Abdul Manaf Ali

Universiti Sultan Zainal Abidin | UniSZA | unisza · School of Agriculture Sciences & Biotechnology

Background: Combination of natural product with chemically synthesised biomaterials as cancer therapy creates many interests lately. Hence, this study aims to investigate the combined effects of goniothalamin and bioactive glass 45S5 (GTN-BG) and evaluate their anticancer properties on human breast cancer cells MCF-7. Methods: The BG 45S5 was prepa...

Diopatra claparedii which is colloquially known as Ruat Sarung can be found along the west coast of Peninsular Malaysia. The species has a unique ability to regenerate anterior and posterior segments upon self-amputation or injury, thus having potential as a wound healing promoter. In this study, the wound healing potential of D. claparedii aqueous...

Analysis of elemental composition of Syzygium polyanthum (Wight) Walp cultivars used by malay ethnic group as Ulam and traditionally for treatement of various ailments in Peninsular Malaysia. The elemental composition was determine using Inductively coupled plasma-mass spectrometry (Icp-Ms) and Neutron activation analysis (NAA) techniques. Standard...

Plants with medicinal potentials have contributed significantly in the history and evolution of modern health care system. Lack of comprehensive written document have made traditional medicinal knowledge disappearing as a result of population growth and development. This necessitates written document of comprehensive knowledge of medicinal plants....

Patients are turning into herbs for the management of diabetes, which cause increasing in the demand of plant-based alternative medicines. Ficus deltoidea or locally known as “Mas Cotek” in Malaysia is a famous herbal plant. However, many varieties of F. deltoidea existed with varied antidiabetic activities inspire us to evaluate in vivo antidiabet...

Aquilaria is a multipurpose plant with high commercial and medicinal values. The present study aimed to evaluate the effects of drying methods and extraction solvents on the phenolic and flavonoids content in A. malaccensis (AMA), A. subintegra (ASU), and A. sinensis (ASI). Leaf samples were either Air-Dried (AD) or Oven-Dried (OD) and extracted us...

According to the recent estimates by the World Health Organization (WHO),422 million adults aged over 18 years were living with diabetes in 2014 globally. Surprising, about 1.6 million deaths was reported causedirected by diabetes in 2016. In SoutheastAsia alone, 96million people have diabetes, and this is predicted to increase. The incidence of di...

Herbs and medicinal plants are major ingredients in traditional or folk medicine for many countries of the world, including Malaysia. This study evaluated the potential of the leaf extract in different solvent polarities and drying methods of Aquilaria malaccensis, in scavenging free radicals and inhibiting the enzyme α-glucosidase as well as antim...

Background: Ficus deltoidea (FD) has been shown to have antidiabetic, anti-inflammatory, antinociceptive and antioxidant properties. However, its effects on key events in the pathogenesis of atherosclerosis are unknown. Aim: To investigate the endothelial activation, inflammation, monocyte-endothelial cell binding and oxidative stress effects of...

Ficus deltoidea is a medicinal plant containing diverse bioactive phytochemicals. However, little is known about the phytochemical variation in aqueous extract of the syconia part. This study aimed to discriminate the chemical fingerprints of aqueous extracts of seven varieties of F. deltoidea (var. trengganuensis, var. kunstleri, var. angustifolia...

Background: Treatment of cancer with chemo-radiotherapy causes severe side effects due to cytotoxic effects towards normal tissues which often results in morbidity. Therefore, developing anticancer agents which can selectively target the cancer cells and cause less side effects are the main objectives of the new therapeutic strategies for treatmen...

[This corrects the article DOI: 10.1155/2019/3059687.].

Honey has been extensively researched on their chemical and biological properties. It's revealed the ability and capability of honey in treating or preventing many diseases. As people concerned, a safer approach using natural based product is critically needed and honey as one of the potential agent to be consider. Therefore, the information on its...

According to the recent estimates by the World Health Organization (WHO),422 million adults aged over 18 years were living with diabetes in 2014 globally. Surprising, about 1.6 million deaths was reported causedirected by diabetes in 2016. In SoutheastAsia alone, 96million people have diabetes, and this is predicted to increase. The incidence of di...

Goniothalamin (GTN) is an isolated compound from several plants of the genus Goniothalamus, and its anticancer effect against several cancers was reported. However, there is no scientific data about effects of its higher doses on internal organs. Accordingly, this study aimed to evaluate the acute and subacute effects of higher doses of GTN on the...

Aim: Newcastle disease virus (NDV) is a member of genus Avulavirus within the family Paramyxoviridae. Interest of using NDV as an anticancer agent has arisen from its ability to kill tumor cells with limited toxicity to normal cells. Methods: In this investigation, the proliferation of brain tumor cell line, glioblastoma multiform (DBTRG.05MG) indu...

Background Ficus deltoidea Jack (Moraceae) is a plant used in Malaysia for various diseases including as a supplement in diabetes management. Morphology distinction of the 7 main varieties (var. angustifolia, var. bilobata, var. deltoidea, var. intermedia, var. kunstleri, var. motleyana and var. trengganuensis) is challenging due to the extreme lea...

Combination of natural products with chemodrugs is becoming a trend in discovering new therapeutics approach for enhancing the cancer treatment process. In the present study, we aimed to investigate the cytotoxic and apoptosis induction of Gelam honey (GH) combined with or without 5-Fluorouracil (5-FU) on HT-29 cells. The cell viability was determi...

Fourier transform infrared spectroscopy (FTIR) was utilised to discriminate Syzygium polyanthum cultivars (Serai Kayu and Serai Kayu Hutan) due to its effectiveness in discriminating plants species based on their chemical constituents. The ATR-FTIR mid infrared region (4000-400 cm–1) of the IR spectrum was applied to the ethanolic and aqueous leave...

Herbs and medicinal plants are major ingredients in traditional or folk medicine for many countries of the world, including Malaysia. This study evaluated the potential of the leaf extract in different solvent polarities and drying methods of Aquilaria malaccensis, in scavenging free radicals and inhibiting the enzyme α-glucosidase as well as antim...

Syzygium polyanthum (Wight) popularly known as Serai Kayu and Serai Kayu Hutan is consumed in Peninsular Malaysia as Ulam and as a remedy to hypertension, diabetes, endometriosis, cancer and postpartum. The medicinal property of Serai Kayu and Serai Kayu Hutan was highlighted by the local traditional healers but not yet ascertained scientifically....

Introduction: Ficus deltoidea is one of the common Malaysian medicinal plants and currently commercialized as raw ingredients in some local food products. However, those products do not discriminate the varieties of Ficus deltoidea used. Methods: FTIR-based metabolomics coupled with chemometric technique was applied to discriminate chemical compone...

Syzygium is the largest genus with medicinal value that is found distributed all over Peninsular Malaysia and widely used for the treatments of diabetes, cancer, endometriosis, hypertension and also used as ulam. To further investigate the pharmacological aspects of Syzygium polyanthum there is the need for morpho-anatomical studies of S. polyanthu...

This study was carried out to assess the traditional knowledge of medicinal and aromatic plants, to explore and record those plants and plant parts used for treating various human ailments by the traditional healers in eight districts of Terengganu, Peninsular Malaysia. It was carried out through face to face interviews with the aid of a semi-struc...

Syzygium is the largest genus with medicinal value that is found distributed all over Peninsular Malaysia and widely used for the treatments of diabetes, cancer, endometriosis, hypertension and also used as ulam. To further investigate the pharmacological aspects of Syzygium polyanthum there is the need for morpho-anatomical studies of S. polyanthu...

FTIR was utilised to discriminate serai kayu and serai kayu hutan due to its effectiveness in discriminating plant species based on their chemical constituents. The FTIR mid-infrared region of the IR spectrum that was applie at 4000-4000 cm-1 to the ethanolic and aqueous leaves extracts of serai kayu and serai kayu hutan, was used to identify vario...

Fourier transform infrared spectroscopy (FTIR) was utilised to discriminate Syzygium polyanthum cultivars (Serai Kayu and Serai Kayu Hutan) due to its effectiveness in discriminating plants species based on their chemical constituents. The ATR-FTIR mid infrared region (4000-400 cm –1 ) of the IR spectrum was applied to the ethanolic and aqueous lea...

Cancer is one of the most common causes of death in the developed world, with one-third of people diagnosed with cancer during their lifetime. Oral cancer commonly occurs involving the buccal mucosa (cheeks), tongue, floor of the mouth and lip. It is one of the most devastating and disfiguring of malignancies. Morinda citrifolia L., commonly known...

This study was carried out to assess the traditional knowledge of some selected medicinal and aromatic plants to explore, record those plants and plant parts used for treating various human ailments by the traditional healers in eight districts of Terengganu, Peninsular Malaysia, Malaysia. It was carried out through face to face oral interviews wit...

In a balanced ecosystem, fungi play an important role and essential to other organisms. The status of Boletus, the cap fungi with pores in Malaysia, was reviewed by botanists more than 40 years ago and to current there were limited findings about the biodiversity of mushroom or toadstool either reported in environmental management, food supply or m...

This study describes antiradical/antioxidant and alpha-glucosidase inhibition and activities as well as total phenolic content (TPC) of syconia extracts from seven varieties of Ficus deltoidea (FD). The ethanol and aqueous extracts of syconia were assayed for α-glucosidase inhibition using p-Nitrophenyl α-D-glucopyranoside (PNPG) as a substrate, an...

The anti-atherosclerotics activity of tocotrienols (TCT) compared to alpha-Tocopherol (α-TOC) in in vitro study is not much being reported especially in human endothelial cells. The aim of the present study was to study the effects of TTMF, TCT and α-TOC on monocytes adherence to stimulated endothelial cells and to investigate the correlation betwe...

There is an increasing interest in bioinspired dynamic materials. Abundant illustrations of protein domains exist in nature, with remarkable ligand binding characteristics and structures that undergo conformational changes. For example, calmodulin (CaM) can have three conformational states, which are the unstructured Apo-state, Ca2+-bound ligand-ex...

Plant breeding is a way of selection of a particular individual for the production of the progeny by separating or combining desired characteristics. The objective of this study was to justify different characteristics of Dioscorea hispida (Ubi gadong) varieties using molecular techniques to select the best variety for sustainable production at the...

Ficus deltoidea Jack var. bilobata is one of the seven varieties found in the Malay Peninsula of Malaysia. Currently five accessions (FD013, FD014, FD335, FD296 and FD378) were available in Germplasm Living Collection Nursery, Faculty of Bioresources and Food Industry, UniSZA. From morphological observation they can be divided into two groups which...

Traditional ‘Malay’ salad or ulam is commonly eaten as side dishes along with main courses. There a more than 120 species of ulam consist of leaves, flowers, seeds, roots, fruits and tubers. A previous study showed several ulam potentially can be developed as fungicidal agent, an oral hypoglycemic agent and many more. This paper reviews on traditio...

Azoxymethane rat model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis. Anti-tumor activity of Newcastle disease virus (NDV) strains AF2240 and V4-UPM was evaluated in-vivo to investigate the effect of different doses of NDV on the development of aberrant crypt foci (ACF) in Sprague–Dawley rats in...

Background: Newcastle Disease Virus (NDV) is a negative-sense single stranded RNA virus that causes a Newcastle Disease (ND), a contagious disease of domestic poultry and wild birds characterized by gastro-intestinal, respiratory and nervous signs. Despite the negative effects of NDV to avian species, this virus was reported to possess significant...

Elders believed bitter taste vegetables provide medicinal benefits but discontinuity of their knowledge leads to its deterioration. From the field visit, a list of accessions was made, continued by analysis for frequencies and dendrogram of linkages between purposes of accessions as alternative medicine by using IBM SPSS Statistics 20 software. The...

Oral cancer is the eleventh most prevalent cancer worldwide. The most prevalent oral cancer is oral squamous cell carcinoma (OSCC). Damnacanthal (DAM) and nordamnacanthal (NDAM), the anthraquinone compounds, are isolated from the root of Morinda citrifolia L. (Noni), which has been used for the treatment of several chronic diseases including cancer...

Gracilaria species are red marine macroalgae that are found abundantly in Malaysia. Gracilaria changii from Morib, Selangor, G. manilaensis and Gracilaria sp. from Gelang Patah, Johor were used in this study. Five compounds were successfully isolated and identified as hexadecanoic acid (1), cholest-5-en-3-ol (2), 2-hydroxymyristic acid (3), cholest...

Background: Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of the action of TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions are not well established. Aims: 1) To compare the effects of different TCT isomers on inflam...

Calcium carbonate (CaCO3) microspheres (μ-spheres) are widely used as inorganic templates (or cores) for fabricating nanoengineered microcapsules. Deionized water is commonly used in the fabrication of CaCO3 μ-spheres using precipitation reaction between calcium chloride (CaCl2) and sodium carbonate (Na2CO3) solutions under vigorous stirring. Howev...

Total phenolics, total flavonoids and antioxidant activity of rambutan peel and seed were investigated. Total phenolics and total flavonoids content were evaluated using folin ciocalteu and aluminium chloride method respectively. The antioxidant activity was evaluated using DPPH scavenging activity. Rambutan peel exhibited significantly (p < 0.05)...

Goniothalamin is a natural occurring styryl-lactone compound isolated from Goniothalamus macrophyllus. It had been demonstrated to process promising anticancer activity on various cancer cell lines. However, little study has been carried out on oral cancer. The aim of this study was to determine the cytotoxic effects of goniothalamin against H400 o...

Gracilaria species are red marine macroalgae that are found abundantly in Malaysia. Gracilaria changii from Morib, Selangor, G. manilaensis and Gracilaria sp. from Gelang Patah, Johor were used in this study. Five compounds were successfully isolated and identified as hexadecanoic acid (1), cholest-5-en-3-ol (2), 2-hydroxymyristic acid (3), cholest...

Since time immemorial, the use of Ficus deltoidea plants as medicinal agents to treat various ailments have got the great public interest. A key point for the expansion in the use of F. deltoidea plants is due to the quality, efficacious and safe products for human consumption. To tackle this issue, seven varieties of F. deltoidea leaves were scree...

The present study was investigated the cytotoxic activity of a new aaptaminoid of A. aaptos against human myeloid leukemia cell line HL-60 and murine myelomonocytic leukemia cell line WEHI-3B, as well as the mode of cells death and antiviral activity against Herpes simplex virus type 1 HSV-1, infected normal mammalian cells, Cercopithecus aethiops...