Abdullah Mohammed Farasani

Background: Peripheral nerve regeneration is a critical research area with significant implications for neurology, neurosurgery, and regenerative medicine. A bibliometric analysis was conducted to provide a structured overview of research trends, intellectual impact, and evolving themes in peripheral nerve regeneration. This study aimed to identify...

Naunyn–Schmiedeberg’s Archives of Pharmacology (NSAP) is the world’s oldest journal in the field of pharmacology. Approximately fourteen bibliometric studies published by NSAP have examined its scholarly trajectory and role in pharmacology. However, no study has yet thoroughly analyzed author contributions throughout the journal’s recent history. T...

Background Gantenerumab (GR), a promising therapeutic agent for Alzheimer's disease (AD), has been the subject of extensive research. In this study, we aimed to provide a comprehensive analysis of the literature on GR. Methods A systematic search was conducted using the PubMed, Scopus, and Web of Science databases. VOSviewer and Bibliometrix were...

Building upon previous bibliometric studies, this analysis expands the dataset and refines analytical methods to offer deeper insights into spirituality in nursing education. Using bibliometric techniques with Scopus, VOSviewer, and R Studio, 1227 papers were analyzed to identify key author contributions, leading institutions, and international col...

The primary objective of this study is to analyze the number of Deutsche Forschungsgemeinschaft (DFG)-sponsored papers published in Naunyn–Schmiedeberg’s Archives of Pharmacology (NSAP), the oldest pharmacology journal in the world. This is the first systematic investigation of DFG-sponsored research in NSAP. Using the Scopus database, which provid...

Naunyn–Schmiedeberg’s Archives of Pharmacology has been a prominent journal in pharmacology since its inception in 1873, contributing significantly to experimental and clinical pharmacology, as well as toxicology. Despite its origins as the official journal of the German Society of Experimental and Clinical Pharmacology and Toxicology, there is a c...

Germany has played a central role in the development of Naunyn–Schmiedeberg’s Archives of Pharmacology (NSAP), historically leading its publication output for nearly 150 years. However, recent bibliometric analysis of 25,935 articles revealed a dramatic decline in German contributions, with the country falling to fifth place between 2021 and 2025....

This study examines twelve (12) bibliometric research published in Naunyn–Schmiedeberg’s Archives of Pharmacology and offers suggestions to improve future bibliometric analyses. By reviewing twelve influential studies, the research focuses on identifying trends in methodologies, databases, and bibliometric indicators. The reviewed studies span dive...

Background/objectives Neutrophil elastase (NE) is a serine protease primarily produced by neutrophils, playing a pivotal role in various physiological and pathological processes. This study aimed to provide insights into the research landscape surrounding NE and its implications in the post-COVID-19 era. Methods The current study employed a cross-s...

Background/objectives Neutrophil elastase (NE) is a serine protease primarily produced by neutrophils, playing a pivotal role in various physiological and pathological processes. This study aimed to provide insights into the research landscape surrounding NE and its implications in the post-COVID-19 era. Methods The current study employed a cross-...

Sleep deprivation research (SDR) has undergone substantial transformations in the aftermath of the COVID-19 pandemic. This comprehensive study explores the SDR’s evolving trends, hotspots, and conceptual structure in the post-COVID-19 era. Using bibliometric analysis with VOSviewer and Bibliometrix software, we examined the SDR publications from Ja...

Research and clinical practice have explored various applications of artificial intelligence (AI) in the field of attention deficit/hyperactivity disorder (ADHD). This study aimed to understand the current landscape and trends in AI-ADHD research. Data were extracted from the Scopus database via search terms generated from the MeSH database and ana...

To conduct a comprehensive bibliometric analysis of the top 100 most cited papers in aesthetic plastic surgery. The analysis utilized VOSviewer, bibliometrix and biblioshiny packages in R. A keyword analysis was performed on all publications. Annual publication trends, mean total citations per article (MeanTCperArt), mean citation rate per year (Me...

The Journal of Religion and Health (JORH) has significantly contributed to the intersection of spirituality and healthcare since its inception in 1961. We analyzed the top 100 most cited papers published in JORH, which may provide insights into authorship patterns, institutional affiliations, and publication dynamics. The data was retrieved from th...

This study provides a comprehensive analysis of ten papers published in Aesthetic Plastic Surgery, focusing on the identification of critical gaps and the integration of diverse analytical approaches. Through a detailed review, we observed missing indicators such as comprehensive bibliometric metrics and qualitative assessments of research impact....

This study analyzed the growth, collaboration, citation trends, and emerging topics in nanoparticle-based vaccine and adjuvant research (NVAR) from 1977 to 2023, using data from the Scopus database. The field showed a steady growth rate of 7.53% per year. Leading researchers Jaafari, M.R. and Alving, C.R. contributed significantly to the field, wit...

Background Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review...

Background Fistulas, abnormal connections between two anatomical structures, significantly impact the quality of life and can result from a variety of causes, including congenital defects, inflammatory conditions, and surgical complications. Stem cell therapy has emerged as a promising alternative due to its potential for regenerative and immunomod...

Abstract Aim: To develop and characterize doxorubicin-loaded sodium selenite nanoparticles (SSNP-DOX) and their surface attachment with cetuximab (mAb-SSNP-DOX). Methods: SSNP-DOX was formulated by gelation and then conjugated with cetuximab to form mAb-SSNP-DOX. Characterization included DLS, SEM, TEM, DSC, Raman spectroscopy and XRD. In vitro, t...

Background Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease marked by severe gastrointestinal inflammation and a broad range of debilitating symptoms. Despite advances in medical treatments, achieving sustained remission remains challenging for many patients. This umbrella review aims to consolidate evidence from various s...

Background This study examined the effects of khat extract on the proinflammatory cytokines, liver, and kidneys of rats. Unlike previous research that focused on broad immune markers and general effects, this study investigated specific proinflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, and TNF-α) and considered gender differences in the immune re...

Background and Purpose In the present work, chitosan is furnished with tin dioxide (CsSnO 2 ) nanoparticles (NPs) synthesized using the green route using Moringa oleifera ( M. oleifera) flower extract. Methods These preparation methods are low-cost, easily reproducible, nontoxic, and eco-friendly. X-ray diffraction (XRD), dynamic light scattering...

The project aimed to conduct an up-to-date and comprehensive bibliometric analysis of robotic surgery to provide a detailed and holistic understanding of the field. Three strategies were employed in the data analysis i.e. search terms were explored in (A) the title, abstract, and keywords and (B) only in the title of the documents. In 3rd part we a...

Objective Liquid biopsy has revolutionized cancer research, diagnosis, and personalized treatment. This study aimed to explore regional contributions and disparities in this rapidly advancing field. Method The Scopus database was utilized for data retrieval in June 2024. A total of 2761 documents, including 1605 articles and 1156 reviews, were ana...

Objective Frankincense (Boswellia) and Myrrh (Commiphora) are natural substances that have a long history of traditional use and potential therapeutic applications. This study aimed to provide comprehensive insights into the literature on Frankincense and Myrrh research (FMR) by examining patterns, perspectives, and research trends within the resea...

Coagulation dysfunction has emerged as a significant aspect of COVID-19 pathophysiology, with abnormal coagulation parameters observed in severe cases. This study aimed to investigate the predictive value of coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (PTT), and international normalized ratio (INR)...

Background Castanea sativa Mill. is important for ecosystems and societies. Its rich historical and cultural significance, remarkable ecological contributions, and diverse applications have inspired scientific research. This comprehensive review and conceptual mapping of chestnut research consolidates existing knowledge, identifies emerging trends,...

Background Research on Coffea arabica focuses on various aspects, including genetics, breeding, climate change resilience, pest and disease management, agronomy, sensory analysis, and sustainability. This study aims to analyze the hotspots, conceptual map and dynamicity, global landscape, and emerging trends in Coffea arabica research (CA-R). Meth...

INTRODUCTION Previous studies have identified several risk factors for acute coronary syndrome (ACS). This study was intended to examine the potential risk of ACS associated with khat and tobacco use. METHODS A case-control study of 344 people (172 cases and 172 controls) was conducted at Prince Mohammed Bin Nasser Hospital in Jazan, Saudi Arabia,...

All authors made significant contributions to the research. Taha MME conducted investigations, played various roles, and wrote the original draft while also curating the data. Abdelwahab SI was involved in data curation, investigations, supervision, and played various roles, as well as contributed to the original draft. Farasani A, Taha MME, Abdelw...

Background: Coronavirus disease 2019 (COVID-19) has had a significant impact on global health and healthcare systems. This retrospective study aimed to assess the association between biochemical parameters and outcomes in COVID-19 patients in Jazan, Saudi Arabia. Methods: After establishing the inclusion criteria and obtaining ethical approval, dat...

Background and Aim: Colorectal cancer stands as a frequently occurring fatal disease for several decades and the use of nanoparticles has long been explored in cancer treatments. Engineering the size and shape to attain an optimal efficacy of the nanoparticles and using a specific plant resource to enhance its compatibility to other healthy cell is...

Background: Accumulating evidence indicates that the incidence of cancer is increasing in the United Arab Emirates (UAE). This analysis aimed to determine the current cancer research output in the UAE to guide future national research. Methods: The Scopus database was searched for cancer-related bibliographic data from the UAE. The number of public...

Chewing khat (Catha edulis) releases cathine and cathinone, which may reduce appetite through an unknown mechanism. This study investigated the peripheral and central effects of fresh leaves and buds of C. edulis water extract (CEWE) on appetite and body weight, using in vivo, ex vivo, and in silico models. Rats of both sexes were used for three di...

Research on camel milk and urine (CMUR) has gained significant attention because of its nutritional and medicinal applications. The aim of this study was to conduct a bibliometric analysis of the CMUR from 1947 to 2023. Following PRISMA rules, the Scopus database was used to extract 1338 English-language studies, which were analyzed using Scopus An...

Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) gene is one of the sub-members of CYP450 family member and it encodes with the families of drug metabolizing enzyme families along with the cancers and leukemias. Among leukemias, AML is considered to be one of the important leukemia which attack the older adults. The aim of this study is to ex...

A wide variety of natural products have been widely used in chemoprevention therapy because they have antioxidant, anti-inflammatory, and anticancer activity. In the present study, we shed light on the 5th day germinated sprouts of N. sativa seeds and evaluated them against HDAC inhibition and anti-oxidant activity. The extract from the seed and sp...

Vaccination is a groundbreaking approach in preventing and controlling infectious diseases. However, the effectiveness of vaccines can be greatly enhanced by the inclusion of adjuvants, which are substances that potentiate and modulate the immune response. This review is based on extensive searches in reputable databases such as Web of Science, Pub...

Introduction: Acute myeloid leukemia (AML) is a clinically defined heterogeneous disease whose pathophysiology is currently unknown. The association of NAT2 acetylation profiles with human cancer risks, particularly with AML, was investigated in molecular epidemiological studies. Additionally, the NAT2 gene was carried out with acute lymphoid leuk...

Acute myeloid leukemia (AML) is a hematological malignancy that contains hereditary subgroups. AML can arise as a result of a previous myeloid malignancy. AML's molecular pathogenesis is not yet complete. NADPH quinone dehydrogenase 1 (NQ01), which is linked to AML, is one of a few handfuls of genes that have a role in AML pathogenesis. The goal of...

Tuberculosis (TB) is a deadly disease which killed 1.6 million people in the year 2021 as per the reports of WHO. The treatment of the disease becomes more difficult once drug resistant TB strains (MDR and XDR TB) develops and its co-infection with HIV AIDS. There is a serious need to investigate and develop novel, cost-effective and potent anti-TB...

Objective: This study describes the development of a cost-effective and sensitive immunosensor for rapid detection of the dengue virus (DENV) antigen in human plasma. Methods: Screen-printed carbon electrodes (SPCEs) were used to fabricate the immunosensor by immobilizing the DENV antibodies to its surface using 1-ethyl-3-(3-dimethylamino propyl)ca...

A high increase witnessed in type II diabetes mellitus (T2DM) globally has increasingly posed a serious threat to global increases in liver cancer with the association between diabetes mellitus type II and the survival rate in liver cancer patients showing unstable findings. An increase in the development and progression of chronic liver disease fr...

Purpose: To develop effective cancer chemopreventive and anti-inflammatory agents, a series of chalcones were prepared by reacting suitable aromatic aldehyde with appropriate acetophenones. Methods: Twenty-four synthesized chalcones (namely, 1 - 24) were assessed for their in vitro anti-cyclooxygenase-1 (COX-1) and anti-cyclooxygenase-2 (COX-2) act...

Objectives: Hyphaene thebaica Mart. (locally known as Doum) is a well-known tropical plant and is traditionally used for the treatment of gastrointestinal tract (GIT) ulcers. The current study aimed to investigate the antioxidative and gastroprotective properties of H. thebaica fruit rind extract against experimentally ethanol-induced gastric ulcer...

Acute Myeloid leukemia (AML) is the most common leukemia among adult population which begins with the bone marrow, but it frequently spreads to the blood stream as well. One of the common polymorphisms in AML is A66G in Methionine Synthase Reductase (MTRR), which converts isoleucine into methionine residue in the protein chain, the methionine/homoc...

Background Monkeypox viral infection is considered as global public health and a rare disease caused by Monkeypox virus (MPXV), which is caused by smallpox-like virus and it causes pustules all over the body. MPV is an emerging zoonotic infection with sporadic occurrence globally and multiple outbreaks have been reported in African regions. The sto...

The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were...

Background: Diabetes is considered one of the most encyclopedic metabolic disorders owing to an alarming rise in the number of patients, which is increasing at an exponential rate. With the current therapeutics, which only aims to provide symptomatic and momentary relief, the scientists are shifting gears to explore alternative therapies which not...

Kava is a herbal supplement and beverage made from the Piper methysticum plant, which is known for its recreational use as a mood enhancer, relaxation, as well as pain relief for centuries. Kava is widely used among alcoholics, but it is dangerous and potentially fatal. The objectives of this study were to examine the sub-acute toxicity effects of...

Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533...

Progress in pathogenesis and therapy of acute myeloid leukemia (AML) is presently accelerating. The Janus kinase 2 gene (JAK2) mutations are rare in de novo AML. The gene codes for the tyrosine kinase that has a significant role in the signal transduction in hematopoietic cells. The aim of this study was to induce V617F mutation in the JAK2 gene in...

The effects of nitric oxide modulators (NO-modulators) and antioxidants on acute (RSx1) restraint stress induced endocrine, cellular and oxidative/nitrosative stress markers was studied in Wistar rats. The results of our study revealed that exposure to RS(x1) enhanced malondialdehyde (MDA), heat shock protein (HSP-70), corticosterone, nuclear facto...

The CLEC-2 receptor protein belongs to the C-type lectin superfamily of transmembrane receptors that have one or more C-type lectin-like domains. CLEC-2 is a physiological binding receptor of podoplanin (PDPN), which is expressed on specific tumour cell types and involved in tumour cell-induced platelet aggregation and tumour metastasis. CLEC-2 and...

The Curcuma longa plant is endowed with multiple traditional and therapeutic utilities and is here explored for its phytochemical constituents and cytotoxic potential. Turmeric rhizomes were extracted from three different solvents and screened for the presence of different phytochemical constituents, observation of which indicated that the polar so...

Coronavirus (COVID-19) was identified in the Chinese city of Wuhan in 2019. COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is now recognized that SARS COV-2 may infect and spread among humans. During the pandemic situation, nurses and health care workers (HCWs) played a vital role in handling the infec...

Arthrospira platensis (Ap) has several advantageous adaptive mechanisms including its efficient response to elevated oxidative stress (OS). This study intends to identify the antioxidant effect, in vitro and in vivo, of a novel peptide (GP13), Ap-derived cysteine-desulfurase (CDS) peptide, for antioxidant role and the associated mechanism(s) by whi...

One and one only most unforgettable pandemic is coronavirus 2019 (COVID 19) which is the most memorable pandemic of the twenty-first century. The diagnosis of COVID19 is based on purely clinical symptoms and real time reverse transcription polymerase chain reaction (RT-PCR) test. The role of COVID19 during this pandemic was horrible in diagnosing t...

A series of the title curcuminoids with structural variance in the heteroatom of the cycloalkanone and the p-substituents of the phenyl rings were tested for their activities against Leishmania major and Toxoplasma gondii parasites. The majority of them showed high activities against both parasite forms with EC50 values in the sub-micromolar concen...

Introduction: SARS-CoV2, first reported in December 2019 in Wuhan as COVID-19 causing respiratory illness, rapidly evolved into a pandemic owing to its very high infectivity. There is insufficient evidence about if and how smoking affects the risk of COVID-19 infection, and the reports on whether smoking increases or reduces the risk of respiratory...

Extensive use of triclosan (2,4,4′‐trichloro‐2′‐hydroxydiphenyl ether) as an antimicrobial agent in household and personal care products has resulted in global exposure of the human population. Its presence in human tissues, including milk, and its oestrogen‐disrupting properties raise concerns for an involvement in breast cancer. Because metastati...

We investigated the protective and in vivo antioxidant effects of p-coumaric acid on carbon tetrachloride-induced hepato-toxicity in Sprague-Dawley rats. The rats were orally pre-treated with p-coumaric acid (at 50 and 100 mg /kg body weight) for 15 days before the subcutaneous injection of carbon tetrachloride (1.5 mL/kg). Silymarin served as a po...

Corona viruses (CoV) are known to cause extreme pandemics in the globe. The year 2020 will be a pandemic with the spread of the novel coronavirus (SARS-CoV-2) across the globe. Coronavirus 2019 (COVID-19) has been a part of our scary life for more than a quarter of a year in 2020. The Wuhan market and China have been the most commonly used terms in...

We describe here the draft genome sequence of AY1MRC, a Mycobacterium tuberculosis strain belonging to lineage 1 (Indo-Oceanic) and the East African Indian spoligotype, isolated from a patient with tuberculosis in Jazan, Saudi Arabia.

Saussurea lappa Clarke (Compositae) is well known as a medicinal plant. Its roots are traditionally used in alleviating pain and swelling. In the current research, we have evaluated the antinociceptive activity of essential oil obtained from the roots of S. lappa. In addition, the development and evaluation of a pharmaceutical-grade cream was also...

Background: Organophosphorus insecticides are well known to induce hepatotoxicity. One among this is chlorpyrifos (CPF), which is an insecticide inducing various toxicities including in liver. Objective: This investigation focused on CPF-induced oxidative damage in rat hepatocytes primary culture and the protective effect of Cactus cladode aqueous...

a Background: Southwest Saudi Arabia is known to be endemic with Brucellosis. The diagnosis of brucellosis is a challenge, culture of the organism from the bone marrow, blood and other tissues is the gold standard for diagnosis in brucellosis. However, it is invasive, time consuming and less sensitive, so the use of alternative methods for rapid an...

We investigated the protective and in vivo antioxidant effects of p-coumaric acid on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. The rats were orally pre-treated with p-coumaric acid (at 50 and 100 mg/kg body weight) for 15 days before the subcutaneous injection of carbon tetrachloride (1.5 mL/kg). Silymarin served as a posi...

Background: Recently, there are clinical reports on the potential of Catha edulis (khat) to induce muscular toxicity. C. edulis (khat) is an evergreen shrub and a well‑known controversial plant due to the content of natural stimulant, cathine and cathinone. Objective: The main objective of the study is to evaluate the possible effect of C. edulis l...

compared to females. The number of cases was relatively higher in the year 2013 in both male and females as compared to the other years. The median age group was found to be 45-47 years. The highest rate of current smoking (15.6%) in Saudis among aged 55 to 64 years. The rate was higher for males (24.7%) when compared to females (4.2%). Among Saudi...

Background: Organophosphorus insecticides are well known to induce hepatotoxicity. One among this is chlorpyrifos (CPF), which is an insecticide inducing various toxicities including in liver. Objective: This investigation focused on CPF‑induced oxidative damage in rat hepatocytes primary culture and the protective effect of Cactus cladode aqueous...

Background: Tacrolimus is a known immunosuppressive drug used widely for organ transplantation, but its nephrotoxicity mechanism is still unclear. Objectives: The present study investigates the protective efficacy of Bacopa monnieri (BM), against tacrolimus‑induced nephrotoxicity in rats. Materials and Methods: Group 1 (control group); administered...

Objective: This study aims to investigate the genetic association of acute myeloid leukemia and glutathione S-transferase (GST) gene polymorphisms in a Saudi population. Method: 100 AML cases and 100 healthy controls were recruited from the Riyadh regional hospital. In the GST gene, GSTM1 and GSTT1 variants were genotyped by multiplex PCR, and G...