Abdul Rasheed Palakkott

United Arab Emirates University | UAEU · Department of Biology

Objectives The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-Cov-2 uses its envelope glycoprotein, the spike S protein, to infect the target cells in the lungs via binding with their transmembrane receptor, the angiotensi...

Lactoferrin (LF) is a milk protein that may be an interesting candidate for the antidiabetic properties of milk due to its well-documented bioactivity and implication in diabetes. Here, we investigated the functional action of LF purified from camel and bovine milk (cLF, bLF) on insulin receptors (IR) and their pharmacology and signaling in hepatoc...

We recently reported a physical interaction between the angiotensin II (AngII) receptor (AT1R) and thrombin receptor (PAR1) in HEK293 cells using bioluminescence resonance energy transfer (BRET) technology. This was characterized by thrombin trans‐activating AT1R and the synergistic responses of the AT1R–PAR1 complex. Here, we investigated the othe...

The molecular basis of the anti-diabetic properties of camel milk reported in many studies and the exact active agent are still elusive. Recent studies have reported effects of camel whey proteins (CWP) and their hydrolysates (CWPH) on the activities of dipeptidyl peptidase IV (DPP-IV) and the human insulin receptor (hIR). In this study, CWPH were...

The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders. Previous studies reported connections between AngII and thrombin in both physiological and pathophysiological models. However, the molecular mechanisms controlling such interplay...

Background Overdose of paracetamol affects liver cells leading to cell death. This is done through hepatic necrosis, which is characterized by a rupture of the plasma membrane. A variety of investigations has been conducted using herbal extracts to assess liver toxicity induced by paracetamol. Here we examined herbal plant species, Acridocarpus ori...

Diabetes mellitus (DM) is recognized as the most common and the world’s fastestgrowing chronic disease with severe complications leading to increased mortality. Many strategies exist for the management of DM and its control including treatment with insulin and insulin analogs, oral hypoglycemic therapy such as insulin secretion stimulators and insu...

Hemorphins are hemoglobin β-chain–derived peptides initially known for their analgesic effects via binding to the opioid receptors belonging to the family of G protein–coupled receptor (GPCR), as well as their physiological action on blood pressure. However, their molecular mechanisms in the regulation of blood pressure are not fully understood. St...

Water stress has been reported to alter morphology and physiology of plants affecting chlorophyll content, stomatal size and density. In this study, drought stress mitigating effects of CO2 enrichment was assessed in greenhouse conditions in the hot climate of UAE. Commercially purchased maize (Zea mays L.) and alfalfa (Medicago sativa L.) were see...

Background: Antioxidant and Anti-LOX properties of plant species are important in the selection of plants for their medicinal and phytochemical assessment. This study aims at comparing antioxidant and anti-LOX properties of ethanolic extracts from different plant parts (leaf and stem) at different phenological stages (mature and immature) of the ra...

It is commonly difficult to extract and amplify DNA from herbarium samples as they are old and preserved using different compounds. In addition, such samples are subjected to the accumulation of intrinsically produced plant substances over long periods (up to hundreds of years). DNA extraction from desert flora may pause added difficulties as many...

Background: Tribulus terrestris, unlike Tribulus macropterus and Tribulus arabicus, is a well-studied plant species and well known for its medicinal properties. It has been used as a medicine to treat sexual dysfunction and to relieve cardiac pain. It also has other properties such as antihypertensive, anti-microbial, anticancer and antihelmintic....