarcopenia. We aimed to investigate the relationship between serum myokines and cirrhosis-related mortality in the early stages of the disease. Methods: In total, 262 p...

Objective: Minimal hepatic encephalopathy is a condition characterized by decreased perception and consequently deterioration in quality of life, and there is still limited data on its treatment. The aim of this study is to compare the efficacy of lactulose and Lactobacillus rhamnosus GG treatments by critical flicker frequency test in minimal hepa...

Background: We aimed to determine the awareness of referring hepatitis C virus patients to the relevant departments and the effect of the pandemic period on this subject. Methods: A total of 65 743 patients with anti-hepatitis C virus requests before and during the COVID-19 pandemic were retrospectively screened. Anti-hepatitis C virus-positive...

Objective: Nailfold Videocapilloroscopy (NVC) is an examination method that is used as an aid in the diagnosis, follow-up, and treatment strategy of rheumatic diseases such as systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and gives an idea about microcirculation by examining the vascular bed. It is a cheap, easily applicab...

Introduction: There is limited research about HBV reactivation (HBVr) due to direct-acting antivirals (DAA) for HCV and most are limited by short duration of follow-up, small sample size and absence of baseline HBV-DNA. We aimed to determine the incidence and clinical course of HBVr in HBsAg and/or anti-HBcIgG positive patients treated with DAA fo...

Background: The exocrine function of the pancreas is controlled by the autonomic nervous system (ANS), and autonomic neuropathy is a common and serious complication of diabetes. There are many factors contributing to the development of autonomic neuropathy in diabetic patients. Cardiovascular tests have been developed to evaluate the function of t...

Clinically significant bleeding is an uncommon complication of diagnostic endoscopic retrograde cholangiopancreatography. But the endoscopists needs to be skilled at prevention and management. Post ERCP bleeding is most often seen following sphincterotomy. The overall risk of bleeding in patients undergoing sphincterotomy is approximately 1-2 perce...

Background/aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population. Material and methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received le...

Amaç: İrritabl bağırsak sendromu olan kadınlarda düşük FODMAP diyet tedavisinin (fermente oligosakkarit, disakkarit, monosakkarit ve polioller) İBS semptomlarına ve yaşam kalitesi üzerine etkilerinin değerlendirilmesidir. Bireyler ve Yöntem: Çalışma, 26 kadın İBS hastası (20-49 yaş) üzerinde yürütülmüştür. Bireyler 6 hafta boyunca düşük FODMAP diye...

The morbidity and mortality associated with obesity have been known since the time of Hippocrates. Obesity has reached epidemic proportions worldwide and becomes a more serious medical, social, and economic problem recently. Lifestyle modification and pharmacotherapy have limited benefit. Bariatric surgery is an effective method of durable weight r...

Objective: Stapedial acoustic reflex is an easily accessible and applicable test which is also valuable for the clinical conditions which affect the various locations of the central nervous system. Searching the diagnostic value of stapedial acoustic reflex at minimal hepatic encephalopathy is the aim of this research. Methods: Diagnosis of mini...

Background: There are limited data about the mortality and morbidity of patients with HBV flare related to immunosuppressive treatments (IST) in the third-generation antivirals era. Herein, we performed a multi-centric study in patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) and evaluated their clinical course. Method...

Background/aims: The primary aim of this study is to identify whether an autoimmune sensorineural hearing loss is an extraintestinal neurological manifestation in adult CD patients. The secondary aim is to identify whether the duration of a gluten-free diet has an effect on the hearing levels of CD patients. Materials and methods: This prospecti...

Introduction: Biliary stent placement is the treatment of choice for malignant biliary obstruction caused by unresectable carcinomas. The purpose of this study was to compare the type of obstructions, changes in biochemical parameters before and after endoscopic retrograde cholangiopancreatography (ERCP), complications, and mortality rate of patien...

Objective: The aim of the present study was to compare relative contribution of apparent diffusion coefficient (ADC) values and ADC ratios (ADC of the lesion/ADC of the neighboring hepatic parenchyma) in the differential diagnosis of benign and malignant focal hepatic lesions.Methods: A total of 80 patients with 94 focal hepatic mass lesions (mean...

Anastomoz darlıkları kolorektal cerrahinin bilinen bir komplikasyonu olmasına rağmen benign hastalıklarda komplet kolonik anastomoz obstrüksiyonu nadirdir. Benign darlıklar low-anterior rezeksiyon sonrası yapılan kolorektal anastomozda nispeten sık görülen bir komplikasyondur ve kolorektal anastomozların %5-22’sinde gelişebilir. Günümüzde benign an...

Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role in duodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection on clinical, laboratory, and endoscopical features of duodenitis in patients with dyspeps...

Background and aims: The application of endoscopic retrograde cholangiopancreatography (ERCP) in the octogenarian population is limited. The aim of the study was to compare the clinical characteristics and outcomes of ERCP in octogenarian patients with non-octogenarian elderly patients. Materials methods: A total of 1044 patients who underwent E...

Introduction: Celiac disease (CD) is a disease that involves many organs including the liver and is caused by autoimmune enteropathy. We aimed to compare the CD frequency between the cryptogenic cirrhosis and cirrhosis due to hepatitis B virus (HBV) and hepatitis C virus (HCV). Materials and methods: Patients with cryptogenic cirrhosis (n=83), HCV...

Experience with endoscopic retrograde cholangiopancreatography in the pediatric population is limited. The aim of this study was to evaluate the outcomes of ERCP in the pediatric population performed by adult gastroenterologists with standard duodenoscopes. This study is a structured retrospective review of endoscopic reports, computerized and pape...

Objectives To observe the effects of both propofol/alfentanil and propofol/ketamine on sedation during upper gastrointestinal system endoscopy in morbidly obese patients (UGSEMOP). Methods In a prospective, double-blinded, randomized clinical study, 52 patients scheduled for UGSEMOP were assigned to either group A (n=26; 10 µg/kg intravenous [IV]...

Objective: Irritable bowel syndrome (IBS) is a common functional intestinal disorder. Although there are marked improvements in the conceptualization of IBS pathophysiology in brain-intestinal interaction disorder, there is no definite consensus in the role of autonomic dysfunction (AD) in disease development and symptom progression. The aim of th...

Introduction: Cirrhosis has various etiologies, and the etiologic distribution differs from center to center. Our aim is to reveal the etiological distribution and clinical features of cirrhotic patients. Materials and methods: We retrospectively recruited 1144 patients. Of patients, 480 were cirrhotic, 664 were non-cirrhotic. Patients were diagnos...

Introduction: According to our national health care system previous guidelines, lamivudine (LAM) or telbivudine treatment should be initiated in the naive chronic hepatitis B (CHB) patients with low viral load. We aimed to investigate the success of LAM treatment in one year period. Materials and methods: We retrospectively recruited 125 naive CHB...

Vasoconstrictor therapy with terlipressin and concomitant albumin can improve renal function in patients with hepatorenal syndrome (HRS) type 1, but the efficacy of therapy in patients with active infection is controversial. The aim of this study was to investigate the efficacy, adverse effects, and predictors of terlipressin therapy and to find ou...

Objective: The aim of this study is to examine the clinical status of the patients who were requiring intensive care as the victims of the Syrian civil war. Material and Methods: Clinical characteristics, health state at admission into General Intensive Care Unit (GICU), treatments in GICU, expected, and actual mortality rates estimated based on AP...

Background/aims: The purpose of this study was to evaluate the technical/hemodynamic success, complications, and biochemical/ hematologic consequences of transjugular intrahepatic portosystemic shunt (TIPS) created with 10-mm bare stents in our patients. Materials and methods: Data of 27 cirrhotic patients (18 men and 9 women; mean age, 39.7±18....

Background/aims: The efficacy of immune response against hepatitis C virus (HCV) is determined by human leukocyte antigen (HLA) molecules of the host which present HCV antigens to CD4 + and CD8 + T lymphocytes. In this study, we aimed to investigate the possible relationship between the frequencies of certain HLA class I-II alleles and the natural...

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease characterized with symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. There has been a dramatic increase in the diagnosis of this disease in recent years. The primary objective of this study was to determine the frequency of EoE...

Background/Aims: The frequency of drug-related gastrointestinal adverse effects, including pancreatitis, has increased with the development and use of chemotherapeutic agents. Methods: In our country, a combination of vincristine, doxorubicin, and dexamethasone is frequently used as the first line of therapy in newly diagnosed multiple myeloma. A c...

Chylous ascites is the accumulation of lipid-rich lymph in the peritoneal cavity. The usual cause in adults is lymphatic obstruction or leakage caused by malignancy. Non-malignant causes include postoperative trauma, cirrhosis, tuberculosis, pancreatitis and filariasis. A variety of treatment options have been proposed for the management of chylous...

Increased serum bilirubin levels are common after living-donor hepatectomy. Little information is available on the characteristics and clinical significance of serum bilirubin levels soon after donor hepatectomy. Since September 2001, we performed 229 living donor hepatectomies for living-donor liver transplantations. The 128 men and 101 women had...