Abdolreza Simchi

• Doctor of Philosophy
• Professor and Humboldt Scholar at Fraunhofer Institute

Real-time monitoring of sweat using wearable devices faces challenges such as limited adhesion, mechanical flexibility, and accurate detection. In this work, we present a stretchable, adhesive, bilayer hydrogel-based patch designed for continuous monitoring of sweat pH and glucose levels using AI-assisted smartphones. The patch is composed of a bot...

The increasing demand for advanced biomaterials in nerve tissue engineering presents numerous challenges due to the complexity of nerve tissues and the need for materials that can accurately replicate their intricate structure and function. In response, this study introduces a novel injectable hydrogel that is thermosensitive, self-healing, and...

Decellularized amnion (dAM)-derived hydrogels have been extensively exploited for versatile medical and therapeutical applications, particularly for soft tissue engineering of skin, vascular graft, and endometrium. In contrast to polyacrylamide-based hydrogels, which have been extensively employed as a 3D cell culture platform, the cell response of...

The interest in bismuth-based anodes for energy storage devices has recently been heightened due to their high specific capacity, low working potential, excellent electrical conductivity, and environmentally friendly nature. However, capacity fading during early battery cycling is associated with solid electrolyte interphase forming and volume chan...

Although hydrogels developed based on the decellularized amniotic membrane (dAM) hold great promise for tissue engineering and regenerative medicine, the development of printable bioinks faces serious limitations considering appropriate rheological behavior and shape fidelity after 3D printing. To improve the printability of dAM, we propose that hy...

In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue regeneration and has been of immense interest for clinical applications. AM is an abundant and cost-effective tissue source that does not face strict ethical issues for biomedical applications. The outstanding biological attributes of AM, including side-dependen...

The development of self-healing and 3D printable hydrogels with decent biocompatibility, mechanical durability, adhesiveness to tissues, and antibacterial activity is of great importance for wound healing applications. In this study,...

Medical applications of nanotechnology in tissue engineering, biomedical devices, biosensors, and biological machines have significantly enhanced over the past decade. Advanced composite and hybrid materials (ACHMs) have become the foundation of nanomedicine research because biological systems are complex in nature and require materials with specif...

Two-dimensional transition metal dichalcogenides (TMDs) offer fascinating opportunities for fundamental nanoscale science and various technological applications. They are a promising platform for next generation optoelectronics and energy harvesting devices due to their exceptional characteristics at the nanoscale, such as tunable bandgap and stron...

Wound healing is a complex process that requires effective management to prevent infections and promote efficient tissue regeneration. In recent years, upconversion nanoparticles (UCNPs) have emerged as promising materials for...

A reliable, fast, and cost-effective method of monitoring morphine (MO) concentration in biological fluids is highly desired in clinical and modern medicine. Nanotechnology has opened up new possibilities for developing morphine biosensors, but the most advanced electrodes available offer a detection limit (LOD) of ≥10 nM. This work introduces a ne...

Despite the benefits of chemotherapy, radiotherapy, and surgical resection in cancer treatment, the efficiency of these techniques is insufficient. The development of nanocarriers enabling combined diagnosis and therapy is progressive but still is limited. In this paper, we developed bandgap-modified Fe3O4@Ag@CuS nanoparticles conjugated with AS141...

Hydrogel-based wearable electrochemical biosensors (HWEBs) are emerging biomedical devices that have recently received immense interest. The exceptional properties of HWEBs include excellent biocompatibility with hydrophilic nature, high porosity, tailorable permeability, the capability of reliable and accurate detection of disease biomarkers, suit...

Recently, decellularized amniotic membranes (dAM) have attracted significant interest as a valuable source for the development of shear-thinning hydrogels and bioinks. However, the inferior rheological behavior and weak mechanical durability restrict the printability of the hydrogels and their stability after three-dimensional (3D) bioprinting. The...

Introduction: Due to the potential positive effects of rosuvastatin (RSV) on human mesenchymal stem cells (MSCs) osteogenesis and new bone regeneration, it is crucial to develop a suitable carrier that can effectively control the release profile of RSV. The primary objective of this study was to introduce a novel drug delivery system based on core/...

Hydrogel-based wearable electrochemical biosensors (HWEBs) are emerging biomedical devices that have recently received immense interest. The exceptional properties of HWEBs include excellent biocompatibility with hydrophilic nature, high porosity, tailorable permeability, the capability of reliable and accurate detection of disease biomarkers, suit...

Additive manufacturing (AM) of biomedical materials provides enormous opportunities to fabricate multifunctional and structurally designed frameworks for tissue engineering, such as dental implants and bone substitutes. Despite several advantages of the binder jet 3D printing technology over other AM methods, for example, no limitations in material...

Thermo-responsive and injectable hydrogel based on chitosan, pluronic, gold-decorated bacterial nanocellulose (CS-CPF-Au@OBC) were synthesized. Au nanoparticles were in situ formed on the surface of the oxidized nanofibers with two important roles of conducting and strengthening the mechanical properties. Fourier transform infrared spectroscopy,...

Recently, organic–inorganic perovskites have manifested great capacity to enhance the performance of photovoltaic systems, owing to their impressive optical and electronic properties. In this simulation survey, we employed the Solar Cell Capacitance Simulator (SCAPS-1D) to numerically analyze the effect of different hole transport layers (HTLs) (Sp...

Additive manufacturing (AM) of biomedical materials provides enormous opportunities to fabricate multifunctional and structurally designed frameworks for tissue engineering, such as dental implants and bone substitutes. Despite several advantages of the binder jet 3D printing technology over other AM methods, the fabrication of biomedical-grade tit...

The ongoing and rapid growth of atmospheric CO2 levels causes a crucial worldwide concern. Herein, an efficient electrocatalyst has been introduced for electrochemical CO2 reduction reaction (CO2RR) to address the...

Two-dimensional (2D) tungsten disulfide (WS2) became fascinating for optoelectronic applications due to its direct bandgap, high carrier mobility, chemical stability, and strong light-matter interactions. The complementary properties of van der Waals (vdW) heterostructures of 2D WS2 with graphene promise excitonic optoelectronic performance; howeve...

Theranostic liposomes have recently found a broad range of applications in nanomedicine due to stability, the high solubility of biomacromolecules, bioavailability, efficacy, and low adverse effects. However, the limitations of liposomes concerning the short systemic circulation in the body, limited controllability of the release rate, and the inab...

Magnesium (Mg) and its alloys have proved promising as biodegradable candidates for the repair of bone tissue. Despite the encouraging bio-related properties of Mg, its high corrosion rate in contact with body fluids still presents a major challenge. An efficient approach to address this issue is to provide a protective coating on Mg. The present r...

It has long been known that Silibinin, a naturally derived herbal phytochemical, is an effective drug for treating toxic thyroid damage; however, its role in cancer treatment is still not approved and is under investigation. In this work, we propose a protocol to prepare liposome-encapsulated Silibinin (LES) with the potential to produce reactive o...

Sintering anisotropy is the major challenge limiting the fabrication of large and complex-shaped parts by binder jet additive manufacturing. We employed 3D shell binder jetting to fabricate green parts with a minimum heterogeneity in the pore structure. The advantages of the process include fast printing speed, minimum consumption of the binder, ea...

Recently, decellularized amniotic membrane-derived hydrogels (DAMHs) have received significant attention for wound care, ocular surface reconstruction, and chondral healing. Despite the advantages of DAMHs for tissue engineering (TE), the loss of structural components during the decellularization process mitigates their mechanical strength and thus...

Background and Objectives: The inability of classic fluorescence-activated cell sorting to single cancer cell sorting is one of the most significant drawbacks of this method. The sorting of cancer cells in microdroplets significantly influences our ability to analyze cancer cell proteins.

Myocardial infarction is a major cause of death worldwide and remains a social and healthcare burden. Injectable hydrogels with the ability to locally deliver drugs or cells to the damaged area can revolutionize the treatment of heart diseases. Herein, we formulate a thermo-responsive and injectable hydrogel based on conjugated chitosan/poloxamers...

The rheological behaviour of powder injection moulding feedstock comprising of 316L stainless steel and 3 wt-%TiC powders was studied using a capillary rheometer. The flowability and the sensitivity of viscosity to shear rate and temperature of the feedstock were investigated and compared with those of the binder system and the 316L SS PIM feedstoc...

The rheological behaviour of powder injection moulding feedstock comprising of 316L stainless steel and 3 wt-%TiC powders was studied using a capillary rheometer. The flowability and the sensitivity of viscosity to shear rate and temperature of the feedstock were investigated and compared with those of the binder system and the 316L SS PIM feedstoc...

Bimodal magnetic-fluorescent materials for diagnostic imaging needs surface-engineered nanoparticles with great biosafety, pronounced colloidal stability, high magnetic moments, and strong photoluminescence (PL) emission. This work presents polymer-coated nanoparticles (PCNPs) based on manganese ferrites covered with a thin shell of nitrogen-doped...

The biodegradation behavior of Mg, coated by polymethyl methacrylate as well as polymethyl methacrylate (PMMA)−bioactive glass (BG) composite was investigated. Electrophoretic deposition and dip coating techniques were adopted to prepare composite coating using a suspension of different percentages of the above two chemical materials. The deposited...

Cardiac troponin-I (cTnI) is a well-known biomarker for the diagnosis and control of acute myocardial infarction in clinical practice. To improve the accuracy and reliability of cTnI electrochemical immunosensors, we propose a multilayer nanostructure consisting of Fe3O4-COOH labeled anti-cTnI monoclonal antibody (Fe3O4-COOH-Ab1) and anti-cTnI poly...

The α-FAPbI3 perovskite nanocrystals exhibit interesting optical properties, which make them attractive for versatile optoelectronic applications; however, the spontaneous phase transformation to the non-perovskite phase (δ-FAPbI3) in humid conditions requires a new strategy to improve the phase stability of the material. We employed 3-Aminopropyl...

The increasing demand and interest in biomedical applications have elicited numerous state-of-the-art researches on a wide range of materials, structures, and fabrication procedures. A very intriguing class of materials utilized for such purpose is graphene-based polymer nanocomposites. They have shown a great promise in biomedical applications tha...

The rheological behaviour of powder injection moulding feedstock comprising of 316L stainless steel and 3 wt-%TiC powders was studied using a capillary rheometer. The flowability and the sensitivity of viscosity to shear rate and temperature of the feedstock were investigated and compared with those of the binder system and the 316L SS PIM feedstoc...

We present a procedure for simultaneous deposition of enzyme-laden chitosan/reduced graphene oxide (rGO) film by electrophoretic deposition (EPD) for fast and efficient detection of glucose. The role of rGO nanosheets is studied on the EPD kinetics of the enzyme-laden suspensions. Investigating the performance of the biosensor by electrochemical te...

The type of passivating ligands and the ligand exchange method influence the quality of lead sulfide quantum dot films. This imssssparts on the efficiency of optoelectronic devices. To get a compact arrangement of the nanocrystals in a thin film (⁓100 nm) via self-assembling, we used organic-inorganic perovskites with mixed halides for the solid-st...

Moving from two-dimensional hexagonal boron nitride (2D h-BN) flatlands towards their quantum sized zero-dimensional (0D) islands, as the newest member of the h-BN family, has recently opened up novel research areas due to the emergence of unique optical and physicochemical properties, excellent thermal and chemical stability, and desirable biocomp...

Metal halide perovskite nanoparticles have recently attracted immense interest for photodetectors due to their outstanding optical and electronic properties such as high carrier diffusion length, tunable band gap (light absorption range), and high photoluminescence (PL) efficiency. Although significant progress has been achieved in the development...

The high mobility of charge carriers in graphene (G) together with the ease of processing and tunable optical properties of colloidal quantum dots (CQD) have provided high-performance hybrids for the next generation of phototransistors. In order to get a higher quality film of PbS QDs, understanding the effect of ligand exchange method is critical....

The development of noble-metal-free electrocatalysts with enhanced active sites is of great significance for the production of renewable energy on large scale. Ultrathin transition metal compounds (e.g., phosphides and sulfides) have unique structural features but their stability and electroactivity must still be improved for practical applications...

To improve the efficiency of electrochemical processes for environmental remediation, we present a new type of hybrid nanomaterials based on leaf-like copper-based quaternary transition metals and spongy monolayer graphene. To demonstrate the functionality of the hybrid electrocatalyst, fast and competent electrooxidation of water and glucose is sh...

Precious metal-free electrocatalysts based on two-dimensional nanomaterials have efficiently been used for oxygen evolution reaction; however, the low activity and stability of these materials as compared with noble metals are still distractive. We present a novel and high-performance electrocatalyst based on nanowires of mixed transition metal oxy...

The hot deformation behavior of coarse-grained (CG), ultrafine-grained (UFG), and oxide dispersion-strengthened (ODS) AA6063 is experimentally recognized though carrying out compression tests at different temperatures (300–450 °C) and strain rates (0.01–1 s−1). Microstructural studies conducted by TEM and EBSD indicate that dynamic softening mechan...

A highly efficient, cost-effective, and durable electrocatalysts based on CoNi metal-organic framework (MOF) nanosheets on highly porous conductive graphene (PCG) is introduced for the hydrogen evolution reaction (HER). The electrocatalyst was fabricated by template-assisted chemical vapor deposition of graphene followed by solvothermal growth of C...

Crystalline anatase TiO2 nanoparticles were synthesized in the gas phase using an H2O-assisted atmospheric-pressure CVS process. Simultaneous oxidation/hydrolysis of TiCl4 in the H2O-assisted APCVS process demonstrates the feasibility of facile fabrication and the designed synthesis of TiO2 nanoparticles in atmospheric pressure. Kinetics and thermo...

Wound healing is a complex process based on the coordinated signaling molecules and dynamic interactions between the engineered scaffold and newly formed tissue. So far, most of the engineered scaffolds used for the healing of full-thickness skin wounds do not mimic the natural extracellular matrix (ECM) complexity and therefore are not able to pro...

Chitosan/poly(vinyl alcohol)/amino-functionalized montmorillonite nanocomposite electrospun membranes with enhanced adsorption capacity and thermomechanical properties were fabricated and utilized for the removal of a model cationic dye (Basic Blue 41). Effects of nanofiller concentrations (up to 3.0 wt %) on the morphology and size of the nanofibe...

This work presents a novel melatonin sensor based on unfunctionalized macroporous graphene networks decorated with gold nanoparticles for the differential pulse voltammetric detection of melatonin in pharmaceutical products. Highly porous graphene structures were prepared by metallic template-assisted chemical vapor deposition, and their active sur...

High performance piezoelectric polymers have been gained increasing attention for wearable electronic devises. In this study, we show that the piezoelectric response of poly (vinylidene fluoride) (PVDF) nanofibrous can be enhanced by zirconium-based metal-organic framework (MOF). The PVDF nanofibers with average size of about 60 to 80 nm were prepa...

One of the major limitations of traditional fluorescence-activated cell sorting (FACS) is its inability to compartmentalize single cancer cells. Sorting of cancer cells in microdroplets significantly influences our ability to the analysis of cancer cell proteins. Here, we adapted a previously developed microfluidic device by the Mazutis group as a...

The development of bioinks based on shear-thinning and self-healing hydrogels has recently attracted significant attention for constructing complex three-dimensional physiological microenvironments. For extrusion-based bioprinting, it is challenging to provide high structural reliability and resolution of printed structures while protecting cells f...

The powder fed friction stir process (FFSP) is a new and attractive solid-state manufacturing technique that enables the fabrication of polymer matrix nanocomposites (PNC). Herein, we present the fabrication of poly-carbonate (PC)-based nanocomposites by in-situ injection of colloidal alumina nanoparticles (<100 nm) into the plasticized polymer und...

Chemical processing of two-dimensional (2D) transition metal dichalcogenides has attracted immense attention due to their unique optical, electrical, and catalytic properties. In this paper, we show that under special conditions during seedless chemical vapor deposition (CVD), it is possible to grow large-area 2D WS2 layers with disc-shaped morphol...

Electrochemical sensing performance of two-dimensional hexagonal boron nitride (2D h-BN) has traditionally been suppressed by their intrinsic electrical insulation and deficient electron transportation mechanism. However, the excellent electrocatalytic activity, high specific surface area, N- and B-active edges, structural defects, adjustable band...

High performance wearable electronic devices with capability of harvesting mechanical force into electrical energy have been gaining increased attention for biomedical monitoring applications. We present a novel wearable piezoelectric sensor based on poly (vinylidene fluoride) (PVDF) nanofibrous membrane containing microporous zirconium-based metal...

The high charge carrier recombination rate and weak oxygen evolution kinetics have impeded the efficiency of WO3 photoelectrodes for water splitting. We present a novel type II heterojunction semiconductor based on mixed WS2 and MoS2 nanosheets on WO3 nanoflakes hydrothermally grown on highly porous W skeletons. The chemically exfoliated transition...

Solution-processed lead sulfide quantum dots (PbS QDs) are very attractive as NIR-active semiconductors for the fabrication of cost-efficient optoelectronic devices. To control the thin film carrier transport, as well as stability, surface passivation is of crucial importance. Here, we present the successful surface passivation of PbS QDs by the fo...

Laminated polymer-steel composites are promising layered materials for practical applications in the automotive industry considering their superior crush resistance capacity in terms of enhanced damping potential. In this research, the sheet lamination (SL) route of friction stir additive manufacturing (FTAM) technology was implemented for the prod...

For the rapid detection of hyperglycemia in human blood, we adopted a facile and two-step electrochemical procedure to prepare nickel/reduced graphene oxide (rGO) hybrid electrodes in the framework of a three-dimensional (3D) nanostructure. High-density and vertically-aligned nickel submicrorods with an average diameter of 155 ± 15 nm and a length...

In the last decade, the friction stir welding of polymers has been increasingly investigated by the means of more and more sophisticated approaches. Since the early studies, which were aimed at proving the feasibility of the process for polymers and identifying suitable processing windows, great improvements have been achieved. This owes to the inc...

Ligand-assisted reprecipitation (LARP) method with 3-Aminopropyl triethoxysilane (APTES) ligand was employed to prepare core/shell formamidinium lead iodide (FAPbI3)/SiO2 quantum dots (QDs) in room temperature. The successful synthesis of spherical core/shell QDs with an average size of 65 5.1  nm is demonstrated by field emission secondary electr...

Hydrogen evolution through photoelectrochemical (PEC) water splitting by tungsten oxide-based photoanodes, as a stable and environmental-friendly material with moderate band gap, has attracted significant interest in recent years. The performance of WO3 photoanode could be hindered by its poor oxygen evolution reaction kinetics and high charge carr...

Underwater dissimilar friction stir welding of an Al-Mg alloy (AA5005) and low carbon steel (ASTM A283) in butt joint configuration was studied. The effect of submerged temperature at three levels of 273, 298 and 333 K on the mechanical and metallurgical properties of the joints was investigated. An improvement in the properties of the submerged di...

We present enhanced electrocatalytic activity of three-dimensional graphene scaffolds by decoration with one-dimensional CoxNi1-x MOF nanostructures (0≤x≤1). Decreased overpotential and fast kinetics of oxygen evolution reaction as compared with existing...

Activated carbon (AC) is an inert adsorbent material that has widely been used in water treatment or removing of environmental pollutants from water. In order to improve the adsorption of AC, which highly depends on its pore size and surface area, we prepared highly porous adsorbent composites of activated carbon (AC)/chromium-based MOF (MIL-101(Cr...

The emergence of textile-based wearable sensors as light-weight portable devices to monitor desired parameters, has recently gained much interest and has led to the development of flexible electronics on non-rigid substrates. The flexible biosensors may result in improved sports performance, to monitor the desired bodies for injuries, improved clin...

In this research, the ZnOG hybrid thin film was produced via solgel method. The surface morphology, band gap and photoactive properties of the films were studied by means of SEM, UV–Vis and photoluminescence analysis. In addition, the ability of the thin film in photocathodic protection of carbon steel (CS) and 304 stainless steel in 3.5 wt.% NaCl...