Abdulhakeem Sulyman

Kwara State University · Department of Biochemistry

Objective: To investigate the effect of leaf aqueous extract from Gongronema latifolium (G. latifolium) on CCl4 induced-oxidative stress in Wistar rat. This effect was assessed by measuring liver marker enzymes activity, analyzing the antioxidant parameters, lipid profile estimation and lipid peroxidation by-product following CCl4 induced-oxidative...

Diabetes mellitus is one of the most widespread diseases affecting the world's population causing substantial morbidity, mortality and long-term complications. This study was designed to investigate possible hypoglycemic, hypolipidemic and antioxidant effect of ethanolic stem bark extract of Anacardium occidentale in streptozotocin (STZ)-induced di...

Cellulases are enzymes that hydrolyse cellulose and related cellu-oligosaccharides derivatives. Its applications are enormous but high cost of production is the bottle-neck against the utilization of cellulase in industries. Therefore, this study investigated the isolation, purification and characterization of cellulase produced by Aspergillus nige...

Antidiabetic effects of methanol and ethyl acetate extracts of roots of Aristolochia ringens (Vahl) were comparatively assessed in streptozotocin (STZ)-induced rats. Pulverized root of A. ringens was soaked with methanol, filtered, and concentrated to dryness. The resulting residue was subsequently dissolved in ethyl acetate, filtered, and concentr...

Context: Pteleopsis suberosa Engl. and Diels (Combretaceae) is an ethnomedicinally valued deciduous shrub with significant therapeutic application against diabetes in West Africa. Aims: This study evaluated the hypoglycaemic and antioxidant activity of its aqueous stem bark extract (PSAE) over a 15-day experimental period in streptozotocin (STZ)-ch...

The antidiarrhoeal potentials of ethanolic extract of Aristolochia ringens stem back was evaluated in castor oil-induced diarrhoeal rats. The A. ringens stem back ethanolic extract was, in addition, screened for its phytoconstituents. Thirty albino rats of 150-180 g were randomized into six groups of five animals each for each of the three experime...

The study was designed to assess antioxidant and antidyslipidaemic effects of terpenoid-rich extract from the root of Aristolochia ringens V. Hyperglycemia-induced oxidative stress and dyslipidemia were established in rats by single intraperitoneal administration of 65 mg/kg bw streptozotocin. Based on therapeutic dose determined in previous study,...

Medicinal spices are used by herbal practitioners as condiments in decoctions for management of diabetes and its associated complications. The study assessed and compared the potentials of phenolic-rich extracts from four selected medicinal spices: Curcuma longa; Allium sativum; Xylopia aethiopica and Syzygium aromaticum to delay carbohydrate diges...

Background: Heliotropium indicum is used by traditional medical practitioners in North Central Nigeria for the management of ailments including diabetes. However, the folkloric use of H. indicum as antidiabetic has been asserted, but its roles on the hyperglycemia-induced organ-specific complications are not yet scientifically proven. Thus, amelior...

This research investigated the purification and partial characterization of cellulase produced by Aspergillus niger cultured on Vitellaria paradoxa shells. Cellulase (endoglucanase) from A. niger was produced under optimum fermentation conditions at 35 °C, pH 4.7, V. paradoxa, 4 g/L, inoculum size of 10 mm and the fermentation media incubated for...

This study evaluated the in vitro antioxidant potential and toxicological effects of aqueous leaf extract of Eucalyptus obliqua via acute and 28-day once daily treatments in Wistar rats. In the acute toxicity test, rats were orally administered the extract up to 5000 mg/kg. The sub-chronic toxicity study was performed by once daily oral administrat...

Background Diabetes mellitus is considered one of the 5 principal causes of death in the world and is recognized as a global public health issue because of its multifactorial facets affecting essential biochemical processes in the body. This study investigated the antidiabetic and antidyslipidemic activities of the aqueous extract of Cochlospermum...

This study investigates the protective potential of honey against lead-induced renal dysfunction. Thirty-two male Wistar rats were used, and they were divided into 4 groups A-D (n=8). The control group (A) were given 1ml/kg distilled water orally; Lead group (B) received 0.2% lead acetate in drinking water; Group (C) and Group (D) rats were given 0...

Ethnopharmacological importance: Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications. Aim of the study: To assess the potentials of root ethanolic extract of Ari...

Context: Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. Objective: The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spon...

Despite the acclaimed phytotherapeutic attributes of Stigma maydis in folkloric medicine, there is paucity of information on its toxicity profile on haematological and lipid parameters. The toxicological effect of aqueous extract of corn silk at 100, 200 and 400 mg/kg body weight on haematological indices in Wistar rats were evaluated progressively...

Background: Despite the rapidly changing concept of gastric ulcer management from conventional vagotomy, H2 receptor antagonists and antacids to proton pump inhibitors, gastrointestinal toxicity remains an impediment to their application in clinical practice. Combined administration of two or more plant extracts with therapeutic efficacy may proffe...

Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficu...