Abdülkadir Tunç

Sakarya Training and Research Hospital · Neurology

A BSTRACT Objective Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder with a variable course that complicates the prediction of remission. This study aimed to evaluate the utility of repetitive nerve stimulation (RNS) in monitoring clinical status through the assessment of decremental response rates in the nasalis and trapezius...

A BSTRACT Context This study evaluated the diagnostic accuracy of repetitive nerve stimulation (RNS) compared with single-fiber electromyography (SF-EMG) in generalized myasthenia gravis (MG). Aims The aim of the study was to determine the diagnostic sensitivity of RNS in various muscles and assess the effect of varying decrement cutoff values on...

Background: Alterations in the cerebral venous system have been increasingly recognized as a significant component of the pathophysiology of multiple sclerosis (MS). This study aimed to explore the relationship between venous sinus diameter and MS to understand potential vascular alterations in MS patients compared with controls. We sought to deter...

This case report details a female patient with multiple sclerosis in her 30s, who experienced a significant fingolimod rebound syndrome post partum, characterised by worsening neurological symptoms and severe demyelinating lesions. Traditional treatments, including steroids and plasmapheresis, were ineffective. However, the introduction of intraven...

Objectives: This study aimed to determine whether exercise reduced alpha-synuclein aggregation and ultimately improved symptoms of Parkinson’s disease (PD). Patients and methods: The prospective study was conducted with 26 PD patients (14 males, 12 females; mean age: 58.5±11.3 years; range, 38 to 79 years) between October 2019 and January 2020. A 1...

Significant advancements have been achieved in delineating the progress of the Global PROMS (PROMS) Initiative. The PROMS Initiative, a collaborative endeavor by the European Charcot Foundation and the Multiple Sclerosis International Federation, strives to amplify the influence of patient input on MS care and establish a cohesive perspective on Pa...

BACKGROUND Upper extremity strength and function are rarely assessed in routine multiple sclerosis (MS) care. This study aimed to evaluate hand muscle strength and functionality in individuals with MS and investigate correlations with upper extremity function, cognitive status, health-related quality of life (HRQOL), and balance. METHODS A cross-s...

Introduction: This study aims to delineate the prevalence, clinical characteristics, diagnostic findings, and treatment outcomes of Myelin Oligodendrocyte Glycoprotein Associated Disease (MOGAD) in a cohort over four years, providing a basis for improved diagnostic criteria and therapeutic strategies. Materials and Methods: In a retrospective cohor...

Objectives: Multiple sclerosis (MS), which is known as a young-adult age disease, is called late-onset MS (LOMS) when it occurs at the age of 50 and older. In our study, we aimed to analyse the clinical and demographic characteristics, comorbidities, diagnostic and treatment challenges and prognosis of LOMS. Methods: In a retrospective analysis of...

Background This study aims to explore the relationship between venous sinus diameters and Multiple Sclerosis (MS) to understand potential vascular alterations in MS patients compared to a control group. It seeks to determine if these alterations correlate with disease characteristics such as duration, lesion types, and disability scores. Methods T...

Objective: This research offers a comprehensive analysis of Myasthenia Gravis (MG), uncovering the remarkable accuracy of spinal accessory, ulnar, and facial nerve repetitive nerve stimulation (RNS), along with the precision of single fiber electromyography (SF-EMG) in MG diagnosis. We also embark on an exploration of clinical features and autoanti...

Introduction: It is known that multiple sclerosis (MS) often coexists with other autoimmune diseases. Hence, autoantibody (auto-Ab) tests may prove useful in the differential diagnosis of MS. The objectives of this study were to: (a) investigate the prevalence of auto-Ab positivity at the beginning of the MS diagnostic process; (b) assess whether...

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system. It is a chronic disease, and in the evaluation of all other health and vital processes, decisions about vaccination should be made considering the disease process and the medications used by the patient. Since vaccination can be performed at any stage...

Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si: Prof. Aslı Tuncer MD, Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system. It is a chronic disease, and in the evaluation of all other health and vital processes, decisions should be made by considering the disease process and the drugs used b...

Objective: Smoking cessation is affected by multiple factors including cognitive status of the patients. In this study, we aimed to investigate the effects of demographic, emotional and cognitive functions of 39 male and 42 female patients who applied to the smoking cessation outpatient clinic on smoking cessation. Patients and methods: This stu...

Background: Brainstem involvement (BSI) has been reported as a major predictive factor for future disability in Multiple Sclerosis (MS). Aims/objectives: To evaluate whether Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) and Video Head Impulse Test (vHIT) can be used to detect demyelinating lesions in vestibular pathways in MS. Materia...

Background: Ulnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy. There is little information about the application of F-wave studies for evaluation of UNE. Objective: The aim of this study was to evaluate the diagnostic value of minimum F-wave (F-min) latency alterations by comparing this with nerve conduction analy...

Background: Restless legs syndrome (RLS) is one of the most common and burdensome sleep disorders in the course of multiple sclerosis (MS). Objective: To evaluate common MS-related symptoms and consequences between groups with and without RLS and further assess the association of quality of life determinants with RLS symptom severity. Methods: Ac...

Fahr sendromu, simetrik ve bilateral intrakraniyal kalsifikasyon ile seyreden nadir bir hastalık tablosu olup psikiyatrik semptomlar, epileptik nöbetler, serebellar bulgular, ekstrapiramidal disfonksiyon ve demans gibi klinik belirtiler ile kendini gösterebilir. Hastalığın birçok farklı klinik tablosu olmasına rağmen etiyolojisi henüz net olarak bi...

Background: Guillain-Barre syndrome is an acute immune-mediated polyneuropathy characterized by rapidly evolving symptoms and disability. Cerebrospinal fluid analysis and electrophysiological studies are crucial in the diagnosis of this syndrome. Objective: To evaluate the prognostic value of the type and number of demyelinating findings and cereb...

Coronaviruses are revealed to target the human respiratory system mainly. However, they also have neuro-invasive abilities and might spread from the respiratory system to the central nervous system. Herein, we report four patients with COVID-19 simultaneously diagnosed with acute ischemic stroke. There were four stroke cases with simultaneously dia...

Özellikle nörolog olmayan hekimler için nörolojik hastalıklara ait semptomlar en çok çekinilen semptomlardandır. Senkoplar da bunun başında gelir. Bu nedenle kitabımızda bu semptomu hem nörolog, hem kardiyolog hem de psikiyatrist açısından ele aldık. Bu kitabın temel amacı sıkça görülen nörolojik semptomları ayrıntılı olarak tanımlamak ve hangi has...

Nöro-Behçet Hastalığı (NBH) parankimal ve non-parankimal tutulum olarak sınıflandırılmıştır. Tanı aftöz lezyonların yanında göz, cilt bulguları, paterji testi pozitifliği ve vasküler lezyonların tanınması ile konmaktadır. Bu yazımızda kliniğimize farklı nörolojik yakınmalarla başvuran ve klinik değerlendirmeler sonucunda NBH tanısı alan 3 olgu sun...

This study investigated the predictors of prognosis at admission and after the first month in Guillain–Barré syndrome (GBS) patients. This retrospective study used the electronic records of 81 GBS patients. Age, gender, previous GBS history, antecedent febrile illness and presence of cranial nerve dysfunction were recorded. Detailed neurological ex...

Aim: The aim of this study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare with levels measured in healthy subjects. Methods: This retrospective case-control study include...

With the rising prevalence of morbid obesity, the numbers of bariatric surgical procedures are also increasing, thus resulting in more neurological complications to be recognized. Among these complications, the most well-defined are Wernicke's encephalopathy and peripheral neuropathies. Guillain Barre Syndrome (GBS) has been reported as a very rare...

Background: Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT. Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare these with healthy individuals. Methods: This prospective case-control study was conducted with...

Background and purpose There is a lack of research on the association between body image perception (BIP) and multiple sclerosis (MS). The aim of this study was to evaluate BIP in MS patients and its correlation with depression, anxiety, duration of the disease, and sociodemographic characteristics of the patients. Methods Fifty patients with MS w...

EVALUATION OF BODY IMAGE PERCEPTION IN MULTIPLE SCLEROSIS PATIENTS WITHOUT NEUROLOGICAL DEFICIT Hakan S SENGUL, Yıldızhan SENGUL, Ali Zeynel Abidin TAK, Müge KOCAK, Abdulkadir TUNÇ. Objective – There is a lack of research on the association between body image perception (BIP) and multiple sclerosis (MS). The aim of this study was to evaluate BIP...

Gerstmann sendromu agrafi , parmak agnozisi, sağ-sol dezoryantasyonu ve akalkuli ile karakterize bir klinik tablodur. Saf vakaların hiçbirinde aleksi görülmemektedir. 62 yaşında erkek hasta sol pariyetotemporal alanda akut iskemik enfarkt ile başvurdu. Kliniğinde Gerstmann tetradının yanısıra aleksi tablosu mevcuttu. Nadir görülen bu tablonun klini...

Background: Craniocervical artery dissection is an important cause of ischemic stroke especially in young and middle aged adults. In this study, we evaluated extracrainal and intracranial artery dissections in terms of etiologies, risk factors, stroke severity and functional outcomes. Methods: A total of 29 patients who were diagnosed with ischemic...

Neuromuscular complications related to colchicine are axonal sensorimotor peripheral neuropathy and myopathy. Myotonic discharges are rarely reported during needle EMG testing. We present a 78-year-old woman with the diagnosis of familial Mediterranean fever suffering from lower extremity weakness, fatigue and pain. The patient showed painful lower...

Amaç: Esansiyel tremor (ET) en sık görülen hareket bozukluklarından biridir. Yüz duygu tanıma (YDT), duygusal işlevin en temel yönlerinden biridir ve sosyal davranışların en kritik bileşenlerindendir. Bu çalışmanın amacı ET hastalarında yüz duygu tanıma becerilerinin değerlendirilmesi ve sağlıklı kontrollerle karşılaştırılmasıdır. Yöntemler: Çalışm...

Objective - Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vertigo. Inflammation is a hypothetic etiological factor in BPPV. The aim of this study was to evaluate inflammatory biomarker levels in BPPV patients and compare these with the healthy subjects. Materials and methods - This prospective case-control study...

Background and purpose: The increasing prevalence of dementia over the previous decades has been accompanied by numerous social and economic problems. The importance of exercise in the prevention of dementia coupled with the impact of aspiration pneumonia on the mortality and morbidity of dementia patients cannot be overstated. This study investig...

Background and purpose: The aim of this study was to evaluate the relationship between electrophysiological stage, symptom severity, functional status and anxiety levels in patients with idiopathic carpal tunnel syndrome (CTS). Methods: This study included 130 patients in the 25-79 age group who were classified as clinically and electrophysiolog...

Background and purpose: Migraine is a common and often debilitating disorder. Although the existence of a link between migraine and certain psychological features has long been known, data on dissociative experiences in migraine patients is insufficient. The aim of this study was to evaluate the presence of psychoform and somatoform dissociative e...

Amaç: Sessiz beyin enfarktları klinik olarak bulgusu ve semptomu olmayan ancak kraniyal radyolojik görüntülemelerde veya otopsi materyallerinde gösterilen vasküler hasarlar için kullanılan bir terimdir. Son yıllarda gelişen kraniyal görüntüleme tekniklerinin gelişimi ile sessiz beyin enfarktlarının saptanması kolaylaşmıştır. Bu çalışmanın amacı ses...

Introduction: This study aimed to evaluate the cognitive performance of migraine patients with (MwA) and without aura (MwoA) and investigate the correlation of white matter hyperintensities (WMHs) and psychological symptoms with their cognitive test scores. Material and methods: Hundred migraine patients aged 20-55 years and 80 healthy volunteer...

Objective: We aimed to investigate whether Serum Prolidase Activity (SPA) levels could be used as a potential diagnostic and/or prognostic biomarker in Acute Ischemic Stroke (AIS) patients or not. Materials and methods: SPA levels were prospectively evaluated in 37 patients aged between 20 and 85 y who were admitted within 24 h of the onset of AIS....

The purpose of this study was to investigate the effects of depression, anxiety and sleep disturbances on cognitive functions in chronic obstructive pulmonary disease (COPD) patients. In this prospective case-control study, demographic data, smoking history, depression, anxiety, sleep quality and cognitive status of 48 COPD patients and 36 healthy...

Abstract Background The aim of this study was to investigate the predictors of intensive care unit (ICU) admission and mortality among stroke patients and the effects of a pulmonary rehabilitation program on stroke patients. Methods This prospective study enrolled 181 acute ischemic stroke patients aged between 40 and 90 years. Demographical charac...

Amaç: Karpal tünel sendromu (KTS) tanısı klinik bulgular, fizik muayene ve elektromiyografi (EMG) ile konur. Vücut kitle indeksi (VKI) KTS gelişiminde önemli bir risk faktörüdür. Bu çalışmanın amacı KTS hastalarında demografik verilerin değerlendirilmesi, klinik evreleme, VKI ve semptom süresi ile elektrofizyolojik KTS grupları arasındaki ilişkinin...

Background: Electro-diagnostic studies are the most reliable methods in diagnosis of carpal tunnel syndrome (CTS). Although there are many risk factors associated with CTS, there are a limited number of studies in the literature indicating that manual milking, which is frequently seen in Turkey, is a risk factor for CTS. Objective: The purpose o...

The aim of this study was to investigate retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, macular changes (central subfield thickness (CST), cube average thickness (CAT), cube volume (CV) in patients with migraine using spectral-domain optical coherence tomography (OCT) and to assess if there was any correlation with white mat...

Objective: This study aimed to evaluate the R-R interval recording sensitivity in the early diagnosis of diabetic autonomic neuropathy (DAN).Methods: Sixty patients who applied to neurology outpatient clinics and were thought to have diabetic polyneuropathy were accepted to the study. The control group was formed by 31 healthy volunteers. The stand...

Amaç: Migren tanısı, büyük oranda başağrısının özellikleri ve eşlik eden semptomlar göz önüne alınarak konur. Kronik inflamatuar sinonazal hastalıklı olgular ciddi baş ağrılarına neden olabilmekte, migreni tetikleyebilmekte, hatta migren yanlış tanısıyla izlenebilmektedir. Bu çalışmada, migren tanısı ile takip edilen tedaviye dirençli hastalarda, k...