Abdülmelik Aras

Iğdır university · Biochemistery

The antioxidant activities of ethanol and water extracts of Nepeta nuda subsp. lydiae leaves were determined by different in vitro methods such as; DPPH, ABTS, FRAP and CUPRAC assays. The results were compared to BHA, BHT and ascorbic acid as standard antioxidant compounds. Both water and ethanol extracts presented high antioxidant potential on DPP...

In this study, 4-((3,4-Dimethoxybenzylidene)amino)-5-alkyl(aryl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (4a-g) reacted with formaldehyde and 2,6-dimethylmorpholine to obtain seven novel potential biologically active 4-((3,4-Dimethoxybenzylidene)amino)-2-((2,6-dimethylmorpholino)methyl)-5-alkyl(aryl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (5a-g). The stru...

In this study, some biological activities extracts of Lamium garganicum subsp. lasioclades (Lgl) have been evaluated as well as identified the phenolic composition. Concentration ranges of 31.25, 62.5, 125, 250, and 500 µg/mL were applied to determine the extract's anti-cancer properties. Significant results were obtained against the osteosarcoma c...

In the last decades, there has been growing attention on plant polyphenols as bioactive components. Polyphenols contain one or more hydroxyl groups. Flavonoids, chalcones, and xanthones are the significant types of polyphenols. They have a broad range of biological activities including acetylcholinesterase, butyrylcholinesterase, α-glucosidase, and...

ÖZET Çeşitli aktif iş sektörlerinde çalışanların sağlığına zararlı olabilecek birçok risk etmeni bulunmaktadır. Biyolojik riskler de bu risk etmenlerden birisidir. Biyolojik etkenlere maruziyet durumunda riskler hakkında farkındalık oluşturmak için ele alınan bu çalışmada amaç hem çevreyi hem de çalışanları korumaktır. Maruziyet şekilleri, yüksek d...

Resinous beehive product propolis has many biological activities. It contains various aromatic substances that have great differences in their chemical composition depending on the natural flora. Thus, chemical characterization and biological properties of propolis samples is an important subject for the pharmaceutical industry. In this study, the...

İş sağlığı ve güvenliği kapsamında, okullarda çalışanların ve öğrencilerin maruz kaldıkları ve insan sağlığı üzerinde etkisi olduğu düşünülen uçucu organik bileşiklerin ölçümü yapılmıştır. Bu çalışmanın değerlendirilmesinde ilgili mevzuat ve standartlarda belirlenen sınır değerleri referans alınmıştır. Çalışma kapsamında elde edilen numuneler Gaz k...

In this study, several metal(II) complexes (Fe, Co, Zn, and Ru) of an azo dye ligand (ADL) that, apart from pyrazole ring (PR), include anisole having (−OCH3) group at the m‐substitue of the phenyl (L: (E)‐4‐((3‐methoxyphenyl)diazenyl)‐3‐methyl‐1H‐pyrazol‐5‐amine) were prepared, characterized, and the biological activity studies were carried out. T...

The form and distribution of trace elements in tissues and fluids of the body have become key details in life sciences and medicine, and they may be used to discover disease biomarkers. In the current study, concentrations of twelve elements in Rumex nepalensis, Inula Discoidea, Tripleurospermum callosum, and Thymus migricus plants samples were det...

In this study, 5-(2-hydroxy-4-methoxybenzylidenamino)-2-mercaptobenzimidazole and 5-(4-hydroxy-3-methoxybenzylidenamino)-2-mercaptobenzimidazole Schiff base compounds were synthesized and their structure were characterized with spectroscopic techniques, namely, 1H NMR, IR, and 13C NMR. In vitro ABTS, DPPH, CUPRAC, and FRAP tests were applied to cal...

In this study, a series of novel Schiff bases (4a-4h) containing 1,2,4-triazole structure were synthesized through a condensation reaction of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 3-(4-methylbenzenesulfonyloxy)-benzaldehyde. The structures of 3-alkyl(aryl)-4-[3-(4-methylsulfonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-tri...

Saponaria prostrata is a medicinal plant that contains various secondary metabolites such as phenolic acid, flavonoids, triterpenoids, and fatty acids that are related to some biological activities. In this study, we evaluated the enzyme inhibitory, antimicrobial potentials of S. prostrata. The antimicrobial activity of S. prostrata was measured us...

Schif bases are well-known compounds for having signifcant biological properties. In this study, a new Schif base ligand and its metal complexes were synthesized, and their antioxidant and enzyme inhibitory activities were evaluated. The new Schif base ligand was synthesized with the condensation reaction of 6-tert-butyl 3-ethyl 2-amino-4,5-dihydro...

Daucus carota L. ssp. major (DCM) plant is widely used in traditional medicine to treat some types of cancer and various diseases. Therefore, we evaluated the biological activities of this plant to define its effects against prostate cancer (PCa), Alzheimer’s disease (AD), oxidation, and diabetes mellitus (DM) as well as identified its phenolic com...

Saponaria prostrata (S. prostrata) is an endemic and medicinal plant that contains secondary metabolites such as flavonoids, phenolic compounds, fatty acids, and triterpenoids. This study was carried out to evaluate the antioxidant potentials, and phenolic composition of S. prostrata. Antioxidant properties of the ethanol and water extracts of S. p...

In the present study, 3-substitued-4-(4-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (S1-8) were synthesized by treating 4-hydroxybenzaldehyde (B) with eight different 3-substitued-4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones (T1-8) in acetic acid medium, separately. The synthesized Schiff bases (S) were reacted with formaldehyde and...

The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II) and palladium(II) complexes were successfully prepared. The structure of the compounds was elucidated by various techniques (NMR, FT-IR, powder X-ray diffraction, microanalysis, TGA, magnetic susceptibilit...

Many plant species have a large diversity of secondary metabolites with different biological activities. This study aims to assess the phenolic constituent, enzyme inhibitory and antioxidant activities of the aqueous (water) and methanol extracts of Inula discoidea. The enzyme assays showed effective enzyme inhibition of the methanol extract agains...

In this study, the novel azo dye FeII, CoII, ZnII, and RuII complexes with an azo dye ligand (L: (E)-4-((4-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were synthesized. The structures of the complexes were characterized by FT-IR, elemental analysis, UV-Vis, mass spectra (FeII and CoII), NMR spectra (only diamagnetic ZnII and RuII), thermog...

A series of Fe(II), Ni(II), and Pd(II) complexes were prepared with a novel Schiff base ligand containing pyridine moiety. The prepared compounds were characterized using FT-IR, ¹H and ¹³ C NMR, UV–Vis, powder XRD, thermogravimetric analysis, mass spectra, magnetic susceptibility, and elemental analysis. The coordination geometry of Fe(II) and Ni(I...

The identification and quantification of the volatile organic compounds profile of the plants is an important tool for food quality and authenticity assessment. In that context, herewith the study, we aimed at quantifying the volatile compounds of three plants Artemisia campestris L. subsp. glutinosa, Lavandula angustifolia Mill., and Zingiber offi...

This study was conducted to evaluate the phenolic content, antioxidant potential, and enzyme inhibitiory properties of Rumex nepalensis by in vitro spectrophotometric methods. The experiments demonstrated that glutathione S-transferase (GST), α-glycosidase (α-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes were strongly...

Novel Ru(II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, ¹H NMR, and ¹³C NMR spectra (only 1b and 1c). Structures of the synthesized Ru(II) complexes (2a-e) were illuminated by elemental analysis, IR, ¹H NMR, ¹³C NMR, and mass...

The synthesized Schiff Bases were reacted with formaldehyde and secondary amine such as 2,6-dimethylmorpho-line to afford N-Mannich bases through the Mannich reaction. 3-Substitued-4-(4-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (4) were treated with 2,6-dimethylmorpholine in the presence of formaldehyde to synthesize eight new 1-(...

In this study, new 1,2,3-triazole derivatives containing chalcone core (1-7) were synthesized. Obtained compounds were characterized by IR, ¹H-NMR, ¹³C-NMR, and mass studies. Characterized compounds (1-7) inhibitory effects were tested against the glutathione S-transferase (GST), acetylcholinesterase (AChE), and Butyrylcholinesterase (BChE). Their...

The compounds (3-6) used in this study were re-synthesized in accordance with our previous study. The inhibitory effect of the complexes on some metabolic enzymes was examined and it was demonstrated that the enzymes inhibited by ligands and their complex molecules at micromolar level. The best Ki value for α-glycosidase enzyme was absorved 1.01±0....

Medicinal plants have been used traditionally since ancient times as alternative medications to treat various human diseases. In this work, we examined the chemical constituent, antioxidant activity, and enzyme inhibition of an endemic plant Thymus migricus. The plant extracts showed remarkable inhibition effects against the acetylcholinesterase (A...

Inhibitory effect of the complexes on some metabolic enzyme results demonstrated that the enzymes inhibited by ligand and it’s complex molecules at the micromolar level. The best inhibition effect for α-Gly enzyme against cobalt complex with 3.77 ± 0.58 µM, Ki values were observed. For AChE, and BChE enzymes against SM-Co complex with 74.23 ± 5.02...

Phenolic content and antioxidant activity of Anthemis kotschyana Boiss. var. discoidea (A. kotschyana) were reported in this study. The ethanol extract of Anthemis kotschyana (EEA) and the water extract of Anthemis kotschyana (WEA) were prepared and used for biochemical analyses. Radical scavenging antioxidant capacities of EEA and WEA were evaluat...

The main aim of this study is to determine the antioxidant activities of ethanol and water extracts of Anthemis kotschyana Boiss. var. discoidea. In order to determine the antioxidant activity, FRAP method (ferric ions reducing antioxidant potentials) and CUPRAC method (cupric ions reducing antioxidant capacity) were performed. The results were com...

Achillea schischkinii Sosn. is an endemic plant species and it belongs to Asteraceae family. It is distributed widely in the Central and East Anatolia. This study was carried out for evaluation of the antioxidant activity, enzyme inhibition effect, elemental and phenolic content of A. schischkinii. Briefly, acetylcholinesterase (AChE), butyrylcholi...

Many chronic diseases such as diabetes and Alzheimer’s disease are related to the type and quality of foods, which are consumed. Particularly, various plant origin products are stated as beneficial against such kind of chronic diseases with secondary metabolites such as their phenolic structures. Satureja cuneifolia is a plant, which is consumed as...

The aim of this work was to investigate the enzyme inhibition, antioxidant activity, and phenolic compounds of Lecokia cretica (Lam.) DC. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glycosidase enzymes were strongly inhibited by the L. cretica extracts. IC 50 values for the three enzymes were found as 3.21 mg/mL, 2.1 mg/mL, and...

Antioxidant activities of Satureja boissieri extracts were detected by using specific in vitro techniques. Standard antioxidant compounds such as ascorbic acid, BHA (Butylated Hydroxyanisole) and BHT (Butylated Hydroxytoluene) were used to compare with the results obtained from ethanol and water extracts of the plant samples. Both extracts prese...

The new complex compounds [RuLCl(p‐cymene)]∙3H2O and [NiL2(H2O)2]∙3H2O (L: 1‐(4‐(2‐hydroxy‐3‐methoxybenzylideneamino)phenyl)ethanone) were prepared and characterized using FT‐IR, 1H and 13C NMR, mass spectroscopy, TGA, elemental analysis, X‐ray powder diffraction and magnetic moment techniques. Octahedral geometry for new Ni(II) and Ru(II) complexe...

Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC–MS/MS (Liquid Chromatography tandem Mass Spectrometry). Salvigenin (158.64 ± 10.8 mg/kg), fumaric acid (123.09 ± 8.54 mg/kg), and quer...

Organic compounds exist abundantly in natural plants. The antioxidant activities of phenolic compounds are mainly attributed to their redox properties which allow them to act as chelating metals, reducing agents, hydrogen donors and quenchers of singlet oxygen. The main objective of the current work is to summarize and compare the phenolic, flavono...

The main objective of the current work is to identified the phenolic compounds of some plants that grow naturally in some mountains of East Anatolia/Turkey. For this purpose, we detected phenolic contents of three Nepeta species plants; Nepeta fissa, Nepeta nuda subsp. lydiae, and Nepeta nuda subsp. albiflora by using UHPLC-ESI-MS/MS.

In this work our main objective was to search antimicrobial activity of Marrubium astracanicum subsp. macrodon and Origanum Accudents plants. Fort this purpose four Gram negative and three Gram positive bacteria species, and three fungi species were used. According to the results of high biological activity and phenolic content, the leaves of Marru...

Phryna ortegioides was investigated for its antioxidant activity by using different in vitro methods. Three standard antioxidant compounds (BHA, BHT, and ascorbic acid) were used for comparing the results that obtained from ethanol and water extracts of the plant material. Ethanol extracts showed high antioxidant potential on FRAP and CUPRAC method...

Natural plants are main source of antioxidants and biochemical components. Antioxidant substances have radical scavenging and reducing properties to protect the causes or effects of oxidative stress. Synthetic or natural antioxidants have been used in diet, food additives or drugs. Many medicinal plants have been reported for their antioxidant capa...

Antioxidant properties of Marrubium astracanicum subsp. macrodon solvent extracts were measured by both cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods. According to the results, ethanol extract of the plant has high potential of reducing antioxidant activity on CUPRAC method. However, water ex...

The main objective of the current work is to search the antioxidant activities of Origanum acutidens leaves by using DPPH, FRAP and CUPRAC methods severally. Three well known antioxidant compounds (BHA, BHT and ascorbic acid) were used as standards for comparing the extracts. Also, phenolic compounds of Origanum acutidens leaves were identified by...

The main objective of the current work is to search the antioxidant activities of Origanum acutidens leaves by using DPPH, FRAP and CUPRAC methods severally. Three well known antioxidant compounds (BHA, BHT and ascorbic acid) were used as standards for comparing the extracts. Also, phenolic compounds of Origanum acutidens leaves were identified by...

Continuing our work on the sources of natural bioactive compounds, we evaluated the antimicrobial and antioxidant activities of Nepeta trachonitica as well as its major phenolic content using the high-performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) technique. For antioxidant activity, ferric reducing antioxidant p...

In this study, UV spectral data. In addition, the synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods, including reducing power, free radical scavenging and metal chelating activity.

Phenolic compounds of Nepeta nuda subsp. Lydiae leaves were identified by UHPLC-ESI-MS/MS. To the best of our knowledge, phenolic compounds in N. nuda subsp. Lydiae are reported for the first time. Chlorogenic acid, rosmarinic acid and quinic acid, were found to be the most abundant compound in the methanol extract of N. nuda subsp. Lydiae, among t...