Abdul Majeed

• Doctor of Philosophy in Pharmacy
• ASSISTANT PROFESSOR at Bahauddin Zakariya University

In the original publication [...]

Introduction Glipizide is an oral antidiabetic drug widely used to treat non-insulin-dependent type II diabetes mellitus (NIDDM). This systematic review extensively examines all reported pharmacokinetic (PK) parameters of glipizide in healthy and diseased populations. Areas covered A total of 31 articles were retrieved after screening various data...

Introduction Nicardipine is a type of calcium channel blocker that is commonly used in the treatment of angina pectoris, hypertension, and related cardiovascular disorders. This systematic review assesses the reported pharmacokinetic (PK) and associated pharmacodynamic (PD) parameters of nicardipine in humans. Areas Covered An exhaustive literatur...

In the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [...]

Purpose: Torasemide is a potassium-sparing loop diuretic used to treat fluid retention associated with congestive heart failure and kidney and hepatic diseases. This systematic review was conducted to combine all accessible data on the pharmacokinetics (PK) of torasemide in healthy and diseased populations, which may help clinicians avert adverse...

Nebivolol is a beta-1 receptor blocker used to treat hypertension, heart failure, erectile dysfunction, vascular disease, and diabetes mellitus. This review investigated the data regarding pharmacokinetic (PK) parameters, drug-drug interactions, dextrorotatory (D), and levorotatory (L) stereoisomers of nebivolol. The articles related to the PK of n...

The evolution in the development of drugs has increased the popularity of physiologically based pharmacokinetic (PBPK) models. This study seeks to assess the PK of metoprolol in populations with healthy, chronic kidney disease (CKD), and acute myocardial infarction (AMI) conditions by developing and evaluating PBPK models. An extensive literature r...

This study was conducted to develop a particular sorbent for the selective extraction of the luteolytic drug cloprostenol from milk samples. Cloprostenol's luteolytic activity has been proved in animals, whereas the production of prostaglandins is discussed extensively in the literature, while extraction of cloprostenol is rarely discussed. The maj...

The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug pharmacokinetics (PK) by combining changes in blood flow and pathophysiological alterations for developing drug-disease models. Cefepime hydrochloride is a parenteral cephalosporin that is used to treat pneumonia, sepsis, and febrile neutropenia, among other things....

Cefixime is an antibiotic from the cephalosporin class used to treat various bacterial infections. The purpose of performing this review is to thoroughly evaluate the pharmacokinetic (PK) data on cefixime.Five databases were systematically searched to identify studies on the PK of cefixime.A total of 38 articles meeting the eligibility criteria wer...

Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of pDDIs and risk factors associated with occurrence of pDDIs in chronic disease patients attending outpatient clin...

Acute respiratory distress syndrome (ARDS), a serious manifestation of acute lung injury (ALI), is a debilitating inflammatory lung disease that is caused by multiple risk factors. One of the primary causes that can lead to ALI/ARDS is cigarette smoke (CS) and its primary mode of action is via oxidative stress. Despite extensive research, no approp...

Terbutaline is used for the management of bronchospasm associated with asthma, bronchitis, emphysema, and chronic obstructive pulmonary disease. A systematic review would be beneficial to assess the impact of routes of administration, stereoisomerism, disease states, smoking, age, exercise, and chronobiology on pharmacokinetics (PK) of terbutaline...

Aim: The current study was conducted to assess the factors contributing to treatment adherence and its impact on the quality of life (QoL) in type 2 diabetes mellitus (T2DM) patients. Methods: A cross-sectional study was conducted between January 2020 to March 2020 among T2DM patients. The data was collected from T2DM outpatient clinics. The partic...

Introduction Hydralazine is a vasodilator used to treat hypertension, pre-eclampsia, and heart failure. The current article reviews the clinical pharmacokinetics (PK) of hydralazine, which can be useful for clinicians in optimizing its dose and dosing frequency to avoid adverse effects and unexpected interactions that could risk patients’ lives. A...

What is known and objective Nadolol is a non-selective beta-adrenergic antagonist that is used for the treatment of hypertension and angina. The primary route for its administration is oral. It is given once daily as it has a longer half-life (t½). The purpose of conducting this systematic review is to provide a comprehensive view of all the availa...

Background Metoprolol is recommended for therapeutic use in multiple cardiovascular conditions, thyroid crisis, and circumscribed choroidal hemangioma. A detailed systematic review on the metoprolol literature would be beneficial to assess all pharmacokinetic parameters in humans and their respective effects on patients with hepatic, renal, and car...

The development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differentiation, migration, and persistence of cells. On t...

The incidence of breast cancer is increasing in Pakistan as well as globally. Awareness of women about breast cancer plays a cornerstone role in its early detection, better management, and prevention. Keeping this in mind, a cross-sectional study was carried out to assess the awareness of female university students about breast cancer’s risk factor...

A cross-sectional study was conducted to determine the vaccination status and barriers to vaccination among the university students by utilizing a simple random sampling technique in the largest public sector university of Southern Punjab, Pakistan. The participants comprised 380 university students. Data was collected by a self-designed questionna...

Purpose: Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder with modifiable risk factors and it is associated with considerable health and economic burden. The current study was conducted to assess the frequency and risk factors related to GERD in the previously unstudied population of Southern Punjab, Pakistan....

In Pakistan, breast cancer (BC) is frequently diagnosed with advanced disease. We aimed to examine the association of breast tumor size with reasons of reporting delays, care intervals in patients with advanced disease. This cross-sectional study enrolled 392 BC patients from tertiary care hospitals. Data were collected from August 2018–March 2019....

Background Ticagrelor (TG), an antiplatelet drug is employed to treat patients with acute coronary syndrome, but its inadequate oral bioavailability due to poor solubility and low permeability restricts its effectiveness. Purpose This contemporary work was aimed to design a novel pH-sensitive nanocomposite hydrogel (NCH) formulation incorporating...

Diazepam is one of the most prescribed anxiolytic and anticonvulsant that is administered through intravenous (IV), oral, intramuscular, intranasal, and rectal routes. To facilitate the clinical use of diazepam, there is a need to develop formulations that are convenient to administer in ambulatory settings. The present study aimed to develop and e...

The increasing frequency of cesarean section (CS) is a major public health issue, and it is on the rise in Pakistan. A cross-sectional study approach was used to assess the frequency of CS and its contributing factors, along with the assessment of knowledge in mothers who had undergone CS in one of the under-developed regions of Pakistan. Data coll...

The aim of present research aims to fabricate a system of enteric coating of hydrogel beads with pH-sensitive polymer, which shows solubility at pH > 7, and explore their potential to target the colon for drug delivery. Hydrogel beads were fabricated through the extrusion-dripping technique followed by ion gelation crosslinking. Moreover, freeze-th...

Objectives The study aimed to assess the knowledge, attitude and practices (KAP) of HCPs regarding the use of probiotics in different health conditions and to identify various barriers that are associated with their use. Methods A cross-sectional study was conducted on 405 HCPs by using a validated self- administered questionnaire for assessing th...

The irrational use of antimicrobials has enormously contributed to antimicrobial resistance (AMR) globally and especially in the developing world. To assess the knowledge and perception regarding AMR and antimicrobial stewardship (AMS), a descriptive cross-sectional study was carried out in university students enrolled in pharmacy, veterinary, and...

The current study aims to assess the beliefs of the general public in Pakistan towards conspiracy theories, acceptance, willingness to pay, and preference for the COVID-19 vaccine. A cross-sectional study was conducted through an online self-administered questionnaire during January 2021. The Chi-square test or Fisher exact test was utilized for st...

An online cross-sectional study was carried out to evaluate the knowledge, attitude, and practice about coronavirus disease 2019 (COVID-19) among primary health care providers (PHPs) at three tertiary care hospital, Peshawar, Pakistan. Data was collected via email and online social media platforms. Statistical package for social science (SPSS) vers...

The current study was designed to convert the poloxamer (PLX) into thiolated poloxamer (TPLX), followed by its physicochemical, biocompatibilities studies, and applications as a pharmaceutical excipient in the development of tacrolimus (TCM)-containing compressed tablets. Thiolation was accomplished by using thiourea as a thiol donor and hydrochlor...

Irrational prescribing of drugs is the main problem that affects globally. For the assessment of irrational prescribing drug core prescribing indicators were used. The main objective of this study was to evaluate the irrational prescribing of drugs in the outpatient departments (OPDs) of district headquarter (DHQ) hospital Sahiwal Punjab province o...

The advancement in the processing speeds of computing machines has facilitated the development of complex physiologically based pharmacokinetic (PBPK) models. These PBPK models can incorporate disease-specific data and could be used to predict pharmacokinetics (PK) of administered drugs in different chronic conditions. The present study aimed to de...

Background The COVID-19 pandemic is not only affecting public health, but it is also impairing the specialized surgical care services in the hospitals. The present study aimed to assess the barriers faced by the surgeons while performing surgical procedures during the COVID-19 pandemic. Methods A cross-sectional, web-based survey was conducted fro...

The current study was planned to investigate the pharmacological basis of Solanum virginianum extract (SV.CR) pertaining to anxiolytic, antidepressant and memory-enhancing effects in rats. The SV.CR was analyzed in-vitro for phytoconstituents, antioxidant potential and anticholinesterase activity. The rats treated in a dose-dependent manner (25, 50...

Aim The current study was conducted to assess the factors contributing to treatment adherence and its impact on the quality of life (QoL) in type 2 diabetes mellitus (T2DM) patients. Methods A cross-sectional study was conducted between January 2020 to March 2020 among T2DM patients. The data was collected from T2DM out-patient clinics. The partic...

Purpose: To evaluate the prescription errors and their contributory factors in Punjab, Pakistan. Methods: An observational, cross-sectional study was conducted in 12 major cities of Punjab, Pakistan. A total of 1,184 prescriptions were collected from patients using a convenient sampling method from homes, pharmacies, clinics, and hospitals. The dat...

Grewia asiatica L. fruit natively called phalsa is a popular berry of Pakistan and widely consumed in the form of fresh juices and carbonated drinks in the summer season. The berry is enriched with antioxidants such as phenols, flavonoids, anthocyanins, and vitamin C. Scientifically, it is the least explored berry in terms of neuromodulatory activi...

The objective of the study was to develop an HPLC-UV method for the analysis of ofloxacin in plasma. An HPLC-UV method has been developed using C 18 column with UV detection at 294 nm. The expected optimal assay condition comprised of methanol and phosphate buffer pH 7.4 in ratio of 40:60 % v/v at a flow rate of 1 mL/min. Under this optimal state,...

Purpose The COVID-19 (coronavirus disease-2019) has been associated with psychological distress during its rapid rise period in Pakistan. The present study aimed to assess the mental health of healthcare workers (HCWs) in the three metropolitan cities of Pakistan. Methods A cross-sectional, web-based study was conducted in 276 HCWs from April 10,...

The release of antibiotics to aquatic environment creates aquatic ecotoxicity and their bioaccumulation results in antibiotic resistance. Hence to lessen the risk of ecotoxicity and depletion of natural resources, it is imperative to disclose alternate precursor raw materials that can be successfully employed for the synthesis of new sorbents capab...

Background and Purpose Over the past few decades, the focus of pharmacy practice has been shifted from the classical role of drug dispenser to pharmacotherapy expert. Pharmacists now are more often involved in the patient care process by addressing the drug-related needs of the patients and this patient-centered approach is known as pharmaceutical...

To evaluate the pharmacist’s preparedness against the COVID-19 during its rapid rise period in Pakistan, an online cross-sectional study was carried out from March 30 to May 22, 2020 among the pharmacists using a pre-validated self-administered questionnaire. A total of 1149 participants completed the survey, amongst which 430(37.9%) were working a...

Th accurate rapid, simple and selective reversed phase high performance liquid chromatography (RP-HPLC) has been established and validated for the determination of captopril (CAP). Chromatographic separation was accomplished using prepacked ODSI C18 column (250 mm × 4.6 mm with 5 μm particle size) in isocratic mode, with mobile phase consisting of...

Background Diabetes mellitus is a major public health issue globally, and type-2 diabetes mellitus is the most prevalent form of this disease. Due to multiple factors, most diabetic patients develop functional disabilities including musculoskeletal complications.Objective To determine the frequency of musculoskeletal complications, the relationship...

The novelty of the present work was focused on the synthesis of pH- and temperature-responsive cross-linked poly(methacrylic acid-co-acrylamide) (p(MAA-co-AM)) microgels for controlled drug delivery. A series of cross-linked microgels was successfully prepared by inverse-suspension polymerization using N,N′-methylenebisacrylamide as a cross-linking...

Theophylline is commonly used for the treatment of asthma and has a low hepatic clearance. The changes in plasma albumin concentration occurring in asthma may affect the exposure of theophylline. The aim of the presented work was to predict theophylline pharmacokinetics (PK) after incorporating the changes in plasma albumin concentration occurring...

Introduction Colorectal cancer is the third most common type of cancer in the world and in Pakistan it ranks at fifth position. The present study was conducted to evaluate the knowledge, attitude, preventive practices and perceived barriers to screening about colorectal cancer among university students. Method A cross-sectional study was conducted...

This work presents a combination of three functional monomers, acrylonitrile, vinyl acetate, and acrylic acid to synthesize template assisted spherules for the selective recognition of chlorfenapyr; a halogenated pyrrole class of pro-pesticides. Chlorfenapyr imprinted polymer spherules (MIPs) were synthesized through precipitation polymerization, c...

The present study aimed to evaluate the in vitro and in vivo behavior of domperidone maleate (DM) from immediate release (IR) tablets. The developed tablets were characterized by various physical tests, in vitro drug release, FTIR, XRD, DSC and conduct pharmacokinetic study. The pharmacokinetic of DM was evaluated using non-compartmental approach....

Purpose: The basic purpose of the current study was to determine the impact of the dietary approach to stop hypertension applying (DASH) pattern of dietary intake on outdoor hypertensive patients based on baseline lipid concentrations and sex. Method: In the current controlled study, 300 patients were assessed through the DASH Trial, where250 patie...

The raft is an emerging drug delivery system that not only provides rapid relief from reflux disorders, but also sustains drug release. The objective of this work was to develop and characterize raft-forming bilayer tablets in which pantoprazole sodium sesquihydrate (PSS) was targeted at sustained release and domperidone maleate (DM) was used to ob...

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug–disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the application of its single dose in healthy and dise...

Traditionally seeds of Sisymbrium irio Linn has been used in different regions of Pakistan for the treatment of gastrointestinal, airways and vascular system ailments. To insight the pharmacological basis in vitro study was conducted in order to validate its folkloric uses in hypertension. 70% aqueous-methanolic extract of seeds from Sisymbrium iri...

A method has been developed for the combined monitoring of pantoprazole sodium sesquihy-drate (PSS) and domperidone maleate (DM) in plasma using high performance liquid chromatography (HPLC) on C18 column with UV detection at 285 nm. Box-Behnken design was used with three independent variables such as flow rate (X 1) mobile phase composition (X 2),...

The aim of this work was the development and evaluation of controlled release formulations consisting of methacrylate derivatives and ethyl cellulose synthesized using oil-in-oil solvent evaporation method. Drug release studies were performed in different dissolution media. Maximum drug released was observed at pH 7.4. Fourier transform infrared sp...

Purpose: To formulate, characterize and optimize nebivolol-loaded sustained release lipospheres (LPs) using beeswax (BW) as the drug carrier. Methods: Nebivolol-loaded LPs were formulated using solvent evaporation technique (SET) and characterized. The impact of independent variables on responses such as percentage yield (PY), entrapment efficiency...

The aim of current work was to develop controlled drug delivery system which is capable of releasing the drug over an extended period of time. For this purpose, pH sensitive acrylamide-acrylic acid hydrogels were prepared using N,N-methylenebisacrylamide (MBA) as crosslinking agent and ammonium persulphate (APS) as an initiator by employing free ra...

Captopril immediate release tablets were optimized through Box-Behnken design (BBD) by taking starch (X1), sodium starch glycolate (X2) and polyvinylpyrrolidone (X3) as independent variables and disintegration time (Y1), % drug release at 10 and 20 min (Y2 and Y3) as dependent variables. Bulk density, tapped density, angle of repose, compressibilit...

Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the "omics" approaches, reevaluate the suitable therapeutic targets, resolve the...

In vivo and in vitro research study was conducted on Cyperus rotundus to evaluate the sound mechanistic background in the treatment of gastrointestinal, bronchial and vascular disorders as well as in pain, emesis, pyrexia and bacterial infections. Results showed that crude extract of Cyperus rotundus (Cr.Cr) exhibited the dose-dependent spasmolytic...

The objective of this study was to formulate and evaluate controlled release formulations of ivabradine hydrochloride (HCl)-loaded microspheres consisting of Kollicoat MAE 100 P and ethyl cellulose prepared by the oil-inoil solvent evaporation method. The drug was encapsulated into microspheres by an in situ method by varying the polymer contents....

The objective of this study was to prepare and evaluate ivabradine HCl-loaded microspheres consisting of Eudragit L100-55 and ethyl cellulose prepared by oil-in-oil solvent evaporation method. Ivabradine HCl was encapsulated into microspheres by in situ method. The resultant microspheres were characterized with respect to drug loading, flow propert...

Background: The objective of this work was to develop and validate a rapid and effective high performance chromatographic method for the analysis of Ivabradine-HCl. Introduction: A sensitive, precise, simple and robust high-performance liquid chromatographic method used for the analysis of Ivabradine-HCl (IBH) in mobile phase and rabbit plasma was...

Ethnopharmacological relevance: Seeds of Sisymbrium irio Linn has been used traditionally in different regions of Pakistan for the treatment of gastrointestinal, airways and vascular system ailments. To insight the pharmacological basis, in vitro study was conducted in order to validate its folkloric uses. Material and methods: 70% aqueous-metha...

In this study, microspheres of Eudragit FS30D and ethyl cellulose (EC) were prepared by oil-in-oil (O/O) solvent evaporation method with the addition of 1% span 80 as emulsifier. Ivabradine HCl (IBH) was encapsulated into microspheres by the in situ method. The resultant microspheres were characterized with respect to drug loading, Fourier transfor...

Tuberculosis is a worldwide health problem affecting one third of world’s population and Pakistan is no exception. In this study, we used a structured and close-ended questionnaire to collect data about socio-demographic prevalence of tuberculosis, its risk factors, multiple drug resistance tuberculosis and clinical characterization of tuberculosis...

Jatropha gossypifolia is used in folkloric system to manage emesis and gastrointestinal motility disorders such as constipation and diarrhea. The present study was undertaken to provide pharmacological evidences for these folkloric uses by in vivo and in vitro experimental setting. Ethanolic extract of J. gossypifolia showed the significant antieme...

Microparticles are one of the recent controlled release dosage form, compressed in the form of tablets or filled in capsules. In this review different methods of preparations and their effects on physical properties i.e. Size, shape and porosity which can be controlled by ingredients used or process variables and characterization will be discussed....

In this study, Saccharum spontaneum (Family: Poaceae), was evaluated for its antibacterial potential against human pathogenic bacterial strains. In-vitro antibacterial tests were performed by disc diffusion method on nutrient agar, in order to analyze the percentage zone of inhibition. Whole plant’s extract showed the significant zone of inhibition...

te er rn na at ti io on na al l J Jo ou ur rn na al l o of f P Ph ha ar rm ma a S Sc ci ie en nc ce es s Vol. 4, No. 5 (2014): 736-741 Research Article Open Access I IS SS SN N: : 2 23 32 20 0--6 68 81 10 0 In vitro comparative study of antimicrobial activity of whole plant and root's bark of Delonix regia (Bojer Ex. ABSTRACT Medicinal plants are t...

Medicinal plants are the potent source of biologically active compounds and have always been of field of interest for the effective chemotherapeutic agents and offering a broad spectrum of activity with greater emphasis on preventive action. The present study was aimed at evaluating and comparing the antimicrobial spectrum of various extracts (meth...

ABSTRACT In this study, Dalbergia sisso (Family: Fabaceae), was evaluated for its antibacterial potential against eight human pathogenic bacterial strains. Triple maceration method was adopted for the methanolic extraction of whole plant (pods, leaves, stem bark, root bark) and leaves. In-vitro, antimicrobial test was performed by disc diffusion me...

I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f P Ph ha ar rm ma a S Sc ci ie en nc ce es s ABSTRACT In this study, Dalbergia sisso (Family: Fabaceae), was evaluated for its antibacterial potential against eight human pathogenic bacterial strains. Triple maceration method was adopted for the methanolic extraction of whole plant...

Biologically active compounds obtained from the medicinal plants are the effective chemotherapeutic agents and offering a broad spectrum of activity with greater emphasis on preventive action. The present study was aimed at evaluating the antimicrobial activities of crude methanolic extract of Oligochaeta ramose (Asteraceae) against pathogenic bact...

iologically active compounds obtained from the medicinal plants are the effective chemotherapeutic agents and offering a broad spectrum of activity with greater emphasis on preventive action. The present study was aimed at evaluating the antimicrobial activities of crude methanolic extract of Oligochaeta ramose (Asteraceae) against pathogenic bacte...

dherence is very important issue in any drug therapy especially in psychiatric illnesses. Medicines do not work if not taken and if taken in accordance with advice, provide maximum benefit in terms of positive clinical outcomes. Adherence is defined as the extent to which a patient's behavior coincides with medical or prescribed health advice. The...

Jasminum officinale Linn. (Chameli / Yasmine; Oleaceae), is native to temperate region and cultivated in France, Italy, China, India and Pakistan. Plant is documented to possess beneficial effect in impotence, menstrual disorder, mental depression, analgesic, antispasmodic galactogogue, antiseptic and skin disease etc,. Although, previous studies h...

Samtia et al Trop J Pharm Res, October 201 3 ;12 ( 5 ): 851 Tropical Journal of Pharmaceutic al Research October 2013; 12 (5 ): 8 5 1 - 8 56 ISSN: 1596 - 5996 (print); 1596 - 9827 (electronic) © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved . Available online at http://www.tjpr.org...

Let C ' =C∪{∞} be the extended complex plane and M=〈x,y:x 2 =y 6 =1〉, where x(z)=-1 3z and y(z)=-1 3(z+1) are the linear fractional transformations from C ' →C ' . Let m be a square-free positive integer. Then Q * (n)=a+n c:a,c≠0,b=a 2 -n c∈Zand(a,b,c)=1 where n=k 2 m, is a proper subset of Q(m) for all k∈N. For non-square n=3 h ∏ i=1 r p i k i , i...

Studying groups through their actions on different sets and algebraic structures has become a useful technique to know about the structure of the groups. The main object of this work is to examine the action of the infinite group H = < x,y : x(2) = y(4) = 1 > where x(z) = -1/2z and y(z) = -1/2(z+1) on the real quadratic field Q(root n) and find inv...